Boy Houben

Associate professor

Alfons (Boy) Houben is Associate Professor at the Department of Internal Medicine of Maastricht UMC+. He graduated in Biology at the University of Nijmegen, and received his PhD, in Maastricht in 1993, on early microcirculatory changes in patients with type 1 diabetes. He has longstanding expertise in human (non-invasive) micro- and macrovascular function tests in combination with (pharmacological) interventions, and in the epidemiological setting (The Maastricht Study). Using this unique approach, his main research interest is on the role of microvascular dysfunction in cardiometabolic diseases. An additional focus in his present research is the effects of lifestyle modifications in order to improve microvascular function. He is President of the European Society for Microcirculation, chair of the Dutch Society for Microcirculation and Vascular Biology, and member of several other international scientific societies.

The focus of my research for many years has been microvascular dysfunction (MVD) as both a cause and a consequence of (cardio)metabolic diseases. One important function of the microcirculation is to deliver oxygen/nutrients to all tissues and to remove waste products. In normal metabolism this includes the delivery of glucose, which taken up by the gut following a meal, to skeletal muscle in order to be stored as glycogen. For that, insulin plays an important role by stimulating the endothelium to produce nitric oxide (NO), which leads to recruitment of capillaries in skeletal muscle and thus an increase in exchange surface. As a result, both glucose and insulin can reach skeletal muscle cells quickly and easily in order to store glucose in the cells. In our working hypothesis, we state that MVD may disturb this insulin-mediated glucose delivery/uptake, leading to metabolic insulin resistance and contributing to the development of type 2 diabetes. Within the framework of The Maastricht Study (a population-based cohort study), we perform deep phenotyping of the microcirculation. By using this approach, we are looking for (early) determinants of MVD, and study the role of MVD in the development and progression of various diseases (e.g. (pre)diabetes, heart failure, and depression).

Department of Internal Medicine
P. Debyelaan 25, 6229 HX Maastricht 
PO Box 5800, 6202 AZ Maastricht

