• 2023
    • Cimen, I., Natarelli, L., Abedi Kichi, Z., Henderson, J. M., Farina, F. M., Briem, E., Aslani, M., Megens, R. T. A., Jansen, Y., Mann-Fallenbuchel, E., Gencer, S., Duchêne, J., Nazari-Jahantigh, M., van der Vorst, E. P. C., Enard, W., Döring, Y., Schober, A., Santovito, D., & Weber, C. (2023). Targeting a cell-specific microRNA repressor of CXCR4 ameliorates atherosclerosis in mice. Science translational medicine, 15(720), Article eadf3357. https://doi.org/10.1126/scitranslmed.adf3357
    • Kassem, M., Crombag, G. A. J. C., Stegers, J., Liem, M. I., Koornstra, E., Schreuder, F. H. B. M., van Dam-Nolen, D. H. K., Lucci, C., van der Geest, R. J., Daemen, M. J., van der Steen, A. F. W., Hendrikse, J., Mess, W. H., Bos, D., Wildberger, J. E., van Oostenbruggeb, R. J., Nederkoorn, P. J., & Kooi, M. E. (2023). The association between antiplatelet therapy and changes in intraplaque hemorrhage in patients with mild to moderate symptomatic carotid stenosis: a longitudinal MRI study. Cerebrovascular Diseases. Advance online publication. https://doi.org/10.1159/000535274
    • Ren, Z., Bosma, H., Wesselius, A., Eussen, S. J. P. M., Kooi, M. E., van der Kallen, C. J. H., Koster, A., van Greevenbroek, M. M. J., Dagnelie, P., Stehouwer, C. D. A., & Brouwers, M. C. G. J. (2023). Traditional lifestyle factors partly mediate the association of socioeconomic position with intrahepatic lipid content: The Maastricht study. JHEP Reports, 5(11), Article 100855. https://doi.org/10.1016/j.jhepr.2023.100855
    • Kassem, M., de Kam, S. S., van Velzen, T. J., van der Geest, R., Wagner, B., Sokolska, M., Pizzini, F. B., Nederkoorn, P. J., Rolf Jäger, H., Brown, M. M., van Oostenbrugge, R. J., Bonati, L. H., & Eline Kooi, M. (2023). Application of mask images of contrast-enhanced MR angiography to detect carotid intraplaque hemorrhage in patients with moderate to severe symptomatic and asymptomatic carotid stenosis. European Journal of Radiology, 168(1), Article 111145. https://doi.org/10.1016/j.ejrad.2023.111145
    • Goertzen, L., Schils, T., & Heeneman, S. (2023). Co-designing formative assessment practices: A collaboration between elementary school teachers and researchers to conceptualize and implement formative assessment as a unified practice. Teaching and Teacher Education, 134, Article 104306. https://doi.org/10.1016/j.tate.2023.104306
    • Konduri, P., Cavalcante, F., van Voorst, H., Rinkel, L., Kappelhof, M., van Kranendonk, K., Treurniet, K., Emmer, B., Coutinho, J., Wolff, L., Hofmeijer, J., Uyttenboogaart, M., van Zwam, W., Roos, Y., Majoie, C., Marquering, H., & MR CLEAN-NO IV Investigators (2023). Role of intravenous alteplase on late lesion growth and clinical outcome after stroke treatment. Journal of Cerebral Blood Flow and Metabolism, 43(2_SUPPL), 116-125. https://doi.org/10.1177/0271678X231167755
    • Lu, C., Donners, M. M. P. C., Karel, J., de Boer, H., van Zonneveld, A. J., den Ruijter, H., Jukema, J. W., Kraaijeveld, A., Kuiper, J., Pasterkamp, G., Cavill, R., Perales-Patón, J., Ferrannini, E., Goossens, P., & Biessen, E. A. L. (2023). Sex-specific differences in cytokine signaling pathways in circulating monocytes of cardiovascular disease patients. Atherosclerosis, 384, Article 117123. https://doi.org/10.1016/j.atherosclerosis.2023.04.005
