Rory Koenen

Associate professor

Dr Rory  Koenen studied biochemistry in Sittard (BSc) and at the Radboud University in Nijmegen (MSc), the Netherlands from 1993-1999. He completed his PhD in cardiovascular sciences at CARIM Maastricht University in 2005. He then worked in Germany at IMCAR, RWTH Aachen University until 2010 and then moved to IPEK at the LMU in Munich chaired by Christian Weber. In 2012, he returned to CARIM as the recipient of a Vidi grant.

Dr Koenen is currently investigating the functions of platelets beyond hemostasis, platelet microvesicles and the role of particular inflammatory molecules in vascular disease e.g. thrombosis and atherosclerosis. For example, he aims to characterise the molecular aspects of chemokine RANTES and platelet factor 4 secretion from platelets and its importance in the development of cardiovascular diseases. In addition, Dr Koenen is interested in the role of cell adhesion molecules in platelet function and in how platelets maintain interactions with other cell types (leukocytes, endothelial and smooth muscle cells). Finally, Dr Koenen investigates how platelets and their microvesicles can influence the behavior and phenotype of these cells.

Department of Biochemistry
Universiteitsingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: 4.366a
T: +31(0)43 388 33 90

  • 2020
    • Denisov, S. S., Ramirez-Escudero, M., Heinzmann, A. C. A., Ippel, J. H., Dawson, P. E., Koenen, R. R., Hackeng, T. M., Janssen, B. J. C., & Dijkgraaf, I. (2020). Structural characterization of anti-CCL5 activity of the tick salivary protein evasin-4. Journal of Biological Chemistry, 295(42), 14367-14378. https://doi.org/10.1074/jbc.RA120.013891
    • Heinzmann, A. C. A., Karel, M. F. A., Coenen, D. M., Vajen, T., Meulendijks, N. M. M., Nagy, M., Suylen, D. P. L., Cosemans, J. M. E. M., Heemskerk, J. W. M., Hackeng, T. M., & Koenen, R. R. (2020). Complementary roles of platelet alpha(IIb)beta(3) integrin, phosphatidylserine exposure and cytoskeletal rearrangement in the release of extracellular vesicles. Atherosclerosis, 310, 17-25. https://doi.org/10.1016/j.atherosclerosis.2020.07.015
    • Koenen, R. R., & Binder, C. J. (2020). Platelets and coagulation factors: Established and novel roles in atherosclerosis and atherothrombosis. Atherosclerosis, 307, 78-79. https://doi.org/10.1016/j.atherosclerosis.2020.07.008
    • Benedikter, B. J., & Koenen, R. R. (2020). Vaping, vapor, vesicles! Electronic cigarettes provoke vascular extracellular vesicle release in healthy volunteers. Atherosclerosis, 301, 79-81. https://doi.org/10.1016/j.atherosclerosis.2020.03.012
    • Denisov, S. S., Heinzmann, A. C. A., Vajen, T., Vries, M. H. M., Megens, R. T. A., Suylen, D., Koenen, R. R., Post, M. J., Ippel, J. H., Hackeng, T. M., & Dijkgraaf, I. (2020). Tick Saliva Protein Evasin-3 Allows for Visualization of Inflammation in Arteries through Interactions with CXC-Type Chemokines Deposited on Activated Endothelium. Bioconjugate Chemistry, 31(3), 948-955. https://doi.org/10.1021/acs.bioconjchem.0c00095
  • 2019
    • Denisov, S. S., Ippel, J. H., Heinzmann, A. C. A., Koenen, R. R., Ortega-Gomez, M., Soehnlein, O., Hackeng, T. M., & Dijkgraaf, I. (2019). Tick saliva protein Evasin-3 modulates chemotaxis by disrupting CXCL8 interactions with glycosaminoglycans and CXCR2. Journal of Biological Chemistry, 294(33), 12370-12379. https://doi.org/10.1074/jbc.RA119.008902
    • Koenen, R. R. (2019). Lysophosphatidylcholine in Platelet Microvesicles: The Grease for Cardiovascular Disease. Thrombosis and Haemostasis, 119(8), 1202-1204. https://doi.org/10.1055/s-0039-1693024
    • Noels, H., Weber, C., & Koenen, R. R. (2019). Chemokines as Therapeutic Targets in Cardiovascular Disease The Road Behind, The Road Ahead. Arteriosclerosis Thrombosis and Vascular Biology, 39(4), 583-592. https://doi.org/10.1161/ATVBAHA.118.312037
    • Koenen, R. R. (2019). No hearty reception: infusion of CXCL4 impedes tissue repair by macrophages after myocardial infarction. Cardiovascular Research, 115(2), 264-265. https://doi.org/10.1093/cvr/cvy241
    • Benedikter, B. J., Bouwman, F. G., Heinzmann, A. C. A., Vajen, T., Mariman, E. C., Wouters, E. F. M., Savelkoul, P. H. M., Koenen, R. R., Rohde, G. G. U., van Oerle, R., Spronk, H. M., & Stassen, F. R. M. (2019). Proteomic analysis reveals procoagulant properties of cigarette smoke-induced extracellular vesicles. Journal of Extracellular Vesicles , 8(1), [1585163]. https://doi.org/10.1080/20013078.2019.1585163