Casper Schalkwijk


Prof. Casper Schalkwijk studied chemistry at University Utrecht and graduated in biochemistry. At the same university he obtained his PhD in 1992. He did post-graduate training in endothelial cell biology at TNO-PG in Leiden. He was appointed in 1995 as assistant professor and staff member at the Department of Clinical Chemistry at the Vrije Universiteit Medical Cente in Amsterdam and from 2004 as associate professor. He has led the Vascular Unit. He moved to the Department of Internal Medicine at Maastricht University in 2005, where he is heading the Laboratory for Metabolism and Vascular Medicine (~15fte). He was appointed as Professor of Experimental Internal Medicine at the Faculty of Health, Medicine and Life Sciences (FHML) of Maastricht UMC+ in 2011.

His main research themes are obesity, insulin resistance, endothelial function and vascular complications. The importance of endothelial dysfunction for the development of diabetic complications is studied in epidemiological setting with the availability of several cohorts and with experimental ex-vivo -, animal - and cell work. He has led several clinical studies. A major aim of his programme is to deliver specific and sensitive diagnostic biomarkers for the identification of patients developing  type 2 diabetes and to identify patients with high risk of vascular complications. Robust analytical techniques for measurements of biomarkers with multi-array technology and with UPLC-MSMS are available. A second aim of his programme is to obtain insight in the pathophysiology of vascular complications in diabetes. His current studies focus mainly on the importance non-enzymatic glycation for the development of diabetes and diabetic complications. He discovered, as one of the first, the link between AGEs and vascular complications in individuals with and without diabetes. He is an (inter)nationally recognised expert in the field of glycation. His lab is one of the most renowned labs in this field.The work has been supported by several grants and is now granted by the Diabetes Fonds Nederland, EFSD, NWO, ZonMw and NVWA.

Department of Internal Medicine
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: 5.324
T: +31(0)43 388 21 86

  • 2021
    • Hanssen, N. M. J., Teraa, M., Scheijen, J. L. J. M., Van de Waarenburg, M., Gremmels, H., Stehouwer, C. D. A., Verhaar, M. C., & Schalkwijk, C. G. (2021). Plasma Methylglyoxal Levels Are Associated With Amputations and Mortality in Severe Limb Ischemia Patients With and Without Diabetes. Diabetes Care, 44(1), 157-163.
  • 2020
    • Atzeni, I. M., Boersema, J., Pas, H. H., Diercks, G. F. H., Scheijen, J. L. J. M., Schalkwijk, C. G., Mulder, D. J., van der Zee, P., & Smit, A. J. (2020). Is skin autofluorescence (SAF) representative of dermal advanced glycation endproducts (AGEs) in dark skin? A pilot study. Heliyon, 6(11), [05364].
    • Geraets, A. F. J., Kohler, S., Muzambi, R., Schalkwijk, C. G., Oenema, A., Eussen, S. J. P. M., Dagnelie, P. C., Stehouwer, C. D. A., Schaper, N. C., Henry, R. M. A., van der Kallen, C. J. H., Wesselius, A., Koster, A., Verhey, F. R. J., & Schram, M. T. (2020). The association of hyperglycaemia and insulin resistance with incident depressive symptoms over 4 years of follow-up: The Maastricht Study. Diabetologia, 63(11), 2315-2328.
    • Buziau, A. M., Scheijen, J. L. J. M., Stehouwer, C. D. A., Simons, N., Brouwers, M. C. G. J., & Schalkwijk, C. G. (2020). Development and validation of a UPLC-MS/MS method to quantify fructose in serum and urine. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1155, [122299].
    • Martens, R. J. H., Broers, N. J. H., Canaud, B., Christiaans, M. H. L., Cornelis, T., Gauly, A., Hermans, M. M. H., Konings, C. J. A. M., van der Sande, F. M., Scheijen, J. L. J. M., Stifft, F., Kooman, J. P., & Schalkwijk, C. G. (2020). Advanced glycation endproducts and dicarbonyls in end-stage renal disease: associations with uraemia and courses following renal replacement therapy. Clinical Kidney Journal, 13(5), 855-866.
    • Cordova, R., Knaze, Viallon, V., Rust, P., Schalkwijk, C. G., Weiderpass, E., Wagner, K-H., Mayen-Chacon, A-L., Aglago, E. K., Dahm, C. C., Overvad, K., Tjonneland, A., Halkjaer, J., Mancini, F. R., Boutron-Ruault, M-C., Fagherazzi, G., Katzke, Kuehn, T., Schulze, M. B., ... Freisling, H. (2020). Dietary intake of advanced glycation end products (AGEs) and changes in body weight in European adults. European Journal of Nutrition, 59(7), 2893-2904.
    • Joris, P. J., Plat, J., Kusters, Y. H. A. M., Houben, A. J. H. M., Stehouwer, C. D. A., Schalkwijk, C. G., & Mensink, R. P. (2020). Effects of diet-induced weight loss on postprandial vascular function after consumption of a mixed meal: Results of a randomized controlled trial with abdominally obese men. Clinical Nutrition, 39(10), 2998-3004.
    • Wouters, K., Kusters, Y. H. A. M., Bijnen, M., Wetzels, S., Zhang, X., Linssen, P. B. C., Gaens, K., Houben, A. J. H. M., Joris, P. J., Plat, J., Kooi, M. E., van der Kallen, C. J. H., Mensink, R. P., Verboven, K., Jocken, J., Hansen, D., Blaak, E. E., Ehlers, F. A. I., Wieten, L., ... Schalkwijk, C. G. (2020). NK cells in human visceral adipose tissue contribute to obesity-associated insulin resistance through low-grade inflammation. Clinical and Translational Medicine, 10(6), [192].
    • Hanssen, N. M. J., Kraakman, M. J., Flynn, M. C., Nagareddy, P. R., Schalkwijk, C. G., & Murphy, A. J. (2020). Postprandial Glucose Spikes, an Important Contributor to Cardiovascular Disease in Diabetes?Frontiers in cardiovascular medicine, 7, [570553].
    • Hammerschlag, A. R., Byrne, E. M., Bartels, M., Wray, N. R., Middeldorp, C. M., eQTLgen Consortium, Stehouwer, C., BIOS Consortium, Isaacs, A., van der Kallen, C., & Schalkwijk, C. (2020). Refining Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder Genetic Loci by Integrating Summary Data From Genome-wide Association, Gene Expression, and DNA Methylation Studies. Biological Psychiatry, 88(6), 470-479.