Frauke Swieringa

Post doc

Dr Frauke Swieringa graduated from the bachelor study Molecular Life Sciences at Maastricht University, after which she specialised in Clinical Molecular Sciences. She carried out her graduate internship, focussing on the identification of blood platelet-reactive sites in collagen, at the Department of Biochemistry at Maastricht University and at the University of Cambridge (UK). After obtaining her (cum laude) diploma in 2010, she started her PhD research at CARIM at the Department of Biochemistry at Maastricht University.  She conducted research in the field of platelets, thrombosis and haemostasis. After being awarded a Humboldt research Fellowship in 2016 she worked as a post-doctoral researcher at the Leibniz Institute for Analytical Sciences – ISAS in Dortmund, Germany, focussing on platelet proteomics in disease.

Since 2018, she is again working at Maastricht University. The current focus of her research is uncovering the complexity of platelet (dys)functions in thrombosis and haemostasis using microscopy-based platelet phenotyping and advanced platelet proteomics. She aims to develop a diagnostic and predictive platform for platelet-related disorders based on the combined characterisation of platelet function and proteomics.

Department of Biochemistry   
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number:4.320
T: +31(0)43 388 15 37

  • 2020
    • Brouns, S. L. N., van Geffen, J. P., Campello, E., Swieringa, F., Spiezia, L., van Oerle, R., Provenzale, I., Verdoold, R., Farndale, R. W., Clemetson, K. J., Spronk, H. M. H., van der Meijden, P. E. J., Cavill, R., Kuijpers, M. J. E., Castoldi, E., Simioni, P., & Heemskerk, J. W. M. (2020). Platelet-primed interactions of coagulation and anticoagulation pathways in flow-dependent thrombus formation. Scientific Reports, 10(1), 11910. [11910]. https://doi.org/10.1038/s41598-020-68438-9
  • 2019
    • Provenzale, I., Brouns, S. L. N., van der Meijden, P. E. J., Swieringa, F., & Heemskerk, J. W. M. (2019). Whole Blood Based Multiparameter Assessment of Thrombus Formation in Standard Microfluidic Devices to Proxy In Vivo Haemostasis and Thrombosis. Micromachines, 10(11), [787]. https://doi.org/10.3390/mi10110787
    • van Geffen, A., Brouns, S., Batista, J., McKinney, H., Kempster, C., Nagy, M., Sivapalaratnam, S., Baaten, C., Bourry, N., Frontini, M., Jurk, K., Krause, M., Pilliteri, D., Swieringa, F., Verdoold, R., Cavill, R., Kuijpers, M., Ouwehand, W. H., Downes, K., & Heemskerk, J. (2019). High-throughput elucidation of thrombus formation reveals sources of platelet function variability. Haematologica-the Hematology Journal, 104(6), 1256-1267. https://doi.org/10.3324/haematol.2018.198853
  • 2018
    • Baaten, C. C. F. M. J., Meacham, S., de Witt, S. M., Feijge, M. A. H., Adams, D. J., Akkerman, J-W. N., Cosemans, J. M. E. M., Grassi, L., Jupe, S., Kostadima, M., Mattheij, N. J. A., Prins, M. H., Ramirez-Solis, R., Soehnlein, O., Swieringa, F., Weber, C., White, J. K., Ouwehand, W. H., & Heemskerk, J. W. M. (2018). A synthesis approach of mouse studies to identify genes and proteins in arterial thrombosis and bleeding. Blood, 132(24), E35-E46. https://doi.org/10.1182/blood-2018-02-831982
    • Baaten, C. C. F. M. J., Swieringa, F., Misztal, T., Mastenbroek, T. G., Feijge, M. A. H., Bock, P. E., Donners, M. M. P. C., Collins, P. W., Li, R., van der Meijden, P. E. J., & Heemskerk, J. W. M. (2018). Platelet heterogeneity in activation-induced glycoprotein shedding: functional effects. Blood advances, 2(18), 2320-2331. https://doi.org/10.1182/bloodadvances.2017011544
    • Lepropre, S., Kautbally, S., Octave, M., Ginion, A., Onselaer, M-B., Steinberg, G. R., Kemp, B. E., Hego, A., Wera, O., Brouns, S., Swieringa, F., Giera, M., Darley-Usmar, V. M., Ambroise, J., Guigas, B., Heemskerk, J., Bertrand, L., Oury, C., Beauloye, C., & Horman, S. (2018). AMPK-ACC signaling modulates platelet phospholipids and potentiates thrombus formation. Blood, 132(11), 1180-1192. https://doi.org/10.1182/blood-2018-02-831503
    • Baaten, C. C. F. M. J., Moenen, F. C. J. I., Henskens, Y. M. C., Swieringa, F., Wetzels, R. J. H., van Oerle, R., Heijnen, H. F. G., ten Cate, H., Holloway, G. P., Beckers, E. A. M., Heemskerk, J. W. M., & van der Meijden, P. E. J. (2018). Impaired mitochondrial activity explains platelet dysfunction in thrombocytopenic cancer patients undergoing chemotherapy. Haematologica-the Hematology Journal, 103(9), 1557-1567. https://doi.org/10.3324/haematol.2017.185165
    • Swieringa, F., Spronk, H. M. H., Heemskerk, J. W. M., & van der Meijden, P. E. J. (2018). Integrating platelet and coagulation activation in fibrin clot formation. Research and practice in thrombosis and haemostasis, 2(3), 450-460. https://doi.org/10.1002/rth2.12107
    • Thomassen, S., Mastenbroek, T. G., Swieringa, F., Winckers, K., Feijge, M. A. H., Schrijver, R., Cosemans, J. M. E. M., Maroney, S. A., Mast, A. E., Hackeng, T. M., & Heemskerk, J. W. M. (2018). Suppressive Role of Tissue Factor Pathway Inhibitor-alpha in Platelet-Dependent Fibrin Formation under Flow Is Restricted to Low Procoagulant Strength. Thrombosis and Haemostasis, 118(3), 502-513. https://doi.org/10.1055/s-0038-1627453
  • 2017