Hugo ten Cate


Prof. Hugo ten Cate graduated in Medicine at the University of Amsterdam in 1987. The title of his PhD thesis was 'Clinical and experimental studies with a low molecular weight heparinoid'. Hugo had his post-doctoral training at the laboratory of Prof. Robert Rosenberg and Dr Kenneth Bauer at the Beth Israel Hospital and Harvard Medical School Boston on mechanisms of inflammation associated coagulation activity (1988-1990). He completed his internal medicine training in 1996 and became a general internist in conjunction with research at Academic Medical Center (laboratory of Experimental Internal medicine, Prof. Pieter Reitsma). He received a Clinical Established Investigator grant from the Dutch Heart Foundation in 1998.

In 2002, Hugo ten Cate was appointed Professor of Clinical Thrombosis and Haemostasis at CARIM. In addition, Prof. ten Cate was appointed adjunct professor at the Center for Thrombosis and Haemostasis (CTH) at Gutenberg University Medical Center, Mainz, Germany in 2017

Since the transfer to CARIM in 2002 his research focus shifted from coagulation-inflammation research in sepsis models, to the broader field of cardiovascular (CV) disease (atherothrombosis and 'thrombo-inflammation'). A specific focus of current research is the pleiotropic actions of coagulation proteases in atherosclerosis, atherothrombosis and ischemia reperfusion injury. Clinical research is aimed at chronic thrombotic disease including peripheral artery disease, high risk patients with coronary disease on antithrombotic medication and, together with Dr Arina ten Cate-Hoek, on venous thrombosis and post thrombotic syndrome (PTS). He is workpackage leader in CVON consortia RACE-5 (coagulation and its impact on atrial fibrillation) and CONTRAST (acute ischemic stroke) and involved in the ITN consortia TAPAS and TICARDIO. His group has an ongoing target finding programme with Bayer (steered from CARIM by Dr Henri Spronk and Prof. Hugo ten Cate) as well as with 2M (on POC development).

Department of Biochemistry
Department of Internal Medicine
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: 4.344
T: +31(0)43 388 42 62

  • 2024
    • Willems, R. A. L., Konings, J., Huskens, D., Middelveld, H., Pepels-Aarts, N., Verbeet, L., de Groot, P. G., Heemskerk, J. W. M., Ten Cate, H., de Vos-Geelen, J., de Laat, B., & Roest, M. (2024). Altered whole blood thrombin generation and hyperresponsive platelets in patients with pancreatic cancer. Journal of Thrombosis and Haemostasis, 22(4), 1132-1144.
    • van Voorst, H., Hoving, J. W., Koopman, M. S., Daems, J. D., Peerlings, D., Buskens, E., Lingsma, H. F., Beenen, L. F. M., de Jong, H. W. A. M., Berkhemer, O. A., van Zwam, W. H., Roos, Y. B. W. E. M., van Walderveen, M. A. A., van den Wijngaard, I., Dippel, D. W. J., Yoo, A. J., Campbell, B. C. V., Kunz, W. G., Emmer, B. J., ... MR CLEAN Registry Investigators (2024). Cost-effectiveness of CT perfusion for the detection of large vessel occlusion acute ischemic stroke followed by endovascular treatment: a model-based health economic evaluation study. European Radiology, 34(4), 2152-2167.
    • Ceulemans, A., Spronk, H. M. H., Ten Cate, H., van Zwam, W. H., van Oostenbrugge, R. J., & Nagy, M. (2024). Current and potentially novel antithrombotic treatment in acute ischemic stroke. Thrombosis Research, 236, 74-84.
    • Luu, I. H. Y., Mostard, G. J. M., van Mil, D., van Berlo, M. H. W., Lobbes, M. B. I., Külcü, K., Cate, H. T., Peeters, J., Palmen, J., Buijs, J., Jie, K. S. G., van Kampen, R. J. W., & van Twist, D. J. L. (2024). Deferring diagnostic evaluation for suspected deep venous thrombosis using a single dose of anticoagulant: Real-world data from a regionwide care pathway. European journal of internal medicine, 122, 54-60.
    • Ten Cate-Hoek, A., & Ten Cate, H. (2024). Stressful experiences and venous thromboembolism. European journal of internal medicine, 122, 38-39.
    • de Jong, M. J., Saadan, H., Hellenbrand, D. L. S., Ten Cate, H., Spaetgens, B., Brüggemann, R. A. G., van Kuijk, S. M. J., Winckers, K., Henskens, Y. M. C., & Magdelijns, F. J. H. (2024). The DOAC-FRAIL study, evaluation of direct oral anticoagulant-levels in acutely admitted frail older patients: An exploratory study. Journal of the American Geriatrics Society. Advance online publication.
    • Iding, A. F. J., Alkarithi, G., Ten Cate, H., Ariëns, R. A. S., & Ten Cate-Hoek, A. J. (2024). Fibrinogen levels and clot properties identify patients that benefit from catheter-directed thrombolysis after DVT. Blood advances. Advance online publication.
    • Busch, M. H., Ysermans, R., Aendekerk, J., Timmermans, S. A., Potjewijd, J., Damoiseaux, J., Spronk, H. M. H., Ten Cate, H., Reutelingsperger, C., Nagy, M., & van Paassen, P. (2024). The intrinsic coagulation pathway plays a dominant role in driving hypercoagulability in ANCA-Associated Vasculitis. Blood advances, 8(5), 1295-1304.
    • Willems, R. A. L., Biesmans, C., Campello, E., Simioni, P., de Laat, B., de Vos-Geelen, J., Roest, M., & Ten Cate, H. (2024). Cellular Components Contributing to the Development of Venous Thrombosis in Patients with Pancreatic Cancer. Seminars in Thrombosis and Hemostasis, 50(3), 429-442.
    • Hulshof, A. M., Nab, L., van Rosmalen, F., de Kok, J., Mulder, M. M. G., Hellenbrand, D., Sels, J. W. E. M., ten Cate, H., Cannegieter, S. C., Henskens, Y. M. C., & van Bussel, B. C. T. (2024). Rotational thromboelastometry as a biomarker for mortality — The Maastricht Intensive Care COVID cohort. Thrombosis Research, 234, 51-58.