Jack Cleutjens

Associate professor

Dr Jack Cleutjens has been working for Maastricht University since 1985. After finishing his thesis 'Basement membrane heterogeneity' in 1989, he started working in the cardiovascular field as a post-doc on the regulation of the wound healing after myocardial infarction. His main interest is in the area of extracellular matrix remodeling, mainly collagen synthesis and degradation.

His area of focus is education and cardiovascular research. He is a specialist in the field of morphometry and (digital) microscopy. Jack Cleutjens is a member of the Dutch Society of Pathology, Experimental Pathology section and of the Dutch Society for Matrix Biology.

Focus areas:
• Cardiovascular examination
• Extracellular matrix turnover
• Myocardial infarction / atherosclerosis
• (Digital) microscopy
• Morphometry


Department of Pathology
Verheylaan 10, 6229 HX Maastricht
Room number: VH10 5.M1-002
T: +31(0)43 387 66 31

  • 2018
    • Bijnen, M., Beelen, N., Wetzels, S., van De Gaar, J., Vroomen, M., Wijnands, E., Scheijen, J. L., van de Waarenburg, M. P. H., Gijbels, M. J., Cleutjens, J. P., Biessen, E. A. L., Stehouwer, C. D. A., Schalkwijk, C. G., & Wouters, K. (2018). RAGE deficiency does not affect non-alcoholic steatohepatitis and atherosclerosis in Western type diet-fed Ldlr(-/-) mice. Scientific Reports, 8, [15256]. https://doi.org/10.1038/s41598-018-33661-y
    • van den Hil, L. C. L., Vogels, R. R. M., van Barneveld, K. W. Y., Gijbels, M. J. J., Peutz-Kootstra, C. J., Cleutjens, J. P. M., Schreinemacher, M. H. F., & Bouvy, N. D. (2018). Comparability of histological outcomes in rats and humans in a hernia model. Journal of Surgical Research, 229, 271-276. https://doi.org/10.1016/j.jss.2018.03.019
    • Barkhuizen, M., van Dijck, F. J. P., Jellema, R. K., Gussenhoven, R., Engelbertink, I., van Mechele, R., Cleutjens, J. P. M., Seehase, M., Steinbusch, H. W. M., Zimmerman, L. J., Gavilanes, A. W. D., & Kramer, B. W. (2018). The influence of anesthetics on substantia nigra tyrosine hydroxylase expression and tau phosphorylation in the hypoxic-ischemic near-term lamb. Pediatric Research, 83(6), 1190-1199. https://doi.org/10.1038/pr.2018.42
    • Henatsch, D., Alsulami, S., Duijvestijn, A. M., Cleutjens, J. P., Peutz-Kootstra, C. J., & Stokroos, R. J. (2018). Histopathological and Inflammatory Features of Chronically Discharging Open Mastoid Cavities Secondary Analysis of a Randomized Clinical Trial. JAMA Otolaryngology - Head and Neck Surgery, 144(3), 211-217. https://doi.org/10.1001/jamaoto.2017.2801
  • 2017
    • Kessels, J., Voeten, L., Nelemans, P., Cleutjens, J., Hillen, L. M., Mosterd, K., & Kelleners-Smeets, N. W. J. (2017). Topical Sinecatechins, 10%, Ointment for Superficial Basal Cell Carcinoma: A Randomized Clinical Trial. JAMA Dermatology, 153(10), 1061-1063. https://doi.org/10.1001/jamadermatol.2017.2529
    • van Hoof, R. H. M., Voo, S. A., Sluimer, J. C., Wijnen, N. J. A., Hermeling, E., Schreuder, F. H. B. M., Truijman, M. T. B., Cleutjens, J. P. M., Daemen, M. J. A. P., Daemen, J-W. H., van Oostenbrugge, R. J., Mess, W. H., Wildberger, J. E., Heeneman, S., & Kooi, M. E. (2017). Vessel Wall and Adventitial DCE-MRI Parameters Demonstrate Similar Correlations With Carotid Plaque Microvasculature on Histology. Journal of Magnetic Resonance Imaging, 46(4), 1053-1059. https://doi.org/10.1002/jmri.25648
    • Theodorou, K., van der Vorst, E. P. C., Gijbels, M. J., Wolfs, I. M. J., Jeurissen, M., Theelen, T. L., Sluimer, J. C., Wijnands, E., Cleutjens, J. P., Li, Y., Jansen, Y., Weber, C., Ludwig, A., Bentzon, J. F., Bartsch, J. W., Biessen, E. A. L., & Donners, M. M. P. C. (2017). Whole body and hematopoietic ADAM8 deficiency does not influence advanced atherosclerotic lesion development, despite its association with human plaque progression. Scientific Reports, 7, [11670]. https://doi.org/10.1038/s41598-017-10549-x
    • Vink, R. G., Roumans, N. J., Cajlakovic, M., Cleutjens, J. P. M., Boekschoten, M. V., Fazelzadeh, P., Vogel, M. A. A., Blaak, E. E., Mariman, E. C., van Baak, M. A., & Goossens, G. H. (2017). Diet-induced weight loss decreases adipose tissue oxygen tension with parallel changes in adipose tissue phenotype and insulin sensitivity in overweight humans. International Journal of Obesity, 41(5), 722-728. https://doi.org/10.1038/ijo.2017.38
    • Uitterdijk, A., Springeling, T., Hermans, K. C. M., Merkus, D., de Beer, V. J., Gorsse-Bakker, C., Mokelke, E., Daskalopoulos, E. P., Wielopolski, P. A., Cleutjens, J. P. M., Blankesteijn, W. M., Prinzen, F. W., van der Giessen, W. J., van Geuns, R-J. M., & Duncker, D. J. (2017). Intermittent pacing therapy favorably modulates infarct remodeling. Basic Research in Cardiology, 112(3), [28]. https://doi.org/10.1007/s00395-017-0616-3
    • Swarts, D. R. A., Rudelius, M., Claessen, S. M. H., Cleutjens, J. P., Seidl, S., Volante, M., Ramaekers, F. C. S., & Speel, E. J. M. (2017). Limited additive value of the Ki-67 proliferative index on patient survival in World Health Organization-classified pulmonary carcinoids. Histopathology, 70(3), 412-422. https://doi.org/10.1111/his.13096