Julie Staals

Associate professor

Dr Julie Staals is working as a clinical neurologist at Maastricht UMC+. Her specialisation is neurovascular diseases. She has obtained her medical degree at Maastricht University. Afterwards, she did a parallel tract in neurology training and PhD research project, both were finished in 2009. In 2013 she did a short research fellowship at the Brain Research Imaging Center in Edinburgh, UK. Her research focus is on clinical studies in cerebral small vessel disease, mainly the effects of hypertension, the rol of endothelial function, blood-brain barrier and the neurovascular unit, advanced imaging, and the cognitive consequences of this disease. She developed the ‘total SVD score’, a highly cited score for MRI severity of cerebral small vessel disease. Other clinical research topics are intracerebral haemorrhage and acute stroke treatments.

She is currently involved in:
SVDs@target, a EU Horizon2020 multicenter project on mechanisms in cerebral small vessel disease (www.svds-at-target.eu)

CRUCIAL, a EU Horizon2020 multicenter project on microvascular rarefaction in vascular cognitive impairment and heart failure (www.crucial-project.eu)

MRCLEAN trials, acute clinical stroke trials aiming at improving outcome in endovascular treatment (www.contrast-consortium.nl)


Department of Neurology
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht

  • 2024
    • van Dinther, M. M., Hooghiemstra, A. E., Bron, E., Versteeg, A. E., Leeuwis, A., Kalay, T. E., Moonen, J., Kuipers, S. H., Backes, W., Jansen, J. F. A., van Osch, M. J. P., Biessels, G.-J., Staals, J. J., van Oostenbrugge, R., & Heart-Brain Connection Consortium (2024). Lower cerebral blood flow predicts cognitive decline in patients with vascular cognitive impairment. Alzheimer's & Dementia, 20(1), 136-144. https://doi.org/10.1002/alz.13408
  • 2023
    • Oestreich, L. K., Lo, J. W., Di Biase, M. A., Sachdev, P. S., Mok, A. H., Wright, P., Crawford, J. D., Lam, B., Traykov, L., Köhler, S., Staals, J. E., van Oostenbrugge, R., Chen, C., Desmond, D. W., Yu, K.-H., Lee, M., Klimkowicz-Mrowiec, A., Bordet, R., O'Sullivan, M. J., & Zalesky, A. (2023). Network analysis of neuropsychiatric, cognitive, and functional complications of stroke: implications for novel treatment targets. Psychiatry and Clinical Neurosciences. Advance online publication. https://doi.org/10.1111/pcn.13633
    • Best, J. G., Ambler, G., Wilson, D., Du, H., Lee, K.-J., Lim, J.-S., Teo, K. C., Mak, H., Kim, Y. D., Song, T.-J., Selcuk Demirelli, D., Nishihara, M., Yoshikawa, M., Kubacka, M., Zietz, A., Al-Shahi Salman, R., Jäger, H. R., Lip, G. Y. H., Panos, L., ... Werring, D. J. (2023). Clinical Associations and Prognostic Value of MRI-Visible Perivascular Spaces in Patients With Ischemic Stroke or TIA. Neurology, 102(1), Article 207795. https://doi.org/10.1212/WNL.0000000000207795
    • Robbe, M. M. Q., Pinckaers, F. M. E., Olthuis, S. G. H., Bos, M. J., van Oostenbrugge, R. J., van Zwam, W. H., Staals, J., & Postma, A. A. (2023). Procedural Blood Pressure and Intracranial Hemorrhage on Dual-Energy Computed Tomography After Endovascular Stroke Treatment. Cardiovascular and Interventional Radiology. Advance online publication. https://doi.org/10.1007/s00270-023-03619-3
    • de Kort, F. A. S., Coenen, M., Weaver, N. A., Kuijf, H. J., Aben, H. P., Bae, H.-J., Bordet, R., Cammà, G., Chen, C. P. L. H., Dewenter, A., Duering, M., Fang, R., van der Giessen, R. S., Hamilton, O. K. L., Hilal, S., Huenges Wajer, I. M. C., Kan, C. N., Kim, J., Kim, B. J., ... Biessels, G. J. (2023). White Matter Hyperintensity Volume and Poststroke Cognition: An Individual Patient Data Pooled Analysis of 9 Ischemic Stroke Cohort Studies. Stroke, 54(12), 3021–3029. https://doi.org/10.1161/STROKEAHA.123.044297
    • Bakker, L., Ramakers, I. H. G. B., J P M Eussen, S., Choe, K., van den Hove, D. L. A., Kenis, G., Rutten, B. P. F., van Oostenbrugge, R. J., Staals, J., Ulvik, A., Ueland, P. M., Verhey, F. R. J., & Köhler, S. (2023). The role of the kynurenine pathway in cognitive functioning after stroke: A prospective clinical study. Journal of the neurological sciences, 454(1), Article 120819. https://doi.org/10.1016/j.jns.2023.120819
    • Kopczak, A., Stringer, M. S., van den Brink, H., Kerkhofs, D., Blair, G. W., van Dinther, M., Reyes, C. A., Garcia, D. J., Onkenhout, L., Wartolowska, K. A., Thrippleton, M. J., Kampaite, A., Duering, M., Staals, J., Lesnik-Oberstein, S., Muir, K. W., Middeke, M., Norrving, B., Bousser, M. G., ... TREAT-SVDs collaborators (2023). Effect of blood pressure-lowering agents on microvascular function in people with small vessel diseases (TREAT-SVDs): a multicentre, open-label, randomised, crossover trial. Lancet Neurology, 22(11), 991-1004. https://doi.org/10.1016/S1474-4422(23)00293-4
    • Elschot, E. P., Backes, W. H., de Jong, J. J. A., Drenthen, G. S., Wong, S. M., Staals, J., Postma, A. A., Rouhl, R. P. W., van Oostenbrugge, R. J., & Jansen, J. F. A. (2023). Assessment of the clinical feasibility of detecting subtle blood-brain barrier leakage in cerebral small vessel disease using dynamic susceptibility contrast MRI. Magnetic Resonance Imaging, 102(1), 55-61. https://doi.org/10.1016/j.mri.2023.04.004
    • ACE Epilepsy Surgery Group (2023). Cerebrovascular glycocalyx damage and microcirculation impairment in patients with temporal lobe epilepsy. Journal of Cerebral Blood Flow and Metabolism, 43(10), 1737-1751. https://doi.org/10.1177/0271678X231179413
    • Voorter, P. H. M., Backes, W. H., Gurney-Champion, O. J., Wong, S.-M., Staals, J., van Oostenbrugge, R. J., van Der Thiel, M. M., Jansen, J. F. A., & Drenthen, G. S. (2023). Improving microstructural integrity, interstitial fluid, and blood microcirculation images from multi-b-value diffusion MRI using physics-informed neural networks in cerebrovascular disease. Magnetic Resonance in Medicine, 90(4), 1657 - 1671. https://doi.org/10.1002/mrm.29753