Rory Koenen

Professor

Dr Rory  Koenen studied biochemistry in Sittard (BSc) and at the Radboud University in Nijmegen (MSc), the Netherlands from 1993-1999. He completed his PhD in cardiovascular sciences at CARIM Maastricht University in 2005. He then worked in Germany at IMCAR, RWTH Aachen University until 2010 and then moved to IPEK at the LMU in Munich chaired by Christian Weber. In 2012, he returned to CARIM as the recipient of a Vidi grant.

Dr Koenen is currently investigating the functions of platelets beyond hemostasis, platelet microvesicles and the role of particular inflammatory molecules in vascular disease e.g. thrombosis and atherosclerosis. For example, he aims to characterise the molecular aspects of chemokine RANTES and platelet factor 4 secretion from platelets and its importance in the development of cardiovascular diseases. In addition, Dr Koenen is interested in the role of cell adhesion molecules in platelet function and in how platelets maintain interactions with other cell types (leukocytes, endothelial and smooth muscle cells). Finally, Dr Koenen investigates how platelets and their microvesicles can influence the behavior and phenotype of these cells.

As of 1 March 2023, Prof. Koenen holds a professorship of Vascular Inflammation and Thrombosis.

Department of Biochemistry
Universiteitsingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: 4.366a
T: +31(0)43 388 33 90

  • 2023
    • Schönichen, C., Montague, S. J., Brouns, S. L. N., Burston, J. J., Cosemans, J. M. E. M., Jurk, K., Kehrel, B. E., Koenen, R. R., Ní Áinle, F., O'Donnell, V. B., Soehnlein, O., Watson, S. P., Kuijpers, M. J. E., Heemskerk, J. W. M., & Nagy, M. (2023). Antagonistic Roles of Human Platelet Integrin aIIbβ3 and Chemokines in Regulating Neutrophil Activation and Fate on Arterial Thrombi Under Flow. Arteriosclerosis Thrombosis and Vascular Biology, 43(9), 1700-1712. https://doi.org/10.1161/ATVBAHA.122.318767
    • Thomassen, M. C. L. G. D., Bouwens, B. R. C., Wichapong, K., Suylen, D. P., Bouwman, F. G., Hackeng, T. M., & Koenen, R. R. (2023). Protein arginine deiminase 4 inactivates tissue factor pathway inhibitor-alpha by enzymatic modification of functional arginine residues. Journal of Thrombosis and Haemostasis, 21(5), 1214-1226. https://doi.org/10.1016/j.jtha.2023.01.017
    • de Winther, M. P. J., Bäck, M., Evans, P., Gomez, D., Goncalves, I., Jørgensen, H. F., Koenen, R. R., Lutgens, E., Norata, G. D., Osto, E., Dib, L., Simons, M., Stellos, K., Ylä-Herttuala, S., Winkels, H., Bochaton-Piallat, M.-L., & Monaco, C. (2023). Translational opportunities of single-cell biology in atherosclerosis. European Heart Journal, 44(14), 1216-1230. https://doi.org/10.1093/eurheartj/ehac686
    • Koenen, R. R. (2023). Platelets: from simple fragments to inflammation regulators. European Heart Journal, 44(8), 633-635. https://doi.org/10.1093/eurheartj/ehac705
  • 2022
    • Brandhofer, M., Hoffmann, A., Blanchet, X., Siminkovitch, E., Rohlfing, A. K., El Bounkari, O., Nestele, J. A., Bild, A., Kontos, C., Hille, K., Rohde, V., Froehlich, A., Golemi, J., Gokce, O., Krammer, C., Scheiermann, P., Tsilimparis, N., Sachs, N., Kempf, W. E., ... Bernhagen, J. (2022). Heterocomplexes between the atypical chemokine MIF and the CXC-motif chemokine CXCL4L1 regulate inflammation and thrombus formation. Cellular and Molecular Life Sciences, 79(10), Article 512. https://doi.org/10.1007/s00018-022-04539-0
    • Sanjurjo, L., Broekhuizen, E. C., Koenen, R. R., & Thijssen, V. L. J. L. (2022). Galectokines: The Promiscuous Relationship between Galectins and Cytokines. Biomolecules, 12(9), Article 1286. https://doi.org/10.3390/biom12091286
    • Karel, M. F. A., Roosen, M. G. C. H., Tullemans, B. M. E., Zhang, C. E., Staals, J., Cosemans, J. M. E. M., & Koenen, R. R. (2022). Characterization of cerebral small vessel disease by neutrophil and platelet activation markers using artificial intelligence. Journal of Neuroimmunology, 367, Article 577863. https://doi.org/10.1016/j.jneuroim.2022.577863
    • Dickhout, A., van de Vijver, P., Bitsch, N., van Hoof, S. J., Thomassen, S. L. G. D., Massberg, S., Timmerman, P., Verhaegen, F., Koenen, R. R., Dijkgraaf, I., & Hackeng, T. M. (2022). Molecular Detection of Venous Thrombosis in Mouse Models Using SPECT/CT. Biomolecules, 12(6), Article 829. https://doi.org/10.3390/biom12060829
    • Lemmens, T. P., Coenen, D. M., Swieringa, F., Niessen, I. C. L., Coort, S. L. M., Koenen, R. R., Kutmon, M., & Cosemans, J. M. E. M. (2022). Finding the "switch" in platelet activation: prediction of key mediators involved in reversal of platelet activation using a novel network biology approach. Journal of Proteomics, 261, Article 104577. https://doi.org/10.1016/j.jprot.2022.104577
    • Koenen, M. T., Brandt, E. F., Kaczor, D. M., Caspers, T., Heinzmann, A. C. A., Fischer, P., Heinrichs, D., Wirtz, T. H., Trautwein, C., Koenen, R. R., & Berres, M.-L. (2022). Extracellular Vesicles from Steatotic Hepatocytes Provoke Pro-Fibrotic Responses in Cultured Stellate Cells. Biomolecules, 12(5), Article 698. https://doi.org/10.3390/biom12050698