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Catheter treatment is not only effective, but also cost-effective for ischemic stroke

Catheter treatment is not only effective, but also cost-effective for ischemic stroke

29 September 2026

With ischemic stroke, every minute counts. However, many patients do not seek hospital care until it is too late, for example, because symptoms are not immediately recognized or because people wake up with signs of neurological deficits. As a result, a group of patients is no longer eligible for catheter treatment. 

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Platelets: more than a band-aid

Platelets: more than a band-aid

23 September 2026

Some processes in our body might seem obvious to us. If you cut your finger, the bleeding will stop shortly and form a scab. Behind that seemingly simple process hides a sophisticated system of platelets and clotting factors. By now, we know that platelets do much more than halt bleeding: they function as information carriers and regulators of disease processes. 

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Carim Maastricht
Carim Maastricht

Fabienne Magdelijns

Assistant Professor

Dr Fabienne Magdelijns obtained her medical degree from Maastricht University in the Netherlands. Her research primarily focuses on healthcare-related adverse events, with a particular emphasis on the frail older population.

She completed her PhD (title: ‘Health-care-related adverse events leading to (re)hospitalization') under the supervision of Prof. Coen Stehouwer, Dr Patricia Stassen and Dr Evelien Pijpers at the Department of Internal Medicine, Maastricht UMC+.

Fabiene currently serves as an internist with a specialization in geriatric care at Maastricht UMC+. She leads the Geriatric Medicine section and started in May 2026 as Medical Director of Expertise Unit for Transmural and Paramedical Care of Maastricht UMC+.

Her current research centres on the DOAC-FRAIL study, which aims to improve the safe prescribing of direct oral anticoagulants (DOACs) in frail older patients. In December 2024, she was awarded a grant from the Netherlands Thrombosis Foundation to conduct a multinational randomized controlled trial. This study will evaluate the effectiveness of a Single Measurement and Adjustment Strategy for DOACs in this vulnerable population. The study started in 2026 at Maastricht UMC+ and surrounding nursing homes. By the end of 2026, additional sites are expected to open for inclusion. The first participants in Belgium are expected to be enrolled in early 2027.

Another of Fabienne’s research lines focuses on improving the organization of transmural care for frail older adults. In 2025, she secured funding from the Citrien Fund to implement the GOLD Clinic. The GOLD Clinic is a new model of care in which a geriatrician works alongside the general practitioner (GP), holding joint consultations within the GP practice. The first GOLD Clinic was launched in January 2026, and the pilot is expected to run for approximately two years.

Carim dscf9575 kopie

Department of Internal Medicine
Subdivision of General Internal Medicine
Section of Geriatric medicine
T: +31(0)43 388 71 95

  • 2026
    • Franssen, I. S., de Jong, M. J., Visseren, L., Teerds, D., Hellenbrand, D., Henskens, Y., Spronk, H., Janssen, D. J. A., Braeken, D. C. W., van Kuijk, S. M. J., Winckers, K., & Magdelijns, F. J. H. (2026). The DOAC-FRAIL Study-Same Dose, Different Story: Prevalence of Deviant Direct Oral Anticoagulant Levels in Nursing Home Residents. Journal of the American Geriatrics Society. Advance online publication. https://doi.org/10.1111/jgs.70559
    • Magdelijns, F. J. H., de Jong, M. J., Winckers, K., Brys, A. D. H., Braeken, D. C. W., van Kuijk, S. M. J., Spronk, H. M. H., Bosman, H., Janssen, D. J. A., van Geel, R. M. J. M., Hellenbrand, D., ten Cate, H., & Henskens, Y. (2026). Assessing the efficacy of a single-cycle measurement and adjustment strategy for direct oral anticoagulants in frail older patients: rationale and design of the DOAC-FRAIL randomized controlled trial. Research and practice in thrombosis and haemostasis, 10(4), Article 106800. https://doi.org/10.1016/j.rpth.2026.106800
    • Franssen, I. S., Jong, M. J. D., Vievermans, A., Stroo, J. F., Henskens, Y. M. C., Spronk, H., Janssen, D. J. A., Braeken, D., van Kuijk, S. M. J., Winckers, K., & Magdelijns, F. J. H. (2026). Adequacy of Direct Oral Anticoagulant Dosing in Nursing Home Residents: Cross-Sectional Data From the DOAC-FRAIL Study. Journal of the American Medical Directors Association, 27(4), Article 106082. https://doi.org/10.1016/j.jamda.2025.106082
    • Nagy, M., Gomes, T., Van Oerle, R., Hacking, T. M., Magdelijns, F. J. H., Henskens, Y. M. C., Reitsma, P., Short, G., Spronk, H. M. H., & Verhoef, D. (2026). Coagulation assays for assessing the bypassing of factor Xa direct oral anticoagulants using VMX-C001. Research and practice in thrombosis and haemostasis, 10(2), Article e103375. https://doi.org/10.1016/j.rpth.2026.103375
    • Magdelijns, F. J. H., de Jong, M. J., Winckers, K., Braeken, D. C. W., & Cate, H. T. (2026). Frail older patients and direct oral anticoagulants: trouble in paradise?Journal of Thrombosis and Haemostasis, 24(2), 781-783. https://doi.org/10.1016/j.jtha.2025.10.034
    • de Jong, M. J., Brys, A. D. H., Braeken, D., Pisters, R., Janssen, D. J. A., Altintas, S., Robben, S. H. M., Nicolai, S., Eurlings, C., Zwietering, A., De Jonghe, M., Vaes, B., De Backer, T., Grymonprez, M., Joosten, H., ten Cate, H., Winckers, K., & Magdelijns, F. J. H. (2026). Healthcare professionals' perspectives on prescribing DOACs to frail older patients; the DOAC-FRAIL questionnaire. BMC Geriatrics, 26(1), Article 418. https://doi.org/10.1186/s12877-026-06972-3
    • van der Walle, K., Denig, P., Boerman, T., Magdelijns, F. J. H., Nielen, J. T. H., & Karapinar-Carkit, F. (2026). Creating Awareness of preScribing Cascades and Managing Adverse Drug Effects (CASC-ADE) Tool: Appraisal by Future End Users. Drugs & Aging. Advance online publication. https://doi.org/10.1007/s40266-026-01334-5
  • 2025
    • Vleeshouwers, K., Bastings, J. J. C., Brüggemann, R., de Jong, M. J., van den Boogaart, M., Poeze, M., van Es, N., Hanssen, N. M. J., Brouns, S., Magdelijns, F., & Spaetgens, B. (2025). Antithrombotic Therapy and Mortality Risk in Older Adults with Hip Fractures. Journal of the American Medical Directors Association, 26(8), Article 105690. https://doi.org/10.1016/j.jamda.2025.105690
    • Nielen, J. T. H., van der Walle, K., Spronk, S., Magdelijns, F., Denig, P., & Karapinar, F. (2025). Real-World Complexity of Prescribing Cascades. Basic & Clinical Pharmacology & Toxicology, 137(1), Article e70063. https://doi.org/10.1111/bcpt.70063
    • Truijen, S., Austen, S., Magdelijns, F., Boonen, A., & van Onna, M. (2025). Getting prepared for the silver wave: challenges in conducting rheumatic and musculoskeletal disease research in older adults. RMD Open, 11(1), Article e005280. https://doi.org/10.1136/rmdopen-2024-005280
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