Pieter Dagnelie


Prof. Pieter Dagnelie is nutritional epidemiologist. He studied human nutrition at Wageningen University and received his PhD in 1988 based on a population-based, mixed-longitudinal cohort study of the nutritional status and growth of children fed macrobiotic diets. Subsequently, he received fellowships from the Dutch Cancer Society (1989) and the Royal Netherlands Academy of Arts and Sciences (1991) to work on the etiology of weight loss in cancer patients, using magnetic resonance spectroscopy and stable isotope tracers as main research tools.

In 1997, he was appointed Associate Professor in Maastricht to lead the nutritional epidemiology research group at the department of epidemiology and to build up the collaboration on nutritional epidemiology within Maastricht UMC+. In 2012, he received a strategic professorship in nutritional epidemiology.

Prof. Dagnelie’s overall aim is to explore new paradigms in the field of health research, lifestyle and nutrition, and to integrate and implement this new knowledge in disease prevention and treatment, thus contributing to improving people’s nutritional and health status, and quality of life. He has performed and supervised numerous observational studies and randomised clinical trials on the role of nutrition and bioactive compounds in the prevention and treatment of chronic diseases and cancer, with the improvement of transmural health care. His central aim has always been to contribute to the wellbeing of healthy individuals and patients. He is former member of the Scientific Committee of  and the Medical Ethical Committee of Maastricht UMC+.

Prof. Dagnelie’s current research is focussed on The Maastricht Study (https://www.demaastrichtstudie.nl/), a large-scale study initiated in 2010 on the etiology and prognosis of diabetes and its comorbidities, with oversampling individuals with type 2 diabetes. Enrolment is still ongoing. The Maastricht Study is one of the largest studies world-wide of its kind. All participants undergo 5 half-days of intensive phenotyping. Prof. Dagnelie was involved in the Life Style collaborative group of The Maastricht Study and the development of the extensive Food Frequency Questionnaire to assess dietary intake, both in terms of nutrients, dietary patterns and processing.

Since 2012, Prof. Dagnelie has been member of the Management Team of The Maastricht Study. Within the MT, his focus is on optimising research methodology, quality, and design of projects within The Maastricht Study. He also contributes to exploring new targets for funding, and is currently coordinator for organizaing a second assessment round of this population study, including obtaining permission from the Health Council of The Netherlands.

Lately, outside The Maastricht Study, Prof. Dagnelie’s aim is to integrate population health and sustainability of the food chain, in relation with climate change, biodiversity, and fair pricing.

Department of Internal Medicine
Randwijcksingel 35, 6229 EG Maastricht
T: +31(0)43 387 66 00

