Clinical atrial fibrillation
The pathophysiology of AF is being studied in the Euro Heart Survey, a large cohort of 5333 European patients. Topics include finding markers of vascular risks including stroke and hemorrhage, trigger factors for AF, progression of AF and assessment of guideline adherence. Diagnosis of the atrial substrate is pursued by a novel technique developed in our centre, which has been named ‘electroechocardiography’. This is a versatile and easily applied clinical tool which provides a multifaceted insight into remodeling of the atrial wall as a cause of stroke and arrhythmogenicity. It can be applied both during sinus rhythm and when in AF. Validation studies are being done and prospective cohorts are being built, aiming to investigate the predictive power of this tool with respect to major adverse vascular events as well as arrhythmia progression.