    • McDermott, M. C., Hendriks, B. M. F., Wildberger, J. E., & de Boer, S. W. (2023). Shaken or Stirred? The Inconsistencies of Manual Contrast Media Dilution in Endovascular Interventions. Investigative Radiology, 58(11), 811-815. https://doi.org/10.1097/RLI.0000000000000994
    • Bianchini, M., Moeller-Ramon, Z., Weber, C., Megens, R., & Duchene, J. (2023). Short-term western diet causes rapid and lasting alterations of bone marrow physiology. Thrombosis and Haemostasis, 123(11), 1100-1104. https://doi.org/10.1055/a-2149-4431
    • Sarad, K., Stefanska, M., Kraszewska, I., Szade, K., Sluimer, J. C., Blyszczuk, P., Dulak, J., & Jazwa-Kusior, A. (2023). Single-cell transcriptomics reveals subtype-specific molecular profiles in Nrf2-deficient macrophages from murine atherosclerotic aortas. Frontiers in Immunology, 14, Article 1249379. https://doi.org/10.3389/fimmu.2023.1249379
    • Berends, E., van Oostenbrugge, R. J., Foulquier, S., & Schalkwijk, C. G. (2023). Methylglyoxal, a highly reactive dicarbonyl compound, as a threat for blood brain barrier integrity. Fluids and barriers of the CNS, 20(1), Article 75. https://doi.org/10.1186/s12987-023-00477-6
    • Nagenborg, J., Jin, H., Ruder, A. V., Temmerman, L., Mees, B., Schalkwijk, C., Müller-Klieser, D., Berg, T., Goossens, P., Donners, M. M. P. C., & Biessen, E. A. L. (2023). GM-CSF-activated STAT5A regulates macrophage functions and inflammation in atherosclerosis. Frontiers in Immunology, 14, Article 1165306. https://doi.org/10.3389/fimmu.2023.1165306
    • Pekayvaz, K., Gold, C., Hoseinpour, P., Engel, A., Martinez-Navarro, A., Eivers, L., Coletti, R., Joppich, M., Dionísio, F., Kaiser, R., Tomas, L., Janjic, A., Knott, M., Mehari, F., Polewka, V., Kirschner, M., Boda, A., Nicolai, L., Schulz, H., ... Stark, K. (2023). Mural cell-derived chemokines provide a protective niche to safeguard vascular macrophages and limit chronic inflammation. Immunity, 56(10), 2325-2341.e15. https://doi.org/10.1016/j.immuni.2023.08.002
    • Dippel, D. W. J., Majoie, C. B. L. M., & van Zwam, W. H. (2023). Acute endovasculaire trombectomie bij herseninfarct. Nederlands Tijdschrift voor Geneeskunde, 167(1), Article D7733. https://www.ntvg.nl/artikelen/acute-endovasculaire-trombectomie-bij-herseninfarct
    • Elschot, E. P., Backes, W. H., de Jong, J. J. A., Drenthen, G. S., Wong, S. M., Staals, J., Postma, A. A., Rouhl, R. P. W., van Oostenbrugge, R. J., & Jansen, J. F. A. (2023). Assessment of the clinical feasibility of detecting subtle blood-brain barrier leakage in cerebral small vessel disease using dynamic susceptibility contrast MRI. Magnetic Resonance Imaging, 102(1), 55-61. https://doi.org/10.1016/j.mri.2023.04.004
    • van Lanen, R. H. G. J., Haeren, R. H. L., Staals, J., Dings, J. T. A., Schijns, O. E. M. G., Hoogland, G., van Kuijk, S. M. J., Kapsokalyvas, D., van Zandvoort, M. A. M. J., Vink, H., Rijkers, K., & ACE Epilepsy Surgery Group (2023). Cerebrovascular glycocalyx damage and microcirculation impairment in patients with temporal lobe epilepsy. Journal of Cerebral Blood Flow and Metabolism, 43(10), 1737-1751. https://doi.org/10.1177/0271678X231179413
    • Giudici, A., van der Laan, K. W. F., van der Bruggen, M. M., Parikh, S., Berends, E., Foulquier, S., Delhaas, T., Reesink, K. D., & Spronck, B. (2023). Constituent-based quasi-linear viscoelasticity: a revised quasi-linear modelling framework to capture nonlinear viscoelasticity in arteries. Biomechanics and modeling in mechanobiology, 22(5), 1607–1623. https://doi.org/10.1007/s10237-023-01711-8
