Dominik Linz

Academic Staff

Dr Dominik Linz is a clinician-scientist who received his PhD from Maastricht University, The Netherlands, in 2013 (Prof. U. Schotten) and completed his Cardiology training in Homburg/Saar, Germany, in 2017 (Prof. M. Böhm). In 2017, he was recruited as an Associate Professor and clinical EP-fellow to Adelaide to initiate and drive a translational research programme focussing on atrial fibrillation and sleep disordered breathing at the Royal Adelaide Hospital and University of Adelaide (Prof. P. Sanders). Since 2019, Dr Dominik Linz is a Staff member and consultant clinician at the Haart en Vaatcentrum, Maastricht UMC+.

Over the past years Dr Dominik Linz has developed a National and International reputation in the field of cardiac arrhythmia research. The focus of this work has been to understand the pathophysiology and mechanisms underlying atrial arrhythmias and the development of treatment approaches. This research has broadly included: (i) Work describing sleep apnoea associated electrophysiological changes in the atria increasing atrial fibrillation susceptibility. (ii) Description of antiarrhythmic effects of autonomic modulation by renal sympathetic denervation under different pathophysiological conditions. (iii) Work describing the role of the lysosomal carboxypeptidase cathepsin A in the development of an atrial arrhythmogenic substrates. Ongoing research is mainly focused on risk factor modification and preventive interventions for AF.

Department of Cardiology

 

  • 2020
    • Hermans, A. N. L., Andrade, J. G., & Linz, D. (2020). Arterial Stiffness Association With Symptom Burden in Patients With Atrial Fibrillation: Direct Cause or Marker of Concomitant Risk Factors?Canadian Journal of Cardiology, 36(12), 1843-1846. https://doi.org/10.1016/j.cjca.2020.08.003
    • Linz, D., Loffler, K. A., Sanders, P., Catcheside, P., Anderson, C. S., Zheng, D., Quan, W., Barnes, M., Redline, S., McEvoy, R. D., Baumert, M., & SAVE (Sleep Apnea Cardiovascular Endpoints) Investigators (2020). Low Prognostic Value of Novel Nocturnal Metrics in Patients With OSA and High Cardiovascular Event Risk Post Hoc Analyses of the SAVE Study. Chest, 158(6), 2621-2631. https://doi.org/10.1016/j.chest.2020.06.072
    • Hermans, A. N. L., van der Velden, R. M. J., Gawalko, M., Verhaert, D. V. M., Desteghe, L., Duncker, D., Manninger, M., Heidbuchel, H., Pisters, R., Hemels, M., Pison, L., Sohaib, A., Sultan, A., Steven, D., Wijtvliet, P., Tieleman, R., Gupta, D., Dobrev, D., Svennberg, E., ... TeleCheck-AF investigators (2020). On-demand mobile health infrastructures to allow comprehensive remote atrial fibrillation and risk factor management through teleconsultation. Clinical Cardiology, 43(11), 1232-1239. https://doi.org/10.1002/clc.23469
    • Linz, D., & Hendriks, J. (2020). Central sleep apnea in atrial fibrillation: Risk factor or marker of untreated underlying disease?IJC Heart & Vasculature, 30, [100650]. https://doi.org/10.1016/j.ijcha.2020.100650
    • Gawalko, M., Kaplon-Cieslicka, A., Hohl, M., Dobrev, D., & Linz, D. (2020). COVID-19 associated atrial fibrillation: Incidence, putative mechanisms and potential clinical implications. IJC Heart & Vasculature, 30, [100631]. https://doi.org/10.1016/j.ijcha.2020.100631
    • Bogossian, H., Linz, D., Heijman, J., Bimpong-Buta, N-Y., Bandorski, D., Frommeyer, G., Erkapic, D., Seyfarth, M., Zarse, M., & Crijns, H. J. (2020). QTc evaluation in patients with bundle branch block. IJC Heart & Vasculature, 30, [100636]. https://doi.org/10.1016/j.ijcha.2020.100636
    • Hohl, M., Mayr, M., Lang, L., Nickel, A. G., Barallobre-Barreiro, J., Yin, X., Speer, T., Selejan, S-R., Goettsch, C., Erb, K., Fecher-Trost, C., Reil, J-C., Linz, B., Ruf, S., Huebschle, T., Maack, C., Boehm, M., Sadowski, T., & Linz, D. (2020). Cathepsin A contributes to left ventricular remodeling by degrading extracellular superoxide dismutase in mice. Journal of Biological Chemistry, 295(36), 12605-12617. https://doi.org/10.1074/jbc.RA120.013488
    • van der Velden, R. M. J., Hermans, A. N. L., Pluymaekers, N. A. H. A., Gawalko, M., Vorstermans, B., Martens, H., Buskes, S., Crijns, H. J. G. M., Linz, D., & Hendriks, J. M. (2020). Coordination of a remote mHealth infrastructure for atrial fibrillation management during COVID-19 and beyond: TeleCheck-AF. International Journal of Care Coordination, 23(2-3), 65-70. [2053434520954619]. https://doi.org/10.1177/2053434520954619
    • Linz, B., Saljic, A., Hohl, M., Gawalko, M., Jespersen, T., Sanders, P., Bohm, M., & Linz, D. (2020). Inhibition of sodium-proton-exchanger subtype 3-mediated sodium absorption in the gut: A new antihypertensive concept. IJC Heart & Vasculature, 29, [100591]. https://doi.org/10.1016/j.ijcha.2020.100591
    • De With, R. R., Erkuner, O., Rienstra, M., Nguyen, B-O., Korver, F. W. J., Linz, D., Ten, H. C., Spronk, H., Kroon, A. A., Maass, A. H., Blaauw, Y., Tieleman, R. G., Hemels, M. E. W., de Groot, J. R., Elvan, A., de Melis, M., Scheerder, C. O. S., Al-Jazairi, M. I. H., Schotten, U., ... RACE V Investigators (2020). Temporal patterns and short-term progression of paroxysmal atrial fibrillation data from RACE V. EP Europace, 22(8), 1162-1172. https://doi.org/10.1093/europace/euaa123