Carine Peutz-Kootstra

Associate professor

Dr Carine Peutz-Kootstra (1967) obtained her MD PhD degree at Leiden University in 1997 on a thesis titled: 'Immunopathology of experimental lupus nephritis'. After her training as pathologist in Utrecht she started working in Maastricht in 2002 with a specific interest in renal, autopsy and immunopathology. In 2003/2004 she did a fellowship in renal pathology in Seattle, WA, USA. She has always combined patient care, research, education and management activities. In pregraduate education she has been involved in the curriculum of 'arts-klinisch onderzoeker' as counselor and in the international track of medicine as block coordinator in 'Diabetes, obesity and Lifestyle'.  She has also been active in the residency programme for pathologists and participated nationally in the introduction of a novel pathology reimbursement system.  

Her research activities are centred around the prevention of chronic kidney disease, and its link with cardiovascular disease. She specifically focusses on the role of microvascular (in-) stability in progression of renal inflammation and fibrosis. In her studies, financed amongst others by the Dutch Kidney Foundation, she implements state-of-the art techniques to unravel pathophysiological pathways in tissue, such as mass spectrometry imaging. She recently embarked on projects to study the role of the kidney in maintaining microvascular stability in other organs, e.g. heart and brain. In her studies she always aims to translate experimental findings to patient care (from bench to bedside), and back.

Department of Pathology
Verheylaan 10, 6229 HX Maastricht
PO Box 616, 6200 MD Maastricht
T: +31(0)43 387 66 20

  • 2020
    • Keijbeck, A., Veenstra, R., Pol, R. A., Konijn, C., Jansen, N., van Goor, H., Hoitsma, A. J., Peutz-Kootstra, C. J., & Moers, C. (2020). The Association Between Macroscopic Arteriosclerosis of the Renal Artery, Microscopic Arteriosclerosis, Organ Discard, and Kidney Transplant Outcome. Transplantation, 104(12), 2567-2574. https://doi.org/10.1097/TP.0000000000003189
  • 2019
    • van Smaalen, T. C., Ellis, S. R., Mascini, N. E., Siegel, T. P., Cillero-Pastor, B., Hillen, L. M., van Heurn, L. W. E., Peutz-Kootstra, C. J., & Heeren, R. M. A. (2019). Rapid Identification of Ischemic Injury in Renal Tissue by Mass-Spectrometry Imaging. Analytical Chemistry, 91(5), 3575-3581. https://doi.org/10.1021/acs.analchem.8b05521
  • 2018
    • Barre, F. P. Y., Claes, B. S. R., Dewez, F., Peutz-Kootstra, C., Munch-Petersen, H. F., Gronbaek, K., Lund, A. H., Heeren, R. M. A., Come, C., & Cillero-Pastor, B. (2018). Specific Lipid and Metabolic Profiles of R-CHOP-Resistant Diffuse Large B-Cell Lymphoma Elucidated by Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging and in Vivo Imaging. Analytical Chemistry, 90(24), 14198-14206. https://doi.org/10.1021/acs.analchem.8b02910
    • van den Hil, L. C. L., Vogels, R. R. M., van Barneveld, K. W. Y., Gijbels, M. J. J., Peutz-Kootstra, C. J., Cleutjens, J. P. M., Schreinemacher, M. H. F., & Bouvy, N. D. (2018). Comparability of histological outcomes in rats and humans in a hernia model. Journal of Surgical Research, 229, 271-276. https://doi.org/10.1016/j.jss.2018.03.019
    • Henatsch, D., Alsulami, S., Duijvestijn, A. M., Cleutjens, J. P., Peutz-Kootstra, C. J., & Stokroos, R. J. (2018). Histopathological and Inflammatory Features of Chronically Discharging Open Mastoid Cavities Secondary Analysis of a Randomized Clinical Trial. JAMA Otolaryngology - Head and Neck Surgery, 144(3), 211-217. https://doi.org/10.1001/jamaoto.2017.2801
  • 2017