    • Voorter, P. H. M., Backes, W. H., Gurney-Champion, O. J., Wong, S.-M., Staals, J., van Oostenbrugge, R. J., van Der Thiel, M. M., Jansen, J. F. A., & Drenthen, G. S. (2023). Improving microstructural integrity, interstitial fluid, and blood microcirculation images from multi-b-value diffusion MRI using physics-informed neural networks in cerebrovascular disease. Magnetic Resonance in Medicine, 90(4), 1657 - 1671. https://doi.org/10.1002/mrm.29753
    • de Wit-Verheggen, V. H. W., Vanweert, F., Raiko, J., Liénard, V., Schaart, G., Gemmink, A., Nascimento, E. B. M., Hesselink, M. K. C., Wildberger, J. E., Wierts, R., Joris, P. J., Haas, J., Montaigne, D., Staels, B., Phielix, E., Schrauwen, P., Schrauwen-Hinderling, V. B., & van de Weijer, T. (2023). The tissue-specific metabolic effects of the PPARa agonist ciprofibrate in insulin-resistant male individuals: a double-blind, randomized, placebo-controlled crossover study. Obesity, 31(10), 2493-2504. https://doi.org/10.1002/oby.23874
    • van der Steen, W., van der Ende, N. A. M., Luijten, S. P. R., Rinkel, L. A., van Kranendonk, K. R., van Voorst, H., Roosendaal, S. D., Beenen, L. F. M., Coutinho, J. M., Emmer, B. J., van Oostenbrugge, R. J., Majoie, C. B. L. M., Lingsma, H. F., van der Lugt, A., Dippel, D. W. J., Roozenbeek, B., MR CLEAN-NO IV Investigators, MR CLEAN-MED investigators, & CONTRAST Investigators (2023). Type of intracranial hemorrhage after endovascular stroke treatment: association with functional outcome. Journal of Neurointerventional Surgery, 15(10), 971-976. https://doi.org/10.1136/jnis-2022-019474
    • van der Weijden, J., De Hoogt, P. A., Leufkens, M. M. E., Keijbeck, A. A., van Goor, H., van den Heuvel, M. C., Cleutjens, J. P. M., Moers, C., Snoeijs, M. G., Navis, G. J., van Londen, M., Nolte, I. M., Berger, S. P., De Borst, M. H., & Peutz-Kootstra, C. J. (2023). The relationship of peritubular capillary density with glomerular volume and kidney function in living kidney donors. Journal of Nephrology, 36(7), 2111-2124. https://doi.org/10.1007/s40620-023-01734-5
    • Ruder, A., Wetzels, S. M. W., Temmerman, L., Biessen, E. A. L., & Goossens, P. (2023). Monocyte heterogeneity in cardiovascular disease. Cardiovascular Research, 119(11), 2033-2045. https://doi.org/10.1093/cvr/cvad069
    • Jeukens, C. R. L. P. N., Brauer, M. T. H., Mihl, C., Laupman, E., Nijssen, E. C., Wildberger, J. E., Martens, B., & van Pul, C. (2023). A New Algorithm for Automatically Calculating Noise, Spatial Resolution, and Contrast Image Quality Metrics: Proof-of-Concept and Agreement With Subjective Scores in Phantom and Clinical Abdominal CT. Investigative Radiology, 58(9), 649-655. https://doi.org/10.1097/RLI.0000000000000954
    • Kerstens, T. P., Weerts, J., van Dijk, A. P. J., Weijers, G., Knackstedt, C., Eijsvogels, T. M. H., Oxborough, D., van Empel, V. P. M., & Thijssen, D. H. J. (2023). Association of left ventricular strain-volume loop characteristics with adverse events in patients with heart failure with preserved ejection fraction. European Heart Journal Cardiovascular Imaging, 24(9), 1168-1176. https://doi.org/10.1093/ehjci/jead117
    • Raafs, A. G., Adriaans, B. P., Henkens, M. T. H. M., Verdonschot, J. A. J., Abdul Hamid, M. A., Díez, J., Knackstedt, C., van Empel, V. P. M., Brunner-La Rocca, H. P., González, A., Wildberger, J. E., Heymans, S. R. B., & Hazebroek, M. R. (2023). Biomarkers of Collagen Metabolism Are Associated with Left Ventricular Function and Prognosis in Dilated Cardiomyopathy: A Multi-Modal Study. Journal of Clinical Medicine, 12(17), Article 5695. https://doi.org/10.3390/jcm12175695
