Sander Verheule

Associate professor

Dr Sander Verheule has studied Biology at the University of Utrecht, with internships at the Hubrecht Laboratory for Developmental Biology and at the Department of Neurophysiology (VU Amsterdam). As a PhD student in the group of Dr Habo Jongsma (Department of Medical Physiology, Utrecht), he investigated the distribution and electrophysiological behavior of gap junction channels in various regions of the heart, defending his PhD thesis in 1999. From 1999-2003, he worked as an AHA post-doctoral fellow in the group of Dr Jeffrey Olgin and Dr Douglas Zipes at the Krannert Institute of Cardiology in Indianapolis, Indiana. There, his research focussed on the impact of structural remodeling on atrial conduction.

In 2003, Dr Verheule joined the electrophysiology group at the Department of Physiology in Maastricht. In his current research, he investigates the pathophysiological mechanisms underlying atrial fibrillation, and the recognition of these mechanisms in patients. His two main research questions are 1) How do atrial vascular and metabolic remodeling contribute to the progression of atrial fibrillation? and 2) How do changes in atrial tissue structure affect atrial electrical propagation?


Department of Physiology
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: F3.118
T: +31(0)43 388 10 76

  • 2021
    • Mighiu, A. S., Recalde, A., Ziberna, K., Carnicer, R., Tomek, J., Bub, G., Brewer, A. C., Verheule, S., Shah, A. M., Simon, J. N., & Casadei, B. (2021). Inducibility, but not stability, of atrial fibrillation is increased by NOX2 overexpression in mice. Cardiovascular Research, 117(11), 2354-2364.
    • Saljic, A., Fenner, M. F., Winters, J., Flethoj, M., Eggertsen, C. E., Carstensen, H., Nissen, S. D., Hesselkilde, E. M., van Hunnik, A., Schotten, U., Sorensen, U., Jespersen, T., Verheule, S., & Buhl, R. (2021). Increased fibroblast accumulation in the equine heart following persistent atrial fibrillation. IJC Heart and Vasculature, 35, [100842].
    • Bosada, F. M., Rivaud, M. R., Uhm, J-S., Verheule, S., van Duijvenboden, K., Verkerk, A. O., Christoffels, V. M., & Boukens, B. J. (2021). A Variant Noncoding Region Regulates Prrx1 and Predisposes to Atrial Arrhythmias. Circulation Research, 129(3), 420-434.
    • van Hunnik, A., Zeemering, S., Podziemski, P., Kuklik, P., Kuiper, M., Verheule, S., & Schotten, U. (2021). Bi-atrial high-density mapping reveals inhibition of wavefront turning and reduction of complex propagation patterns as main antiarrhythmic mechanisms of vernakalant. EP Europace, 23(7), 1114-1123.
    • Dudink, E. A. M. P., Bidar, E., Jacobs, J., van Hunnik, A., Zeemering, S., Weijs, B., Luermans, J. G. L. M., Maesen, B. A. E., Cheriex, E. C., Maessen, J. G., Hoorntje, J. C. A., Schotten, U., Crijns, H. J. G. M., & Verheule, S. (2021). The relation between the atrial blood supply and the complexity of acute atrial fibrillation. IJC Heart & Vasculature, 34, [100794].
    • Gilbers, M. D., Bidar, E., Maesen, B., Zeemering, S., Isaacs, A., Crijns, H., van Gelder, I., Rienstra, M., Verheule, S., Maessen, J., Stoll, M., & Schotten, U. (2021). Reappraisal of Atrial fibrillation: interaction between hyperCoagulability, Electrical remodelling and Vascular destabilisation in the progression of AF (RACE V) Tissue Bank Project: study design. Netherlands Heart Journal, 29(5), 280-287.
    • Opacic, D., van Hunnik, A., Zeemering, S., Dhalla, A., Belardinelli, L., Schotten, U., & Verheule, S. (2021). Electrophysiological effects of ranolazine in a goat model of lone atrial fibrillation. Heart Rhythm, 18(4), 615-622.
    • van Rosmalen, F., Maesen, B., van Hunnik, A., Hermans, B. J. M., Bonizzi, P., Bidar, E., Nijs, J., Maessen, J. G., Verheule, S., Delhaas, T., Schotten, U., & Zeemering, S. (2021). Incidence, prevalence, and trajectories of repetitive conduction patterns in human atrial fibrillation. EP Europace, 23(Supplement_1), i123-i132.
    • Gharaviri, A., Pezzuto, S., Potse, M., Conte, G., Zeemering, S., Sobota, V., Verheule, S., Krause, R., Auricchio, A., & Schotten, U. (2021). Synergistic antiarrhythmic effect of inward rectifier current inhibition and pulmonary vein isolation in a 3D computer model for atrial fibrillation. EP Europace, 23, I161-I168.
    • Fenner, M. F., Gatta, G., Sattler, S., Kuiper, M., Hesselkilde, E. M., Adler, D. M. T., Smerup, M., Schotten, U., Sorensen, U., Diness, J. G., Jespersen, T., Verheule, S., Van Hunnik, A., & Buhl, R. (2021). Inhibition of Small-Conductance Calcium-Activated Potassium Current (IK,Ca) Leads to Differential Atrial Electrophysiological Effects in a Horse Model of Persistent Atrial Fibrillation. Frontiers in physiology, 12, [614483].