Paola van der Meijden

Assistant Professor

Initially trained in Biological Health Sciences at Maastricht University, Dr Paola van der Meijden has obtained a PhD in Biochemistry on the interaction mechanisms of platelets and coagulation; focus on P2Y₁₂receptor and factor XII.

In 2010, she acquired a unique bridging position, encapsulated within the Maastricht Thrombosis Expertise Center (TEC), aiming to link basic research on thrombosis and hemostasis with clinical research and applications. In 2014, she received the ISTH-EHA Fellowship to gain new insights into the determinants of bleeding in patients with thrombocytopenia due to hematological malignancies and chemotherapy. The focus of her current work is on the interactions between platelets and coagulation in acquired hemostatic dysfunction as a consequence of disease and treatment. She has a special interest in the negative and positive priming of platelets and the functional specialisation of platelet populations. Overall, knowledge on the factors contributing to hemostasis and thrombosis enables the development of predictive and diagnostic tests, resulting in improved disease management.

Department of Biochemistry
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room: 4.322
T: +31(0)43 388 16 84

2024
- Provenzale, I., Solari, F. A., Schoenichen, C., Brouns, S. L. N., Fernandez, D. I., Kuijpers, M. J. E., van Der Meijden, P. E. J., Gibbins, J. M., Sickmann, A., Jones, C., & Heemskerk, J. W. M. (2024). Endothelium-mediated regulation of platelet activation: Involvement of multiple protein kinases. Faseb Journal, 38(4), Article e23468. https://doi.org/10.1096/fj.202300360RR
- Baaten, C. C. F. M. J., Nagy, M., Bergmeier, W., Spronk, H. M. H., & van der Meijden, P. E. J. (2024). Platelet biology and function: plaque erosion vs. rupture. European Heart Journal, 45(1), 18-31. https://doi.org/10.1093/eurheartj/ehad720
2023
- Provenzale, I., De Simone, I., Gibbins, J. M., Heemskerk, J. W. M., van der Meijden, P. E. J., & Jones, C. I. (2023). Regulation of Glycoprotein VI-Dependent Platelet Activation and Thrombus Formation by Heparan Sulfate Proteoglycan Perlecan. International Journal of Molecular Sciences, 24(17), Article 13352. https://doi.org/10.3390/ijms241713352
- Akbalut, C., Arisz, R., Baaten, C., Baildildinova, G., Barakzie, A., Bauersachs, R., Ten Berg, J. M., van den Broek, W., de Boer, H. C., Broker, V., Buka, R., Ten Cate, H., Cate, A. T., De Luca, C., De Simone, I., Dignat-George, F., Freson, K., Gazzaniga, G., van Gorp, E., ... van Zonneveld, A.-J. (2023). Blood coagulation and beyond: Position paper from the Fourth Maastricht Consensus Conference on Thrombosis. Thrombosis and Haemostasis, 123(8), 808-839. https://doi.org/10.1055/a-2052-9175
- De Simone, I., Baaten, C. C. F. M. J., Gibbins, J. M., Ten Cate, H., Heemskerk, J. W. M., Jones, C. I., & van der Meijden, P. E. J. (2023). Repeated platelet activation and the potential of previously activated platelets to contribute to thrombus formation. Journal of Thrombosis and Haemostasis, 21(5), 1289-1306. https://doi.org/10.1016/j.jtha.2023.01.006
2022
- Baidildinova, G., Ten Cate, V., Nagler, M., Panova-Noeva, M., Rapp, S., Köck, T., Prochaska, J. H., Heitmeier, S., Gerdes, C., Schwers, S., Konstantinides, S. V., Münzel, T., Espinola-Klein, C., Lackner, K. J., Spronk, H. M. N., Ten Cate, H., van der Meijden, P. E. J., Leineweber, K., Wild, P. S., & Jurk, K. (2022). Subtype-specific plasma signatures of platelet-related protein releasate in acute pulmonary embolism. Thrombosis Research, 220, 75-87. https://doi.org/10.1016/j.thromres.2022.10.005
- Nagy, M., van der Meijden, P. E. J., Glunz, J., Schurgers, L., Lutgens, E., Ten Cate, H., Heitmeier, S., & Spronk, H. M. H. (2022). Integrating Mechanisms in Thrombotic Peripheral Arterial Disease. Pharmaceuticals, 15(11), Article 1428. https://doi.org/10.3390/ph15111428
- De Simone, I., Baaten, C. C. F. M. J., Jandrot-Perrus, M., Gibbins, J. M., Ten Cate, H., Heemskerk, J. W. M., Jones, C. I., & van der Meijden, P. E. J. (2022). Coagulation Factor XIIIa and Activated Protein C Activate Platelets via GPVI and PAR1. International journal of molecular sciences, 23(18), Article 10203. https://doi.org/10.3390/ijms231810203
- Veninga, A., Handtke, S., Aurich, K., Tullemans, B., Brouns, S., Schwarz, S. L., Heubel-Moenen, F. C., Greinacher, A., Heemskerk, J. W. M., van der Meijden, P., & Thiele, T. (2022). GPVI expression is linked to platelet size, age, and reactivity. Blood advances, 6(14), 4162-4173. https://doi.org/10.1182/bloodadvances.2021006904
- Lundstroem, A., Sanden, P., Mitroulis, I., & van der Meijden, P. E. J. (2022). Editorial: Platelet Function in COVID-19. Frontiers in Cardiovascular Medicine, 9, Article 912472. https://doi.org/10.3389/fcvm.2022.912472

Overview

Latest news & events

Professorship Julie Staals

22 April 2024

ERC Advanced Grant awarded to Prof. Andy Baker

15 April 2024

Paola van der Meijden

Assistant Professor