Judith Cosemans

Associate professor

Dr Judith Cosemans holds a master’s degree in Biological Health Sciences with specialisation in molecular biology from Maastricht University. She became fascinated to unravel the role of platelets in arterial thrombosis during her PhD research, which focussed on the dynamic regulation of thrombus stability. After finishing her PhD in 2009, she executed an award-winning postdoc project to develop flow chamber technology as a compatible alternative for experimental animal models of arterial thrombosis.

Dr Cosemans subsequently obtained two personal grants from the Dutch Heart Foundation (2011, 2015) and a Vidi grant from the Netherlands Organisation for Scientific Research (NWO, 2016). These grants facilitate her current research line, which lies on the interface of platelet signalling and vascular biology.

Her team aims to:
• provide novel mechanistic insight into the pathophysiology of thrombosis in the heart and in the brain
• develop better diagnostic tools and novel druggable targets to prevent recurrentthrombotic events

Department of Biochemistry
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht

  • 2022
    • Karel, M. F. A., Roosen, M. G. C. H., Tullemans, B. M. E., Zhang, C. E., Staals, J., Cosemans, J. M. E. M., & Koenen, R. R. (2022). Characterization of cerebral small vessel disease by neutrophil and platelet activation markers using artificial intelligence. Journal of Neuroimmunology, 367, [577863]. https://doi.org/10.1016/j.jneuroim.2022.577863
    • Cosemans, J. M. E. M. (2022). Platelet-derived MMP-2 in the prevention of plaque formation: how many strokes is par?European Heart Journal, 43(6), 515–517. https://doi.org/10.1093/eurheartj/ehab665
    • Karel, M. F. A., Lemmens, T. P., Tullemans, B. M. E., Wielders, S. J. H., Gubbins, E., van Beurden, D., van Rijt, S., & Cosemans, J. M. E. M. (2022). Characterization of Atherosclerotic Plaque Coating for Thrombosis Microfluidics Assays. Cellular and Molecular Bioengineering, 15(1), 55-65. https://doi.org/10.1007/s12195-021-00713-9
  • 2021
    • Heinzmann, A. C. A., Coenen, D. M., Vajen, T., Cosemans, J. M. E. M., & Koenen, R. R. (2021). Combined Antiplatelet Therapy Reduces the Proinflammatory Properties of Activated Platelets. TH open : companion journal to thrombosis and haemostasis, 5(4), e533-e542. https://doi.org/10.1055/a-1682-3415
    • Coenen, D. M., Heinzmann, A. C. A., Oggero, S., Albers, H. J., Nagy, M., Hague, P., Kuijpers, M. J. E., Vanderwinden, J. M., van der Meer, A. D., Perretti, M., Koenen, R. R., & Cosemans, J. M. E. M. (2021). Inhibition of Phosphodiesterase 3A by Cilostazol Dampens Proinflammatory Platelet Functions. Cells, 10(8), [1998]. https://doi.org/10.3390/cells10081998
    • Mangin, P. H., Neeves, K. B., Lam, W. A., Cosemans, J. M. E. M., Korin, N., Kerrigan, S. W., Panteleev, M. A., & Subcommittee on Biorheology (2021). In vitro flow-based assay: From simple toward more sophisticated models for mimicking hemostasis and thrombosis. Journal of Thrombosis and Haemostasis, 19(2), 582-587. https://doi.org/10.1111/jth.15143
    • Coenen, D. M., Heinzmann, A. C. A., Karel, M. F. A., Cosemans, J. M. E. M., & Koenen, R. R. (2021). The multifaceted contribution of platelets in the emergence and aftermath of acute cardiovascular events. Atherosclerosis, 319, 132-141. https://doi.org/10.1016/j.atherosclerosis.2020.12.017
    • Panteleev, M. A., Korin, N., Reesink, K. D., Bark, D. L., Cosemans, J. M. E. M., Gardiner, E. E., & Mangin, P. H. (2021). Wall shear rates in human and mouse arteries: Standardization of hemodynamics for in vitro blood flow assays: Communication from the ISTH SSC subcommittee on biorheology. Journal of Thrombosis and Haemostasis, 19(2), 588-595. https://doi.org/10.1111/jth.15174
    • Tullemans, B., Karel, M., Léopold, V., ten Brink, M. S., Baaten, C., Maas, S. L., de Vos, A. F., Eble, J. A., Nijziel, M. R., van der Vorst, E., Cosemans, J., Heemskerk, J., Claushuis, T. A. M., & Kuijpers, M. (2021). Comparison of inhibitory effects of irreversible and reversible Btk inhibitors on platelet function. eJHaem, 2(4), 685–699. https://doi.org/10.1002/jha2.269
  • 2020
    • Mastenbroek, T. G., Karel, M. F. A., Nagy, M., Chayoua, W., Korsten, E. I. J., Coenen, D. M., Debets, J., Konings, J., Brouns, A. E., Leenders, P. J. A., van Essen, H., van Oerle, R., Heitmeier, S., Spronk, H. M., Kuijpers, M. J. E., & Cosemans, J. M. E. M. (2020). Vascular protective effect of aspirin and rivaroxaban upon endothelial denudation of the mouse carotid artery. Scientific Reports, 10(1), [19360]. https://doi.org/10.1038/s41598-020-76377-8