    • Pierssens, D. D. C. G., Borgemeester, M. C., van der Heijden, S. J. H., Peutz-Kootstra, C. J., Ruland, A. M., Haesevoets, A. M., Kessler, P. A. W. H., Kremer, B., & Speel, E-J. M. (2017). Chromosome instability in tumor resection margins of primary OSCC is a predictor of local recurrence. Oral Oncology, 66, 14-21. https://doi.org/10.1016/j.oraloncology.2016.12.029
  • 2016
    • Goceroglu, A., Rahmattulla, C., Berden, A. E., Reinders, M. E. J., Wolterbeek, R., Steenbergen, E. J., Hilbrands, L. B., Noorlander, I., Berger, S. P., Peutz-Kootstra, C. J., Christiaans, M., van Dijk, M. C. R. F., de Joode, A. A. E., Goldschmeding, R., van Zuilen, A. D., Harper, L., Little, M. A., Hagen, E. C., Bruijn, J. A., & Bajema, I. M. (2016). The Dutch Transplantation in Vasculitis (DUTRAVAS) Study: Outcome of Renal Transplantation in Antineutrophil Cytoplasmic Antibody-associated Glomerulonephritis. Transplantation, 100(4), 916-924. https://doi.org/10.1097/TP.0000000000000910
    • Hillen, L. M., Kamsteeg, E. J., Schoots, J., Tiebosch, A. T., Speel, E. J., Roemen, G. M., Peutz - Kootstra, C., & Stumpel, C. T. R. M. (2016). Refining the Diagnosis of Congenital Nephrotic Syndrome on Long-term Stored Tissue: c.1097G>A (p.(Arg366His)) WT1 Mutation Causing Denys Drash Syndrome. Fetal and Pediatric Pathology, 35(2), 112-119. https://doi.org/10.3109/15513815.2016.1139018
  • 2015
    • Boor, P., Babickova, J., Steegh, F., Hautvast, P., Martin, I. V., Djudjaj, S., Nakagawa, T., Ehling, J., Gremse, F., Buecher, E., Eriksson, U., van Roeyen, C. R. C., Eitner, F., Lammers, T., Floege, J., Peutz-Kootstra, C. J., & Ostendorf, T. (2015). Role of Platelet-Derived Growth Factor-CC in Capillary Rarefaction in Renal Fibrosis. American Journal of Pathology, 185(8), 2132-2142. https://doi.org/10.1016/j.ajpath.2015.04.022
  • 2014
    • Mooren, J. J., Gultekin, S. E., Straetmans, J. M. J. A. A., Haesevoets, A., Peutz-Kootstra, C. J., Huebbers, C. U., Dienes, H. P., Wieland, U., Ramaekers, F. C. S., Kremer, B., Speel, E-J. M., & Klussmann, J. P. (2014). P16(INK4A) immunostaining is a strong indicator for high-risk-HPV-associated oropharyngeal carcinomas and dysplasias, but is unreliable to predict low-risk-HPV-infection in head and neck papillomas and laryngeal dysplasias. International Journal of Cancer, 134(9), 2108-2117. https://doi.org/10.1002/ijc.28534
    • te Riet, L., van den Heuvel, M., Peutz-Kootstra, C. J., van Esch, J. H. M., van Veghel, R., Garrelds, I. M., Musterd-Bhaggoe, U., Bouhuizen, A. M., Leijten, F. P. J., Danser, A. H. J., & Batenburg, W. W. (2014). Deterioration of kidney function by the (pro)renin receptor blocker handle region peptide in aliskiren-treated diabetic transgenic (mRen2)27 rats. American Journal of Physiology-Renal Physiology, 306(10), F1179-F1189. https://doi.org/10.1152/ajprenal.00010.2014
    • Brouwers, O., Niessen, P. M. G., Miyata, T., Ostergaard, J. A., Flyvbjerg, A., Peutz-Kootstra, C. J., Sieber, J., Mundel, P. H., Brownlee, M., Janssen, B. J. A., De Mey, J. G. R., Stehouwer, C. D. A., & Schalkwijk, C. G. (2014). Glyoxalase-1 overexpression reduces endothelial dysfunction and attenuates early renal impairment in a rat model of diabetes. Diabetologia, 57(1), 224-235. https://doi.org/10.1007/s00125-013-3088-5
  • 2013
    • Brunings, J. W., Schepens, J. J. B. F. G., Peutz-Kootstra, C. J., & Kross, K. W. (2013). The Expression of Estrogen and Progesterone Receptors in the Human Larynx. Journal of Voice, 27(3), 376-380. https://doi.org/10.1016/j.jvoice.2013.01.011
    • Heijnen, B. F. J., Nelissen, J., van Essen, H., Fazzi, G. E., Tervaert, J. W. C., Peutz-Kootstra, C. J., Mullins, J. J., Schalkwijk, C. G., Janssen, B. J. A., & Struijker-Boudier, H. A. J. (2013). Irreversible Renal Damage after Transient Renin-Angiotensin System Stimulation: Involvement of an AT(1)-Receptor Mediated Immune Response. PLOS ONE, 8(2), [e57815]. https://doi.org/10.1371/journal.pone.0057815
