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Uyên Châu Nguyên wins UM Dissertation Prize 2025

Uyên Châu Nguyên wins UM Dissertation Prize 2025

29 January 2026

During the Dies Natalis of Maastricht University, Uyên Châu Nguyên received the UM Dissertation Prize 2025.

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Global research network launched to study menopause and heart health

Global research network launched to study menopause and heart health

20 January 2026

Ten international health research funders, including the Dutch Heart Foundation, are investing $10 million in a new global research network to improve early prevention of cardiovascular disease in women. The initiative focuses on understanding how menopause affects heart health and how early intervention can reduce risk.

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Carim Maastricht
Carim Maastricht

Iwan van der Horst

Professor

 Prof. Iwan van der Horst was the principal investigator of the Simple Intensive Care Studies (SICS). In this ongoing registry, up to 2000 patients were included to unravel the diagnostic and prognostic value of physical and physiological examination. Based on the variables included, physicians make clinical decisions in the sickest patients every day. The design paper is published in the BMJ Open.

He was a leading investigator of clinical studies on critically ill patients focusing on hemodynamics, the heart in non-cardiac disease and acute kidney failure at the ICU. The team was involved in initiatives that combine the best of a prospective cohort study (like SICS-I, SOCCS and SICS-II) and randomised controlled trial design. The protocols were based upon results of systematic reviews (see Prospero).

He was also a co-primary investigator in clinical studies on myocardial infarction and heart failure, especially about (glucose) metabolism. Like the Metformin to Reduce Heart Failure After Myocardial Infarction (GIPS-III), NCT01217307. With this study, they obtained a grant of the Netherlands Organization for Health Research and Development (ZonMW; project no. 40-41200-98-9139). Over 20 publications out of this structured study have been published.

Therefore, he was an investigator in the Glucose Insulin Potassium Study (GIPS) I and II, both supported by the Netherlands Heart Foundation (99.028 and 2003B277). Studies on the diagnostic and prognostic value of routine laboratory measures in critically ill patients and implementation study on secondary prevention.

Currently, he is part of a team dedicated to monitoring and big data in critical care patients. A big database is created and cleaned for specific questions regarding mortality. The first projects focus on clustering and validation of prediction models. With the heart on team science, this research line is open to collaboration.

Iwanvdhorst1

Department of Intensive Care
P. Debyelaan 25
6229 HX, Maastricht
Room number: 3.C1.056  
T: +31(0)43 387 63 87 

