Simone Eussen

Assistant Professor

Dr Simone Eussen's research focusses on the role of nutrition and underlying metabolic and molecular processes in the aetiology of common chronic diseases. She has built a strong track record on B-vitamins, related molecular one-carbon and kynurenine pathways, and chronic diseases during her PhD (Wageningen Universtiy) and post-doc (Bergen, Norway; also supported by a prestigious personal research grant from the Norwegian Research Council). She integrated this expertise to study quality of food intake at Maastricht University. Funds granted by the NWO (BBMRI) and the European JPI (Dedipac) focussed on methodological aspects of dietary assessment.

Her current work involves study of dietary quality (at nutrient and bioactive compound, food group, and dietary patterns level) in relation to chronic disease, including T2DM, CVD and mental disorders. Additionally, she expanded her focus to the emerging field of ‘chrono-nutrition’, and is member of the CIRCLE-DOME (CIRcadian CLock and timing of Eating on Diabetes, Obesity ad MEtabolism) network. Different aspects of dietary timing will be studied in relation to metabolic, cardiovascular and mental phenotypes to gain new insight in the role of chrono-nutrition in common pathologies within the framework of population based studies (for example The Maastricht Study; one of the world’s leading deep-phenotying population-based studies on T2DM and its comorbidities).

Department of Epidemiology
P. Debeyeplein 1, 6229 HX Maastricht 
PO Box 5800, 6202 AZ Maastricht
Room number: A2.018
T: +31(0)43 388 24 51

  • 2026
    • Holthuijsen, D. D. B., Rijnhart, J. J. M., van Roekel, E. H., Bours, M. J. L., Ueland, P. M., Breukink, S. O., Janssen-heijnen, M. L. G., Konsten, J. L., Keulen, E. T. P., McCann, A., Brezina, S., Gigic, B., Ose, J., Weijenberg, M. P., & Eussen, S. J. P. M. (2026). The mediating role of the kynurenine pathway in longitudinal associations between dietary intake and quality of life in colorectal cancer survivors up to 12 months posttreatment. International Journal of Cancer, 159(1), 122-143. https://doi.org/10.1002/ijc.70363
    • Valente, M. J., Cao, B., Holthuijsen, D. D. B., Bours, M. J. L., Eussen, S. J. P. M., Weijenberg, M. P., & Rijnhart, J. J. M. (2026). Response to “Ratios are misleading exposure variables that compromise a regression model unless fundamental scaling assumptions are satisfied: a comment on Valente et al.”. Journal of Clinical Epidemiology, 195, Article 112257. https://doi.org/10.1016/j.jclinepi.2026.112257
    • Okoro, C., Zhou, T. L., van der Kallen, C. J. H., Koster, A., Sutedja, N. A., Berendschot, T. T. J. M., de Galan, B. E., Eussen, S. J. P. M., Schram, M. T., & Kroon, A. A. (2026). Association of type 2 diabetes according to the number of cardiovascular risk factors within the recommended range with neuropathy - The Maastricht Study. Diabetes Research and Clinical Practice, 235, Article 113212. https://doi.org/10.1016/j.diabres.2026.113212
    • Yu, Y., Berendschot, T. T. J. M., Eussen, S. J. P. M., van der Kallen, C. J. H., Webers, C. A. B., & Ramdas, W. D. (2026). The Association Between Adherence to the Dutch Healthy Diet Index and Glaucoma Prevalence-The Maastricht Study. Nutrients, 18(9), Article 1360. https://doi.org/10.3390/nu18091360
    • Phillips, N. E., Ajdacic-Gross, V., Rebeaud, J., Thevoz, G., Iaquinto, S., Baum, C., Kamm, C. P., Kuhle, J., Rapold, I., Roth, P., Zecca, C., von Wyl, V., Eussen, S. J. P. M., Steinemann, N., Pot, C., & Collet, T.-H. (2026). Associations of chrononutrition and sleep with fatigue in multiple sclerosis: an analysis of the Swiss Multiple Sclerosis Registry. BMJ Neurology Open, 8(1), Article e001471. https://doi.org/10.1136/bmjno-2025-001471
    • Chong, M. Y., Koster, A., Meertens, R. M., Pot, G. K., Galan, B. E. D., Kallen, C. J. H. V. D., Savelberg, H. H. C. M., Bosma, H., Simons, S. O., Bours, M. J. L., Weijenberg, M. P., & Eussen, S. J. P. M. (2026). Associations of chrono-nutrition with sleep and quality of life: The Maastricht Study. Clinical Nutrition, 59, Article 106593. https://doi.org/10.1016/j.clnu.2026.106593
    • Chong, M. Y., Henson, J., Bours, M. J. L., Bosma, H., de Galan, B. E., van der Kallen, C. J. H., Meertens, R. M., Savelberg, H. H. C. M., Schram, M. T., Weijenberg, M. P., Yates, T., Koster, A., & Eussen, S. J. P. M. (2026). Physical activity and meal timing alignment with chronotype and their associations with glucose metabolism: The Maastricht Study. Diabetes Obesity & Metabolism, 28(4), 3295-3304. https://doi.org/10.1111/dom.70526
    • Chong, M. Y., Eussen, S. J. P. M., van der Velde, J. H. P. M., de Galan, B. E., Savelberg, H. H. C. M., Bosma, H., Bours, M. J. L., Weijenberg, M. P., & Koster, A. (2026). Reallocating morning physical activity to later-day activity and its association with type 2 diabetes incidence: The Maastricht Study. Diabetes Obesity & Metabolism, 28(4), 2642-2650. https://doi.org/10.1111/dom.70438
    • Maasen, K., Mayen, A.-L., Hana, C., Knaze, V., Van Greevenbroek, M. M. J., Eussen, S. J. P. M., Debras, C., Stehouwer, C. D. A., Tjonneland, A., Kyro, C., Ibsen, D. B., Dah, C. C., Mancini, F., Laouali, N., Hajji, M., Schulze, M. B., Bajracharya, R., Katzke, V., Masala, G., ... Schalkwijk, C. G. (2026). Higher intake of dietary dicarbonyl compounds is associated with lower incidence of type 2 diabetes: European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study. European Journal of Nutrition, 65(3), Article 98. https://doi.org/10.1007/s00394-026-03904-0
    • Berends, E., Eussen, S. J. P. M., Backes, W. H., Dagnelie, P. C., Jansen, J. F. A., Galan, B. E. D., Greevenbroek, M. M. J. V., Kohler, S., Schram, M. T., Wesselius, A., Oostenbrugge, R. J., Foulquier, S., & Schalkwijk, C. G. (2026). Associations between methylglyoxal and cerebral small vessel disease and cognitive function-The Maastricht Study. Journal of Stroke & Cerebrovascular Diseases, 35(3), Article 108578. https://doi.org/10.1016/j.jstrokecerebrovasdis.2026.108578