My research and education focus is on cardiovascular structure and function.
Specific topics include arterial wall biomechanics and adaptation, and ventricular-vascular interaction.
My approach is to merge the disciplines and tools of engineering and clinical sciences to develop improved assessment methods to better understand degenerative and adaptive processes.
- Non-invasive assessment of dynamic vascular properties in diabetes.
- Ventricular-vascular interaction in hypertension and diastolic heart failure.
- Integrated methods to characterize vascular structure-function relationships.
Examples of future graduate student projects:
A processing pipeline to estimate the force-length relation of a fiber network - effect of structural damage
Consitutive model extension to account for smooth muscle tone - how to modulate vessel stiffness?
Establishing the reliability of axial stretch setting in biaxial mechanical testing of mouse arteries - how precise do we need to be?
Effect of the cold pressor test on carotid artery distensibility - can we learn more from modulated vessel stiffness?
Extraction of cardiac timing intervals from carotid distension waveforms - a window on the heart
Changes in left ventricular relaxation due to an acute decrease in arterial compliance - data from pigs
MSc in Electrical Engineering, PhD in Biomedical Engineering
Vascular Structure & Function, Hemodynamics, Ultrasound, Signal Processing, Control Systems Theory, Biomedical Instrumentation, Electronics