Carine Peutz-Kootstra

Associate professor

Dr Carine Peutz-Kootstra (1967) obtained her MD PhD degree at Leiden University in 1997 on a thesis titled: 'Immunopathology of experimental lupus nephritis'. After her training as pathologist in Utrecht she started working in Maastricht in 2002 with a specific interest in renal, autopsy and immunopathology. In 2003/2004 she did a fellowship in renal pathology in Seattle, WA, USA. She has always combined patient care, research, education and management activities. In pregraduate education she has been involved in the curriculum of 'arts-klinisch onderzoeker' as counselor and in the international track of medicine as block coordinator in 'Diabetes, obesity and Lifestyle'.  She has also been active in the residency programme for pathologists and participated nationally in the introduction of a novel pathology reimbursement system.  

Her research activities are centred around the prevention of chronic kidney disease, and its link with cardiovascular disease. She specifically focusses on the role of microvascular (in-) stability in progression of renal inflammation and fibrosis. In her studies, financed amongst others by the Dutch Kidney Foundation, she implements state-of-the art techniques to unravel pathophysiological pathways in tissue, such as mass spectrometry imaging. She recently embarked on projects to study the role of the kidney in maintaining microvascular stability in other organs, e.g. heart and brain. In her studies she always aims to translate experimental findings to patient care (from bench to bedside), and back.

Department of Pathology
Verheylaan 10, 6229 HX Maastricht
PO Box 616, 6200 MD Maastricht
T: +31(0)43 387 66 20

  • 2021
    • Hoogenboom, L. A., Wolfs, T. G. A. M., Hutten, M. C., Peutz-Kootstra, C. J., & Schreuder, M. F. (2021). Prematurity, perinatal inflammatory stress, and the predisposition to develop chronic kidney disease beyond oligonephropathy. Pediatric Nephrology, 36(7), 1673-1681. https://doi.org/10.1007/s00467-020-04712-2
  • 2020
    • Keijbeck, A., Veenstra, R., Pol, R. A., Konijn, C., Jansen, N., van Goor, H., Hoitsma, A. J., Peutz-Kootstra, C. J., & Moers, C. (2020). The Association Between Macroscopic Arteriosclerosis of the Renal Artery, Microscopic Arteriosclerosis, Organ Discard, and Kidney Transplant Outcome. Transplantation, 104(12), 2567-2574. https://doi.org/10.1097/TP.0000000000003189
  • 2019
    • van Smaalen, T. C., Ellis, S. R., Mascini, N. E., Siegel, T. P., Cillero-Pastor, B., Hillen, L. M., van Heurn, L. W. E., Peutz-Kootstra, C. J., & Heeren, R. M. A. (2019). Rapid Identification of Ischemic Injury in Renal Tissue by Mass-Spectrometry Imaging. Analytical Chemistry, 91(5), 3575-3581. https://doi.org/10.1021/acs.analchem.8b05521
  • 2018
    • Barre, F. P. Y., Claes, B. S. R., Dewez, F., Peutz-Kootstra, C., Munch-Petersen, H. F., Gronbaek, K., Lund, A. H., Heeren, R. M. A., Come, C., & Cillero-Pastor, B. (2018). Specific Lipid and Metabolic Profiles of R-CHOP-Resistant Diffuse Large B-Cell Lymphoma Elucidated by Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging and in Vivo Imaging. Analytical Chemistry, 90(24), 14198-14206. https://doi.org/10.1021/acs.analchem.8b02910
    • van den Hil, L. C. L., Vogels, R. R. M., van Barneveld, K. W. Y., Gijbels, M. J. J., Peutz-Kootstra, C. J., Cleutjens, J. P. M., Schreinemacher, M. H. F., & Bouvy, N. D. (2018). Comparability of histological outcomes in rats and humans in a hernia model. Journal of Surgical Research, 229, 271-276. https://doi.org/10.1016/j.jss.2018.03.019
    • Henatsch, D., Alsulami, S., Duijvestijn, A. M., Cleutjens, J. P., Peutz-Kootstra, C. J., & Stokroos, R. J. (2018). Histopathological and Inflammatory Features of Chronically Discharging Open Mastoid Cavities Secondary Analysis of a Randomized Clinical Trial. JAMA Otolaryngology - Head and Neck Surgery, 144(3), 211-217. https://doi.org/10.1001/jamaoto.2017.2801
  • 2017
    • Pierssens, D. D. C. G., Borgemeester, M. C., van der Heijden, S. J. H., Peutz-Kootstra, C. J., Ruland, A. M., Haesevoets, A. M., Kessler, P. A. W. H., Kremer, B., & Speel, E-J. M. (2017). Chromosome instability in tumor resection margins of primary OSCC is a predictor of local recurrence. Oral Oncology, 66, 14-21. https://doi.org/10.1016/j.oraloncology.2016.12.029
  • 2016
    • Goceroglu, A., Rahmattulla, C., Berden, A. E., Reinders, M. E. J., Wolterbeek, R., Steenbergen, E. J., Hilbrands, L. B., Noorlander, I., Berger, S. P., Peutz-Kootstra, C. J., Christiaans, M., van Dijk, M. C. R. F., de Joode, A. A. E., Goldschmeding, R., van Zuilen, A. D., Harper, L., Little, M. A., Hagen, E. C., Bruijn, J. A., & Bajema, I. M. (2016). The Dutch Transplantation in Vasculitis (DUTRAVAS) Study: Outcome of Renal Transplantation in Antineutrophil Cytoplasmic Antibody-associated Glomerulonephritis. Transplantation, 100(4), 916-924. https://doi.org/10.1097/TP.0000000000000910
    • Hillen, L. M., Kamsteeg, E. J., Schoots, J., Tiebosch, A. T., Speel, E. J., Roemen, G. M., Peutz - Kootstra, C., & Stumpel, C. T. R. M. (2016). Refining the Diagnosis of Congenital Nephrotic Syndrome on Long-term Stored Tissue: c.1097G>A (p.(Arg366His)) WT1 Mutation Causing Denys Drash Syndrome. Fetal and Pediatric Pathology, 35(2), 112-119. https://doi.org/10.3109/15513815.2016.1139018
  • 2015
    • Boor, P., Babickova, J., Steegh, F., Hautvast, P., Martin, I. V., Djudjaj, S., Nakagawa, T., Ehling, J., Gremse, F., Buecher, E., Eriksson, U., van Roeyen, C. R. C., Eitner, F., Lammers, T., Floege, J., Peutz-Kootstra, C. J., & Ostendorf, T. (2015). Role of Platelet-Derived Growth Factor-CC in Capillary Rarefaction in Renal Fibrosis. American Journal of Pathology, 185(8), 2132-2142. https://doi.org/10.1016/j.ajpath.2015.04.022