  • 2020
    • Geraets, A. F. J., Kohler, S., Muzambi, R., Schalkwijk, C. G., Oenema, A., Eussen, S. J. P. M., Dagnelie, P. C., Stehouwer, C. D. A., Schaper, N. C., Henry, R. M. A., van der Kallen, C. J. H., Wesselius, A., Koster, A., Verhey, F. R. J., & Schram, M. T. (2020). The association of hyperglycaemia and insulin resistance with incident depressive symptoms over 4 years of follow-up: The Maastricht Study. Diabetologia, 63(11), 2315-2328. https://doi.org/10.1007/s00125-020-05247-9
    • Vandercappellen, E. J., Henry, R. M. A., Savelberg, H. H. C. M., van der Berg, J. D., Reesink, K. D., Schaper, N. C., Eussen, S. J. P. M., van Dongen, M. C. J. M., Dagnelie, P. C., Schram, M. T., van Greevenbroek, M. M. J., Wesselius, A., van der Kallen, C. J. H., Kohler, S., Stehouwer, C. D. A., & Koster, A. (2020). Association of the Amount and Pattern of Physical Activity With Arterial Stiffness: The Maastricht Study. Journal of the American Heart Association, 9(20), [017502]. https://doi.org/10.1161/JAHA.120.017502
    • Zhou, T. L., Rensma, S. P., van der Heide, F. C. T., Henry, R. M. A., Kroon, A. A., Houben, A. J. H. M., Jansen, J. F. A., Backes, W. H., Berendschot, T. T. J. M., Schouten, J. S. A. G., van Dongen, M. C. J. M., Eussen, S. J. P. M., Dagnelie, P. C., Webers, C. A. B., Schram, M. T., Schalkwijk, C. G., van Sloten, T. T., & Stehouwer, C. D. A. (2020). Blood pressure variability and microvascular dysfunction: the Maastricht Study. Journal of Hypertension, 38(8), 1541-1550. https://doi.org/10.1097/HJH.0000000000002444
    • De Clerck, E. E. B., Schouten, J. S. A. G., Berendschot, T. T. J. M., Koolschijn, R. S., Nuijts, R. M. M. A., Schram, M. T., Schaper, N. C., Henry, R. M. A., Dagnelie, P. C., Ruggeri, A., Guimarães, P., Stehouwer, C. D. A., & Webers, C. A. B. (2020). Reduced corneal nerve fibre length in prediabetes and type 2 diabetes: The Maastricht Study. Acta Ophthalmologica, 98(5), 485-491. https://doi.org/10.1111/aos.14359
    • Martens, R. J. H., Henry, R. M. A., Bekers, O., Dagnelie, P. C., van Dongen, M. C. J. M., Eussen, S. J. P. M., van Greevenbroek, M., Kroon, A. A., Stehouwer, C. D. A., Wesselius, A., Meex, S. J. R., & Kooman, J. P. (2020). Associations of 24-Hour Urinary Sodium and Potassium Excretion with Cardiac Biomarkers: The Maastricht Study. Journal of Nutrition, 150(6), 1413-1424. https://doi.org/10.1093/jn/nxaa080
    • Rensma, S. P., Stehouwer, C. D. A., Van Boxtel, M. P. J., Houben, A. J. H. M., Berendschot, T. T. J. M., Jansen, J. F. A., Schalkwijk, C. G., Verhey, F. R. J., Kroon, A. A., Henry, R. M. A., Backes, W. H., Dagnelie, P. C., van Dongen, M. C. J. M., Eussen, S. J. P. M., Bosma, H., Köhler, S., Reesink, K. D., Schram, M. T., & van Sloten, T. T. (2020). Associations of Arterial Stiffness With Cognitive Performance, and the Role of Microvascular Dysfunction: The Maastricht Study. Hypertension, 75(6), 1607-1614. https://doi.org/10.1161/HYPERTENSIONAHA.119.14307
    • Nielen, J. T. H., Driessen, J. H. M., Dagnelie, P. C., Boonen, A., van den Bemt, B., van Onzenoort, H. A. W., Neef, C., Henry, R. M. A., Burden, A. M., Sep, S. J. S., van der Kallen, C. J., Schram, M. T., Schaper, N., Stehouwer, C. D. A., Smits, L., & de Vries, F. (2020). Drug utilization in the Maastricht Study: A comparison with nationwide data. Medicine, 99(1), [18524]. https://doi.org/10.1097/MD.0000000000018524
    • Vergoossen, L. W., Schram, M. T., de Jong, J. J., Stehouwer, C. D., Schaper, N. C., Henry, R. M., van der Kallen, C. J., Dagnelie, P. C., van Boxtel, M. P., Eussen, S. J., Backes, W. H., & Jansen, J. F. (2020). White Matter Connectivity Abnormalities in Prediabetes and Type 2 Diabetes: The Maastricht Study. Diabetes Care, 43(1), 201-208. https://doi.org/10.2337/dc19-0762
  • 2019
    • Smulders, M. W., Kietselaer, B. L. J. H., Wildberger, J. E., Dagnelie, P. C., Brunner-La Rocca, H-P., Mingels, A. M. A., van Cauteren, Y. J. M., Theunissen, R. A. L. J., Post, M. J., Schalla, S., van Kuijk, S. M. J., Das, M., Kim, R. J., Crijns, H. J. G. M., & Bekkers, S. C. A. M. (2019). Initial Imaging-Guided Strategy Versus Routine Care in Patients With Non-ST-Segment Elevation Myocardial Infarction. Journal of the American College of Cardiology, 74(20), 2466-2477. https://doi.org/10.1016/j.jacc.2019.09.027
    • Ginsberg, C., Houben, A. J. H. M., Malhotra, R., Berendschot, T. T. J. M., Dagnelie, P. C., Kooman, J. P., Webers, C. A., Stehouwer, C. D. A., & Ix, J. H. (2019). Serum Phosphate and Microvascular Function in a Population-Based Cohort. Clinical journal of the American Society of Nephrology, 14(11), 1626-1633. https://doi.org/10.2215/CJN.02610319