    • Canto, E. D., van Deursen, L., Hoek, A. G., Elders, P. J. M., den Ruijter, H. M., van der Velden, J., van Empel, V., Serné, E. H., Eringa, E. C., & Beulens, J. W. J. (2023). Microvascular endothelial dysfunction in skin is associated with higher risk of heart failure with preserved ejection fraction in women with type 2 diabetes: the Hoorn Diabetes Care System Cohort. Cardiovascular Diabetology, 22(1), Article 234. https://doi.org/10.1186/s12933-023-01935-z
    • Alers, R.-J., Ghossein-Doha, C., Canjels, L. P. W., Muijtjens, E. S. H., Brandt, Y., Kooi, M. E., Gerretsen, S. C., Jansen, J. F. A., Backes, W. H., Hurks, P. P. M., van de Ven, V., & Spaanderman, M. E. A. (2023). Attenuated cognitive functioning decades after preeclampsia. American Journal of Obstetrics and Gynecology, 229(3), 294.e1-294.e14. https://doi.org/10.1016/j.ajog.2023.02.020
    • Rudilosso, S., Stringer, M. S., Thrippleton, M., Chappell, F., Blair, G. W., Garcia, D. J., Doubal, F., Hamilton, I., Janssen, E., Kopczak, A., Ingrisch, M., Kerkhofs, D., Backes, W. H., Staals, J., Duering, M., Dichgans, M., Wardlaw, J. M., & SVDs@Target Investigators (2023). Blood-brain barrier leakage hotspots collocating with brain lesions due to sporadic and monogenic small vessel disease. Journal of Cerebral Blood Flow and Metabolism, 43(9), 1490-1502. https://doi.org/10.1177/0271678X231173444
    • Huijberts, I., Pinckaers, F. M. E., van Zwam, W. H., Boogaarts, H. D., van Oostenbrugge, R. J., & Postma, A. A. (2023). Cerebral Arterial Air Emboli on Immediate Post-Endovascular Treatment CT are Associated with Poor Short- and Long-Term Clinical Outcomes in Acute Ischemic Stroke Patients. Journal of Neuroradiology, 50(5), 530-536. https://doi.org/10.1016/j.neurad.2023.06.001
    • Schaper, F. L. W. V. J., Nordberg, J., Cohen, A. L., Lin, C., Hsu, J., Horn, A., Ferguson, M. A., Siddiqi, S. H., Drew, W., Soussand, L., Winkler, A. M., Simo, M., Bruna, J., Rheims, S., Guenot, M., Bucci, M., Nummenmaa, L., Staals, J., Colon, A. J., ... Fox, M. D. (2023). Mapping Lesion-Related Epilepsy to a Human Brain Network. JAMA Neurology, 80(9), 891-902. https://doi.org/10.1001/jamaneurol.2023.1988
    • Exalto, L. G., Weaver, N. A., Kuijf, H. J., Aben, H. P., Bae, H.-J., Best, J. G., Bordet, R., Chen, C. P. L. H., van der Giessen, R. S., Godefroy, O., Gyanwali, B., Hamilton, O. K. L., Hilal, S., Huenges Wajer, I. M. C., Kim, J., Kappelle, L. J., Kim, B. J., Köhler, S., de Kort, P. L. M., ... Biessels, G. J. (2023). Sex Differences in Poststroke Cognitive Impairment: A Multicenter Study in 2343 Patients With Acute Ischemic Stroke. Stroke, 54(9), 2296-2303. https://doi.org/10.1161/STROKEAHA.123.042507
    • Wagner, J. U. G., Tombor, L. S., Malacarne, P. F., Kettenhausen, L. M., Panthel, J., Kujundzic, H., Manickam, N., Schmitz, K., Cipca, M., Stilz, K. A., Fischer, A., Muhly-Reinholz, M., Abplanalp, W. T., John, D., Mohanta, S. K., Weber, C., Habenicht, A. J. R., Buchmann, G. K., Angendohr, S., ... Dimmeler, S. (2023). Aging impairs the neurovascular interface in the heart. Science, 381(6660), 897-906. https://doi.org/10.1126/science.ade4961
