Frits Prinzen


Frits Prinzen is emeritus professor of Physiology. He studied Medical Biology in Utrecht and defended his PhD in Maastricht in 1982. His research focusses on the relation between the electrical activation and mechanical contraction and pump function of the heart, with specific application to pacemaker therapies in heart failure. His work is highly translational, ranging from preclinical to clinical research and more recently also using computer simulations. Results from his work provided new insights in and opportunities for pacemaker therapies. He has participated in the CTMM-COHFAR consortium and has been and is workpackage leader in several EU-funded projects, including an International Training Network (Personalised in silico Cardiology). Several of his team members achieved personal grants (ZonMw Veni, Vidi, Clinical Fellow; Netherlands Heart Foundation junior and senior postdoc; young staff member). Besides, he ran multiple investigator-initiated studies that were funded by industry. He has been chairman of the Cardiovascular System Dynamics Society and of the Innovation Committee of the European Heart Rhythm Association (EHRA). Currently he is member of the Scientific Initiatives Committee of EHRA. He is (co-)author on 330 scientific articles, with >10,000 citations and H-index of 56.

His main research topic is regional cardiac mechanics and long-term structural and functional adaptations to various conditions, with emphasis on asynchronous electrical activation and cardiac resynchronisation. Primarily animal experimental work, but with important links to Biomedical Engineering (computer models of cardiac electrophysiology and mechanics) and Cardiology (patients with pacemakers, bundle branch block, heart failure). With this background Prof. Frits Prinzen is a world expert on pacing therapies, both for bradycardia and for heart failure (cardiac resynchronisation therapy, CRT).

Department of Physiology
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
T: +31(0)43 3881080
  • 2024
    • Brandt, Y., Lubrecht, J. M., Adriaans, B. P., Aben, J.-P., Gerretsen, S. C., Ghossein-Doha, C., Spaanderman, M. E. A., Prinzen, F. W., & Kooi, M. E. (2024). Quantification of left ventricular myocardial strain: Comparison between MRI tagging, MRI feature tracking, and ultrasound speckle tracking. NMR in Biomedicine, Article e5164. Advance online publication.
    • Aydeniz, E., van Rosmalen, F., de Kok, J., Martens, B., Mingels, A. M. A., Canakci, M. E., Mihl, C., Vernooy, K., Prinzen, F. W., Wildberger, J. E., van der Horst, I. C. C., van Bussel, B. C. T., & Driessen, R. G. H. (2024). The association between coronary artery calcification and vectorcardiography in mechanically ventilated COVID-19 patients: the Maastricht Intensive Care COVID cohort. Intensive Care Medicine Experimental, 12(1), Article 26.
    • Leinveber, P., Halamek, J., Curila, K., Prinzen, F., Lipoldova, J., Matejkova, M., Smisek, R., Plesinger, F., Nagy, A., Novak, M., Viscor, I., Vondra, V., & Jurak, P. (2024). Ultra-high-frequency ECG volumetric and negative derivative epicardial ventricular electrical activation pattern. Scientific Reports, 14(1), Article 5681.
    • Nguyên, U. C., Rijks, J. H. J., Plesinger, F., Rademakers, L. M., Luermans, J., Smits, K. C., van Stipdonk, A. M. W., Prinzen, F. W., Vernooy, K., Halamek, J., Curila, K., & Jurak, P. (2024). Ultra-High-Frequency ECG in Cardiac Pacing and Cardiac Resynchronization Therapy: From Technical Concept to Clinical Application. Journal of Cardiovascular Development and Disease, 11(3), Article 76.
    • Nguyên, U. C., Prinzen, F. W., & Vernooy, K. (2024). Left ventricular lead placement in cardiac resynchronization therapy: Current data and potential explanations for the lack of benefit. Heart Rhythm, 21(2), 197-205.
    • Koopsen, T., Gerrits, W., van Osta, N., van Loon, T., Wouters, P., Prinzen, F. W., Vernooy, K., Delhaas, T., Teske, A. J., Meine, M., Cramer, M. J., & Lumens, J. (2024). Virtual pacing of a patient’s digital twin to predict left ventricular reverse remodelling after cardiac resynchronization therapy. EP Europace, 26(1), Article euae009.
    • Dural, M., Ghossein, M. A., Gerrits, W., Daniels, F., Meine, M., Maass, A. H., Rienstra, M., Prinzen, F. W., Vernooy, K., & van Stipdonk, A. M. W. (2024). Association of vectorcardiographic T-wave area with clinical and echocardiographic outcomes in cardiac resynchronization therapy. EP Europace, 26(1), Article euad370.
  • 2023
    • Wouters, P. C., Zweerink, A., van Everdingen, W. M., Ghossein, M. A., de Roest, G. J., Cramer, M. J., Doevendans, P. A. F. M., Vernooy, K., Prinzen, F. W., Allaart, C. P., & Meine, M. (2023). Prognostic implications of invasive hemodynamics during cardiac resynchronization therapy: stroke work outperforms dP/dt<inf>max</inf>Heart Rhythm O2, 4(12), 777-783.
    • Westphal, P., Luo, H., Shahmohammadi, M., Prinzen, F. W., Delhaas, T., & Cornelussen, R. N. (2023). Machine learning–powered, device-embedded heart sound measurement can optimize AV delay in patients with CRT. Heart Rhythm, 20(9), 1316-1324.
    • Munneke, A. G., Lumens, J., Arts, T., Prinzen, F. W., & Delhaas, T. (2023). Myocardial perfusion and flow reserve in the asynchronous heart: mechanistic insight from a computational model. Journal of Applied Physiology, 135(3), 489-499.