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Uyên Châu Nguyên wins UM Dissertation Prize 2025

Uyên Châu Nguyên wins UM Dissertation Prize 2025

29 January 2026

During the Dies Natalis of Maastricht University, Uyên Châu Nguyên received the UM Dissertation Prize 2025.

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Global research network launched to study menopause and heart health

Global research network launched to study menopause and heart health

20 January 2026

Ten international health research funders, including the Dutch Heart Foundation, are investing $10 million in a new global research network to improve early prevention of cardiovascular disease in women. The initiative focuses on understanding how menopause affects heart health and how early intervention can reduce risk.

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Carim Maastricht
Carim Maastricht

Henri Spronk

Professor

Initially trained in Biochemistry and Molecular Biology at Nijmegen University, Dr Henri Spronk obtained a PhD in Biochemistry on the effects of impaired vitamin K-dependent protein carboxylation.

The focus of his current work is on the bidirectional relation between coagulation and inflammation, as well as on the applicability of functional plasma assays such as thrombin generation, for atherothrombotic risk prediction. He has a special interest in the role of active coagulation factors, mainly thrombin, in activation of protein-activated receptors (PARs) which can regulate the balance between vascular protective and disruptive. Overall, knowledge on the non-haemostatic functions of thrombin and factor Xa enables pharmacological interference in cellular processes contributing to the the development and progression of atherosclerosis or atrial fibrillation.

Henri-spronk

Department of Biochemistry
Department of Internal Medicine
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: H.1.328
T: +31(0)43 388 42 61

  • 2025
    • Obino, G., Nieddu, G., Nagy, M., Ippel, H., Cubeddu, T., Spronk, H. M. H., Hackeng, T. M., Formato, M., Lepedda, A. J., & Moroni, L. (2025). Marine-derived sulfated polysaccharides enhance hemocompatibility and endothelialization of nanofibrous PCL for vascular graft applications. Cell Biomaterials, 1(10), Article 100155. https://doi.org/10.1016/j.celbio.2025.100155
    • van der Bie, J., Coleon, A., Visser, D., Bogers, W. M., den Dunnen, J., Spronk, H. M. H., Langermans, J. A. M., Willemen, H. L. D. M., De Melo, G. D., Middeldorp, J., & Stammes, M. A. (2025). Post Pandemic Problem, is there an animal model suitable to investigate PASC. npj Imaging, 3(1), Article 41. https://doi.org/10.1038/s44303-025-00101-2
    • Wang, M., Taha, A., Nagy, M., Raben, J. D., van Noort, R., Volovici, V., Dammers, R., Duncker, D. J., Spronk, H., Ten Cate, H., Dippel, D., Bobi, J., & van Beusekom, H. M. M. (2025). Microvascular Occlusion and Postrecanalization Hyperperfusion in a Swine Model of Acute Ischemic Stroke. Journal of the American Heart Association, 14(18), Article e042663. https://doi.org/10.1161/JAHA.125.042663
    • Baaten, C. C. F. M. J., Wollenhaupt, J., Henning, T. M., Vondenhoff, S., Schröer, J. R., Stamellou, E., Saritas, T., Kurt, B., Boger, L., Antwerpen, A., Hermann, J., Nagy, M., Sternkopf, M., Buhl, E. M., Raffetseder, U., van der Meijden, P. E. J., Kuijpers, M. J. E., Spronk, H. M. H., Schunk, S. J., ... Noels, H. (2025). Impaired Secondary Platelet Response in Chronic Kidney Disease as a Consequence of Prior Platelet Activation. JACC: Basic to Translational Science, 10(9), Article 101355. https://doi.org/10.1016/j.jacbts.2025.101355
    • Gomez-Rosas, P., Nagy, M., Spronk, H. M. H., Russo, L., Gamba, S., Tartari, C. J., Bolognini, S., Ticozzi, C., Schieppati, F., Sarmiento, R., De Braud, F., Masci, G., Tondini, C., Petrelli, F., Giuliani, F., D'Alessio, A., Santoro, A., Gasparini, G., Labianca, R., ... HYPERCAN Investigators (2025). Activated factor XI–antithrombin and thrombin–antithrombin complexes in the prediction of venous thromboembolism and mortality in patients with non–small-cell lung cancer. Journal of Thrombosis and Haemostasis, 23(6), 1908-1919. https://doi.org/10.1016/j.jtha.2025.02.029
    • Taha, A., Nagy, M., Hund, H. M., van Doormaal, P. J., van Noorden, K., Spronk, H. M. H., Ceulemans, A., van Oostenbrugge, R. J., Duncker, D. J., ten Cate, H., Dippel, D., van Es, A. C. G. M., Bobi, J., & van Beusekom, H. M. M. (2025). Vascular injury and occurrence of microthrombi after endovascular therapy for acute ischaemic stroke in a thromboembolic model. BMJ Neurology Open, 7(1), Article e000989. https://doi.org/10.1136/bmjno-2024-000989
    • Ceulemans, A., Barakzie, A., Spronk, H. M. H., de Maat, M. P. M., van Beusekom, H. M. M., Taha, A., Emmer, B. J., Roos, Y. B. W. E. M., Dippel, D. W. J., Majoie, C. B. L. M., van Zwam, W. H., ten Cate, H., van Oostenbrugge, R. J., & Nagy, M. (2025). Association between coagulation activity and clinical and imaging outcomes in acute ischemic stroke patients - A sub-study of the MR CLEAN NO-IV trial. Thrombosis Research, 245, Article 109212. https://doi.org/10.1016/j.thromres.2024.109212
    • van Mourik, D. J. M., Jansen, V. L. B. I., Coppens, M., Middeldorp, S., ten Cate, H., Buller, H. R., Spronk, H. M. H., Nagy, M., & van Mens, T. E. (2025). Intrinsic pathway activation in patients with antiphospholipid syndrome and healthy controls. Research and practice in thrombosis and haemostasis, 9(1), Article 102694. https://doi.org/10.1016/j.rpth.2025.102694
    • Monegatti, S., Martinelli, N., Friso, S., Spronk, H. M., & Ten Cate, H. (2025). Mechanisms and management of thrombosis in cancer: focus on gastrointestinal malignancies. Journal of Pharmacology and Experimental Therapeutics, 392(1), Article 100018. https://doi.org/10.1124/jpet.124.002203
  • 2024
    • Velt, M. J. H., Crijns, H. J. G. M., van Gelder, I. C., Linz, D., van de Lande, M. E., Ten Cate, H., Spronk, H. M. H., de Melis, M., Rienstra, M., & Mulder, B. A. (2024). Dynamic biomarker profiles in patients with paroxysmal atrial fibrillation: Assessing the differences between sinus rhythm and acute atrial fibrillation episode. International Journal of Cardiology, 417, Article 132526. https://doi.org/10.1016/j.ijcard.2024.132526
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