29 August 2018

Diabetes II Breakthrough projects Marleen van Greevenbroek

Dr Marleen van Greevenbroek has received one of the Diabetes II Breakthrough projects within the joined ZonMW / DFN programme ‘Partnership Diabetes’ for her project ‘Control of insulin secretion: Methylglyoxal (MGO)-modification of intracellular CD59 impairs insulin secretion by ß-cells’. In this project she will focus on a newly-identified molecule in the ß-cell that has been classified as a novel player in the secretion of insulin from its secretory granules. The main goal of this project is to investigate how modifications of this protein, CD59, in prediabetes and (early) diabetes can impair the insulin secretion process.