  • 2012
    • Gelens, M. A., Steegh, F. M., van Hooff, J. P., van Suylen, R. J., Nieman, F. H. M., van Heurn, L. W. E., Peutz-Kootstra, C. J., & Christiaans, M. H. (2012). Immunosuppressive regimen and interstitial fibrosis and tubules atrophy at 12 months postrenal transplant. Clinical journal of the American Society of Nephrology, 7(6), 1010-1017. https://doi.org/10.2215/CJN.09030911
  • 2011
    • Heijnen, B. F. J., Peutz-Kootstra, C. J., Mullins, J. J., Janssen, B. J. A., & Struijker-Boudier, H. A. J. (2011). Transient renin-angiotensin system stimulation in an early stage of life causes sustained hypertension in rats. Journal of Hypertension, 29(12), 2369-2380. https://doi.org/10.1097/HJH.0b013e32834cfcf4
    • Steegh, F. M., Gelens, M. A., Nieman, F. H. M., van Hooff, J. P., Cleutjens, J. P., van Suylen, R. J., Daemen, M. J., van Heurn, E. L., Christiaans, M. H., & Peutz-Kootstra, C. J. (2011). Early loss of peritubular capillaries after kidney transplantation.Journal of the American Society of Nephrology, 22(6), 1024-1029. https://doi.org/10.1681/ASN.2010050531
    • Snoeijs, M. G., Hoogland, P. E. R., Boonen, B. T. C., Coffman, T. M., Peutz-Kootstra, C. J., Buurman, W. A., & van Heurn, L. W. E. (2011). Thromboxane receptor signalling in renal ischemia reperfusion injury.Free Radical Research, 45(6), 699-706. https://doi.org/10.3109/10715762.2011.571686
    • Snoeijs, M. G., Vaahtera, L., de Vries, E. E., Schurink, G. W. H., Haenen, G. R. M. M., Peutz-Kootstra, C. J., Buurman, W. A., van Heurn, L. W. E., & Parkkinen, J. (2011). Addition of a water-soluble propofol formulation to preservation solution in experimental kidney transplantation. Transplantation, 92(3), 296-302. https://doi.org/10.1097/TP.0b013e3182247b78
    • Snoeijs, M. G., Matthijsen, R. A., Seeldrayers, S., Marcus, M. A., Daemen, J. W., Peutz-Kootstra, C. J., Buurman, W. A., Schurink, G. W. H., & van Heurn, L. W. E. (2011). Autologous transplantation of ischemically injured kidneys in pigs.Journal of Surgical Research, 171(2), 844-850. https://doi.org/10.1016/j.jss.2010.05.064
    • Oostendorp, M., de Vries, E. E., Slenter, J. M., Peutz-Kootstra, C. J., Snoeijs, M. G., Post, M. J., van Heurn, L. W. E., & Backes, W. H. (2011). MRI of renal oxygenation and function after normothermic ischemia-reperfusion injury.Nmr in Biomedicine, 24(2), 194-200. https://doi.org/10.1002/nbm.1572
  • 2010
    • de Jong, M. C., Pramana, J., van der Wal, J. E., Lacko, M., Peutz-Kootstra, C. J., de Jong, J. M., Takes, R. P., Kaanders, J. H. A. M., van der Laan, B. F., Wachters, J., Jansen, J. C., Rasch, C. R., van Velthuysen, M-L. F., Grenman, R., Hoebers, F. J., Schuuring, E., van den Brekel, M. W. M., & Begg, A. C. (2010). CD44 Expression Predicts Local Recurrence after Radiotherapy in Larynx Cancer. Clinical Cancer Research, 16(21), 5329-5338. https://doi.org/10.1158/1078-0432.CCR-10-0799
    • Snoeijs, M. G., Vink, H., Voesten, N., Christiaans, M. H., Daemen, J. W., Peppelenbosch, A. G., Tordoir, J. H. M., Peutz-Kootstra, C. J., Buurman, W. A., Schurink, G. W. H., & van Heurn, E. L. (2010). Acute ischemic injury to the renal microvasculature in human kidney transplantation.American Journal of Physiology-Renal Physiology, 299(5), F1134-F1140. https://doi.org/10.1152/ajprenal.00158.2010
    • Snoeijs, M. G., Boonstra, L. A., Buurman, W. A., Goldschmeding, R., van Suylen, R. J., van Heurn, L. W., & Kootstra, C. J. (2010). Histological assessment of pre-transplant kidney biopsies is reproducible and representative. Histopathology, 56(2), 198-202. https://doi.org/10.1111/j.1365-2559.2009.03469.x
  • 2009
