Miranda Schram

Associate professor

Dr Miranda Schram holds a MSc in Biomedical Sciences (1999) and in Epidemiology (2002). She recieved her PhD entitled 'Patophysiology of diabetic complications, arterial stiffness, endothelial dysfunction and inflammation' at VU University Medical Center in Amsterdam in 2004, and is a registered Epidemiologist B. She has worked as post-doc epidemiologist at Erasmus MC in Rotterdam, at Leiden University Medical Center and as senior investigator at the National Institute for Public Health and the Environment in Bilthoven. From 2008 onwards, she has been working at Maastricht UMC+ as senior investigator at The Maastricht Study.

Miranda Schram is one of the founders of The Maastricht Study, a novel population-based cohort study on type 2 diabetes and its complications. Her scientific work focusses on the etiology and epidemiology of cognitive decline and depression in type 2 diabetes with a specific interest in the role of early vascular dysfunction. A second research line focusses on psychosocial aspects of diabetes, to understand how social networks, but also ethnicity and diabetes distress can affect diabetes treatment and the development of complications. Miranda is board member of The Maastricht Study, coordinator of the Dutch Diabetes Pearlstring Initiative, active member of the PSAD study group of the EASD and involved in the Netherlands Consortium of Demetia Cohorts.

Department of Internal Medicine
Randwycksingel 35, 6229 EG Maastricht
T: +31(0)6 122 64 289

  • 2021
    • van Dinther, M., Schram, M. T., Jansen, J. F. A., Backes, W. H., Houben, A. J. H. M., Berendschot, T. T. J. M., Schalkwijk, C. G., Stehouwer, C. D. A., van Oostenbrugge, R. J., & Staals, J. (2021). Extracerebral microvascular dysfunction is related to brain MRI markers of cerebral small vessel disease: The Maastricht Study. Geroscience. https://doi.org/10.1007/s11357-021-00493-0
    • van der Heide, F. C. T., Steens, I. L. M., Geraets, A. F. J., Foreman, Y. D., Henry, R. M. A., Kroon, A. A., van der Kallen, C. J. H., van Sloten, T. T., Dagnelie, P. C., van Dongen, M. C. J. M., Eussen, S. J. P. M., Berendschot, T. T. J. M., Schouten, J. S. A. G., Webers, C. A. B., van Greevenbroek, M. M. J., Wesselius, A., Koster, A., Schaper, N. C., Schram, M. T., ... Stehouwer, C. D. A. (2021). Association of Retinal Nerve Fiber Layer Thickness, an Index of Neurodegeneration, With Depressive Symptoms Over Time. Jama network open, 4(11), e2134753. [2134753]. https://doi.org/10.1001/jamanetworkopen.2021.34753
    • Strikwerda, M., Beulens, J. W., Remmelzwaal, S., Schoonmade, L. J., van Straten, A., Schram, M. T., Elders, P. J., & Rutters, F. (2021). The Association of Burnout and Vital Exhaustion With Type 2 Diabetes: A Systematic Review and Meta-Analysis. Psychosomatic Medicine, 83(9), 1013-1030. https://doi.org/10.1097/PSY.0000000000000995
    • Bakker, L., Ramakers, I. H. G. B., van Boxtel, M. P. J., Schram, M. T., Stehouwer, C. D. A., van der Kallen, C. J. H., Dagnelie, P. C., van Greevenbroek, M. M. J., Wesselius, A., Midttun, Ø., Ueland, P. M., Verhey, F. R. J., Eussen, S. J. P. M., & Köhler, S. (2021). Associations between plasma kynurenines and cognitive function in individuals with normal glucose metabolism, prediabetes and type 2 diabetes: the Maastricht Study. Diabetologia, 64(11), 2445-2457. https://doi.org/10.1007/s00125-021-05521-4
    • Gianfredi, V., Beran, M., Koster, A., Eussen, S. J. P. M., Odone, A., Signorelli, C., Schaper, N. C., Kohler, S., Bosma, H., Dagnelie, P. C., Stehouwer, C. D. A., Wesselius, A., Amerio, A., Brinkhues, S., Dukers-Muijrers, N., & Schram, M. T. (2021). Association between social network characteristics and prevalent and incident depression: The Maastricht Study. Journal of Affective Disorders, 293, 338-346. https://doi.org/10.1016/j.jad.2021.06.046
    • Janssen, E. P. C. J., Kohler, S., Geraets, A. F. J., Stehouwer, C. D. A., Schaper, N. C., Sep, S. J. S., Henry, R. M. A., van der Kallen, C. J. H., Schalkwijk, C. G., Koster, A., Verhey, F. R., & Schram, M. T. (2021). Low-grade inflammation and endothelial dysfunction predict four-year risk and course of depressive symptoms: The Maastricht study. Brain Behavior and Immunity, 97, 61-67. https://doi.org/10.1016/j.bbi.2021.06.013
    • van Gennip, A. C. E., Stehouwer, C. D. A., van Boxtel, M. P. J., Verhey, F. R. J., Koster, A., Kroon, A. A., Köhler, S., van Greevenbroek, M. M. J., Wesselius, A., Eussen, S. J. P. M., Backes, W. H., Jansen, J. F., Schram, M. T., Henry, R. M. A., Singh-Manoux, A., & van Sloten, T. T. (2021). Association of Type 2 Diabetes, According to the Number of Risk Factors Within Target Range, With Structural Brain Abnormalities, Cognitive Performance, and Risk of Dementia. Diabetes Care. https://doi.org/10.2337/dc21-0149
    • Heger, I. S., Deckers, K., Schram, M. T., Stehouwer, C. DA., Dagnelie, P. C., van der Kallen, C. J., Koster, A., Eussen, S. J., Jansen, J. F., Verhey, F. R., van Boxtel, M. P., & Köhler, S. (2021). Associations of the Lifestyle for Brain Health Index With Structural Brain Changes and Cognition: Results From the Maastricht Study. Neurology, 97(13), E1300-E1312. https://doi.org/10.1212/WNL.0000000000012572
    • Linkens, A. M. A., Houben, A. J. H. M., Kroon, A. A., Schram, M. T., Berendschot, T. T. J. M., Webers, C. A. B., van Greevenbroek, M., Henry, R. M. A., de Galan, B., Stehouwer, C. D. A., Eussen, S. J. M. P., & Schalkwijk, C. G. (2021). Habitual intake of dietary advanced glycation end products is not associated with generalized microvascular function-the Maastricht Study. American Journal of Clinical Nutrition. https://doi.org/10.1093/ajcn/nqab302
    • Beran, M., Muzambi, R., Geraets, A., Albertorio-Diaz, J. R., Adriaanse, M. C., Iversen, M. M., Kokoszka, A., Nefs, G., Nouwen, A., Pouwer, F., Huber, J. W., Schmitt, A., Schram, M. T., & European Depression in Diabetes (EDID) Research Consortium (2021). The bidirectional longitudinal association between depressive symptoms and HbA(1c): A systematic review and meta-analysis. Diabetic Medicine, [e14671]. https://doi.org/10.1111/dme.14671