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ERC Advanced Grant awarded to Prof. Andy Baker

ERC Advanced Grant awarded to Prof. Andy Baker

15 April 2024

Prof. Andy Baker (Dept of Pathology) has been awarded a European Research Council (ERC) Advanced Grant of €2,5M for his research project PolymiRize: Poly-miRNA targeting to prevent and reverse complex tissue remodelling after acute cardiovascular events'.

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Longer and better lives for patients with atrial fibrillation

Longer and better lives for patients with atrial fibrillation

15 April 2024

An international panel of experts published recommendations to improve management of atrial fibrillation (AF).

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Carim Maastricht
Carim Maastricht

Remco Megens

Guest scientist

Dr Remco Megens combines his PI position at IPEK/LMU (Munich) with a position as visiting scientist at CARIM Department of Biomedical Engineering. His major research focus is the development and application of advanced microscopic methods and novel labeling strategies for atherosclerosis research. Advanced microscopic techniques have been extensively used to study various aspects of atherosclerosis in various experimental models. Application of two-photon laser scanning microscopy (TPLSM) for our research has a strong emphasis on its utilisation in the cardiovascular field. Novel TPLSM methods and labeling strategies have been developed that enable specific imaging of morphological and functional aspects of large arteries and leukocyte recruitment both in vivo and ex vivo. Besides imaging of samples at a microscopic resolution, Remco utilises and develops novel applications and staining strategies for multicolor superresolution (utilizing STED) to study atherosclerosis in 3D at a nanoscopic level.

Remco-megens

Department of Biomedical engineering
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht

  • 2024
    • Döring, Y., van der Vorst, E. P. C., Yan, Y., Neideck, C., Blanchet, X., Jansen, Y., Kemmerich, M., Bayasgalan, S., Peters, L. J. F., Hristov, M., Bidzhekov, K., Yin, C., Zhang, X., Leberzammer, J., Li, Y., Park, I., Kral, M., Nitz, K., Parma, L., ... Weber, C. (2024). Identification of a non-canonical chemokine-receptor pathway suppressing regulatory T cells to drive atherosclerosis. Nature cardiovascular research, 3(2), 221-242. https://doi.org/10.1038/s44161-023-00413-9
    • Frenz-Wiessner, S., Fairley, S. D., Buser, M., Goek, I., Salewskij, K., Jonsson, G., Illig, D., zu Putlitz, B., Petersheim, D., Li, Y., Chen, P. H., Kalauz, M., Conca, R., Sterr, M., Geuder, J., Mizoguchi, Y., Megens, R. T. A., Linder, M. I., Kotlarz, D., ... Klein, C. (2024). Generation of complex bone marrow organoids from human induced pluripotent stem cells. Nature Methods. Advance online publication. https://doi.org/10.1038/s41592-024-02172-2
  • 2023
    • Cimen, I., Natarelli, L., Abedi Kichi, Z., Henderson, J. M., Farina, F. M., Briem, E., Aslani, M., Megens, R. T. A., Jansen, Y., Mann-Fallenbuchel, E., Gencer, S., Duchêne, J., Nazari-Jahantigh, M., van der Vorst, E. P. C., Enard, W., Döring, Y., Schober, A., Santovito, D., & Weber, C. (2023). Targeting a cell-specific microRNA repressor of CXCR4 ameliorates atherosclerosis in mice. Science translational medicine, 15(720), Article eadf3357. https://doi.org/10.1126/scitranslmed.adf3357
    • Bianchini, M., Moeller-Ramon, Z., Weber, C., Megens, R., & Duchene, J. (2023). Short-term western diet causes rapid and lasting alterations of bone marrow physiology. Thrombosis and Haemostasis, 123(11), 1100-1104. https://doi.org/10.1055/a-2149-4431
    • Egea, V., Megens, R. T. A., Santovito, D., Wantha, S., Brandl, R., Siess, W., Khani, S., Soehnlein, O., Bartelt, A., Weber, C., & Ries, C. (2023). Properties and fate of human mesenchymal stem cells upon miRNA let-7f-promoted recruitment to atherosclerotic plaques. Cardiovascular Research, 119(1), 155-166. Article cvac022. https://doi.org/10.1093/cvr/cvac022
  • 2022
    • Brandhofer, M., Hoffmann, A., Blanchet, X., Siminkovitch, E., Rohlfing, A. K., El Bounkari, O., Nestele, J. A., Bild, A., Kontos, C., Hille, K., Rohde, V., Froehlich, A., Golemi, J., Gokce, O., Krammer, C., Scheiermann, P., Tsilimparis, N., Sachs, N., Kempf, W. E., ... Bernhagen, J. (2022). Heterocomplexes between the atypical chemokine MIF and the CXC-motif chemokine CXCL4L1 regulate inflammation and thrombus formation. Cellular and Molecular Life Sciences, 79(10), Article 512. https://doi.org/10.1007/s00018-022-04539-0
    • Nitz, K., Lacy, M., Bianchini, M., Wichapong, K., Kücükgöze, I. A., Bonfiglio, C. A., Migheli, R., Wu, Y., Burger, C., Li, Y., Forné, I., Ammar, C., Janjic, A., Mohanta, S., Duchene, J., Heemskerk, J. W. M., Megens, R. T. A., Schwedhelm, E., Huveneers, S., ... Atzler, D. (2022). The Amino Acid Homoarginine Inhibits Atherogenesis by Modulating T-Cell Function. Circulation Research, 131(8), 701-712. https://doi.org/10.1161/CIRCRESAHA.122.321094
    • Taş, K., Volta, B. D., Lindner, C., El Bounkari, O., Hille, K., Tian, Y., Puig-Bosch, X., Ballmann, M., Hornung, S., Ortner, M., Prem, S., Meier, L., Rammes, G., Haslbeck, M., Weber, C., Megens, R. T. A., Bernhagen, J., & Kapurniotu, A. (2022). Designed peptides as nanomolar cross-amyloid inhibitors acting via supramolecular nanofiber co-assembly. Nature Communications, 13(1), Article 5004. https://doi.org/10.1038/s41467-022-32688-0
    • Karshovska, E., Mohibullah, R., Zhu, M. Y., Zahedi, F., Thomas, D., Magkrioti, C., Geissler, C., Megens, R. T. A., Bianchini, M., Nazari-Jahantigh, M., Ferreiros, N., Aidinis, V., & Schober, A. (2022). Endothelial ENPP2 (Ectonucleotide Pyrophosphatase/Phosphodiesterase 2) Increases Atherosclerosis in Female and Male Mice. Arteriosclerosis Thrombosis and Vascular Biology, 42(8), 1023-1036. https://doi.org/10.1161/ATVBAHA.122.317682
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