Kanin Wichapong

Post doc

Dr Kanin Wichapong received his PhD degree in chemistry from Chulalongkorn University, Bangkok, Thailand. After completion of his PhD, he went back and worked as a postdoctoral researcher at Institute of Pharmacy, Martin-Luther University Halle-Wittenberg, Halle (Saale), Germany where he also carried out parts of his PhD. During his PhD and post-doc period, he worked on computational and physical chemistry subjects by applying in silico drug discovery and design technologies (e.g. virtual screening and molecular docking) to identify and develop novel inhibitors against different target proteins.

To broaden his research horizons with respect to new research fields in a new science environment, in December 2012 he moved to work at the Department of Biochemistry, Maastricht University. His main research focusses on applications of in silico approaches (such as molecular docking, molecular dynamics simulations, and binding free energy calculation) to study and investigate protein-protein interactions as well as to identify and design novel compounds (small compounds or peptides) to modulate protein-protein interactions. The identified bioactive compounds can be further developed as drugs to treat for several related diseases (e.g. cardiovascular diseases and cancer).

 

Department of Biochemistry
Universiteitsingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: H4.301

  • 2023
    • Huckriede, J. B., Beurskens, D. M. H., Wildhagen, K. C. C. A., Reutelingsperger, C. P. M., Wichapong, K., & Nicolaes, G. A. F. (2023). Design and characterization of novel activated protein C variants for the proteolysis of cytotoxic extracellular histone H3. Journal of Thrombosis and Haemostasis. Advance online publication. https://doi.org/10.1016/j.jtha.2023.08.023
    • Thomassen, M. C. L. G. D., Bouwens, B. R. C., Wichapong, K., Suylen, D. P., Bouwman, F. G., Hackeng, T. M., & Koenen, R. R. (2023). Protein arginine deiminase 4 inactivates tissue factor pathway inhibitor-alpha by enzymatic modification of functional arginine residues. Journal of Thrombosis and Haemostasis, 21(5), 1214-1226. https://doi.org/10.1016/j.jtha.2023.01.017
    • Chabronova, A., van den Akker, G. G. H., Housmans, B. A. C., Caron, M. M. J., Cremers, A., Surtel, D. A. M., Wichapong, K., Peffers, M. M. J., van Rhijn, L. W., Marchand, V., Motorin, Y., & Welting, T. J. M. (2023). Ribosomal RNA-based epitranscriptomic regulation of chondrocyte translation and proteome in osteoarthritis. Osteoarthritis and Cartilage, 31(3), 374-385. https://doi.org/10.1016/j.joca.2022.12.010
    • de Vries, F., Huckriede, J., Wichapong, K., Reutelingsperger, C., & Nicolaes, G. A. F. (2023). The role of extracellular histones in COVID-19. Journal of Internal Medicine, 293(3), 275-292. https://doi.org/10.1111/joim.13585
    • Pavlic, A., Poelman, H., Wasilewski, G., Wichapong, K., Lux, P., Maassen, C., Lutgens, E., Schurgers, L. J., Reutelingsperger, C. P., & Nicolaes, G. A. F. (2023). Inhibition of Neutral Sphingomyelinase 2 by Novel Small Molecule Inhibitors Results in Decreased Release of Extracellular Vesicles by Vascular Smooth Muscle Cells and Attenuated Calcification. International Journal of Molecular Sciences, 24(3), Article 2027. https://doi.org/10.3390/ijms24032027
    • Beukenhorst, A. L., Frallicciardi, J., Koch, C. M., Klap, J. M., Phillips, A., Desai, M. M., Wichapong, K., Nicolaes, G. A. F., Koudstaal, W., Alter, G., & Goudsmit, J. (2023). The influenza hemagglutinin stem antibody CR9114: Evidence for a narrow evolutionary path towards universal protection ( vol 2 , 1049134 , 2022). Frontiers in Virology, 3, Article 1130102. https://doi.org/10.3389/fviro.2023.1130102
  • 2022
    • Beghi, S., Furmanik, M., Jaminon, A., Veltrop, R., Rapp, N., Wichapong, K., Bidar, E., Buschini, A., & Schurgers, L. J. (2022). Calcium Signalling in Heart and Vessels: Role of Calmodulin and Downstream Calmodulin-Dependent Protein Kinases. International journal of molecular sciences, 23(24), Article 16139. https://doi.org/10.3390/ijms232416139
    • Nitz, K., Lacy, M., Bianchini, M., Wichapong, K., Kücükgöze, I. A., Bonfiglio, C. A., Migheli, R., Wu, Y., Burger, C., Li, Y., Forné, I., Ammar, C., Janjic, A., Mohanta, S., Duchene, J., Heemskerk, J. W. M., Megens, R. T. A., Schwedhelm, E., Huveneers, S., ... Atzler, D. (2022). The Amino Acid Homoarginine Inhibits Atherogenesis by Modulating T-Cell Function. Circulation Research, 131(8), 701-712. https://doi.org/10.1161/CIRCRESAHA.122.321094
    • van den Kerkhof, D. L., Nagy, M., Wichapong, K., Brouns, S. L. N., Suylen, D. P. L., Hackeng, T. M., & Dijkgraaf, I. (2022). Unraveling the role of the homoarginine residue in antiplatelet drug eptifibatide in binding to the αIIbβ3 integrin receptor. Thrombosis Research, 217, 96-103. https://doi.org/10.1016/j.thromres.2022.07.011
    • Huang, J., Jooss, N. J., Fernández, D. I., Sickmann, A., García, Á., Wichapong, K., Dijkgraaf, I., & Heemskerk, J. W. M. (2022). Roles of Focal Adhesion Kinase PTK2 and Integrin αIIbβ3 Signaling in Collagen- and GPVI-Dependent Thrombus Formation under Shear. International journal of molecular sciences, 23(15), Article 8688. https://doi.org/10.3390/ijms23158688