    • Kassem, M., Nies, K. P. H., Boswijk, E., van der Pol, J., Aizaz, M., Gijbels, M. J. J., Li, D., Bucerius, J., Mess, W. H., Wildberger, J. E., van Oostenbrugge, R. J., Moonen, R. P. M., Fan, Z., & Kooi, M. E. (2023). Quantification of carotid plaque composition with a multi-contrast atherosclerosis characterization (MATCH) MRI sequence. Frontiers in Cardiovascular Medicine, 10, Article 1227495. https://doi.org/10.3389/fcvm.2023.1227495
    • Sachs, S., Götz, A., Finan, B., Feuchtinger, A., DiMarchi, R. D., Döring, Y., Weber, C., Tschöp, M. H., Müller, T. D., & Hofmann, S. M. (2023). GIP receptor agonism improves dyslipidemia and atherosclerosis independently of body weight loss in preclinical mouse model for cardio-metabolic disease. Cardiovascular Diabetology, 22(1), Article 217. https://doi.org/10.1186/s12933-023-01940-2
    • Jung, S. A., Malyaran, H., Demco, D. E., Manukanc, A., Häser, L. S., Kucikas, V., van Zandvoort, M., Neuss, S., & Pich, A. (2023). Fibrin-Dextran Hydrogels with Tunable Porosity and Mechanical Properties. Biomacromolecules, 24(9), 3972-3984. https://doi.org/10.1021/acs.biomac.3c00269
    • Manukjan, N., Majcher, D., Leenders, P., Caiment, F., van Herwijnen, M., Smeets, H. J. J., Suidgeest, E., van der Weerd, L., Vanmierlo, T., Jansen, J. F. A., Backes, W. H. H., van Oostenbrugge, R. J. J., Staals, J., Fulton, D., Ahmed, Z., Blankesteijn, W. M., & Foulquier, S. (2023). Hypoxic oligodendrocyte precursor cell-derived VEGFA is associated with blood-brain barrier impairment. Acta neuropathologica communications, 11(1), Article 128. https://doi.org/10.1186/s40478-023-01627-5
    • Maas, S., Jin, H., Lu, C., Nagenborg, J., Manca, M., Karel, J., Cavill, R., Sikkink, C., Yu, B., Nadeau, S., Dos Santos, J., Gijbels, M., Mees, B., Smirnov, E., Sluimer, J., Martins, G., Van der Vorst, E., & Biessen, E. (2023). Identification Of A Prdm1-Regulated T-Cell Network Which Controls T-Cell Driven Plaque Inflammation In Human And Mouse Atherosclerosis. Atherosclerosis, 379(S1), S11-S11. https://doi.org/10.1016/j.atherosclerosis.2023.06.914
    • Weber, C., Habenicht, A. J. R., & von Hundelshausen, P. (2023). Novel mechanisms and therapeutic targets in atherosclerosis: inflammation and beyond. European Heart Journal, 44(29), 2672-2681. https://doi.org/10.1093/eurheartj/ehad304
    • Ganizada, B. H., Reesink, K. D., Parikh, S., Ramaekers, M. J. F. G., Akbulut, A. C., Saraber, P. J. M. H., Debeij, G. P., Jaminon, A. M., Natour, E., Lorusso, R., Wildberger, J. E., Mees, B., Schurink, G. W., Jacobs, M. J., Cleutjens, J., Krapels, I., Gombert, A., Maessen, J. G., Accord, R., ... MUMC TAA Student Team (2023). The Maastricht Acquisition Platform for Studying Mechanisms of Cell-Matrix Crosstalk (MAPEX): An Interdisciplinary and Systems Approach towards Understanding Thoracic Aortic Disease. Biomedicines, 11(8), Article 2095. https://doi.org/10.3390/biomedicines11082095
    • You, W., Zhou, T., Knoops, K., Berendschot, T. T. J. M., van Zandvoort, M. A. M. J., Germeraad, W. T. V., Benedikter, B., Webers, C. A. B., Reutelingsperger, C. P. M., & Gorgels, T. G. M. F. (2023). Stressed neuronal cells can recover from profound membrane blebbing, nuclear condensation and mitochondrial fragmentation, but not from cytochrome c release. Scientific Reports, 13(1), Article 11045. https://doi.org/10.1038/s41598-023-38210-w
