Coen Stehouwer

Professor

Prof. Coen Stehouwer (born Rotterdam, 1960) obtained an MD at the Erasmus University in Rotterdam (1985; cum laude). He was registered as internist in 1990 and obtained a PhD in 1992 (Vrije Universiteit Medical Centre, Amsterdam). He received postgraduate training in epidemiology and molecular biology. He was appointed professor of medicine and vice-chair of the Department of Medicine in 2000 at the Vrije Universiteit in Amsterdam). In 2004, he accepted a position as professor of medicine and chair of the Department of Medicine at the University of Maastricht. Coen Stehouwer currently is Professor of Internal Medicine and Chair of the Department of Internal Medicine at Maastricht University in the Netherlands.

He is an internationally recognised clinician-scientist in the field of microcirculatory as well as large artery research, notably in the context of cardiovascular complications of diabetes and the metabolic syndrome. Since 1990, the work of Professor Stehouwer and his group has led to 77 completed PhD theses, and more than 800 peer-reviewed papers in international journals.

His work is well-recognised, as shown by a Hirsh index of 109 (Web of Science); >52,000 citations; several awards, such as the Dr F. Gerritzen Award for excellent diabetes research (Dutch Diabetes Research Foundation, 1993); the Castelli-Pedroli Award for excellent research into the complications of diabetes (European Association for the Study of Diabetes, 2005); the Dutch Society of Vascular Medicine Career Award (2007); the Ruitenga Van Swieten honorary professorship of the University of Amsterdam (2009); and the Donald McDonald Award of Artery Society (2017); as well as many invited lectures at (inter)national meetings, such as those of the European Society for Microcirculation, the World Congress for Microcirculation, the European Society for the Study of Diabetes, the American Diabetes Association, the European Society for Cardiology, and the American Heart Association.

His research programme focuses on the elucidation of how metabolic changes in (pre)diabetes and the metabolic syndrome cause micro- and macrovascular disease. A key element of the programme is to combine epidemiology, clinical physiology and experimental approaches, in the conviction that these approaches should complement and mutually inspire each other. He is one of the principal investigators of the well-known Hoorn Study (since 1992). He also obtained national and European funding (16 M€) for, and is the initiator and Scientific Director of the Maastricht Study (started 2010), which combines very detailed phenotyping (with a focus on microcirculatory, large artery and cardiac function and structure) with an ‘omics’ approach in 7000 individuals without and 2000 with type 2 diabetes to elucidate how diabetes leads not only to classic complications but also to so-called emerging complications such as cognitive dysfunction, mood disorders, liver disease, musculoskeletal disease, pulmonary disease, sleep-disordered breathing, and infectious diseases.

Department of Internal Medicine
P. Debyelaan 25, 6229 HX Maastricht
PO Box 616, 6200 MD Maastricht
T:+31(0)43 387 70 06

