Paula da Costa Martins

Associate professor

Dr Paula da Costa Martins has graduated in Biology at the Faculty of Sciences, University of Lisbon, in Portugal. Afterwards, she moved to Amsterdam, in the Netherlands, to work on cellular and molecular biology, focussing on the interactions between immune and endothelial cells, and their contribution to inflammation and atherosclerosis, at Sanquin Research, and for which she obtained her PhD at the University of Amsterdam. Subsequently, she followed her post-doctoral research at the Hubrecht Institute (Utrecht, The Netherlands), studying the contribution of noncoding RNAs in the onset and development of heart disease.

She has been working at Maastricht University since 2010. The focus of her research is deciphering the contribution of non-coding RNAs, specially microRNAs, to the development and progression of cardiac disease. More specifically, she centres her research on understanding how different cardiac cell types communicate to influence each other’s phenotype and in a concerted manner contribute to pathologic cardiac remodelling. Her main interest is unveiling how cardiomyocytes send 'microRNA messages’ to cardiac endothelial cells and inflammatory cells via exosomes, to alter their angiogenic and inflammatory properties, respectively. In this way she expects to identify new gene targets or processes where one can intervene to prevent or cure heart disease.

Department of Cardiology
Department of Molecular Biology and RNA Technology 
Universiteitsingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
T: +31 (0)43 388 22 22

  • 2022
    • Raso, A., Dirkx, E., Sampaio-Pinto, V., El Azzouzi, H., Cubero, R. J., Sorensen, D. W., Ottaviani, L., Olieslagers, S., Huibers, M. M., de Weger, R., Siddiqi, S., Moimas, S., Torrini, C., Zentillin, L., Braga, L., Nascimento, D. S., da Costa Martins, P. A., van Berlo, J. H., Zacchigna, S., ... De Windt, L. J. (2022). Author Correction: A microRNA program regulates the balance between cardiomyocyte hyperplasia and hypertrophy and stimulates cardiac regeneration. Nature Communications, 13(1), [4977]. https://doi.org/10.1038/s41467-022-32785-0
    • Fernandes, H., Zonnari, A., Abreu, R., Aday, S., Barão, M., Albino, I., Lino, M., Branco, A., Seabra, C., Barata, T., Leal, E. C., Tralhão, J. G., Gonçalves, L., de Jong, A., Peters, H. A. B., de Vries, M. R., da Costa Martins, P., Quax, P. H. A., & Ferreira, L. (2022). Extracellular vesicles enriched with an endothelial cell pro-survival microRNA affects skin tissue regeneration. Molecular Therapy - Nucleic Acids, 28, 307-327. https://doi.org/10.1016/j.omtn.2022.03.018
    • Ottaviani, L., Juni, R. P., de Abreu, R. C., Sansonetti, M., Sampaio-Pinto, V., Halkein, J., Hegenbarth, J. C., Ring, N., Knoops, K., Kocken, J. M. M., Jesus, C. D., Ernault, A. C., El Azzouzi, H., Rühle, F., Olieslagers, S., Fernandes, H., Ferreira, L., Braga, L., Stoll, M., ... da Costa Martins, P. A. (2022). Intercellular transfer of miR-200c-3p impairs the angiogenic capacity of cardiac endothelial cells. Molecular Therapy, 30(6), 2257-2273. https://doi.org/10.1016/j.ymthe.2022.03.002
    • Silva, J., & da Costa Martins, P. A. (2022). Non-Coding RNAs in the Therapeutic Landscape of Pathological Cardiac Hypertrophy. Cells, 11(11), [1805]. https://doi.org/10.3390/cells11111805
  • 2021
    • Raso, A., Dirkx, E., Sampaio-Pinto, V., el Azzouzi, H., Cubero, R. J., Sorensen, D. W., Ottaviani, L., Olieslagers, S., Huibers, M. M., de Weger, R., Siddiqi, S., Moimas, S., Torrini, C., Zentillin, L., Braga, L., Nascimento, D. S., da Costa Martins, P. A., van Berlo, J. H., Zacchigna, S., ... De Windt, L. J. (2021). A microRNA program regulates the balance between cardiomyocyte hyperplasia and hypertrophy and stimulates cardiac regeneration. Nature Communications, 12(1), [4808]. https://doi.org/10.1038/s41467-021-25211-4
    • Abreu, R. C., Ramos, C., Becher, C., Lino, M., Jesus, C., da Costa Martins, P. A., Martins, P. A. T., Moreno, M. J., Fernandes, H., & Ferreira, L. (2021). Exogenous loading of miRNAs into small extracellular vesicles. Journal of Extracellular Vesicles , 10(10), [12111]. https://doi.org/10.1002/jev2.12111
    • Sampaio-Pinto, V., Silva, E. D., Laundos, T. L., Martins, P. D. C., Pinto-do-O, P., & Nascimento, D. S. (2021). Stereological estimation of cardiomyocyte number and proliferation. Methods, 190, 55-62. https://doi.org/10.1016/j.ymeth.2020.06.002
    • D'Souza, A., Wang, Y. W., Anderson, C., Bucchi, A., Baruscotti, M., Olieslagers, S., Mesirca, P., Johnsen, A. B., Mastitskaya, S., Ni, H. B., Zhang, Y., Black, N., Cox, C., Wegner, S., Bano-Otalora, B., Petit, C., Gill, E., Logantha, S. J. R. J., Dobrzynski, H., ... Boyett, M. R. (2021). A circadian clock in the sinus node mediates day-night rhythms in Hcn4 and heart rate. Heart Rhythm, 18(5), 801-810. https://doi.org/10.1016/j.hrthm.2020.11.026
  • 2020
    • Kocken, J. M. M., & da Costa Martins, P. A. (2020). Epigenetic Regulation of Pulmonary Arterial Hypertension-Induced Vascular and Right Ventricular Remodeling: New Opportunities?International journal of molecular sciences, 21(23), [8901]. https://doi.org/10.3390/ijms21238901