Coen Stehouwer

Professor

Prof. Coen Stehouwer (born Rotterdam, 1960) obtained an MD at the Erasmus University in Rotterdam (1985; cum laude). He was registered as internist in 1990 and obtained a PhD in 1992 (Vrije Universiteit Medical Centre, Amsterdam). He received postgraduate training in epidemiology and molecular biology. He was appointed professor of medicine and vice-chair of the Department of Medicine in 2000 at the Vrije Universiteit in Amsterdam). In 2004, he accepted a position as professor of medicine and chair of the Department of Medicine at the University of Maastricht. Coen Stehouwer currently is Professor of Internal Medicine and Chair of the Department of Internal Medicine at Maastricht University in the Netherlands.

He is an internationally recognised clinician-scientist in the field of microcirculatory as well as large artery research, notably in the context of cardiovascular complications of diabetes and the metabolic syndrome. Since 1990, the work of Professor Stehouwer and his group has led to 77 completed PhD theses, and more than 800 peer-reviewed papers in international journals.

His work is well-recognised, as shown by a Hirsh index of 109 (Web of Science); >52,000 citations; several awards, such as the Dr F. Gerritzen Award for excellent diabetes research (Dutch Diabetes Research Foundation, 1993); the Castelli-Pedroli Award for excellent research into the complications of diabetes (European Association for the Study of Diabetes, 2005); the Dutch Society of Vascular Medicine Career Award (2007); the Ruitenga Van Swieten honorary professorship of the University of Amsterdam (2009); and the Donald McDonald Award of Artery Society (2017); as well as many invited lectures at (inter)national meetings, such as those of the European Society for Microcirculation, the World Congress for Microcirculation, the European Society for the Study of Diabetes, the American Diabetes Association, the European Society for Cardiology, and the American Heart Association.

His research programme focuses on the elucidation of how metabolic changes in (pre)diabetes and the metabolic syndrome cause micro- and macrovascular disease. A key element of the programme is to combine epidemiology, clinical physiology and experimental approaches, in the conviction that these approaches should complement and mutually inspire each other. He is one of the principal investigators of the well-known Hoorn Study (since 1992). He also obtained national and European funding (16 M€) for, and is the initiator and Scientific Director of the Maastricht Study (started 2010), which combines very detailed phenotyping (with a focus on microcirculatory, large artery and cardiac function and structure) with an ‘omics’ approach in 7000 individuals without and 2000 with type 2 diabetes to elucidate how diabetes leads not only to classic complications but also to so-called emerging complications such as cognitive dysfunction, mood disorders, liver disease, musculoskeletal disease, pulmonary disease, sleep-disordered breathing, and infectious diseases.

Department of Internal Medicine
P. Debyelaan 25, 6229 HX Maastricht
PO Box 616, 6200 MD Maastricht
T:+31(0)43 387 70 06

