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Marja van Dieijen Prize PreCIS

Marja van Dieijen Prize PreCIS

24 November 2023

After tallying both the audience score and the jury's score, the innovative project 'PreCIS, addressing medication prescribing cascades' won the Marja van Dieijen Award 2023, worth 25,000 euros.

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€22 million for international research into cardiovascular disease

€22 million for international research into cardiovascular disease

27 October 2023

Prof. Hans-Peter Brunner-La Rocca (Dept. of Cardiology) leads an international research project, focused on personalised prevention and treatment of cardiovascular diseases.

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Carim Maastricht
Carim Maastricht

Pieter Goossens

Post doc

Dr Pieter Goossens graduated in 2012 at the Maastricht University, studying atherosclerotic plaque macrophage accumulation in the group of Prof. Menno de Winther (Department of Molecular Genetics ). He then joined the lab of Dr Toby Lawrence at the Centre d’Immunologie de Marseille-Luminy in Marseille (France) as a post-doctoral researcher, where he investigated the mechanisms through which tumor-associated macrophages obtain their characteristic phenotype. In 2016, he returned to the Maastricht University where, in the lab of Prof. Erik Biessen at the Department of Pathology, he studies macrophage phenotypical and functional heterogeneity in the atherosclerosis context.

Macrophages display a high degree of phenotypic heterogeneity that reflects the cells’ micro-environment. Pieter combines classical histology with transcriptomics, multi-label fluorescent microscopy and mass spectrometry imaging to study the spatial distribution of macrophage subsets in human and murine atherosclerotic plaques and the impact of local triggers on their phenotype and functions.

 

Pieter-goossens

Department of Pathology
P. Debyelaan 25, 6229 HX Maastricht
Room number: 5.06
T: +31(0)43 387 46 30

  • 2023
    • Wieland, E. B., Kempen, L. J., Donners, M. M., Biessen, E. A., & Goossens, P. (2023). Macrophage heterogeneity in atherosclerosis: A matter of context. European journal of immunology, Article 2350464. https://doi.org/10.1002/eji.202350464
    • Nagenborg, J., Jin, H., Ruder, A. V., Temmerman, L., Mees, B., Schalkwijk, C., Müller-Klieser, D., Berg, T., Goossens, P., Donners, M. M. P. C., & Biessen, E. A. L. (2023). GM-CSF-activated STAT5A regulates macrophage functions and inflammation in atherosclerosis. Frontiers in Immunology, 14, Article 1165306. https://doi.org/10.3389/fimmu.2023.1165306
    • Wieland, E. B., Kempen, L. J. A. P., Lu, C., Donners, M. M. P. C., Biessen, E. A. L., & Goossens, P. (2023). Protocol for multispectral imaging on cryosections to map myeloid cell heterogeneity in its spatial context. STAR protocols, 4(4), Article 102601. Advance online publication. https://doi.org/10.1016/j.xpro.2023.102601
    • Ruder, A., Wetzels, S. M. W., Temmerman, L., Biessen, E. A. L., & Goossens, P. (2023). Monocyte heterogeneity in cardiovascular disease. Cardiovascular Research, 119(11), 2033-2045. https://doi.org/10.1093/cvr/cvad069
    • van Kuijk, K., McCracken, I. R., Tillie, R. J. H. A., Asselberghs, S. E. J., Kheder, D. A., Muitjens, S., Jin, H., Taylor, R. S., Schreur, R. W., Kuppe, C., Dobie, R., Ramachandran, P., Gijbels, M. J., Temmerman, L., Kirkwoord, P. M., Luyten, J., Li, Y. M., Noels, H., Goossens, P., ... Sluimer, J. C. (2023). Human and murine fibroblast single-cell transcriptomics reveals fibroblast clusters are differentially affected by ageing and serum cholesterol. Cardiovascular Research, 119(7), 1509-1523. https://doi.org/10.1093/cvr/cvad016
    • Lu, C., Donners, M. M. P. C., Karel, J., de Boer, H., van Zonneveld, A. J., den Ruijter, H., Jukema, J. W., Kraaijeveld, A., Kuiper, J., Pasterkamp, G., Cavill, R., Perales-Patón, J., Ferrannini, E., Goossens, P., & Biessen, E. A. L. (2023). Sex-specific differences in cytokine signaling pathways in circulating monocytes of cardiovascular disease patients. Atherosclerosis. Advance online publication. https://doi.org/10.1016/j.atherosclerosis.2023.04.005
    • Ruder, A. V., Temmerman, L., van Dommelen, J. M. A., Nagenborg, J., Lu, C., Sluimer, J. C., Goossens, P., & Biessen, E. A. L. (2023). Culture density influences the functional phenotype of human macrophages. Frontiers in Immunology, 14, Article 1078591. https://doi.org/10.3389/fimmu.2023.1078591
  • 2022
    • Goossens, P., Lu, C., Cao, J., Gijbels, M. J., Karel, J. M. H., Wijnands, E., Claes, B. S. R., Fazzi, G. E., Hendriks, T. F. E., Wouters, K., Smirnov, E., van Zandvoort, M. J. M., Balluff, B., Cuypers, E., Donners, M. M. P. C., Heeren, R. M. A., & Biessen, E. A. L. (2022). Integrating multiplex immunofluorescent and mass spectrometry imaging to map myeloid heterogeneity in its metabolic and cellular context. Cell Metabolism, 34(8), 1214-1225.e6. https://doi.org/10.1016/j.cmet.2022.06.012
    • Christ, A., Goossens, P. G., Wijnands, E., Jin, H., Legein, B., Oth, T., Isaacs, A., Stoll, M., Vanderlocht, J., Lutgens, E., Daemen, M. J. A. P., Zenke, M., & Biessen, E. A. L. (2022). Low Density Lipoprotein Exposure of Plasmacytoid Dendritic Cells Blunts Toll-like Receptor 7/9 Signaling via NUR77. Biomedicines, 10(5), Article 1152. https://doi.org/10.3390/biomedicines10051152
  • 2021
    • Jin, H., Goossens, P., Juhasz, P., Eijgelaar, W-J., Manca, M., Karel, J., Smirnov, E., Sikkink, C. J. J. M., Mees, B., Waring, O., van Kuijk, K., Fazzi, G., Gijbels, M., Kutmon, M., Evelo, C., Hedin, U., Daemen, M. J., Sluimer, J., Matic, L. P., & Biessen, E. (2021). Integrative multiomics analysis of human atherosclerosis reveals a serum response factor-driven network associated with intraplaque hemorrhage. Clinical and Translational Medicine, 11(6), Article e458. https://doi.org/10.1002/ctm2.458
Overview