Frits Prinzen


Frits Prinzen is emeritus professor of Physiology. He studied Medical Biology in Utrecht and defended his PhD in Maastricht in 1982. His research focusses on the relation between the electrical activation and mechanical contraction and pump function of the heart, with specific application to pacemaker therapies in heart failure. His work is highly translational, ranging from preclinical to clinical research and more recently also using computer simulations. Results from his work provided new insights in and opportunities for pacemaker therapies. He has participated in the CTMM-COHFAR consortium and has been and is workpackage leader in several EU-funded projects, including an International Training Network (Personalised in silico Cardiology). Several of his team members achieved personal grants (ZonMw Veni, Vidi, Clinical Fellow; Netherlands Heart Foundation junior and senior postdoc; young staff member). Besides, he ran multiple investigator-initiated studies that were funded by industry. He has been chairman of the Cardiovascular System Dynamics Society and of the Innovation Committee of the European Heart Rhythm Association (EHRA). Currently he is member of the Scientific Initiatives Committee of EHRA. He is (co-)author on 330 scientific articles, with >10,000 citations and H-index of 56.

His main research topic is regional cardiac mechanics and long-term structural and functional adaptations to various conditions, with emphasis on asynchronous electrical activation and cardiac resynchronisation. Primarily animal experimental work, but with important links to Biomedical Engineering (computer models of cardiac electrophysiology and mechanics) and Cardiology (patients with pacemakers, bundle branch block, heart failure). With this background Prof. Frits Prinzen is a world expert on pacing therapies, both for bradycardia and for heart failure (cardiac resynchronisation therapy, CRT).

Department of Physiology
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
T: +31(0)43 3881080
  • 2022
    • Holtackers, R. J., Gommers, S., Heckman, L. I. B., Van De Heyning, C. M., Chiribiri, A., & Prinzen, F. W. (2022). Histopathological Validation of Dark-Blood Late Gadolinium Enhancement MRI Without Additional Magnetization Preparation. Journal of Magnetic Resonance Imaging, 55(1), 190-197.
  • 2021
    • Curila, K., Jurak, P., Vernooy, K., Jastrzebski, M., Waldauf, P., Prinzen, F., Halamek, J., Susankova, M., Znojilova, L., Smisek, R., Karch, J., Plesinger, F., Moskal, P., Heckman, L., Mizner, J., Viscor, I., Vondra, V., Leinveber, P., & Osmancik, P. (2021). Left Ventricular Myocardial Septal Pacing in Close Proximity to LBB Does Not Prolong the Duration of the Left Ventricular Lateral Wall Depolarization Compared to LBB Pacing. Frontiers in cardiovascular medicine, 8, [787414].
    • Wouters, P. C., van Everdingen, W. M., Vernooy, K., Geelhoed, B., Allaart, C. P., Rienstra, M., Maass, A. H., Vos, M. A., Prinzen, F. W., Meine, M., & Cramer, M. J. (2021). Does mechanical dyssynchrony in addition to QRS area ensure sustained response to cardiac resynchronization therapy?European Heart Journal Cardiovascular Imaging.
    • Augustin, C. M., Gsell, M. A. F., Karabelas, E., Willemen, E., Prinzen, F. W., Lumens, J., Vigmond, E. J., & Plank, G. (2021). A computationally efficient physiologically comprehensive 3D-0D closed-loop model of the heart and circulation. Computer Methods in Applied Mechanics and Engineering, 386, [114092].
    • Prinzen, F. W., Lumens, J., Duchenn, J., & Vernooy, K. (2021). Electro-energetics of Biventricular, Septal and Conduction System Pacing. Arrhythmia & Electrophysiology Review, 10(4), 250-257.
    • Ghossein, M. A., Zanon, F., Salden, F., van Stipdonk, A., Marcantoni, L., Engels, E., Luermans, J., Westra, S., Prinzen, F., & Vernooy, K. (2021). Left Ventricular Lead Placement Guided by Reduction in QRS Area. Journal of Clinical Medicine, 10(24), [5935].
    • Hedeer, F., Ostenfeld, E., Heden, B., Prinzen, F. W., Arheden, H., Carlsson, M., & Engblom, H. (2021). To what extent are perfusion defects seen by myocardial perfusion SPECT in patients with left bundle branch block related to myocardial infarction, ECG characteristics, and myocardial wall motion?Journal of Nuclear Cardiology, 28(6), 2910-2922.
    • Bouwmeester, S., Mast, T. P., Keulards, D. C. J., de Lepper, A. G. W., Herold, I. H. F., Dekker, L. R., Prinzen, F. W., & Houthuizen, P. (2021). Left atrial reverse remodeling predicts long-term survival after cardiac resynchronization therapy. Journal of Echocardiography.
    • Salden, F. C. W. M., Huntjens, P. R., Schreurs, R., Willemen, E., Kuiper, M., Wouters, P., Maessen, J. G., Bordachar, P., Delhaas, T., Luermans, J., Meine, M., Allaart, C. P., van Stipdonk, A. M. W., Prinzen, F. W., Lumens, J., & Vernooy, K. (2021). Pacing therapy for atrioventricular dromotropathy: a combined computational-experimental-clinical study. EP Europace.
    • Heckman, L., Luermans, J., Salden, F., van Stipdonk, A. M. W., Mafi-Rad, M., Prinzen, F., & Vernooy, K. (2021). Physiology and Practicality of Left Ventricular Septal Pacing. Arrhythmia & Electrophysiology Review, 10(3), 165-171.