Marijke Kuijpers

Associate professor

Dr Marijke Kuijpers studied Biological Health Sciences at Maastricht University, after which she could start on a joint PhD project of the Department of Biochemistry and Physiology, studying studied platelet receptors and procoagulant activity in thrombus formation. After obtaining her PhD, she received a Kootstra fellowship, and started on a post-doc project from the Dutch Heart Foundation to investigate the role of platelets and coagulation in thrombus formation on ruptured atherosclerotic plaques.

Since 2011, she has been working as a scientific researcher in the Laboratory on Cell Biochemistry of Thrombosis and Haemostasis, chaired by Prof. Johan Heemskerk, within the Department of Biochemistry. Furthermore, she is connected to the Thrombosis Expertise Center (TEC) from Maastrich UMC+, which main aim is to improve translational research.

The current focus of her research is (hyper)active platelet function under pathologic circumstances: cancer, atherosclerosis, thrombosis, hyperlipidemia (diabetes type 2, Alzheimer). Main research questions are: the full characterisation gain-of-function platelet phenotypes and exploration of the underlying signaling mechanisms. She has a particular interest in the effects of tyrosine kinase inhibitors, often used as anti-cancer treatment, on platelet functions in vitro and in patients. Furthermore, she is part of the EU Horizon2020 TAPAS, investigating whether targeting platelet adhesion receptors can lead to better anti-thrombotic treatment without bleeding.

Department of Biochemistry
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: 4.320

  • 2021
    • Veninga, A., Baaten, C. C. F. M. J., De Simone, I., Tullemans, B. M. E., Kuijpers, M. J. E., Heemskerk, J. W. M., & van der Meijden, P. E. J. (2021). Effects of Platelet Agonists and Priming on the Formation of Platelet Populations. Thrombosis and Haemostasis. https://doi.org/10.1055/s-0041-1735972
    • Fernandez, D. I., Kuijpers, M. J. E., & Heemskerk, J. W. M. (2021). Platelet calcium signaling by G-protein coupled and ITAM-linked receptors regulating anoctamin-6 and procoagulant activity. Platelets, 32(7), 863-871. https://doi.org/10.1080/09537104.2020.1859103
    • Tullemans, B. M. E., Veninga, A., Fernandez, D. I., Aarts, M. J. B., Eble, J. A., van der Meijden, P. E. J., Heemskerk, J. W. M., & Kuijpers, M. J. E. (2021). Multiparameter Evaluation of the Platelet-Inhibitory Effects of Tyrosine Kinase Inhibitors Used for Cancer Treatment. International Journal of Molecular Sciences, 22(20), [11199]. https://doi.org/10.3390/ijms222011199
    • D'Ambrosi, S., Visser, A., Antunes-Ferreira, M., Poutsma, A., Giannoukakos, S., Sol, N., Sabrkhany, S., Bahce, I., Kuijpers, M. J. E., Egbrink, M. G. A. O., Griffioen, A. W., Best, M. G., Koppers-Lalic, D., Oudejans, C., & Wurdinger, T. (2021). The Analysis of Platelet-Derived circRNA Repertoire as Potential Diagnostic Biomarker for Non-Small Cell Lung Cancer. Cancers, 13(18), [4644]. https://doi.org/10.3390/cancers13184644
    • Coenen, D. M., Heinzmann, A. C. A., Oggero, S., Albers, H. J., Nagy, M., Hague, P., Kuijpers, M. J. E., Vanderwinden, J. M., van der Meer, A. D., Perretti, M., Koenen, R. R., & Cosemans, J. M. E. M. (2021). Inhibition of Phosphodiesterase 3A by Cilostazol Dampens Proinflammatory Platelet Functions. Cells, 10(8), [1998]. https://doi.org/10.3390/cells10081998
    • Lacy, M., Buerger, C., Shami, A., Ahmadsei, M., Winkels, H., Nitz, K., van Tiel, C. M., Seijkens, T. T. P., Kusters, P. J. H., Karshovka, E., Prange, K. H. M., Wu, Y., Brouns, S. L. N., Unterlugauer, S., Kuijpers, M. J. E., Reiche, M. E., Steffens, S., Edsfeldt, A., Megens, R. T. A., ... Lutgens, E. (2021). Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease. Nature Communications, 12(1), [3754]. https://doi.org/10.1038/s41467-021-23909-z
    • Tullemans, B. M. E., Fernandez, D. I., Veninga, A., Baaten, C. C. F. M. J., Peters, L. J. F., Aarts, M. J. B., Eble, J. A., Campello, E., Spiezia, L., Simioni, P., van der Vorst, E. P. C., van der Meijden, P. E. J., Heemskerk, J. W. M., & Kuijpers, M. J. E. (2021). Tyrosine Kinase Inhibitor Sunitinib Delays Platelet-Induced Coagulation: Additive Effects of Aspirin. Thrombosis and Haemostasis. https://doi.org/10.1055/s-0041-1730312
    • Sabrkhany, S., Kuijpers, M. J. E., Egbrink, M. G. A. O., & Griffioen, A. W. (2021). Platelets as messengers of early-stage cancer. Cancer and Metastasis Reviews, 40(2), 563-573. https://doi.org/10.1007/s10555-021-09956-4
    • Dickhout, A., Tullemans, B. M. E., Heemskerk, J. W. M., Thijssen, V. L. J. L., Kuijpers, M. J. E., & Koenen, R. R. (2021). Galectin-1 and platelet factor 4 (CXCL4) induce complementary platelet responses in vitro. PLOS ONE, 16(1), [0244736]. https://doi.org/10.1371/journal.pone.0244736
  • 2020
    • van Geffen, J. P., Swieringa, F., van Kuijk, K., Tullemans, B. M. E., Solari, F. A., Peng, B., Clemetson, K. J., Farndale, R. W., Dubois, L. J., Sickmann, A., Zahedi, R. P., Ahrends, R., Biessen, E. A. L., Sluimer, J. C., Heemskerk, J. W. M., & Kuijpers, M. J. E. (2020). Mild hyperlipidemia in mice aggravates platelet responsiveness in thrombus formation and exploration of platelet proteome and lipidome. Scientific Reports, 10(1), [21407]. https://doi.org/10.1038/s41598-020-78522-9