Stephane Heymans

Professor

Stephane Heymans is Professor of Cardiomyopathies and Head of the Centre for Heart Failure Research, Department of Cardiology, Maastricht University. He obtained his Medical Degree from the KU Leuven (Belgium) in 1995 and went on to get a PhD in Medical Sciences in 2000, studying the role of proteinases in acute myocardial infarction. In 2003, he joined the Department of Cardiology of Maastricht UMC+ as an academic medical specialist and in 2006 he took over the Multidisciplinary Cardiomyopathy Program (Genetics, Immunology, Microbiology and Pathology departments).

In 2008, he established his independent research laboratory at Cardiovascular Research Institute Maastricht. His research interests focus on the molecular mechanisms of heart failure, looking at the interplay between inflammatory cells, fibroblasts and cardiomyocytes. Particular focus is on the role of non-structural matrix proteins, matrix turnover and non-coding RNAs.

Furthermore, he is Professor of 'Inflammation and Matrix Biology in Cardiomyopathies' at the University of Leuven and he is a board member of the ESC Heart Failure Association, ESC Working Group of Myocardial Function, ESC Heart Failure Association Committee on Diastolic Heart Failure and ESC Heart Failure Association Committee on Translational Research.

Website www.hfresearch.eu

Department of Cardiology
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: G3.230
T: +31(0)43 388 43 04

  • 2024
    • Van Linthout, S., Stellos, K., Giacca, M., Bertero, E., Cannata, A., Carrier, L., Garcia-Pavia, P., Ghigo, A., Gonzalez, A., Haugaa, K. H., Imazio, M., Lopes, L. R., Most, P., Pollesello, P., Schunkert, H., Streckfuss-Boemeke, K., Thum, T., Tocchetti, C. G., Tschoepe, C., ... Heymans, S. (2024). State of the art and perspectives of gene therapy in heart failure. A scientific statement of the Heart Failure Association of the ESC, the ESC Council on Cardiovascular Genomics and the ESC Working Group on Myocardial & Pericardial Diseases. European journal of heart failure. Advance online publication. https://doi.org/10.1002/ejhf.3516
    • Wei, F.-F., Pellicori, P., Ferreira, J. P., González, A., Mariottoni, B., An, D.-W., Verdonschot, J. A. J., Liu, C., Ahmed, F. Z., Petutschnigg, J., Rossignol, P., Heymans, S., Cuthbert, J., Girerd, N., Clark, A. L., Li, Y., Nawrot, T. S., Díez, J., Zannad, F., ... HOMAGE investigators (2024). Effects of spironolactone on exercise blood pressure in patients at increased risk of developing heart failure: report from the HOMAGE trial. Hypertension Research, 47(11), 3225-3236. https://doi.org/10.1038/s41440-024-01843-z
    • Sikking, M. A., Harding, D., Henkens, M. T. H. M., Stroeks, S. L. V. M., Venner, M. F. G. H. M., Nihant, B., van Leeuwen, R. E. W., Fanti, S., Li, X., van Paassen, P., Knackstedt, C., Brunner-la Rocca, H.-P., van Empel, V. P. M., Verdonschot, J. A. J., Marelli-Berg, F. M., & Heymans, S. R. B. (2024). Cytotoxic T-Cells Drive Outcome in Inflammatory Dilated Cardiomyopathy. Circulation Research. Advance online publication. https://doi.org/10.1161/CIRCRESAHA.124.325183
    • Stroeks, S. L. V. M., Henkens, M. T. H. M., Dominguez, F., Merlo, M., Hellebrekers, D. M. E. I., Gonzalez-Lopez, E., Dal Ferro, M., Ochoa, J. P., Venturelli, F., Claes, G. R. F., Venner, M. F. G. H. M., Krapels, I. P. C., Vanhoutte, E. K., van Paassen, P., van den Wijngaard, A., Sikking, M. A., van Leeuwen, R., Abdul Hamid, M., Li, X., ... Verdonschot, J. A. J. (2024). Genetic Landscape of Patients With Dilated Cardiomyopathy and a Systemic Immune-Mediated Disease. JACC: Heart Failure. Advance online publication. https://doi.org/10.1016/j.jchf.2024.08.011
    • Verdonschot, J. A. J., Fuster, J. J., Walsh, K., & Heymans, S. R. B. (2024). The emerging role of clonal haematopoiesis in the pathogenesis of dilated cardiomyopathy. European Heart Journal, Article ehae682. https://doi.org/10.1093/eurheartj/ehae682
    • Verdonschot, J. A. J., Heymans, S. R. B., & Van Linthout, S. (2024). The next era of gene-specific clinical care in patients with dilated cardiomyopathy. European journal of heart failure, 26(10), 2169-2172. https://doi.org/10.1002/ejhf.3446
    • Yu, Y.-L., Siwy, J., An, D.-W., González, A., Hansen, T., Latosinska, A., Pellicori, P., Ravassa, S., Mariottoni, B., Verdonschot, J. A., Ahmed, F., Petutschnigg, J., Rossignol, P., Heymans, S., Cuthbert, J. J., Girerd, N., Clark, A. L., Verhamme, P., Nawrot, T. S., ... HOMAGE investigators (2024). Urinary proteomic signature of mineralocorticoid receptor antagonism by spironolactone: evidence from the HOMAGE trial. Heart, 110(19), 1180-1187. Article heartjnl-2023-323796. https://doi.org/10.1136/heartjnl-2023-323796
    • Wei, F.-F., Mariottoni, B., An, D.-W., Pellicori, P., Yu, Y.-L., Verdonschot, J. A. J., Liu, C., Ahmed, F. Z., Petutschnigg, J., Rossignol, P., Heymans, S., Cuthbert, J., Girerd, N., Li, Y., Clark, A. L., Nawrot, T. S., Ferreira, J. P., Zannad, F., Cleland, J. G. F., ... HOMAGE investigators (2024). Heart rate reactivity, recovery, and endurance of the incremental shuttle walk test in patients prone to heart failure. Esc heart failure. Advance online publication. https://doi.org/10.1002/ehf2.15000
    • Beijnink, C. W. H., Raafs, A. G., Vos, J. L., Verdonschot, J. A. J., Sikking, M. A., Rodwell, L., Heymans, S. R. B., & Nijveldt, R. (2024). Papillary Muscle Delayed Hyperenhancement: Prevalence and Clinical Implications in a Large Population With Dilated Cardiomyopathy. JACC: Advances, 3(8), Article 101103. https://doi.org/10.1016/j.jacadv.2024.101103
    • Machiraju, P., Srinivas, R., Kannan, R., George, R., Heymans, S., Mukhopadhyay, R., & Ghosh, A. (2024). Paired Transcriptomic Analyses of Atheromatous and Control Vessels Reveal Novel Autophagy and Immunoregulatory Genes in Peripheral Artery Disease. Cells, 13(15), Article 1269. https://doi.org/10.3390/cells13151269