Hans Ippel

Technical staff

Hans Ippel studied Chemistry at Leiden University and received his PhD degree (1992) in Chemistry at Leiden University as well. He has worked as post-doc researcher in several job positions at Nijmegen University, Umeå University (Sweden), Wageningen University, and Utrecht University, and was also shortly employed as bioinformatician at the biotech company Catchmabs in Wageningen. In 2011, he joined the Biochemistry group of Tilman Hackeng, working as senior researcher doing structural NMR spectroscopy of peptides and proteins. He is currently employed as supervisor of the NMR facility supporting various academic researchers at CARIM and Maastricht UMC+. In addition, he is responsible for assisting external NMR users and doing contract work to third parties. Besides having expertise in structural biophysics and bioinformatics, Hans is an avid collector of Natural Art and all kinds of science stuff.

Research topics of interest are blood coagulation factors and potent inhibitory chemokines and peptides, e.g. derived from ticks. Here, NMR spectroscopy is used to determine 3D structures of native protein and the protein-target complex, in order to come up with new ways of drug targeting. Another research topic is on the structural biology of galectins (such as Gal1, Gal3 and Gal8) that are important proteins involved in cancer development. It is a collaboration project carried out between CARIM and the groups of Prof. Kevin Mayo (Minnesota University) and Prof Christian Weber (LUM München). NMR is also applied for metabolomic profiling of patients blood and urine samples, as well as being used as a structural validation tool towards the design of smart biopolymers.  

 

Department of Biochemistry
Universiteitsingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: H4.301
T: +31(0)43-388 24 92

  • 2021
    • Denisov, S. S., Ippel, J. H., Castoldi, E., Mans, B. J., Hackeng, T. M., & Dijkgraaf, I. (2021). Molecular basis of anticoagulant and anticomplement activity of the tick salivary protein Salp14 and its homologs. Journal of Biological Chemistry, 297(1), [100865]. https://doi.org/10.1016/j.jbc.2021.100865
    • Miller, M. C., Zheng, Y., Suylen, D., Ippel, H., Canada, F. J., Berbis, M. A., Jimenez-Barbero, J., Tai, G., Gabius, H-J., & Mayo, K. H. (2021). Targeting the CRD F-face of Human Galectin-3 and Allosterically Modulating Glycan Binding by Angiostatic PTX008 and a Structurally Optimized Derivative. Chemmedchem, 16(4), 713-723. https://doi.org/10.1002/cmdc.202000742
  • 2020
    • Denisov, S. S., Ramirez-Escudero, M., Heinzmann, A. C. A., Ippel, J. H., Dawson, P. E., Koenen, R. R., Hackeng, T. M., Janssen, B. J. C., & Dijkgraaf, I. (2020). Structural characterization of anti-CCL5 activity of the tick salivary protein evasin-4. Journal of Biological Chemistry, 295(42), 14367-14378. https://doi.org/10.1074/jbc.RA120.013891
    • Weterings, J., Rijcken, C. J. F., Veldhuis, H., Meulemans, T., Hadavi, D., Timmers, M., Honing, M., Ippel, H., & Liskamp, R. M. J. (2020). TMTHSI, a superior 7-membered ring alkyne containing reagent for strain-promoted azide-alkyne cycloaddition reactions. Chemical Science, 11(33), 9011-9016. https://doi.org/10.1039/d0sc03477k
    • Miller, M. C., Nesmelova, I. V., Daragan, V. A., Ippel, H., Michalak, M., Dregni, A., Kaltner, H., Kopitz, J., Gabius, H. J., & Mayo, K. H. (2020). Pro4 prolyl peptide bond isomerization in human galectin-7 modulates the monomer-dimer equilibrum to affect function. Biochemical Journal, 477(17), 3147-3165. https://doi.org/10.1042/BCJ20200499
    • Eckardt, V., Miller, M. C., Blanchet, X., Duan, R., Leberzammer, J., Duchene, J., Soehnlein, O., Megens, R. T. A., Ludwig, A-K., Dregni, A., Faussner, A., Wichapong, K., Ippel, H., Dijkgraaf, I., Kaltner, H., Doering, Y., Bidzhekov, K., Hackeng, T. M., Weber, C., ... Mayo, K. H. (2020). Chemokines and galectins form heterodimers to modulate inflammation. Embo Reports, 21(4), [47852]. https://doi.org/10.15252/embr.201947852
    • Denisov, S. S., Heinzmann, A. C. A., Vajen, T., Vries, M. H. M., Megens, R. T. A., Suylen, D., Koenen, R. R., Post, M. J., Ippel, J. H., Hackeng, T. M., & Dijkgraaf, I. (2020). Tick Saliva Protein Evasin-3 Allows for Visualization of Inflammation in Arteries through Interactions with CXC-Type Chemokines Deposited on Activated Endothelium. Bioconjugate Chemistry, 31(3), 948-955. https://doi.org/10.1021/acs.bioconjchem.0c00095
  • 2019
    • Zhang, H., Ippel, H., Miller, M. C., Wong, T. J., Griffioen, A. W., Mayo, K. H., & Pieters, R. J. (2019). Hybrid ligands with calixarene and thiodigalactoside groups: galectin binding and cytotoxicity. Organic Chemistry Frontiers, 6(16), 2981-2990. https://doi.org/10.1039/c9qo00810a
    • Denisov, S. S., Ippel, J. H., Heinzmann, A. C. A., Koenen, R. R., Ortega-Gomez, M., Soehnlein, O., Hackeng, T. M., & Dijkgraaf, I. (2019). Tick saliva protein Evasin-3 modulates chemotaxis by disrupting CXCL8 interactions with glycosaminoglycans and CXCR2. Journal of Biological Chemistry, 294(33), 12370-12379. https://doi.org/10.1074/jbc.RA119.008902
    • Streefkerk, D. E., Schmidt, M., Ippel, J. H., Hackeng, T. M., Nuijens, T., Timmerman, P., & van Maarseveen, J. H. (2019). Synthesis of Constrained Tetracyclic Peptides by Consecutive CEPS, CLIPS, and Oxime Ligation. Organic Letters, 21(7), 2095-2100. https://doi.org/10.1021/acs.orglett.9b00378