    • Rensen, S. S., Slaats, Y., Driessen, A., Kootstra, C. J., Nijhuis, J., Steffensen, R., Greve, J. W., & Buurman, W. A. (2009). Activation of the complement system in human nonalcoholic fatty liver disease. Hepatology, 50(6), 1809-1817. https://doi.org/10.1002/hep.23228
    • Debats, I. B., Wolfs, T. G., Gotoh, T., Cleutjens, J. P., Kootstra, C. J., & van der Hulst, R. R. (2009). Role of arginine in superficial wound healing in man.Nitric Oxide-Biology and Chemistry, 21(3-4), 175-183. https://doi.org/10.1016/j.niox.2009.07.006
  • 2008
    • Snoeijs, M. G., Buurman, W. A., Christiaans, M. H., van Hooff, J. P., Goldschmeding, R., van Suylen, R. J., Kootstra, C. J., & van Heurn, L. W. (2008). Histological assessment of preimplantation biopsies may improve selection of kidneys from old donors after cardiac death. American Journal of Transplantation, 8(9), 1844-51. https://doi.org/10.1111/j.1600-6143.2008.02318.x
    • Wolfs, T. G., Dunn-Siegrist, I., van 't Veer, C., Hodin, C. M., Germeraad, W. T. V., van Zoelen, M., van Suylen, R. J., Peutz-Kootstra, C. J., Elson, G., Pugin, J., & Buurman, W. A. (2008). Increased release of sMD-2 during human endotoxemia and sepsis: a role for endothelial cells.Molecular Immunology, 45(11), 3268-3277. https://doi.org/10.1016/j.molimm.2008.02.014
  • 2007
    • Huugen, D., van Esch, A., Xiao, H., Peutz-Kootstra, C. J., Buurman, W. A., Cohen Tervaert, J. W., Jennette, J. C., & Heeringa, P. (2007). Inhibition of complement factor C5 protects against anti-myeloperoxidase antibody-mediated glomerulonephritis in mice. Kidney International, 71(7), 646-654. https://doi.org/10.1038/sj.ki.5002103
    • Matthijsen, R. A., Huugen, D., Hoebers, N. T., de Vries, B., Peutz-Kootstra, C. J., Aratani, Y., Daha, M. R., Tervaert, J. W., Buurman, W. A., & Heeringa, P. (2007). Myeloperoxidase Is Critically Involved in the Induction of Organ Damage after Renal Ischemia Reperfusion. American Journal of Pathology, 171(6), 1743-1752. https://doi.org/10.2353/ajpath.2007.070184
  • 2006
    • Gelens, M. A., Christiaans, M. H., van Heurn, L. W. E., van de Berg-Loonen, E. P., Peutz-Kootstra, C. J., & van Hooff, J. P. (2006). High rejection rate during calcineurin inhibitor-free and early steroid withdrawal immunosuppression in renal transplantation. Transplantation, 82(9), 1221-1223. https://doi.org/10.1097/01.tp.0000232688.76018.19
    • Snoeijs, M. G., Schaefer, S., Christiaans, M. H., van Hooff, J. P., van den Berg-Loonen, E. M., Peutz-Kootstra, C. J., Buurman, W. A., & van Heurn, L. W. E. (2006). Kidney transplantation using elderly non-heart-beating donors: a single-center experience. American Journal of Transplantation, 6(5 Pt 1), 1066-1071. https://doi.org/10.1111/j.1600-6143.2006.01312.x
  • 2005
    • Huugen, D., Xiao, H., van Esch, A., Falk, R. J., Peutz-Kootstra, C. J., Buurman, W. A., Cohen Tervaert, J. W., Jennette, J. C., & Heeringa, P. (2005). Aggravation of anti-myeloperoxidase antibody-induced glomerulonephritis by bacterial lipopolysaccharide: role of tumor necrosis factor-alpha. American Journal of Pathology, 167(1), 47-58. https://doi.org/10.1016/S0002-9440(10)62952-5
    • Wolfs, T. G. A. M., de Vries, B., Walter, S. J., Peutz-Kootstra, C. J., van Heurn, L. W., Oosterhof, G. O. N., & Buurman, W. A. (2005). Apoptotic cell death is initiated during normothermic ischemia in human kidneys. American Journal of Transplantation, 5(1), 68-75. https://doi.org/10.1111/j.1600-6143.2004.00657.x
  • 2004
    • de Vries, B., Walter, S. J., Peutz-Kootstra, C. J., Wolfs, T. G. A. M., van Heurn, L. W., & Buurman, W. A. (2004). The mannose-binding lectin-pathway is involved in complement activation in the course of renal ischemia-reperfusion injury. American Journal of Pathology, 165(5), 1677-1688. https://doi.org/10.1016/S0002-9440(10)63424-4