  • 2021
    • Foreman, Y. D., van Doorn, W. P. T. M., Schaper, N. C., van Greevenbroek, M. M. J., van der Kallen, C. J. H., Henry, R. M. A., Koster, A., Eussen, S. J. P. M., Wesselius, A., Reesink, K. D., Schram, M. T., Dagnelie, P. C., Kroon, A. A., Brouwers, M. C. G. J., & Stehouwer, C. D. A. (2021). Greater daily glucose variability and lower time in range assessed with continuous glucose monitoring are associated with greater aortic stiffness: The Maastricht Study. Diabetologia, 64(8), 1880-1892. https://doi.org/10.1007/s00125-021-05474-8
    • Top, W. M. C., Lehert, P., Schalkwijk, C. G., Stehouwer, C. D. A., & Kooy, A. (2021). Metformin and N-terminal pro B-type natriuretic peptide in type 2 diabetes patients, a post-hoc analysis of a randomized controlled trial. PLOS ONE, 16(4), [0247939]. https://doi.org/10.1371/journal.pone.0247939
    • de Jong, M., Peters, S. A. E., de Ritter, R., van der Kallen, C. J. H., Sep, S. J. S., Woodward, M., Stehouwer, C. D. A., Bots, M. L., & Vos, R. C. (2021). Sex Disparities in Cardiovascular Risk Factor Assessment and Screening for Diabetes-Related Complications in Individuals With Diabetes: A Systematic Review. Frontiers in Endocrinology, 12, [617902]. https://doi.org/10.3389/fendo.2021.617902
    • Hanssen, N. M. J., Teraa, M., Scheijen, J. L. J. M., Van de Waarenburg, M., Gremmels, H., Stehouwer, C. D. A., Verhaar, M. C., & Schalkwijk, C. G. (2021). Plasma Methylglyoxal Levels Are Associated With Amputations and Mortality in Severe Limb Ischemia Patients With and Without Diabetes. Diabetes Care, 44(1), 157-163. https://doi.org/10.2337/dc20-0581
  • 2020
    • Ginsberg, C., Houben, A. J. H. M., Malhotra, R., Berendschot, T. T. J. M., Kooman, J. P., Webers, C. A. B., Stehouwer, C. D. A., & Ix, J. H. (2020). Urinary Phosphate Excretion and Microvascular Function in a Population-Based Cohort. Kidney Medicine, 2(6), 812-815. https://doi.org/10.1016/j.xkme.2020.08.009
    • Dal Canto, E., Beulens, J. W. J., Elders, P., Rutters, F., Stehouwer, C. D. A., van der Heijden, A. A., & van Ballegooijen, A. J. (2020). The Association of Vitamin D and Vitamin K Status with Subclinical Measures of Cardiovascular Health and All-Cause Mortality in Older Adults: The Hoorn Study. Journal of Nutrition, 150(12), 3171-3179. https://doi.org/10.1093/jn/nxaa293
    • Bruggemann, R. A. G., Spaetgens, B., Gietema, H. A., Brouns, S. H. A., Stassen, P. M., Magdelijns, F. J., Rennenberg, R. J., Henry, R. M. A., Mulder, M. M. G., van Bussel, B. C. T., Schnabel, R. M., van der Horst, I. C. C., Wildberger, J. E., Stehouwer, C. D. A., & ten Cate, H. (2020). The prevalence of pulmonary embolism in patients with COVID-19 and respiratory decline: A three-setting comparison. Thrombosis Research, 196, 486-490. https://doi.org/10.1016/j.thromres.2020.10.012
    • Lakerveld, J., Wagtendonk, A., Vaartjes, I., Karssenberg, D., GECCO Consortium, Koster, A., & Stehouwer, C. (2020). Deep phenotyping meets big data: the Geoscience and hEalth Cohort COnsortium (GECCO) data to enable exposome studies in The Netherlands. International Journal of Health Geographics, 19(1), [49]. https://doi.org/10.1186/s12942-020-00235-z
    • Geraets, A. F. J., Kohler, S., Muzambi, R., Schalkwijk, C. G., Oenema, A., Eussen, S. J. P. M., Dagnelie, P. C., Stehouwer, C. D. A., Schaper, N. C., Henry, R. M. A., van der Kallen, C. J. H., Wesselius, A., Koster, A., Verhey, F. R. J., & Schram, M. T. (2020). The association of hyperglycaemia and insulin resistance with incident depressive symptoms over 4 years of follow-up: The Maastricht Study. Diabetologia, 63(11), 2315-2328. https://doi.org/10.1007/s00125-020-05247-9
    • Vandercappellen, E. J., Henry, R. M. A., Savelberg, H. H. C. M., van der Berg, J. D., Reesink, K. D., Schaper, N. C., Eussen, S. J. P. M., van Dongen, M. C. J. M., Dagnelie, P. C., Schram, M. T., van Greevenbroek, M. M. J., Wesselius, A., van der Kallen, C. J. H., Kohler, S., Stehouwer, C. D. A., & Koster, A. (2020). Association of the Amount and Pattern of Physical Activity With Arterial Stiffness: The Maastricht Study. Journal of the American Heart Association, 9(20), [017502]. https://doi.org/10.1161/JAHA.120.017502