Kristiaan Wouters

Associate professor

Dr Kristiaan Wouters has studied Biomedical Sciences at Hasselt University (Belgium). In 2003, he started his PhD research at the Dept. of Molecular Genetics at Maastricht University on the role of macrophages and inflammation in nonalcoholic fatty liver disease. After obtaining his PhD in 2008, he worked as a post-doc in the laboratory of Prof. Bart Staels at the Pasteur Institute in Lille, France, on the role of macrophage polarisation in obesity, diabetes, and atherosclerosis. Kristiaan has returned to Maastricht at the Dept. of Internal Medicine as tenure track researcher setting up his research group 'Translational Immunometabolism'. Since 2019, he has been appointed as Associate Professor.

The group focusses on the immunological events in adipose tissue during obesity and the impact of these events on cardiometabolic complications, such as type 2 diabetes, cardiovascular disease and nonalcoholic fatty liver disease, with a specific focus on the interplay between metabolism and inflammation in innate immune cells.

Current projects focus on the role of reactive dicarbonyls formed during glycolysis on immune cell function in cardiometabolic diseases, and on multivariate analysis of flow cytometry data.



Department of Internal Medicine
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: H5.310
T: +31(0)43 388 42 33

  • 2021
    • van Dongen, K. C. W., Linkens, A. M. A., Wetzels, S. M. W., Wouters, K., Vanmierlo, T., van de Waarenburg, M. P. H., Scheijen, J. L. J. M., de Vos, W. M., Belzer, C., & Schalkwijk, C. G. (2021). Dietary advanced glycation endproducts (AGEs) increase their concentration in plasma and tissues, result in inflammation and modulate gut microbial composition in mice; evidence for reversibility. Food Research International, 147, [110547].
    • Wouters, K., Cento, A. S., Gaens, K. H., Teunissen, M., Scheijen, J. L. J. M., Barutta, F., Chiazza, F., Collotta, D., Aragno, M., Gruden, G., Collino, M., Schalkwijk, C. G., & Mastrocola, R. (2021). Deletion of RAGE fails to prevent hepatosteatosis in obese mice due to impairment of other AGEs receptors and detoxifying systems. Scientific Reports, 11(1), [17373].
    • Mastrocola, R., Dal Bello, F., Cento, A. S., Gaens, K., Collotta, D., Aragno, M., Medana, C., Collino, M., Wouters, K., & Schalkwijk, C. G. (2021). Altered hepatic sphingolipid metabolism in insulin resistant mice: Role of advanced glycation endproducts. Free Radical Biology and Medicine, 169, 425-435.
    • Crivelli, S. M., Luo, Q., Stevens, J. A. A., Giovagnoni, C., van Kruining, D., Bode, G., den Hoedt, S., Hobo, B., Scheithauer, A. L., Walter, J., Mulder, M. T., Exley, C., Mold, M., Mielke, M. M., De Vries, H. E., Wouters, K., van den Hove, D. L. A., Berkes, D., Ledesma, M. D., ... Martinez-Martinez, P. (2021). CERTL reduces C16 ceramide, amyloid-β levels, and inflammation in a model of Alzheimer’s disease. Alzheimer's Research & Therapy, 13(1), [45].
    • Maalmi, H., Wouters, K., Savelberg, H. H. C. M., van der Velde, J. H. P. M., Reulen, J. P. H., Mess, W., Schalkwijk, C. G., Stehouwer, C. D. A., Roden, M., Ziegler, D., Herder, C., & Schaper, N. C. (2021). Associations of cells from both innate and adaptive immunity with lower nerve conduction velocity: the Maastricht Study. BMJ Open Diabetes Research & Care, 9(1), [001698].
  • 2020
    • Wouters, K., Kusters, Y. H. A. M., Bijnen, M., Wetzels, S., Zhang, X., Linssen, P. B. C., Gaens, K., Houben, A. J. H. M., Joris, P. J., Plat, J., Kooi, M. E., van der Kallen, C. J. H., Mensink, R. P., Verboven, K., Jocken, J., Hansen, D., Blaak, E. E., Ehlers, F. A. I., Wieten, L., ... Schalkwijk, C. G. (2020). NK cells in human visceral adipose tissue contribute to obesity-associated insulin resistance through low-grade inflammation. Clinical and Translational Medicine, 10(6), [192].
    • Folcarelli, R., Tinnevelt, G. H., Hilvering, B., Wouters, K., van Staveren, S., Postma, G. J., Vrisekoop, N., Buydens, L. M. C., Koenderman, L., & Jansen, J. J. (2020). Multi-set Pre-processing of Multicolor Flow Cytometry Data. Scientific Reports, 10(1), [9716].
    • Simons, N., Bijnen, M., Wouters, K. A. M., Rensen, S. S., Beulens, J. W. J., van Greevenbroek, M. M. J., 't Hart, L. M., Greve, J. W. M., van der Kallen, C. J. H., Schaper, N. C., Schalkwijk, C. G., Stehouwer, C. D. A., & Brouwers, M. C. G. J. (2020). The endothelial function biomarker soluble E-selectin is associated with nonalcoholic fatty liver disease. Liver International, 40(5), 1079-1088.
    • Sari, G., Meester, E. J., van der Zee, L. C., Wouters, K., van Lennep, J. R., Peppelenbosch, M., Boonstra, A., Van der Heiden, K., Mulder, M. M. T., & Vanwolleghem, T. (2020). A mouse model of humanized liver shows a human-like lipid profile, but does not form atherosclerotic plaque after western type diet. Biochemical and Biophysical Research Communications, 524(2), 510-515.
    • Wetzels - van Hooijdonk, S., Bijnen, M., Wijnands, E., van de Gaar, M. J., Tan, A., Coort, S., Biessen, E., Schalkwijk, C., & Wouters, K. (2020). CD11c−MHC2low Macrophages Are a New Inflammatory and Dynamic Subset in Murine Adipose Tissue. Immunometabolism, 2(2), [e200015].