Ingrid Dijkgraaf

Associate professor

Dr Ingrid Dijkgraaf has graduated with specialisation in Organic Chemistry at Wageningen University. Subsequently, she has worked on synthesis and biologic evaluation of alpha-v-beta-3-binding peptides and peptidomimetics at the Department of Medicinal Chemistry and Chemical Biology at Utrecht University, and at the Department of Nuclear Medicine at the Radboud University Nijmegen. After obtaining her PhD, she worked as post-doc at the Technical University of Munich, the Radboud University of Nijmegen and The Scripps Research Institute.

Since 2011, she has been working at Maastricht University. Focus of her research is design and synthesis of peptides and proteins using Solid-Phase Peptide Synthesis and Native Chemical Ligation. These compounds are conjugated with chelators, fluorescent labels, and multimodality tags allowing molecular imaging of cardiovascular diseases and cancer. Synthesised compounds are evaluated in in vitro and in vivo studies.

Department of Biochemistry
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: 4.350

  • 2020
    • Eckardt, V., Miller, M. C., Blanchet, X., Duan, R., Leberzammer, J., Duchene, J., Soehnlein, O., Megens, R. T. A., Ludwig, A-K., Dregni, A., Faussner, A., Wichapong, K., Ippel, H., Dijkgraaf, I., Kaltner, H., Doering, Y., Bidzhekov, K., Hackeng, T. M., Weber, C., ... Mayo, K. H. (2020). Chemokines and galectins form heterodimers to modulate inflammation. Embo Reports, 21(4), [47852]. https://doi.org/10.15252/embr.201947852, https://doi.org/10.15252/embr.201947852
    • Denisov, S. S., Heinzmann, A. C. A., Vajen, T., Vries, M. H. M., Megens, R. T. A., Suylen, D., Koenen, R. R., Post, M. J., Ippel, J. H., Hackeng, T. M., & Dijkgraaf, I. (2020). Tick Saliva Protein Evasin-3 Allows for Visualization of Inflammation in Arteries through Interactions with CXC-Type Chemokines Deposited on Activated Endothelium. Bioconjugate Chemistry, 31(3), 948-955. https://doi.org/10.1021/acs.bioconjchem.0c00095
  • 2019
    • Siitonen, R., Peuhu, E., Autio, A., Liljenback, H., Mattila, E., Metsala, O., Kakela, M., Saanijoki, T., Dijkgraaf, I., Jalkanen, S., Ivaska, J., & Roivainen, A. (2019). Ga-68-DOTA-E[c(RGDfK)](2) PET Imaging of SHARPIN-Regulated Integrin Activity in Mice. Journal of Nuclear Medicine, 60(10), 1380-1387. https://doi.org/10.2967/jnumed.118.222026
    • Denisov, S. S., Ippel, J. H., Heinzmann, A. C. A., Koenen, R. R., Ortega-Gomez, M., Soehnlein, O., Hackeng, T. M., & Dijkgraaf, I. (2019). Tick saliva protein Evasin-3 modulates chemotaxis by disrupting CXCL8 interactions with glycosaminoglycans and CXCR2. Journal of Biological Chemistry, 294(33), 12370-12379. https://doi.org/10.1074/jbc.RA119.008902
    • Denisov, S. S., Ippel, J. H., Mans, B. J., Dijkgraaf, I., & Hackeng, T. M. (2019). SecScan: a general approach for mapping disulfide bonds in synthetic and recombinant peptides and proteins. Chemical Communications, 55(10), 1374-1377. https://doi.org/10.1039/c8cc08777f
    • Bucerius, J., Dijkgraaf, I., Mottaghy, F. M., & Schurgers, L. J. (2019). Target identification for the diagnosis and intervention of vulnerable atherosclerotic plaques beyond F-18-fluorodeoxyglucose positron emission tomography imaging: promising tracers on the horizon. European Journal of Nuclear Medicine and Molecular Imaging, 46(1), 251-265. https://doi.org/10.1007/s00259-018-4176-z
  • 2017
    • von Hundelshausen, P., Agten, S. M., Eckardt, V., Blanchet, X., Schmitt, M. M., Ippel, H., Neideck, C., Bidzhekov, K., Leberzammer, J., Wichapong, K., Faussner, A., Drechsler, M., Grommes, J., van Geffen, J. P., Li, H., Ortega-Gomez, A., Megens, R. T. A., Naumann, R., Dijkgraaf, I., ... Weber, C. (2017). Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation. Science Translational Medicine, 9(384), [eaah6650]. https://doi.org/10.1126/scitranslmed.aah6650
    • Beer, A. J., & Dijkgraaf, I. (2017). Editorial European Journal of Nuclear Medicine and Molecular Imaging. European Journal of Nuclear Medicine and Molecular Imaging, 44(2), 284-285. https://doi.org/10.1007/s00259-016-3559-2
    • Hendrikx, G., Hackeng, T. M., van Gorp, R., Bauwens, M., Schurgers, L. J., Mottaghy, F. M., Post, M. J., & Dijkgraaf, I. (2017). Use of Cyclic Backbone NGR-Based SPECT to Increase Efficacy of Postmyocardial Infarction Angiogenesis Imaging. Contrast Media & Molecular Imaging, 2017, [8638549]. https://doi.org/10.1155/2017/8638549
  • 2016
    • Caolo, V., Vries, M., Zupancich, J., Houben, M., Mihov, G., Wagenaar, A., Swennen, G., Nossent, Y., Quax, P., Suylen, D., Dijkgraaf, I., Molin, D., Hackeng, T., & Post, M. (2016). CXCL1 microspheres: a novel tool to stimulate arteriogenesis. Drug Delivery, 23(8), 2919-2926. https://doi.org/10.3109/10717544.2015.1120366