Henri Spronk

Professor

Initially trained in Biochemistry and Molecular Biology at Nijmegen University, Dr Henri Spronk obtained a PhD in Biochemistry on the effects of impaired vitamin K-dependent protein carboxylation.

The focus of his current work is on the bidirectional relation between coagulation and inflammation, as well as on the applicability of functional plasma assays such as thrombin generation, for atherothrombotic risk prediction. He has a special interest in the role of active coagulation factors, mainly thrombin, in activation of protein-activated receptors (PARs) which can regulate the balance between vascular protective and disruptive. Overall, knowledge on the non-haemostatic functions of thrombin and factor Xa enables pharmacological interference in cellular processes contributing to the the development and progression of atherosclerosis or atrial fibrillation.

Department of Biochemistry
Department of Internal Medicine
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: H.1.328
T: +31(0)43 388 42 61

2026
- Bondi, E., Obino, G., Guidotti, G., Sensini, A., Nagy, M., Spronk, H. M. H., van Griensven, M., Lepedda, A. J., Lotti, N., & Moroni, L. (2026). Aromatic Copolyesters Based on Poly(butylene furanoate) and Poly(butylene isophthalate) for Small-Diameter Vascular Applications. ACS Biomaterial Science and Engineering. Advance online publication. https://doi.org/10.1021/acsbiomaterials.6c00106
- Schellens, J., Nagy, M., Hulshof, A. M., van Rosmalen, F., van Oerle, R., van Herpt, T. T. W., Alnima, T., Mulder, M. M. G., Hellenbrand, D., ten Cate, H., Driessen, R. G. H., Sels, J. W. E. M., van der Horst, I. C. C., Henskens, Y. M. C., van Bussel, B. C. T., Spronk, H. M. H., & Dutch Covid and Thrombosis Coalition (2026). Inhibition of inflammation reduces hypofibrinolysis in severe COVID-19: A nested case-control study within the MaastrICCht cohort. Thrombosis Research, 262, Article 109723. https://doi.org/10.1016/j.thromres.2026.109723
- Urlings, E. H., Heubel-Moenen, F. C. J. I., van Oerle, R., Hellenbrand, D. L. S., van der Meijden, P. E. J., Hackeng, T. M., Cate, H. T., Nagy, M., Henskens, Y. M. C., & Spronk, H. M. H. (2026). Intrinsic activated thrombin generation for treatment efficacy and monitoring of octocog alfa and emicizumab in severe hemophilia A. Research and practice in thrombosis and haemostasis, 10(4), Article 106627. https://doi.org/10.1016/j.rpth.2026.106627
- Franssen, I. S., Jong, M. J. D., Vievermans, A., Stroo, J. F., Henskens, Y. M. C., Spronk, H., Janssen, D. J. A., Braeken, D., van Kuijk, S. M. J., Winckers, K., & Magdelijns, F. J. H. (2026). Adequacy of Direct Oral Anticoagulant Dosing in Nursing Home Residents: Cross-Sectional Data From the DOAC-FRAIL Study. Journal of the American Medical Directors Association, 27(4), Article 106082. https://doi.org/10.1016/j.jamda.2025.106082
- Nagy, M., Gomes, T., Van Oerle, R., Hacking, T. M., Magdelijns, F. J. H., Henskens, Y. M. C., Reitsma, P., Short, G., Spronk, H. M. H., & Verhoef, D. (2026). Coagulation assays for assessing the bypassing of factor Xa direct oral anticoagulants using VMX-C001. Research and practice in thrombosis and haemostasis, 10(2), Article e103375. https://doi.org/10.1016/j.rpth.2026.103375
- D'alessandro, E., Scaf, B., Opacic, D., van Hunnik, A., Sobota, V., Kuiper, M., Viola, M., Hutschalik, T., Langione, M., Pioner, J. M., Munts, C., Simons, J., Winters, J., Isaacs, A., Heitmeier, S., Stoll, M., van Oerle, R., Ten Cate, H., Spronk, H. M. H., ... Schotten, U. (2026). Rivaroxaban Treatment Prevents Atrial Myocyte Hypertrophy in Goats with Persistent Atrial Fibrillation by Inhibition of Protease-Activated Receptor-1. Thrombosis and Haemostasis. Advance online publication. https://doi.org/10.1055/a-2761-6106
2025
- Obino, G., Nieddu, G., Nagy, M., Ippel, H., Cubeddu, T., Spronk, H. M. H., Hackeng, T. M., Formato, M., Lepedda, A. J., & Moroni, L. (2025). Marine-derived sulfated polysaccharides enhance hemocompatibility and endothelialization of nanofibrous PCL for vascular graft applications. Cell Biomaterials, 1(10), Article 100155. https://doi.org/10.1016/j.celbio.2025.100155
- van der Bie, J., Coleon, A., Visser, D., Bogers, W. M., den Dunnen, J., Spronk, H. M. H., Langermans, J. A. M., Willemen, H. L. D. M., De Melo, G. D., Middeldorp, J., & Stammes, M. A. (2025). Post Pandemic Problem, is there an animal model suitable to investigate PASC. npj Imaging, 3(1), Article 41. https://doi.org/10.1038/s44303-025-00101-2
- Wang, M., Taha, A., Nagy, M., Raben, J. D., van Noort, R., Volovici, V., Dammers, R., Duncker, D. J., Spronk, H., Ten Cate, H., Dippel, D., Bobi, J., & van Beusekom, H. M. M. (2025). Microvascular Occlusion and Postrecanalization Hyperperfusion in a Swine Model of Acute Ischemic Stroke. Journal of the American Heart Association, 14(18), Article e042663. https://doi.org/10.1161/JAHA.125.042663
- Baaten, C. C. F. M. J., Wollenhaupt, J., Henning, T. M., Vondenhoff, S., Schröer, J. R., Stamellou, E., Saritas, T., Kurt, B., Boger, L., Antwerpen, A., Hermann, J., Nagy, M., Sternkopf, M., Buhl, E. M., Raffetseder, U., van der Meijden, P. E. J., Kuijpers, M. J. E., Spronk, H. M. H., Schunk, S. J., ... Noels, H. (2025). Impaired Secondary Platelet Response in Chronic Kidney Disease as a Consequence of Prior Platelet Activation. JACC: Basic to Translational Science, 10(9), Article 101355. https://doi.org/10.1016/j.jacbts.2025.101355

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Henri Spronk

Professor