Vascular complications of diabetes and the metabolic syndrome
A major aim of the program is to deliver specific and sensitive diagnostic biomarkers for the identification of patients developing insulin resistance and type 2 diabetes and to identify patients with high risk of micro- and macrovascular complications. A second aim of our program is to obtain insight in the pathophysiology of vascular complications in patients with the metabolic syndrome and diabetes at the molecular level.
In the past years we have directed our research towards the development of insulin resistance, insulin-resistance-associated adverse large artery changes (atherosclerosis and stiffening), impaired capillary recruitment and vascular complications. These existing research programs are continued and extended with the integration of findings obtained from epidemiological studies in the different cohorts within in vitro experiments (especially cultures of endothelial cells, adipocytes and hepatocytes), animal models and in man. Current studies focus mainly on the relationships between insulin resistance and microvascular function both in man and in animal models and on the importance of specific advanced glycation end products, chronic low-grade inflammatory activity, and the relation between these phenomena for the development of diabetic complications.