Rory Koenen

Associate professor

Dr Rory  Koenen studied biochemistry in Sittard (BSc) and at the Radboud University in Nijmegen (MSc), the Netherlands from 1993-1999. He completed his PhD in cardiovascular sciences at CARIM Maastricht University in 2005. He then worked in Germany at IMCAR, RWTH Aachen University until 2010 and then moved to IPEK at the LMU in Munich chaired by Christian Weber. In 2012, he returned to CARIM as the recipient of a Vidi grant.

Dr Koenen is currently investigating the functions of platelets beyond hemostasis, platelet microvesicles and the role of particular inflammatory molecules in vascular disease e.g. thrombosis and atherosclerosis. For example, he aims to characterise the molecular aspects of chemokine RANTES and platelet factor 4 secretion from platelets and its importance in the development of cardiovascular diseases. In addition, Dr Koenen is interested in the role of cell adhesion molecules in platelet function and in how platelets maintain interactions with other cell types (leukocytes, endothelial and smooth muscle cells). Finally, Dr Koenen investigates how platelets and their microvesicles can influence the behavior and phenotype of these cells.

Department of Biochemistry
Universiteitsingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: 4.366a
T: +31(0)43 388 33 90

  • 2021
    • Coenen, D. M., Heinzmann, A. C. A., Oggero, S., Albers, H. J., Nagy, M., Hague, P., Kuijpers, M. J. E., Vanderwinden, J. M., van der Meer, A. D., Perretti, M., Koenen, R. R., & Cosemans, J. M. E. M. (2021). Inhibition of Phosphodiesterase 3A by Cilostazol Dampens Proinflammatory Platelet Functions. Cells, 10(8), [1998]. https://doi.org/10.3390/cells10081998
    • Dickhout, A., Kaczor, D. M., Heinzmann, A. C. A., Brouns, S. L. N., Heemskerk, J. W. M., van Zandvoort, M. A. M. J., & Koenen, R. R. (2021). Rapid Internalization and Nuclear Translocation of CCL5 and CXCL4 in Endothelial Cells. International journal of molecular sciences, 22(14), [7332]. https://doi.org/10.3390/ijms22147332
    • Koenen, R. R. (2021). Conformation-Crooking CXCL4 to Unravel Autoimmune Heparin-Induced Thrombocytopenia. Thrombosis and Haemostasis, 121(03), 258-260. https://doi.org/10.1055/s-0040-1721774
    • Coenen, D. M., Heinzmann, A. C. A., Karel, M. F. A., Cosemans, J. M. E. M., & Koenen, R. R. (2021). The multifaceted contribution of platelets in the emergence and aftermath of acute cardiovascular events. Atherosclerosis, 319, 132-141. https://doi.org/10.1016/j.atherosclerosis.2020.12.017
    • Dickhout, A., Tullemans, B. M. E., Heemskerk, J. W. M., Thijssen, V. L. J. L., Kuijpers, M. J. E., & Koenen, R. R. (2021). Galectin-1 and platelet factor 4 (CXCL4) induce complementary platelet responses in vitro. PLOS ONE, 16(1), [0244736]. https://doi.org/10.1371/journal.pone.0244736
  • 2020
    • Denisov, S. S., Ramirez-Escudero, M., Heinzmann, A. C. A., Ippel, J. H., Dawson, P. E., Koenen, R. R., Hackeng, T. M., Janssen, B. J. C., & Dijkgraaf, I. (2020). Structural characterization of anti-CCL5 activity of the tick salivary protein evasin-4. Journal of Biological Chemistry, 295(42), 14367-14378. https://doi.org/10.1074/jbc.RA120.013891
    • Heinzmann, A. C. A., Karel, M. F. A., Coenen, D. M., Vajen, T., Meulendijks, N. M. M., Nagy, M., Suylen, D. P. L., Cosemans, J. M. E. M., Heemskerk, J. W. M., Hackeng, T. M., & Koenen, R. R. (2020). Complementary roles of platelet αIIbβ3 integrin, phosphatidylserine exposure and cytoskeletal rearrangement in the release of extracellular vesicles. Atherosclerosis, 310, 17-25. https://doi.org/10.1016/j.atherosclerosis.2020.07.015
    • Koenen, R. R., & Binder, C. J. (2020). Platelets and coagulation factors: Established and novel roles in atherosclerosis and atherothrombosis. Atherosclerosis, 307, 78-79. https://doi.org/10.1016/j.atherosclerosis.2020.07.008
    • Benedikter, B. J., & Koenen, R. R. (2020). Vaping, vapor, vesicles! Electronic cigarettes provoke vascular extracellular vesicle release in healthy volunteers. Atherosclerosis, 301, 79-81. https://doi.org/10.1016/j.atherosclerosis.2020.03.012
    • Denisov, S. S., Heinzmann, A. C. A., Vajen, T., Vries, M. H. M., Megens, R. T. A., Suylen, D., Koenen, R. R., Post, M. J., Ippel, J. H., Hackeng, T. M., & Dijkgraaf, I. (2020). Tick Saliva Protein Evasin-3 Allows for Visualization of Inflammation in Arteries through Interactions with CXC-Type Chemokines Deposited on Activated Endothelium. Bioconjugate Chemistry, 31(3), 948-955. https://doi.org/10.1021/acs.bioconjchem.0c00095