Marc Van Bilsen

Associate professor

Dr Marc van Bilsen obtained a Master degree in Cellular Biology (University of Leiden) in 1982, and received his PhD degree at the Department of Physiology of the Faculty of Medicine of the Maastricht University in 1988, where he studied the relation between cardiac lipid metabolism and tissue injury during myocardial ischemia and reperfusion. As a post-doc, he worked at the University California, San Diego, CA (UCSD), as a recipient of NATO-Science Fellowship award (NWO) and an American Heart Association award, on the regulation of gene transcription in cardiac hypertrophy (1990–1992). After his return to Maastricht he was appointed as Senior Investigator of the Royal Dutch Academy of Science (KNAW, 1993-1998). In 1998, he was awarded the Edmond Hustinx Price for Science by the Maastricht University and became appointed as Established Investigator by the Dutch Heart Foundation (NHS,1998-2003) to continue his studies on cardiac metabolism in hypertrophy, especially on the role of fatty acids as signaling molecules and regulators of cardiac gene expression. Since 1998, he holds the position of Associate Professor in Molecular Physiology at the Faculty of Medicine of the Maastricht University.

Furthermore, he is currently appointed Chairman of the CARIM Education Programme Committee (EPC) and acts as PhD Coordinator for the CARIM graduate programme.

He has been principal investigator on several national and international grants on the topic of cardiac metabolic remodeling, including a Netherlands Organisation for Scientific Research (NWO) TOP-Program Grant (2004-2009) and an European integratedproject (EUGeneHeart, FP6 LifeSciHealth, 2006-2011). He (co)authored over 120 papers in the cardiovascular field. His current research interest focusses on the interplay between cardiac metabolism and inflammation in the development of cardiometabolic disease in general, and in heart failure with preserved ejection fraction (HFpEF) in particular.

Department of Physiology
Universiteitsingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: 3.156
T: +31(0)43 388 12 04

  • 2022
    • Kuhn, A-R., & van Bilsen, M. (2022). Oncometabolism: A Paradigm for the Metabolic Remodeling of the Failing Heart. International journal of molecular sciences, 23(22), Article 13902.
    • Godsman, N., Kohlhaas, M., Nickel, A., Cheyne, L., Mingarelli, M., Schweiger, L., Hepburn, C., Munts, C., Welch, A., Delibegovic, M., Van Bilsen, M., Maack, C., & Dawson, D. K. (2022). Metabolic alterations in a rat model of Takotsubo syndrome. Cardiovascular Research, 118(8), 1932-1946.
  • 2021
    • Ploeg, M. C., Munts, C., Prinzen, F. W., Turner, N. A., van Bilsen, M., & van Nieuwenhoven, F. A. (2021). Piezo1 Mechanosensitive Ion Channel Mediates Stretch-Induced Nppb Expression in Adult Rat Cardiac Fibroblasts. Cells, 10(7), Article 1745.
    • van Haare, J., Kooi, M. E., van Teeffelen, J. W. G. E., Vink, H., Slenter, J., Cobelens, H., Strijkers, G. J., Koehn, D., Post, M. J., & van Bilsen, M. (2021). Correction to: Metformin and sulodexide restore cardiac microvascular perfusion capacity in diet‑induced obese rats. Cardiovascular Diabetology, 20(1), Article 53.
    • van Haare, J., Kooi, M. E., Vink, H., Post, M. J., van Teeffelen, J. W. G. E., Slenter, J., Munts, C., Cobelens, H., Strijkers, G. J., Koehn, D., & van Bilsen, M. (2021). Correction to: Early impairment of coronary microvascular perfusion capacity in rats on a high fat diet. Cardiovascular Diabetology, 20(1), Article 51.
  • 2020
    • Summer, G., Kuhn, A. R., Munts, C., Miranda-Silva, D., Leite-Moreira, A. F., Lourenco, A. P., Heymans, S., Falcao-Pires, I., & van Bilsen, M. (2020). A directed network analysis of the cardiome identifies molecular pathways contributing to the development of HFpEF. Journal of Molecular and Cellular Cardiology, 144, 66-75.
    • Cuijpers, I., Simmonds, S. J., van Bilsen, M., Czarnowska, E., Miqueo, A. G., Heymans, S., Kuhn, A. R., Mulder, P., Ratajska, A., Jones, E. A., & Brakenhielm, E. (2020). Microvascular and lymphatic dysfunction in HFpEF and its associated comorbidities. Basic Research in Cardiology, 115(4), Article 39.
    • Verdonschot, J. A. J., Wang, P., Van Bilsen, M., Hazebroek, M. R., Merken, J. J., Vanhoutte, E. K., Henkens, M. T. H. M., Van Den Wijngaard, A., Glatz, J. F. C., Krapels, I. P. C., Brunner, H. G., Heymans, S. R. B., & Bierau, J. (2020). Metabolic Profiling Associates with Disease Severity in Nonischemic Dilated Cardiomyopathy. Journal of Cardiac Failure, 26(3), 212-222.
    • Liapi, E., van Bilsen, M., Verjans, R., & Schroen, B. (2020). tRNAs and tRNA fragments as modulators of cardiac and skeletal muscle function. Biochimica et Biophysica Acta-Molecular Cell Research, 1867(3), Article 118465.
    • Verjans, R., van Bilsen, M., & Schroen, B. (2020). Reviewing the Limitations of Adult Mammalian Cardiac Regeneration: Noncoding RNAs as Regulators of Cardiomyogenesis. Biomolecules, 10(2), Article 262.