Remco Megens

Guest scientist

Dr Remco Megens combines his PI position at IPEK/LMU (Munich) with a position as visiting scientist at CARIM Department of Biomedical Engineering. His major research focus is the development and application of advanced microscopic methods and novel labeling strategies for atherosclerosis research. Advanced microscopic techniques have been extensively used to study various aspects of atherosclerosis in various experimental models. Application of two-photon laser scanning microscopy (TPLSM) for our research has a strong emphasis on its utilisation in the cardiovascular field. Novel TPLSM methods and labeling strategies have been developed that enable specific imaging of morphological and functional aspects of large arteries and leukocyte recruitment both in vivo and ex vivo. Besides imaging of samples at a microscopic resolution, Remco utilises and develops novel applications and staining strategies for multicolor superresolution (utilizing STED) to study atherosclerosis in 3D at a nanoscopic level.

Department of Biomedical engineering
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht

  • 2020
    • Kontos, C., El Bounkari, O., Krammer, C., Sinitski, D., Hille, K., Zan, C., Yan, G., Wang, S., Gao, Y., Brandhofer, M., Megens, R. T. A., Hoffmann, A., Pauli, J., Asare, Y., Gerra, S., Bourilhon, P., Leng, L., Eckstein, H-H., Kempf, W. E., ... Bernhagen, J. (2020). Designed CXCR4 mimic acts as a soluble chemokine receptor that blocks atherogenic inflammation by agonist-specific targeting. Nature Communications, 11(1), [5981]. https://doi.org/10.1038/s41467-020-19764-z
    • Santovito, D., Egea, V., Bidzhekov, K., Natarelli, L., Mourao, A., Blanchet, X., Wichapong, K., Aslani, M., Brunssen, C., Horckmans, M., Hristov, M., Geerlof, A., Lutgens, E., Daemen, M. J. A. P., Hackeng, T., Ries, C., Chavakis, T., Morawietz, H., Naumann, R., ... Weber, C. (2020). Autophagy unleashes noncanonical microRNA functions. Autophagy, 16(12), 2294-2296. https://doi.org/10.1080/15548627.2020.1830523
    • Asare, Y., Campbell-James, T. A., Bokov, Y., Yu, L. L., Prestel, M., El Bounkari, O., Roth, S., Megens, R. T. A., Straub, T., Thomas, K., Yan, G., Schneider, M., Ziesch, N., Tiedt, S., Silvestre-Roig, C., Braster, Q., Huang, Y., Schneider, M., Malik, R., ... Dichgans, M. (2020). Histone Deacetylase 9 Activates IKK to Regulate Atherosclerotic Plaque Vulnerability. Circulation Research, 127(6), 811-823. https://doi.org/10.1161/circresaha.120.316743
    • Shami, A., Atzler, D., Bosmans, L. A., Winkels, H., Meiler, S., Lacy, M., van Tiel, C., Megens, R. T., Nitz, K., Baardman, J., Kusters, P., Seijkens, T., Buerger, C., Janjic, A., Riccardi, C., Edsfeldt, A., Monaco, C., Daemen, M., de Winther, M. P. J., ... Lutgens, E. (2020). Glucocorticoid-induced tumour necrosis factor receptor family-related protein (GITR) drives atherosclerosis in mice and is associated with an unstable plaque phenotype and cerebrovascular events in humans. European Heart Journal, 41(31), 2938-2948. https://doi.org/10.1093/eurheartj/ehaa484
    • Santovito, D., Egea, V., Bidzhekov, K., Natarelli, L., Mourao, A., Blanchet, X., Wichapong, K., Aslani, M., Brunssen, C., Horckmans, M., Hristov, M., Geerlof, A., Lutgens, E., Daemen, M. J. A. P., Hackeng, T. M., Ries, C., Chavakis, T., Morawietz, H., Naumann, R., ... Weber, C. (2020). Noncanonical inhibition of caspase-3 by a nuclear microRNA confers endothelial protection by autophagy in atherosclerosis. Science Translational Medicine, 12(546), [2294]. https://doi.org/10.1126/scitranslmed.aaz2294
    • Zhang, D., Ebrahim, M., Adler, K., Blanchet, X., Jamasbi, J., Megens, R. T. A., Uhland, K., Ungerer, M., Muench, G., Deckmyn, H., Weber, C., Elia, N., Lorenz, R., & Siess, W. (2020). Glycoprotein VI is not a Functional Platelet Receptor for Fibrin Formed in Plasma or Blood. Thrombosis and Haemostasis, 120(6), 977-993. https://doi.org/10.1055/s-0040-1710012
    • Eckardt, V., Miller, M. C., Blanchet, X., Duan, R., Leberzammer, J., Duchene, J., Soehnlein, O., Megens, R. T. A., Ludwig, A-K., Dregni, A., Faussner, A., Wichapong, K., Ippel, H., Dijkgraaf, I., Kaltner, H., Doering, Y., Bidzhekov, K., Hackeng, T. M., Weber, C., ... Mayo, K. H. (2020). Chemokines and galectins form heterodimers to modulate inflammation. Embo Reports, 21(4), [47852]. https://doi.org/10.15252/embr.201947852
    • Denisov, S. S., Heinzmann, A. C. A., Vajen, T., Vries, M. H. M., Megens, R. T. A., Suylen, D., Koenen, R. R., Post, M. J., Ippel, J. H., Hackeng, T. M., & Dijkgraaf, I. (2020). Tick Saliva Protein Evasin-3 Allows for Visualization of Inflammation in Arteries through Interactions with CXC-Type Chemokines Deposited on Activated Endothelium. Bioconjugate Chemistry, 31(3), 948-955. https://doi.org/10.1021/acs.bioconjchem.0c00095
  • 2019
    • Bianchini, M., Duchene, J., Santovito, D., Schloss, M. J., Evrard, M., Winkels, H., Aslani, M., Mohanta, S. K., Horckmans, M., Blanchet, X., Lacy, M., von Hundelshausen, P., Atzler, D., Habenicht, A., Gerdes, N., Pelisek, J., Ng, L. G., Steffens, S., Weber, C., & Megens, R. T. A. (2019). PD-L1 expression on nonclassical monocytes reveals their origin and immunoregulatory function. Science Immunology, 4(36), [3054]. https://doi.org/10.1126/sciimmunol.aar3054
    • Silvestre-Roig, C., Braster, Q., Wichapong, K., Lee, E. Y., Marie Teulon, J., Berrebeh, N., Winter, J., Adrover, J. M., Santos, G. S., Froese, A., Lemnitzer, P., Ortega-Gomez, A., Chevre, R., Marschner, J., Schumski, A., Winter, C., Perez-Olivares, L., Pan, C., Paulin, N., ... Soehnlein, O. (2019). Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death. Nature, 569(7755), 236-240. https://doi.org/10.1038/s41586-019-1167-6