Hugo ten Cate


Prof. Hugo ten Cate graduated in Medicine at the University of Amsterdam in 1987. The title of his PhD thesis was 'Clinical and experimental studies with a low molecular weight heparinoid'. Hugo had his post-doctoral training at the laboratory of Prof. Robert Rosenberg and Dr Kenneth Bauer at the Beth Israel Hospital and Harvard Medical School Boston on mechanisms of inflammation associated coagulation activity (1988-1990). He completed his internal medicine training in 1996 and became a general internist in conjunction with research at Academic Medical Center (laboratory of Experimental Internal medicine, Prof. Pieter Reitsma). He received a Clinical Established Investigator grant from the Dutch Heart Foundation in 1998.

In 2002, Hugo ten Cate was appointed Professor of Clinical Thrombosis and Haemostasis at CARIM. In addition, Prof. ten Cate was appointed adjunct professor at the Center for Thrombosis and Haemostasis (CTH) at Gutenberg University Medical Center, Mainz, Germany in 2017

Since the transfer to CARIM in 2002 his research focus shifted from coagulation-inflammation research in sepsis models, to the broader field of cardiovascular (CV) disease (atherothrombosis and 'thrombo-inflammation'). A specific focus of current research is the pleiotropic actions of coagulation proteases in atherosclerosis, atherothrombosis and ischemia reperfusion injury. Clinical research is aimed at chronic thrombotic disease including peripheral artery disease, high risk patients with coronary disease on antithrombotic medication and, together with Dr Arina ten Cate-Hoek, on venous thrombosis and post thrombotic syndrome (PTS). He is workpackage leader in CVON consortia RACE-5 (coagulation and its impact on atrial fibrillation) and CONTRAST (acute ischemic stroke) and involved in the ITN consortia TAPAS and TICARDIO. His group has an ongoing target finding programme with Bayer (steered from CARIM by Dr Henri Spronk and Prof. Hugo ten Cate) as well as with 2M (on POC development).

Department of Biochemistry
Department of Internal Medicine
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: 4.344
T: +31(0)43 388 42 62

  • 2020
    • Seelig, J., Hemels, M. E. W., Xhaet, O., Bongaerts, M. C. M., de Wolf, A., Groenemeijer, B. E., Heyse, A., Hoogslag, P., Voet, J., Herrman, J-P. R., Vervoort, G., Hermans, W., Wollaert, B., Boersma, L. V. A., Hermans, K., Lucassen, A., Verstraete, S., Adriaansen, H. J., Mairesse, G. H., ... GARFIELD-AF Investigators (2020). Impact of different anticoagulation management strategies on outcomes in atrial fibrillation: Dutch and Belgian results from the GARFIELD-AF registry. Journal of Thrombosis and Haemostasis, 18(12), 3280-3288.
    • Bavalia, R., Abdoellakhan, R., Beenen, L. F., Brekelmans, M. P. A., Olie, R. H., ten Cate, H., Huisman, M., Kruip, M., Middeldorp, S., Meijer, K., Hutten, B. A., & Coppens, M. (2020). Outcome of intracranial bleeding managed with prothrombin complex concentrate in patients on direct factor Xa inhibitors or vitamin K antagonists. Thrombosis Research, 196, 404-409.
    • Bruggemann, R. A. G., Spaetgens, B., Gietema, H. A., Brouns, S. H. A., Stassen, P. M., Magdelijns, F. J., Rennenberg, R. J., Henry, R. M. A., Mulder, M. M. G., van Bussel, B. C. T., Schnabel, R. M., van der Horst, I. C. C., Wildberger, J. E., Stehouwer, C. D. A., & ten Cate, H. (2020). The prevalence of pulmonary embolism in patients with COVID-19 and respiratory decline: A three-setting comparison. Thrombosis Research, 196, 486-490.
    • Busch, M. H., Timmermans, S. A. M. E. G., Nagy, M., Visser, M., Huckriede, J., Aendekerk, J. P., de Vries, F., Potjewijd, J., Jallah, B., Ysermans, R., Oude Lashof, A. M. L., Breedveld, P. H., van de Poll, M. C. G., van de Horst, I. C. C., van Bussel, B. C. T., Theunissen, R. O. M. F. I. H., Spronk, H. M. H., Damoiseaux, J. G. M. C., ten Cate, H., ... van Paassen, P. (2020). Neutrophils and Contact Activation of Coagulation as Potential Drivers of COVID-19. Circulation, 142(18), 1787-1790.
    • Chayoua, W., Yin, D., Kelchtermans, H., Moore, G. W., Gris, J-C., Musial, J., Zuily, S., ten Cate, H., de Laat, B., & Devreese, K. M. J. (2020). Is There an Additional Value in Detecting Anticardiolipin and Anti-beta 2 glycoprotein I IgA Antibodies in the Antiphospholipid Syndrome?Thrombosis and Haemostasis, 120(11), 1557-1568.
    • Mulder, B. A., ten Berg, J., ten Cate, H., van Es, N., Hemels, M. E. W., Kappelle, L. J., Bakker, H. B. B., de Borst, G. J., Drenth, D. J., Geersing, G. J., & Rienstra, M. (2020). Complex clinical scenarios with the use of direct oral anticoagulants in patients with atrial fibrillation: a multidisciplinary expert advisory board. Netherlands Heart Journal, 28(10), 504-513.
    • Panova-Noeva, M., Wagner, B., Nagler, M., Koeck, T., ten Cate, V., Prochaska, J. H., Heitmeier, S., Meyer, I., Gerdes, C., Laux, V., Konstantinides, S., Spronk, H. M., Muenzel, T., Lackner, K. J., Leineweber, K., ten Cate, H., & Wild, P. S. (2020). Comprehensive platelet phenotyping supports the role of platelets in the pathogenesis of acute venous thromboembolism - results from clinical observation studies. EBioMedicine, 60, [102978].
    • Oudkerk, M., Buller, H. R., Kuijpers, D., van Es, N., Oudkerk, S. F., McLoud, T., Gommers, D., van Dissel, J., ten Cate, H., & van Beek, E. J. R. (2020). Diagnosis, Prevention, and Treatment of Thromboembolic Complications in COVID-19: Report of the National Institute for Public Health of the Netherlands. Radiology, 297(1), E216-E222.
    • Streng, A. S., Delnoij, T. S. R., Mulder, M. M. G., Sels, J. W. E. M., Wetzels, R. J. H., Verhezen, P. W. M., Olie, R. H., Kooman, J. P., van Kuijk, S. M. J., Brandts, L., Ten Cate, H., Lorusso, R., van der Horst, I. C. C., van Bussel, B. C. T., & Henskens, Y. M. C. (2020). Monitoring of Unfractionated Heparin in Severe COVID-19: An Observational Study of Patients on CRRT and ECMO. TH open : companion journal to thrombosis and haemostasis, 4(4), e365-e375.
    • Keller, K., Goebel, S., ten Cate, V., Panova-Noeva, M., Eggebrecht, L., Nagler, M., Coldewey, M., Foebel, M., Bickel, C., Lauterbach, M., Espinola-Klein, C., Lackner, K. J., ten Cate, H., Muenzel, T., S. Wild, P., & H. Prochaska, J. (2020). Telemedicine-Based Specialized Care Improves the Outcome of Anticoagulated Individuals with Venous Thromboembolism-Results from the thrombEVAL Study. Journal of Clinical Medicine, 9(10), [3281].