Martijn Brouwers

Professor

Dr Martijn Brouwers obtained his MD degree (with honours) in 2002, after which he started his PhD project that focused on hepatic steatosis in familial combined hyperlipidemia. In 2006, he worked as a trainee at the Department of Internal Medicine and Endocrinology. Since 2012, he has been a staff member (internist-endocrinologist) at Maastricht UMC+ and in 2019 he was appointed as the head of the division of Endocrinology and Metabolic Disease.

His research focusses on the cardiometabolic consequences of nonalcoholic fatty liver disease (NAFLD). NAFLD consists of a histological spectrum comprising simple steatosis, steatohepatitis (NASH), fibrosis and cirrhosis. Evidence is accumulating that NAFLD is not only a liver disease per se, it is also a risk factor for type 2 diabetes, chronic kidney disease and cardiovascular disease. This research line aims to elucidate the exact mechanistic link between NAFLD and these systemic diseases. For this, a diverse set of studies is used, ranging from (genetic) epidemiology, to ‘human knockout’ models, to randomised controlled trials and experimental animal work. This research is in part funded by the Dutch Heart Foundation, the Dutch Diabetes Foundation and the European Foundation for the Study of Diabetes.

Department ofInternal Medicine
P. Debeyelaan 25, 6229 HX Maastricht 
PO Box 5800, 6202 AZ Maastricht
T: +31(0)43 388 70 19

  • 2022
    • Simons, P. I. H. G., Cornelissen, M. E. B., Valkenburg, O., Onland-Moret, N. C., van der Schouw, Y. T., Stehouwer, C. D. A., Burgess, S., & Brouwers, M. C. G. J. (2022). Causal relationship between polycystic ovary syndrome and coronary artery disease: A Mendelian randomisation study. Clinical Endocrinology, 96(4), 599-604. https://doi.org/10.1111/cen.14593
  • 2021
    • van Dalem, J., Driessen, J. H. M., Burden, A. M., Stehouwer, C. D. A., Klungel, O. H., de Vries, F., & Brouwers, M. C. G. J. (2021). Thiazolidinediones and Glucagon-Like Peptide-1 Receptor Agonists and the Risk of Nonalcoholic Fatty Liver Disease: A Cohort Study. Hepatology, 74(5), 2467-2477. https://doi.org/10.1002/hep.32012
    • Foreman, Y. D., van Doorn, W. P. T. M., Schaper, N. C., van Greevenbroek, M. M. J., van der Kallen, C. J. H., Henry, R. M. A., Koster, A., Eussen, S. J. P. M., Wesselius, A., Reesink, K. D., Schram, M. T., Dagnelie, P. C., Kroon, A. A., Brouwers, M. C. G. J., & Stehouwer, C. D. A. (2021). Greater daily glucose variability and lower time in range assessed with continuous glucose monitoring are associated with greater aortic stiffness: The Maastricht Study. Diabetologia, 64(8), 1880-1892. https://doi.org/10.1007/s00125-021-05474-8
    • Simons, P. I. H. G., Valkenburg, O., Stehouwer, C. D. A., & Brouwers, M. C. G. J. (2021). Sex hormone-binding globulin: biomarker and hepatokine?Trends in Endocrinology and Metabolism, 32(8), 544-553. https://doi.org/10.1016/j.tem.2021.05.002
    • Brouwers, M. C. G. J. (2021). When to Consider an Inborn Error of Metabolism in Adults?Journal of Endocrinology and Metabolism, 11(3-4), 65-68. https://doi.org/10.14740/jem750
    • Simons, P. I. H. G., Valkenburg, O., Telgenkamp, I., van der Waaij, K. M., de Groot, D. M., Veeraiah, P., Bons, J. A. P., Taskinen, M. R., Boren, J., Schrauwen, P., Rutten, J. H. W., Cassiman, D., Schalkwijk, C. G., Stehouwer, C. D. A., Schrauwen-Hinderling, V. B., Hodson, L., & Brouwers, M. C. G. J. (2021). Relationship between de novo lipogenesis and serum sex hormone binding globulin in humans. Clinical Endocrinology, 95(1), 101-106. https://doi.org/10.1111/cen.14459
    • Simons, P. I. H. G., Valkenburg, O., Bons, J. A. P., Stehouwer, C. D. A., & Brouwers, M. C. G. J. (2021). The relationships of sex hormone-binding globulin, total testosterone, androstenedione and free testosterone with metabolic and reproductive features of polycystic ovary syndrome. Endocrinology, Diabetes & Metabolism, 4(3), [00267]. https://doi.org/10.1002/edm2.267
    • van Doorn, W. P. T. M., Foreman, Y. D., Schaper, N. C., Savelberg, H. H. C. M., Koster, A., van der Kallen, C. J. H., Wesselius, A., Schram, M. T., Henry, R. M. A., Dagnelie, P. C., de Galan, B. E., Bekers, O., Stehouwer, C. D. A., Meex, S. J. R., & Brouwers, M. C. G. J. (2021). Machine learning-based glucose prediction with use of continuous glucose and physical activity monitoring data: The Maastricht Study. PLOS ONE, 16(6), [0253125]. https://doi.org/10.1371/journal.pone.0253125
    • Timmons, J. G., Greenlaw, N., Boyle, J. G., Chaturvedi, N., Ford, I., Brouwers, M. C. G. J., Tillin, T., Hramiak, I., Hughes, A. D., Jenkins, A. J., Klein, B. E. K., Klein, R., Ooi, T. C., Rossing, P., Stehouwer, C. D. A., Sattar, N., Colhoun, H. M., Petrie, J. R., & REMOVAL Study Grp (2021). Metformin and carotid intima-media thickness in never-smokers with type 1 diabetes: The REMOVAL trial. Diabetes Obesity & Metabolism, 23(6), 1371-1378. https://doi.org/10.1111/dom.14350
    • Dalem, J. V., Brouwers, M. C. G. J., Burden, A. M., Stehouwer, C. D. A., Klungel, O. H., Vries, F. D., & Driessen, J. H. M. (2021). Determinants of treatment modification before and after implementation of the updated 2015 NICE guideline on type 2 diabetes: A retrospective cohort study. Diabetes Research and Clinical Practice, 176, [108828]. https://doi.org/10.1016/j.diabres.2021.108828