Frits Prinzen


Frits Prinzen is emeritus professor of Physiology. He studied Medical Biology in Utrecht and defended his PhD in Maastricht in 1982. His research focusses on the relation between the electrical activation and mechanical contraction and pump function of the heart, with specific application to pacemaker therapies in heart failure. His work is highly translational, ranging from preclinical to clinical research and more recently also using computer simulations. Results from his work provided new insights in and opportunities for pacemaker therapies. He has participated in the CTMM-COHFAR consortium and has been and is workpackage leader in several EU-funded projects, including an International Training Network (Personalised in silico Cardiology). Several of his team members achieved personal grants (ZonMw Veni, Vidi, Clinical Fellow; Netherlands Heart Foundation junior and senior postdoc; young staff member). Besides, he ran multiple investigator-initiated studies that were funded by industry. He has been chairman of the Cardiovascular System Dynamics Society and of the Innovation Committee of the European Heart Rhythm Association (EHRA). Currently he is member of the Scientific Initiatives Committee of EHRA. He is (co-)author on 330 scientific articles, with >10,000 citations and H-index of 56.

His main research topic is regional cardiac mechanics and long-term structural and functional adaptations to various conditions, with emphasis on asynchronous electrical activation and cardiac resynchronisation. Primarily animal experimental work, but with important links to Biomedical Engineering (computer models of cardiac electrophysiology and mechanics) and Cardiology (patients with pacemakers, bundle branch block, heart failure). With this background Prof. Frits Prinzen is a world expert on pacing therapies, both for bradycardia and for heart failure (cardiac resynchronisation therapy, CRT).

Department of Physiology
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
T: +31(0)43 3881080
  • 2022
    • Wouters, P. C., van Everdingen, W. M., Vernooy, K., Geelhoed, B., Allaart, C. P., Rienstra, M., Maass, A. H., Vos, M. A., Prinzen, F. W., Meine, M., & Cramer, M. J. (2022). Does mechanical dyssynchrony in addition to QRS area ensure sustained response to cardiac resynchronization therapy?European Heart Journal Cardiovascular Imaging, 23(12), 1628-1635.
    • Shahmohammadi, M., Huberts, W., Luo, H. X., Westphal, P., Cornelussen, R. N., Prinzen, F. W., & Delhaas, T. (2022). Hemodynamics-driven mathematical model of third heart sound generation. Frontiers in physiology, 13, [847164].
    • Ploeg, M. C., Munts, C., Seddiqi, T., ten Brink, T. J. L., Breemhaar, J., Moroni, L., Prinzen, F. W., & van Nieuwenhoven, F. A. (2022). Culturing of Cardiac Fibroblasts in Engineered Heart Matrix Reduces Myofibroblast Differentiation but Maintains Their Response to Cyclic Stretch and Transforming Growth Factor beta 1. Bioengineering, 9(10), [551].
    • Verzaal, N. J., van Deursen, C. J. M., Pezzuto, S., Wecke, L., van Everdingen, W. M., Vernooy, K., Delhaas, T., Auricchio, A., & Prinzen, F. W. (2022). Synchronization of repolarization after cardiac resynchronization therapy: A combined clinical and modeling study. Journal of Cardiovascular Electrophysiology, 33(8), 1837-1846.
    • Bouwmeester, S., Mast, T., Prinzen, F., Dekker, L., & Houthuizen, P. (2022). Predictive value of left atrial remodeling for response to cardiac resynchronization therapy. Journal of Ultrasonography, 22(90), E168-E173.
    • Bouwmeester, S., Mast, T. P., Keulards, D. C. J., de Lepper, A. G. W., Herold, I. H. F., Dekker, L. R., Prinzen, F. W., & Houthuizen, P. (2022). Left atrial reverse remodeling predicts long-term survival after cardiac resynchronization therapy. Journal of Echocardiography, 20(2), 115-123.
    • Rijks, J., Luermans, J., Heckman, L., van Stipdonk, A. M. W., Prinzen, F., Lumens, J., & Vernooy, K. (2022). Physiology of Left Ventricular Septal Pacing and Left Bundle Branch Pacing. Cardiac Electrophysiology Clinics, 14(2), 181-189.
    • Westphal, P., Luo, H. X., Shahmohammadi, M., Heckman, L. I. B., Kuiper, M., Prinzen, F. W., Delhaas, T., & Cornelussen, R. N. (2022). Left Ventricular Pressure Estimation Using Machine Learning-Based Heart Sound Classification. Frontiers in cardiovascular medicine, 9, [763048].
    • Prinzen, F. W., Auricchio, A., Mullens, W., Linde, C., & Huizar, J. F. (2022). Electrical management of heart failure: from pathophysiology to treatment. European Heart Journal, 43(20), 1917-1927.
    • Koopsen, T., Van Osta, N., Van Loon, T., Van Nieuwenhoven, F. A., Prinzen, F. W., Van Klarenbosch, B. R., Kirkels, F. P., Teske, A. J., Vernooy, K., Delhaas, T., & Lumens, J. (2022). A Lumped Two-Compartment Model for Simulation of Ventricular Pump and Tissue Mechanics in Ischemic Heart Disease. Frontiers in physiology, 13, 782592. [782592].