Hugo ten Cate


Prof. Hugo ten Cate graduated in Medicine at the University of Amsterdam in 1987. The title of his PhD thesis was 'Clinical and experimental studies with a low molecular weight heparinoid'. Hugo had his post-doctoral training at the laboratory of Prof. Robert Rosenberg and Dr Kenneth Bauer at the Beth Israel Hospital and Harvard Medical School Boston on mechanisms of inflammation associated coagulation activity (1988-1990). He completed his internal medicine training in 1996 and became a general internist in conjunction with research at Academic Medical Center (laboratory of Experimental Internal medicine, Prof. Pieter Reitsma). He received a Clinical Established Investigator grant from the Dutch Heart Foundation in 1998.

In 2002, Hugo ten Cate was appointed Professor of Clinical Thrombosis and Haemostasis at CARIM. In addition, Prof. ten Cate was appointed adjunct professor at the Center for Thrombosis and Haemostasis (CTH) at Gutenberg University Medical Center, Mainz, Germany in 2017

Since the transfer to CARIM in 2002 his research focus shifted from coagulation-inflammation research in sepsis models, to the broader field of cardiovascular (CV) disease (atherothrombosis and 'thrombo-inflammation'). A specific focus of current research is the pleiotropic actions of coagulation proteases in atherosclerosis, atherothrombosis and ischemia reperfusion injury. Clinical research is aimed at chronic thrombotic disease including peripheral artery disease, high risk patients with coronary disease on antithrombotic medication and, together with Dr Arina ten Cate-Hoek, on venous thrombosis and post thrombotic syndrome (PTS). He is workpackage leader in CVON consortia RACE-5 (coagulation and its impact on atrial fibrillation) and CONTRAST (acute ischemic stroke) and involved in the ITN consortia TAPAS and TICARDIO. His group has an ongoing target finding programme with Bayer (steered from CARIM by Dr Henri Spronk and Prof. Hugo ten Cate) as well as with 2M (on POC development).

Department of Biochemistry
Department of Internal Medicine
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: 4.344
T: +31(0)43 388 42 62

  • 2023
    • Iding, A. F. J., Limpens, T. M. P., Ten Cate, H., & Ten Cate-Hoek, A. J. (2023). Chronic inflammatory diseases increase the risk of post-thrombotic syndrome: A prospective cohort study. European journal of internal medicine. Advance online publication.
    • Jacobs, L. M. C., Wintjens, M. S. J. N., Nagy, M., Willems, L., ten Cate, H., Spronk, H. M. H., van Kuijk, S. M. J., Ghossein-Doha, C., Netea, M. G., Groh, L. A., van Petersen, A. S., & Warle, M. C. (2023). Biomarkers of sustained systemic inflammation and microvascular dysfunction associated with post-COVID-19 condition symptoms at 24 months after SARS-CoV-2-infection. Frontiers in Immunology, 14, Article 1182182.
    • Heuts, S., Ceulemans, A., Kuiper, G. J. A. J. M., Schreiber, J. U., van Varik, B. J., Olie, R. H., Ten Cate, H., Maessen, J. G., Milojevic, M., & Maesen, B. (2023). Optimal management of cardiac surgery patients using direct oral anticoagulants: recommendations for clinical practice. European Journal of Cardio-Thoracic Surgery, 64(4), Article ezad340.
    • V. Kock, R., Berend, K., Florquin, S., & ten Cate, H. (2023). Pitfalls in anticoagulant-related nephropathy. Clinical Nephrology.
    • Baidildinova, G., Pallares Robles, A., ten Cate, V., Kremers, B. M. M., Heitmeier, S., ten Cate, H., Mees, B. M. E., Spronk, H. M. H., Wild, P. S., ten Cate-Hoek, A. J., & Jurk, K. (2023). Plasma protein signatures for high on-treatment platelet reactivity to aspirin and clopidogrel in peripheral artery disease. Thrombosis Research, 230, 105-118.
    • Olie, R. H., Winckers, K., Rocca, B., & Ten Cate, H. (2023). Oral Anticoagulants Beyond Warfarin. Annual Review of Pharmacology and Toxicology, 64. Advance online publication.
    • Alnima, T., Meijer, R. I., Spronk, H. M. H., Warlé, M., & Cate, H. T. (2023). Diabetes- versus smoking-related thrombo-inflammation in peripheral artery disease. Cardiovascular Diabetology, 22(1), Article 257.
    • van Voorst, H., Hoving, J. W., Koopman, M. S., Daems, J. D., Peerlings, D., Buskens, E., Lingsma, H. F., Beenen, L. F. M., de Jong, H. W. A. M., Berkhemer, O. A., van Zwam, W. H., Roos, Y. B. W. E. M., van Walderveen, M. A. A., van den Wijngaard, I., Dippel, D. W. J., Yoo, A. J., Campbell, B. C. V., Kunz, W. G., Emmer, B. J., ... MR CLEAN Registry Investigators (2023). Cost-effectiveness of CT perfusion for the detection of large vessel occlusion acute ischemic stroke followed by endovascular treatment: a model-based health economic evaluation study. European Radiology.
    • Verheugt, F. W. A., Fox, K. A. A., Virdone, S., Ambrosio, G., Gersh, B. J., Haas, S., Pieper, K. S., Kayani, G., Camm, A. J., Parkhomenko, A., Misselwitz, F., Ragy, APH., Ten Cate, H., Keltai, M., Kakkar, A. K., & GARFIELD-AF Investigators (2023). Outcomes of Oral Anticoagulation in Atrial Fibrillation Patients with or without Comorbid Vascular Disease: Insights from the GARFIELD-AF Registry. The American Journal of Medicine. Advance online publication.
    • Sun, S., Campello, E., Zou, J., Konings, J., Huskens, D., Wan, J., Fernández, D. I., Reutelingsperger, C., Ten Cate, H., Toffanin, S., Bulato, C., de Groot, P. G., de Laat, B., Simioni, P., Heemskerk, J. W. M., & Roest, M. (2023). Crucial roles of red blood cells and platelets in whole blood thrombin generation. Blood advances.