  • 2025
    • Kishna, Y. S., Baars, S., van der Horst, I. C. C., Mess, W. H., Hendrix, R., Delnoij, T. S. R., & Aries, M. (2025). Cerebral monitoring responses to bedside physiological challenges in comatose post-cardiac arrest patients. Journal of Clinical Monitoring and Computing. Advance online publication. https://doi.org/10.1007/s10877-025-01393-w
    • Verberght, H. C. R., Delnoij, T. S. R., Suverein, M. M., Lunsing, J., Hermanides, R. C., Otterspoor, L., Elzo Kraemer, C. V., Vlaar, A. P. J., Van Der Heijden, J. J., Scholten, E., Uil, C. A. D., Miranda, D. D. R., Akin, S., Metz, J. D., Van Der Horst, I. C. C., Mathot, B. J., De Jonge, J., Nijboer, M. W. N., De Meijer, V. E., ... Van De Poll, M. C. G. (2025). Organ Donor Potential After Extracorporeal Cardiopulmonary Resuscitation for Out-of-Hospital Cardiac Arrest: A Post-Hoc Analysis of a Randomized Controlled Trial. Clinical Transplantation, 39(11), Article e70382. https://doi.org/10.1111/ctr.70382
    • Swinnen, B., Olsthoorn, J. R., Mihl, C., Smulders, M. W., Singh, S. K., van Brakel, T., van der Horst, I. C. C., Mingels, A. M. A., Myers, P. O., van 't Hof, A. W. J., Gorgels, A. P. M., Thielmann, M., De Caterina, R., Cerqueira, R. J., Bonaros, N., Oosterlinck, W., Jacobs, S., Lorusso, R., Bidar, E., ... Heuts, S. (2025). Periprocedural Myocardial Infarction After Coronary Artery Bypass Grafting: Current Clinical Practices and Future Perspectives. European Journal of Cardio-Thoracic Surgery, 67(10), Article ezaf344. https://doi.org/10.1093/ejcts/ezaf344
    • Klein, D. O., Waardenburg, S. F., Janssen, E. B. N. J., Wintjens, M. S. J. N., Imkamp, M., Heemskerk, S. C. M., Birnie, E., Bonsel, G. J., Warlé, M. C., Jacobs, L. M. C., Hemmen, B., Verbunt, J., van Bussel, B. C. T., van Santen, S., Kietelaer, B. L. J. H., Jansen, G., Klok, F. A., de Kruif, M. D., Vernooy, K., ... CAPACITY-COVID collaborative consortium (2025). Two years and counting: a prospective cohort study on the scope and severity of post-COVID symptoms across diverse patient groups in the Netherlands-insights from the CORFU study. BMJ Open, 15(9), Article e093639. https://doi.org/10.1136/bmjopen-2024-093639
    • Romeo, J. L., Vriesendorp, P. A., Gerritsen, K., Nader, M., Mahtab, E., Maessen, J. G., van 't Hof, A. W. J., Gollmann-Tepeköylü, C., van Rosmalen, F., van der Horst, I. C. C., Mingels, A. M. A., & Heuts, S. (2025). Modeling creatine-kinase MB concentrations following coronary artery bypass grafting. Journal of Thoracic and Cardiovascular Surgery, 170(3), 752-760.e3. https://doi.org/10.1016/j.jtcvs.2024.08.019
    • Gerardu, V. C. A., Mosch, L. K., Kloeze, C., de Kok, J. W. T. M., Herold, I. H. F., De Bie, A. J. R., Schnabel, R. M., Strauch, U., Dormans, T., Wunderlich, M. M., Bouwman, R. A., Balzer, F., van der Horst, I. C. C., van Bussel, B. C. T., Poncette, A.-S., Driessen, R. G. H., & Alarm Fatigue Study Group (2025). Measuring alarm fatigue in intensive care units: translation and validation of the Charité Alarm Fatigue Questionnaire. Journal of Critical Care, 91, Article 155223. https://doi.org/10.1016/j.jcrc.2025.155223
    • Saugel, B., Hapfelmeier, A., Flick, M., Rinehart, J., Thiele, R. H., Vistisen, S. T., Bartels, K., Cannesson, M., Cecconi, M., Chew, M. S., De Backer, D., Joosten, A., Khanna, A. K., Levy, J. H., Meidert, A. S., Messina, A., Monnet, X., Myatra, S. N., Pinsky, M. R., ... Kouz, K. (2025). Statistical Analysis and Reporting of Cardiac Output Method Comparison Studies (COMPARE) Statement. Anesthesiology, 143(3), 518-532. https://doi.org/10.1097/ALN.0000000000005559
    • Aydeniz, E., Heines, S. J. H., van Rosmalen, F., van der Horst, I. C. C., van Bussel, B. C. T., & Bergmans, D. C. J. J. (2025). Comparison of regional lung mechanics using electrical impedance tomography in mechanically ventilated COVID-19 vs pre-pandemic patients: A retrospective study. Respiratory Medicine, 247, Article 108286. https://doi.org/10.1016/j.rmed.2025.108286
    • Hulsewe, H. H. M., Wilbers, T., van Rosmalen, F., van Bommel, J., Brinkman, S., van Bussel, B. C. T., van der Horst, I. C. C., & Schnabel, R. M. (2025). Accuracy between ICU admission and discharge diagnoses in non-survivors: A retrospective cohort study. Journal of Critical Care, 88, Article 155065. https://doi.org/10.1016/j.jcrc.2025.155065
    • Tiels, L. M., Wintjens, M. S. J. N., Waardenburg, S., van Rosmalen, F., van Kuijk, S. M. J., van Der Horst, I. C. C., Luiten, R., van Bussel, B. C. T., van Mook, W. N. K. A., Hemmen, B., & van Santen, S. (2025). More self-efficacy is associated with longitudinally higher health-related quality of life in mechanically ventilated COVID-19 ICU survivors: The prospective MaastrICCht cohort. Nursing in Critical Care, 30(4), Article e13241. https://doi.org/10.1111/nicc.13241
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