Chris Reutelingsperger


Prof. Chris Reutelingsperger studied Biochemistry at the University of Utrecht. As a PhD student, he discovered and patented the anticoagulant annexin A5 (VAscular Anticoagulant) and defended the thesis 'Vascular anticoagulant, a novel anticoagulant mechanism' at Maastricht University in 1987. He was awarded the five-year Senior Fellowship of the Royal Dutch Academy of Sciences (KNAW) and spent part of his post-doc time at the Boehringer Ingelheim Institute für Arzneimittelforschung in Vienna, to work on elucidating the genetic code of annexin A5.

In 1994, he discovered and patented the power of annexin A5 to detect apoptotic cells. In 1992, he received a tenure track at the Department of Biochemistry of Maastricht University, resulting in a tenured position as Associate Professor in 1997. In 2009, he was appointed Professor of Biochemistry of Apoptosis at Maastricht University. He (co-)authored over 200 peer reviewed papers (H-index 68, source Scholar Google). He is (co-)inventor of 12 granted patents and CSO of PharmaTarget, a biotech company which he co-founded in 2006. He was President of the 8th International Conference on Annexins in 2015. Currently, he chairs the Scientific Advisory Board of Matisse Pharmaceuticals (Netherlands), a biotech company developing therapeutic drugs to treat sepsis.

Chris Reutelingsperger's research activities address molecular and cellular mechanisms of vascular remodeling, vasculitis, atherosclerosis and vascular calcification. His interests focus on vascular calcification, cell death programs, phagocytosis, complement, vitamin K-dependent proteins and annexins, with emphasis on annexins A1 and A5. His major experimental approach utilises in vitrocell biology an in-house developed integrated in vitro assay platform (The BioHybrid, 'organ on-a-chip') covering all major vascular cell types and processes in the pathophysiology of vascular diseases. His strategy encompasses linking basic research to clinical application by establishing collaborations with clinical research and with industry.

Department of Biochemistry
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: H4.354
T: +31(0)43 388 16 74

  • 2023
    • Huckriede, J. B., Beurskens, D. M. H., Wildhagen, K. C. C. A., Reutelingsperger, C. P. M., Wichapong, K., & Nicolaes, G. A. F. (2023). Design and characterization of novel activated protein C variants for the proteolysis of cytotoxic extracellular histone H3. Journal of Thrombosis and Haemostasis, 21(12), 3557-3567.
    • Sun, S., Campello, E., Zou, J., Konings, J., Huskens, D., Wan, J., Fernández, D. I., Reutelingsperger, C., Ten Cate, H., Toffanin, S., Bulato, C., de Groot, P. G., de Laat, B., Simioni, P., Heemskerk, J. W. M., & Roest, M. (2023). Crucial roles of red blood cells and platelets in whole blood thrombin generation. Blood advances, 7(21), 6717-6731.
    • You, W., Zhou, T., Knoops, K., Berendschot, T. T. J. M., van Zandvoort, M. A. M. J., Germeraad, W. T. V., Benedikter, B., Webers, C. A. B., Reutelingsperger, C. P. M., & Gorgels, T. G. M. F. (2023). Stressed neuronal cells can recover from profound membrane blebbing, nuclear condensation and mitochondrial fragmentation, but not from cytochrome c release. Scientific Reports, 13(1), Article 11045.
    • Aendekerk, J. P., Ysermans, R., Busch, M. H., Theunissen, R. O. M. F. I. H., Bijnens, N., Potjewijd, J., Damoiseaux, J. G. M. C., Reutelingsperger, C. P., & van Paassen, P. (2023). Assessment of longitudinal serum neutrophil extracellular trap-inducing activity in anti-neutrophil cytoplasmic antibody-associated vasculitis and glomerulonephritis in a prospective cohort using a novel bio-impedance technique. Kidney International, 104(1), 151-162.
    • Busch, M. H., Timmermans, S. A. M. E. G., Van Kuijk, S. M. J., Aendekerk, J. P., Ysermans, R., Van Doorn, D. P. C., Potjewijd, J., Van de Poll, M. C. G., Van der Horst, I. C. C., Damoiseaux, J. G. M. C., Spronk, H. M. H., Cate, H. T., Reutelingsperger, C. P., Nagy, M., & Van Paassen, P. (2023). Thrombin formation via the intrinsic coagulation pathway and von Willebrand factor reflect disease severity in COVID-19. Haematologica-the Hematology Journal, 108(5), 1417-1422.
    • Park, H. Y., van Bruggen, V. L. E., Peutz-Kootstra, C. J., Ophelders, D. R. M. G., Jellema, R. K., Reutelingsperger, C. P. M., Rutten, B. P. F., & Wolfs, T. G. A. M. (2023). Time Dependent Changes in the Ovine Neurovascular Unit; A Potential Neuroprotective Role of Annexin A1 in Neonatal Hypoxic-Ischemic Encephalopathy. International Journal of Molecular Sciences, 24(6), Article 5929.
    • de Vries, F., Huckriede, J., Wichapong, K., Reutelingsperger, C., & Nicolaes, G. A. F. (2023). The role of extracellular histones in COVID-19. Journal of Internal Medicine, 293(3), 275-292.
    • Pavlic, A., Poelman, H., Wasilewski, G., Wichapong, K., Lux, P., Maassen, C., Lutgens, E., Schurgers, L. J., Reutelingsperger, C. P., & Nicolaes, G. A. F. (2023). Inhibition of Neutral Sphingomyelinase 2 by Novel Small Molecule Inhibitors Results in Decreased Release of Extracellular Vesicles by Vascular Smooth Muscle Cells and Attenuated Calcification. International Journal of Molecular Sciences, 24(3), Article 2027.
    • Sandri, S., Hebeda, C. B., Broering, M. F., Silva, M. D., Moredo, L. F., Silva, M. J. D. E., Molina, A. S., Pinto, C. A. L., Neto, J. P. D., Reutelingsperger, C. P., Gil, C. D., & Farsky, S. H. P. (2023). Role of Annexin A1 Secreted by Neutrophils in Melanoma Metastasis. Cells, 12(3), Article 425.
    • van Smaalen, T. C., Beurskens, D. M. H., Kox, J. J. H. F. M., Polonia, R., Vos, R., Duimel, H., van de Wetering, W. J., Lopez-Iglesias, C., Reutelingsperger, C. P., van Heurn, L. W. E., Peutz-Kootstra, C. J., & Nicolaes, G. A. F. (2023). Extracellular histone release by renal cells after warm and cold ischemic kidney injury: Studies in an ex-vivo porcine kidney perfusion model. PLOS ONE, 18(1), Article e0279944.