  • 2020
    • Geraets, A. F. J., van Agtmaal, M. J. M., Stehouwer, C. D. A., Sörensen, B. M., Berendschot, T. T. J. M., Webers, C. A. B., Schaper, N. C., Henry, R. M. A., van der Kallen, C. J. H., Eussen, S. J. P. M., Koster, A., van Sloten, T. T., Köhler, S., Schram, M. T., & Houben, A. J. H. M. (2020). Association of Markers of Microvascular Dysfunction With Prevalent and Incident Depressive Symptoms: The Maastricht Study. Hypertension, 76(2), 342-349. https://doi.org/10.1161/HYPERTENSIONAHA.120.15260
    • Zhou, T. L., Rensma, S. P., van der Heide, F. C. T., Henry, R. M. A., Kroon, A. A., Houben, A. J. H. M., Jansen, J. F. A., Backes, W. H., Berendschot, T. T. J. M., Schouten, J. S. A. G., van Dongen, M. C. J. M., Eussen, S. J. P. M., Dagnelie, P. C., Webers, C. A. B., Schram, M. T., Schalkwijk, C. G., van Sloten, T. T., & Stehouwer, C. D. A. (2020). Blood pressure variability and microvascular dysfunction: the Maastricht Study. Journal of Hypertension, 38(8), 1541-1550. https://doi.org/10.1097/HJH.0000000000002444
    • Li, W., Schram, M. T., Berendschot, T. T. J. M., Webers, C. A. B., Kroon, A. A., van der Kallen, C. J. H., Henry, R. M. A., Schaper, N. C., Huang, F., Dashtbozorg, B., Tan, T., Zhang, J., Abbasi-Sureshjani, S., Ter Haar Romeny, B. M., Stehouwer, C. D. A., & Houben, A. J. H. M. (2020). Type 2 diabetes and HbA1c are independently associated with wider retinal arterioles: the Maastricht study. Diabetologia, 63(7), 1408-1417. https://doi.org/10.1007/s00125-020-05146-z
    • Rensma, S. P., Stehouwer, C. D. A., Van Boxtel, M. P. J., Houben, A. J. H. M., Berendschot, T. T. J. M., Jansen, J. F. A., Schalkwijk, C. G., Verhey, F. R. J., Kroon, A. A., Henry, R. M. A., Backes, W. H., Dagnelie, P. C., van Dongen, M. C. J. M., Eussen, S. J. P. M., Bosma, H., Köhler, S., Reesink, K. D., Schram, M. T., & van Sloten, T. T. (2020). Associations of Arterial Stiffness With Cognitive Performance, and the Role of Microvascular Dysfunction: The Maastricht Study. Hypertension, 75(6), 1607-1614. https://doi.org/10.1161/HYPERTENSIONAHA.119.14307
    • Sorensen, B. M., van der Heide, F. C. T., Houben, A. J. H. M., Koster, A., Berendschot, T. T. J. M., Schouten, J. S. A. G., Kroon, A. A., van der Kallen, C. J. H., Henry, R. M. A., van Dongen, M. C. J. M., Eussen, S. J. P. M., Savelberg, H. H. C. M., van der Berg, J. D., Schaper, N. C., Schram, M. T., & Stehouwer, C. D. A. (2020). Higher levels of daily physical activity are associated with better skin microvascular function in type 2 diabetes-The Maastricht Study. Microcirculation, 27(4), [12611]. https://doi.org/10.1111/micc.12611
    • Schutten, M. T. J., Kusters, Y. H. A. M., Houben, A. J. H. M., Niessen, H. E., Roodt, J. O., Scheijen, J. L. J. M., van de Waardenburg, M. P., Schalkwijk, C. G., de Leeuw, P. W., & Stehouwer, C. D. A. (2020). Glucocorticoids affect metabolic but not muscle microvascular insulin sensitivity following high versus low salt intake. JCI INSIGHT, 5(6), [127530]. https://doi.org/10.1172/jci.insight.127530
    • Rensma, S. P., van Sloten, T. T., Houben, A. J. H. M., Koehler, S., van Boxtel, M. P. J., Berendschot, T. T. J. M., Jansen, J. F. A., Verhey, F. R. J., Kroon, A. A., Koster, A., Backes, W. H., Schaper, N., Dinant, G-J., Schalkwijk, C. G., Henry, R. M. A., Wolfs, E. M. L., van Heumen, M. J. A., Schram, M. T., & Stehouwer, C. D. A. (2020). Microvascular Dysfunction Is Associated With Worse Cognitive Performance The Maastricht Study. Hypertension, 75(1), 237-245. https://doi.org/10.1161/HYPERTENSIONAHA.119.13023
  • 2019
    • Foreman, Y. D., Brouwers, M. C. G. J., Berendschot, T. T. J. M., van Dongen, M. C. J. M., Eussen, S. J. P. M., van Greevenbroek, M. M. J., Henry, R. M. A., Houben, A. J. H. M., van der Kallen, C. J. H., Kroon, A. A., Reesink, K. D., Schram, M. T., Schaper, N. C., & Stehouwer, C. D. A. (2019). The oral glucose tolerance test-derived incremental glucose peak is associated with greater arterial stiffness and maladaptive arterial remodeling: The Maastricht Study. Cardiovascular Diabetology, 18(1), [152]. https://doi.org/10.1186/s12933-019-0950-x
    • Ginsberg, C., Houben, A. J. H. M., Malhotra, R., Berendschot, T. T. J. M., Dagnelie, P. C., Kooman, J. P., Webers, C. A., Stehouwer, C. D. A., & Ix, J. H. (2019). Serum Phosphate and Microvascular Function in a Population-Based Cohort. Clinical journal of the American Society of Nephrology, 14(11), 1626-1633. https://doi.org/10.2215/CJN.02610319
    • Telgenkamp, I., Kusters, Y. H. A. M., Schalkwijk, C. G., Houben, A. J. H. M., Kooi, M. E., Lindeboom, L., Bons, J. A. P., Schaper, N. C., Joris, P. J., Plat, J., Mensink, R. P., Stehouwer, C. D. A., & Brouwers, M. C. G. J. (2019). Contribution of Liver Fat to Weight Loss-Induced Changes in Serum Hepatokines: A Randomized Controlled Trial. Journal of Clinical Endocrinology & Metabolism, 104(7), 2719-2727. https://doi.org/10.1210/jc.2018-02378