    • van Kuijk, K., McCracken, I. R., Tillie, R. J. H. A., Asselberghs, S. E. J., Kheder, D. A., Muitjens, S., Jin, H., Taylor, R. S., Schreur, R. W., Kuppe, C., Dobie, R., Ramachandran, P., Gijbels, M. J., Temmerman, L., Kirkwoord, P. M., Luyten, J., Li, Y. M., Noels, H., Goossens, P., ... Sluimer, J. C. (2023). Human and murine fibroblast single-cell transcriptomics reveals fibroblast clusters are differentially affected by ageing and serum cholesterol. Cardiovascular Research, 119(7), 1509-1523. https://doi.org/10.1093/cvr/cvad016
    • Ramaekers, M. J. F. G., Westenberg, J. J. M., Adriaans, B. P., Nijssen, E. C., Wildberger, J. E., Lamb, H. J., & Schalla, S. (2023). A clinician's guide to understanding aortic 4D flow MRI. Insights into Imaging, 14(1), Article 114. https://doi.org/10.1186/s13244-023-01458-x
    • Reiche, M. E., Poels, K., Bosmans, L. A., Vos, W. G., Van Tiel, C. M., Gijbels, M. J. J., Aarts, S. A. B. M., Den Toom, M., Beckers, L., Weber, C., Atzler, D., Rensen, P. C. N., Kooijman, S., & Lutgens, E. (2023). Adipocytes control hematopoiesis and inflammation through CD40 signaling. Haematologica-the Hematology Journal, 108(7), 1873-1885. https://doi.org/10.3324/haematol.2022.281482
    • Kerkhofs, D., Helgers, R., Hermes, D., Steinbusch, H. P. J., Van Essen, H., Leenders, P., Prickaerts, J., Staals, J., Biessen, E. A., Van Oostenbrugge, R. J., & Foulquier, S. (2023). Amlodipine limits microglia activation and cognitive dysfunction in aged hypertensive mice. Journal of Hypertension, 41(7), 1159-1167. https://doi.org/10.1097/HJH.0000000000003445
    • Knapen, R. R. M. M., Bernsen, M. L. E., Langezaal, L. C. M., Olthuis, S. G. H., Michel, P., Hofmeijer, J., Vos, J.-A., van Kuijk, S. M. J., Majoie, C. B., Emmer, B. J., Nijeholt, G. J. L. A., Boiten, J., Puetz, V., Gerber, J., Mazighi, M., Pontes-Neto, O. M., Mont'Alverne, F., Yoo, A. J., van Doormaal, P.-J., ... Schonewille, W. J. (2023). Aspiration Versus Stent Retriever Thrombectomy in Basilar-Artery Occlusion; Results From the BASICS Trial. Stroke: vascular and interventional neurology, 3(4), Article e000768. https://doi.org/10.1161/SVIN.122.000768
    • Parikh, S., Moerman, K. M., Ramaekers, M. J. F. G., Schalla, S., Bidar, E., Delhaas, T., Reesink, K., & Huberts, W. (2023). Biomechanical Characterisation of Thoracic Ascending Aorta with Preserved Pre-Stresses. Bioengineering, 10(7), Article 846. https://doi.org/10.3390/bioengineering10070846
    • Canjels, L. P. W., Alers, R. J., van de Ven, V., Hurks, P. P. M., Gerretsen, S. C., Brandt, Y., Kooi, M. E., Jansen, J. F. A., Backes, W. H., Ghossein-Doha, C., & Spaanderman, M. E. A. (2023). Cerebral volume is unaffected after pre-eclampsia. Ultrasound in Obstetrics & Gynecology, 62(1), 115-121. https://doi.org/10.1002/uog.26172
    • Blanchet, X., Weber, C., & von Hundelshausen, P. (2023). Chemokine Heteromers and Their Impact on Cellular Function-A Conceptual Framework. International Journal of Molecular Sciences, 24(13), Article 10925. https://doi.org/10.3390/ijms241310925
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    • Duering, M., Biessels, G. J., Brodtmann, A., Chen, C., Cordonnier, C., de Leeuw, F.-E., Debette, S., Frayne, R., Jouvent, E., Rost, N. S., ter Telgte, A., Salman, R. A.-S., Backes, W. H., Bae, H.-J., Brown, R., Chabriat, H., De Luca, A., deCarli, C., Dewenter, A., ... Et al. (2023). Neuroimaging standards for research into small vessel disease-advances since 2013. Lancet Neurology, 22(7), 602-618. https://doi.org/10.1016/S1474-4422(23)00131-X