Stephane Heymans


Stephane Heymans is Professor of Cardiomyopathies and Head of the Centre for Heart Failure Research, Department of Cardiology, Maastricht University. He obtained his Medical Degree from the KU Leuven (Belgium) in 1995 and went on to get a PhD in Medical Sciences in 2000, studying the role of proteinases in acute myocardial infarction. In 2003, he joined the Department of Cardiology of Maastricht UMC+ as an academic medical specialist and in 2006 he took over the Multidisciplinary Cardiomyopathy Program (Genetics, Immunology, Microbiology and Pathology departments).

In 2008, he established his independent research laboratory at Cardiovascular Research Institute Maastricht. His research interests focus on the molecular mechanisms of heart failure, looking at the interplay between inflammatory cells, fibroblasts and cardiomyocytes. Particular focus is on the role of non-structural matrix proteins, matrix turnover and non-coding RNAs.

Furthermore, he is Professor of 'Inflammation and Matrix Biology in Cardiomyopathies' at the University of Leuven and he is a board member of the ESC Heart Failure Association, ESC Working Group of Myocardial Function, ESC Heart Failure Association Committee on Diastolic Heart Failure and ESC Heart Failure Association Committee on Translational Research.


Department of Cardiology
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: G3.230
T: +31(0)43 388 43 04

  • 2024
    • Sikking, M. A., Stroeks, S. L. V. M., Henkens, M. T. H. M., Raafs, A. G., Cossins, B., van Deuren, R. C., Steehouwer, M., Riksen, N. P., van den Wijngaard, A., Brunner, H. G., Hoischen, A., Verdonschot, J. A. J., & Heymans, S. R. B. (2024). Clonal Hematopoiesis has Prognostic Value in Dilated Cardiomyopathy independent of Age and Clone Size. JACC: Heart Failure, 12(5), 905-914.
    • Verdonschot, J. A. J., Hellebrekers, D. M. E. I., van Empel, V. P. M., Heijligers, M., de Munnik, S., Coonen, E., Dreesen, J. C. M. F., van den Wijngaard, A., Brunner, H. G., Zamani Esteki, M., Heymans, S. R. B., de Die-Smulders, C. E. M., & Paulussen, A. D. C. (2024). Clinical Guideline for Preimplantation Genetic Testing in Inherited Cardiac Diseases. Circulation: Genomic and Precision Medicine, 17(2), Article E004416.
    • Verdonschot, J. A. J., & Heymans, S. R. B. (2024). Dilated cardiomyopathy: second hits knock-down the heart. European Heart Journal, 45(7), 500-501.
    • Santos-Ferreira, D., Diaz, S. O., Ferreira, J. P., Girerd, N., Pellicori, P., Mariottoni, B., Cosmi, F., Hazebroek, M., Verdonschot, J. A. J., Cuthbert, J., Petutschnigg, J., Heymans, S., Staessen, J. A., Pieske, B., Edelmann, F., Clark, A. L., Rossignol, P., Fontes-Carvalho, R., Cleland, J. G. F., & Zannad, F. (2024). Phenotyping patients with ischaemic heart disease at risk of developing heart failure: an analysis of the HOMAGE trial. Esc heart failure, 11(1), 209-218.
    • Shanbagh, S., Gadde, S. G., Shetty, R., Heymans, S., Abilash, V. G., Chaurasia, S. S., & Ghosh, A. (2024). Hyperglycemia-induced miR182-5p drives glycolytic and angiogenic response in Proliferative Diabetic Retinopathy and RPE cells via depleting FoxO1. Experimental Eye Research, 238, Article 109713.
    • McDonagh, T. A., Metra, M., Adamo, M., Gardner, R. S., Baumbach, A., Boehm, M., Burri, H., Butler, J., Celutkiene, J., Chioncel, O., Cleland, J. G. F., Crespo-Leiro, M. G., Farmakis, D., Gilard, M., Heymans, S., Hoes, A. W., Jaarsma, T., Jankowska, E. A., Lainscak, M., ... ESC Scientific Document Group (2024). 2023 Focused Update of the 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. European journal of heart failure, 26(1), 5-17.
    • Simmonds, S. J., Grootaert, M. O. J., Cuijpers, I., Carai, P., Geuens, N., Herwig, M., Baatsen, P., Hamdani, N., Luttun, A., Heymans, S., & Jones, E. A. V. (2024). Pericyte loss initiates microvascular dysfunction in the development of diastolic dysfunction. European heart journal open, 4(1), Article oead129.
    • Kobayashi, M., Ferreira, J. P., Kevin, D., Bresso, E., Huttin, O., Bozec, E., Brunner La Rocca, H.-P., Delles, C., Clark, A. L., Edelmann, F., González, A., Heymans, S., Pellicori, P., Petutschnigg, J., Verdonschot, J. A. J., Rossignol, P., Cleland, J. G. F., Zannad, F., Girerd, N., & HOMAGE Trial Committees and Investigators (2024). Proteomic profiles of left atrial volume and its influence on response to spironolactone: Findings from the HOMAGE trial and STANISLAS cohort. European journal of heart failure. Advance online publication.
  • 2023
    • Ciccarelli, M., Pires, I. F., Bauersachs, J., Bertrand, L., Beauloye, C., Dawson, D., Hamdani, N., Hilfiker-Kleiner, D., van Laake, L. W., Lezoualc'h, F., Linke, W. A., Lunde, I. G., Rainer, P. P., Rispoli, A., Visco, V., Carrizzo, A., Ferro, M. D., Stolfo, D., van der Velden, J., ... Tocchetti, C. G. (2023). Acute heart failure: mechanisms and pre-clinical models-a Scientific Statement of the ESC Working Group on Myocardial Function. Cardiovascular Research, 119(14), 2390-2404. Article cvad088.
    • Babu, V. S., Mallipatna, A., Dudeja, G., Shetty, R., Nair, A. P., Tun, S. B. B., Ho, C. E. H., Chaurasia, S. S., Bhattacharya, S. S., Verma, N. K., Lakshminarayanan, R., Guha, N., Heymans, S., Barathi, V. A., & Ghosh, A. (2023). Depleted hexokinase1 and lack of AMPKα activation favor OXPHOS-dependent energetics in retinoblastoma tumors. Translational Research, 261(1), 41-56.