Henri Spronk

Associate professor

Initially trained in Biochemistry and Molecular Biology at Nijmegen University, Dr Henri Spronk obtained a PhD in Biochemistry on the effects of impaired vitamin K-dependent protein carboxylation.

The focus of his current work is on the bidirectional relation between coagulation and inflammation, as well as on the applicability of functional plasma assays such as thrombin generation, for atherothrombotic risk prediction. He has a special interest in the role of active coagulation factors, mainly thrombin, in activation of protein-activated receptors (PARs) which can regulate the balance between vascular protective and disruptive. Overall, knowledge on the non-haemostatic functions of thrombin and factor Xa enables pharmacological interference in cellular processes contributing to the the development and progression of atherosclerosis or atrial fibrillation.

Department of Biochemistry
Department of Internal Medicine
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: 4.326
T: +31(0)43 388 42 61

  • 2020
    • Kremers, B., Wubbeke, L., Mees, B., ten Cate, H., Spronk, H., & ten Cate-Hoek, A. (2020). Plasma Biomarkers to Predict Cardiovascular Outcome in Patients With Peripheral Artery Disease A Systematic Review and Meta-Analysis. Arteriosclerosis Thrombosis and Vascular Biology, 40(9), 2018-2032. https://doi.org/10.1161/ATVBAHA.120.314774
    • van Paridon, P. C. S., Panova-Noeva, M., van Oerle, R., Schultz, A., Hermanns, I. M., Prochaska, J. H., Arnold, N., Binder, H., Schmidtmann, I., Beutel, M. E., Pfeiffer, N., Münzel, T., Lackner, K. J., Ten Cate, H., Wild, P. S., & Spronk, H. M. H. (2020). Thrombin generation in cardiovascular disease and mortality - results from the Gutenberg Health Study. Haematologica-the Hematology Journal, 105(9), 2327-2334. https://doi.org/10.3324/haematol.2019.221655
    • Heuberger, J. A. A. C., Posthuma, J. J., Ziagkos, D., Rotmans, J., Daniels, J. M. A., Gal, P., Stuurman, F. E., Spronk, H. M. H., Cate, H. T., Burggraaf, J., Moerland, M., & Cohen, A. F. (2020). Additive effect of erythropoietin use on exercise-induced endothelial activation and hypercoagulability in athletes. European Journal of Applied Physiology, 120(8), 1893-1904. https://doi.org/10.1007/s00421-020-04419-0
    • Brouns, S. L. N., van Geffen, J. P., Campello, E., Swieringa, F., Spiezia, L., van Oerle, R., Provenzale, I., Verdoold, R., Farndale, R. W., Clemetson, K. J., Spronk, H. M. H., van der Meijden, P. E. J., Cavill, R., Kuijpers, M. J. E., Castoldi, E., Simioni, P., & Heemskerk, J. W. M. (2020). Platelet-primed interactions of coagulation and anticoagulation pathways in flow-dependent thrombus formation. Scientific Reports, 10(1), 11910. [11910]. https://doi.org/10.1038/s41598-020-68438-9
    • Visser, M., Heitmeier, S., ten Cate, H., & Spronk, H. M. H. (2020). Role of Factor XIa and Plasma Kallikrein in Arterial and Venous Thrombosis. Thrombosis and Haemostasis, 120(6), 883-893. https://doi.org/10.1055/s-0040-1710013
    • Grover, S. P., Schmedes, C. M., Auriemma, A. C., Butler, E., Parrish, M. L., Miszta, A., Cleuren, A. C., Visser, M., Heitmeier, S., Posma, J. J., Spronk, H. M., Antoniak, S., Wolberg, A. S., Pawlinski, R., Gailani, D., & Mackman, N. (2020). Differential roles of factors IX and XI in murine placenta and hemostasis under conditions of low tissue factor. Blood advances, 4(1), 207-216. https://doi.org/10.1182/bloodadvances.2019000921
    • Visser, M., van Oerle, R., ten Cate, H., Laux, V., Mackman, N., Heitmeier, S., & Spronk, H. M. H. (2020). Plasma Kallikrein Contributes to Coagulation in the Absence of Factor XI by Activating Factor IX. Arteriosclerosis Thrombosis and Vascular Biology, 40(1), 103-111. https://doi.org/10.1161/ATVBAHA.119.313503
  • 2019
    • Panova-Noeva, M., Wagner, B., Nagler, M., Arnold, N., Prochaska, J. H., Eckerle, S., Spronk, H. M., Merzenich, H., Wingerter, A., Schneider, A., Danckwardt, S., ten Cate, H., Faber, J., & Wild, P. S. (2019). Relation between platelet coagulant and vascular function, sex-specific analysis in adult survivors of childhood cancer compared to a population-based sample. Scientific Reports, 9, [20090]. https://doi.org/10.1038/s41598-019-56626-1
    • Heestermans, M., de Jong, A., van Tilburg, S., Reitsma, P. H., Versteeg, H. H., Spronk, H. M., & van Vlijmen, B. J. M. (2019). Use of "C9/11 Mismatch" Control Small Interfering RNA Reveals Sequence-Related Off-Target Effect on Coagulation of an Small Interfering RNA Targeting Mouse Coagulation Factor XII. Nucleic Acid Therapeutics, 29(4), 218-223. https://doi.org/10.1089/nat.2018.0767
    • Olie, R. H., van der Meijden, P. E. J., Spronk, H. M. H., van Oerle, R., Barvik, S., Bonarjee, V. V. S., Ten Cate, H., & Nilsen, D. W. T. (2019). Effects of the PAR-1 Antagonist Vorapaxar on Platelet Activation and Coagulation Biomarkers in Patients with Stable Coronary Artery Disease. TH open : companion journal to thrombosis and haemostasis, 3(3), e259-e262. https://doi.org/10.1055/s-0039-1695710