Hugo ten Cate

Professor

Prof. Hugo ten Cate graduated in Medicine at the University of Amsterdam in 1987. The title of his PhD thesis was 'Clinical and experimental studies with a low molecular weight heparinoid'. Hugo had his post-doctoral training at the laboratory of Prof. Robert Rosenberg and Dr Kenneth Bauer at the Beth Israel Hospital and Harvard Medical School Boston on mechanisms of inflammation associated coagulation activity (1988-1990). He completed his internal medicine training in 1996 and became a general internist in conjunction with research at Academic Medical Center (laboratory of Experimental Internal medicine, Prof. Pieter Reitsma). He received a Clinical Established Investigator grant from the Dutch Heart Foundation in 1998.

In 2002, Hugo ten Cate was appointed Professor of Clinical Thrombosis and Haemostasis at CARIM. In addition, Prof. ten Cate was appointed adjunct professor at the Center for Thrombosis and Haemostasis (CTH) at Gutenberg University Medical Center, Mainz, Germany in 2017

Since the transfer to CARIM in 2002 his research focus shifted from coagulation-inflammation research in sepsis models, to the broader field of cardiovascular (CV) disease (atherothrombosis and 'thrombo-inflammation'). A specific focus of current research is the pleiotropic actions of coagulation proteases in atherosclerosis, atherothrombosis and ischemia reperfusion injury. Clinical research is aimed at chronic thrombotic disease including peripheral artery disease, high risk patients with coronary disease on antithrombotic medication and, together with Dr Arina ten Cate-Hoek, on venous thrombosis and post thrombotic syndrome (PTS). He is workpackage leader in CVON consortia RACE-5 (coagulation and its impact on atrial fibrillation) and CONTRAST (acute ischemic stroke) and involved in the ITN consortia TAPAS and TICARDIO. His group has an ongoing target finding programme with Bayer (steered from CARIM by Dr Henri Spronk and Prof. Hugo ten Cate) as well as with 2M (on POC development).

Department of Biochemistry
Department of Internal Medicine
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: 4.344
T: +31(0)43 388 42 62

  • 2022
    • Willers, A., Swol, J., von Kuijk, S. M. J., Buscher, H., McQuilten, Z., ten Cate, H., Rycus, P. T., McKellar, S., Lorusso, R., & Tonna, J. E. (2022). HEROES V-V-HEmorRhagic cOmplications in Veno-Venous Extracorporeal life Support-Development and internal validation of multivariable prediction model in adult patients. Artificial Organs, 46(5), 932-952. https://doi.org/10.1111/aor.14148
    • Panova-Noeva, M., Wagner, B., Nagler, M., Koeck, T., Ten Cate, V., Eggebrecht, L., Prochaska, J. H., Meyer, I., Gerdes, C., Spronk, H. M., Lackner, K. J., Ten Cate, H., Leineweber, K., Heitmeier, S., Konstantinides, S., & Wild, P. S. (2022). Variation of platelet function in clinical phenotypes of acute venous thromboembolism - Results from the GMP-VTE project. Journal of Thrombosis and Haemostasis, 20(3), 705-715. https://doi.org/10.1111/jth.15595
    • De With, R. R., Artola Arita, V., Nguyen, B-O., Linz, D., Ten Cate, H., Spronk, H., Schotten, U., van Zonneveld, A. J., Erküner, Ö., Bayón, M. A., Schmidt, A. S., Luermans, J. G. L. M., Crijns, H. J. G. M., Van Gelder, I. C., & Rienstra, M. (2022). Different circulating biomarkers in women and men with paroxysmal atrial fibrillation: results from the AF-RISK and RACE V studies. EP Europace, 24(2), 193-201. https://doi.org/10.1093/europace/euab179
    • Vignoli, A., Gamba, S., van der Meijden, P. E. J., Marchetti, M., Russo, L., Tessarolo, S., Giaccherini, C., Swieringa, F., Cate, H. T., Finazzi, G., Heemskerk, J. W. M., & Falanga, A. (2022). Increased platelet thrombus formation under flow conditions in whole blood from polycythaemia vera patients. Blood Transfusion, 20(2), 143-151. https://doi.org/10.2450/2021.0456-20
  • 2021
    • Hulshof, A-M., Olie, R. H., Vries, M. J. A., Verhezen, P. W. M., van der Meijden, P. E. J., Ten Cate, H., & Henskens, Y. M. C. (2021). Rotational Thromboelastometry in High-Risk Patients on Dual Antithrombotic Therapy After Percutaneous Coronary Intervention. Frontiers in cardiovascular medicine, 8, [788137]. https://doi.org/10.3389/fcvm.2021.788137
    • Willems, L. H., Nagy, M., Ten Cate, H., Spronk, H. M. H., Jacobs, L. M. C., Kranendonk, J., van Leeuwen, M., Meijer, D., Middeldorp, S., Groh, L. A., & Warle, M. C. (2021). ChAdOx1 vaccination, blood coagulation, and inflammation: No effect on coagulation but increased interleukin-6. Research and practice in thrombosis and haemostasis, 5(8), [e12630]. https://doi.org/10.1002/rth2.12630
    • Sun, S. Y., Urbanus, R. T., ten Cate, H., de Groot, P. G., de Laat, B., Heemskerk, J. W. M., & Roest, M. (2021). Platelet Activation Mechanisms and Consequences of Immune Thrombocytopenia. Cells, 10(12), [3386]. https://doi.org/10.3390/cells10123386
    • van Haaps, T. F. V., Collard, D., van Osch, F. H. M. V., Middeldorp, S., Coppens, M., de Kruif, M. D., Vlot, E. A., Douma, R. A., ten Cate, H., Juffermans, N. P., Gritters, N., Vlaar, A. P., Reidinga, A. C., Heuvelmans, M. A., Oudkerk, M., Buller, H. R., van den Bergh, J. P. W. V., Maas, A., Ten Wolde, M., ... Dutch COVID & Thrombosis Coalition (2021). Pre-admission anticoagulant therapy and mortality in hospitalized COVID-19 patients: A retrospective cohort study. Thrombosis Research, 208, 35-38. https://doi.org/10.1016/j.thromres.2021.10.006
    • D'Alessandro, E., Scaf, B., van Oerle, R., van Nieuwenhoven, F. A., van Hunnik, A., Verheule, S., Schotten, U., Ten Cate, H., & Spronk, H. M. H. (2021). Thrombin generation by calibrated automated thrombography in goat plasma: Optimization of an assay. Research and practice in thrombosis and haemostasis, 5(8), [e12620]. https://doi.org/10.1002/rth2.12620
    • van der Bruggen, M. M., Kremers, B., van Oerle, R., van Oostenbrugge, R. J., & ten Cate, H. (2021). Potential value of the calibrated automated thrombogram in patients after a cerebral venous sinus thrombosis; an exploratory study. Thrombosis Journal, 19(1), [81]. https://doi.org/10.1186/s12959-021-00335-1