Frits Prinzen


Frits Prinzen is professor of Physiology. He studied Medical Biology in Utrecht and defended his PhD in Maastricht in 1982. His research focusses on the relation between the electrical activation and mechanical contraction and pump function of the heart, with specific application to pacemaker therapies in heart failure. His work is highly translational, ranging from preclinical to clinical research and more recently also using computer simulations. Results from his work provided new insights in and opportunities for pacemaker therapies. He has participated in the CTMM-COHFAR consortium and has been and is workpackage leader in several EU-funded projects, including an International Training Network (Personalised in silico Cardiology). Several of his team members achieved personal grants (ZonMw Veni, Vidi, Clinical Fellow; Netherlands Heart Foundation junior and senior postdoc; young staff member). Besides, he ran multiple investigator-initiated studies that were funded by industry. He has been chairman of the Cardiovascular System Dynamics Society and of the Innovation Committee of the European Heart Rhythm Association (EHRA). Currently he is member of the Scientific Initiatives Committee of EHRA. He is (co-)author on 280 scientific articles, with 7740 citations and H-index of 50.

His main research topic is regional cardiac mechanics and long-term structural and functional adaptations to various conditions, with emphasis on asynchronous electrical activation and cardiac resynchronisation. Primarily animal experimental work, but with important links to Biomedical Engineering (computer models of cardiac electrophysiology and mechanics) and Cardiology (patients with pacemakers, bundle branch block, heart failure). With this background Prof. Frits Prinzen is a world expert on pacing therapies, both for bradycardia and for heart failure (cardiac resynchronisation therapy, CRT).

Department of Physiology
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
T: +31(0)43 3881080
  • 2021
    • Luo, H., Westphal, P., Shahmohammadi, M., Heckman, L. I. B., Kuiper, M., Cornelussen, R. N., Delhaas, T., & Prinzen, F. W. (2021). Second heart sound splitting as an indicator of interventricular mechanical dyssynchrony using a novel splitting detection algorithm. Physiological Reports, 9(1), e14687. [14687].
  • 2020
    • Corral-Acero, J., Margara, F., Marciniak, M., Rodero, C., Loncaric, F., Feng, Y., Gilbert, A., Fernandes, J. F., Bukhari, H. A., Wajdan, A., Martinez, M. V., Santos, M. S., Shamohammdi, M., Luo, H., Westphal, P., Leeson, P., DiAchille, P., Gurev, V., Mayr, M., ... Lamata, P. (2020). The 'Digital Twin' to enable the vision of precision cardiology. European Heart Journal, 41(48), 4556-4564.
    • Heckman, L., Vijayaraman, P., Luermans, J., Stipdonk, A. M. W., Salden, F., Maass, A. H., Prinzen, F. W., & Vernooy, K. (2020). Novel bradycardia pacing strategies. Heart, 106(24), 1883-1889.
    • Salden, F., Luermans, J. G., Van Stipdonk, A. M. W., Allaart, C. P., Meine, M., Prinzen, F. W., & Vernooy, K. (2020). Improving atrioventricular coupling in heart failure patients with PR prolongation, the ReachPR Trial. European Heart Journal, 41, 1036-1036.
    • Deshmukh, A., Prinzen, F. W., & Deshmukh, P. (2020). Response to: Next-level examination of His-optimized cardiac resynchronization therapy by noninvasive electrocardiographic activation mapping. Journal of Cardiovascular Electrophysiology, 31(11), 3064-3064.
    • Prinzen, F. W., & Lumens, J. (2020). Investigating myocardial work as a CRT response predictor is not a waste of work. European Heart Journal, 41(39), 3824-3826.
    • Lyon, A., Dupuis, L. J., Arts, T., Crijns, H. J. G. M., Prinzen, F. W., Delhaas, T., Heijman, J., & Lumens, J. (2020). Differentiating the effects of beta-adrenergic stimulation and stretch on calcium and force dynamics using a novel electromechanical cardiomyocyte model. American Journal of Physiology-heart and Circulatory Physiology, 319(3), H519-H530.
    • Deshmukh, A., Sattur, S., Bechtol, T., Heckman, L. I. B., Prinzen, F. W., & Deshmukh, P. (2020). Sequential His bundle and left ventricular pacing for cardiac resynchronization. Journal of Cardiovascular Electrophysiology, 31(9), 2448-2454.
    • Castro, E., Korver, F., Merry, A., van Moorsel, F., Hazebroek, M., Smid, M., Ploux, S., Bordachar, P., Prinzen, F., Sipers, W., & Strik, M. (2020). Should we still monitor QTc duration in frail older patients on low-dose haloperidol? A prospective observational cohort study. Age and Ageing, 49(5), 829-836.
    • Lumens, J., Willemen, E., & Prinzen, F. W. (2020). Does the Right Go Wrong During Cardiac Resynchronization Therapy?JACC-Cardiovascular Imaging, 13(7), 1485-1488.