  • 2020
    • Geraets, A. F. J., van Agtmaal, M. J. M., Stehouwer, C. D. A., Sörensen, B. M., Berendschot, T. T. J. M., Webers, C. A. B., Schaper, N. C., Henry, R. M. A., van der Kallen, C. J. H., Eussen, S. J. P. M., Koster, A., van Sloten, T. T., Köhler, S., Schram, M. T., & Houben, A. J. H. M. (2020). Association of Markers of Microvascular Dysfunction With Prevalent and Incident Depressive Symptoms: The Maastricht Study. Hypertension, 76(2), 342-349. https://doi.org/10.1161/HYPERTENSIONAHA.120.15260
    • Zhou, T. L., Rensma, S. P., van der Heide, F. C. T., Henry, R. M. A., Kroon, A. A., Houben, A. J. H. M., Jansen, J. F. A., Backes, W. H., Berendschot, T. T. J. M., Schouten, J. S. A. G., van Dongen, M. C. J. M., Eussen, S. J. P. M., Dagnelie, P. C., Webers, C. A. B., Schram, M. T., Schalkwijk, C. G., van Sloten, T. T., & Stehouwer, C. D. A. (2020). Blood pressure variability and microvascular dysfunction: the Maastricht Study. Journal of Hypertension, 38(8), 1541-1550. https://doi.org/10.1097/HJH.0000000000002444
    • van der Velde, J. H. P. M., Koster, A., Strotmeyer, E. S., Mess, W. H., Hilkman, D., Reulen, J. P. H., Stehouwer, C. D. A., Henry, R. M. A., Schram, M. T., van der Kallen, C. J. H., Schalkwijk, C. G., Savelberg, H. H. C. M., & Schaper, N. C. (2020). Cardiometabolic risk factors as determinants of peripheral nerve function: the Maastricht Study. Diabetologia, 63(8), 1648-1658. https://doi.org/10.1007/s00125-020-05194-5
    • Simo, R., Stehouwer, C. D. A., & Avogaro, A. (2020). Diabetic retinopathy: looking beyond the eyes. Diabetologia, 63(8), 1662-1664. https://doi.org/10.1007/s00125-020-05195-4
    • De Clerck, E. E. B., Schouten, J. S. A. G., Berendschot, T. T. J. M., Koolschijn, R. S., Nuijts, R. M. M. A., Schram, M. T., Schaper, N. C., Henry, R. M. A., Dagnelie, P. C., Ruggeri, A., Guimarães, P., Stehouwer, C. D. A., & Webers, C. A. B. (2020). Reduced corneal nerve fibre length in prediabetes and type 2 diabetes: The Maastricht Study. Acta Ophthalmologica, 98(5), 485-491. https://doi.org/10.1111/aos.14359
    • Li, W., Schram, M. T., Berendschot, T. T. J. M., Webers, C. A. B., Kroon, A. A., van der Kallen, C. J. H., Henry, R. M. A., Schaper, N. C., Huang, F., Dashtbozorg, B., Tan, T., Zhang, J., Abbasi-Sureshjani, S., Ter Haar Romeny, B. M., Stehouwer, C. D. A., & Houben, A. J. H. M. (2020). Type 2 diabetes and HbA1c are independently associated with wider retinal arterioles: the Maastricht study. Diabetologia, 63(7), 1408-1417. https://doi.org/10.1007/s00125-020-05146-z
    • Consolazio, D., Koster, A., Sarti, S., Schram, M. T., Stehouwer, C. D. A., Timmermans, E. J., Wesselius, A., & Bosma, H. (2020). Neighbourhood property value and type 2 diabetes mellitus in the Maastricht study: A multilevel study. PLOS ONE, 15(6), [0234324]. https://doi.org/10.1371/journal.pone.0234324
    • den Biggelaar, L. J. C. J., Sep, S. J. S., Mari, A., Ferrannini, E., van Dongen, M. C. J. M., Wijckmans, N. E. G., Schram, M. T., van der Kallen, C. J., Schaper, N., Henry, R. M. A., van Greevenbroek, M. M., Stehouwer, C. D. A., & Eussen, S. J. P. M. (2020). Association of artificially sweetened and sugar-sweetened soft drinks with β-cell function, insulin sensitivity, and type 2 diabetes: the Maastricht Study. European Journal of Nutrition, 59(4), 1717-1727. https://doi.org/10.1007/s00394-019-02026-0
    • Martens, R. J. H., Henry, R. M. A., Bekers, O., Dagnelie, P. C., van Dongen, M. C. J. M., Eussen, S. J. P. M., van Greevenbroek, M., Kroon, A. A., Stehouwer, C. D. A., Wesselius, A., Meex, S. J. R., & Kooman, J. P. (2020). Associations of 24-Hour Urinary Sodium and Potassium Excretion with Cardiac Biomarkers: The Maastricht Study. Journal of Nutrition, 150(6), 1413-1424. https://doi.org/10.1093/jn/nxaa080
    • Rensma, S. P., Stehouwer, C. D. A., Van Boxtel, M. P. J., Houben, A. J. H. M., Berendschot, T. T. J. M., Jansen, J. F. A., Schalkwijk, C. G., Verhey, F. R. J., Kroon, A. A., Henry, R. M. A., Backes, W. H., Dagnelie, P. C., van Dongen, M. C. J. M., Eussen, S. J. P. M., Bosma, H., Köhler, S., Reesink, K. D., Schram, M. T., & van Sloten, T. T. (2020). Associations of Arterial Stiffness With Cognitive Performance, and the Role of Microvascular Dysfunction: The Maastricht Study. Hypertension, 75(6), 1607-1614. https://doi.org/10.1161/HYPERTENSIONAHA.119.14307