Chris Reutelingsperger


Prof. Chris Reutelingsperger studied Biochemistry at the University of Utrecht. As a PhD student, he discovered and patented the anticoagulant annexin A5 (VAscular Anticoagulant) and defended the thesis 'Vascular anticoagulant, a novel anticoagulant mechanism' at Maastricht University in 1987. He was awarded the five-year Senior Fellowship of the Royal Dutch Academy of Sciences (KNAW) and spent part of his post-doc time at the Boehringer Ingelheim Institute für Arzneimittelforschung in Vienna, to work on elucidating the genetic code of annexin A5.

In 1994, he discovered and patented the power of annexin A5 to detect apoptotic cells. In 1992, he received a tenure track at the Department of Biochemistry of Maastricht University, resulting in a tenured position as Associate Professor in 1997. In 2009, he was appointed Professor of Biochemistry of Apoptosis at Maastricht University. He (co-)authored over 200 peer reviewed papers (H-index 68, source Scholar Google). He is (co-)inventor of 12 granted patents and CSO of PharmaTarget, a biotech company which he co-founded in 2006. He was President of the 8th International Conference on Annexins in 2015. Currently, he chairs the Scientific Advisory Board of Matisse Pharmaceuticals (Netherlands), a biotech company developing therapeutic drugs to treat sepsis.

Chris Reutelingsperger's research activities address molecular and cellular mechanisms of vascular remodeling, vasculitis, atherosclerosis and vascular calcification. His interests focus on vascular calcification, cell death programs, phagocytosis, complement, vitamin K-dependent proteins and annexins, with emphasis on annexins A1 and A5. His major experimental approach utilises in vitrocell biology an in-house developed integrated in vitro assay platform (The BioHybrid, 'organ on-a-chip') covering all major vascular cell types and processes in the pathophysiology of vascular diseases. His strategy encompasses linking basic research to clinical application by establishing collaborations with clinical research and with industry.

Department of Biochemistry
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: H4.354
T: +31(0)43 388 16 74

  • 2016
    • Burgmaier, M., Schurgers, L., & Reutelingsperger, C. (2016). Response to letter to the editor: annexin A5 levels or circulating microparticles: what we see depends mainly on what we look for. Journal of Internal Medicine, 279(6), 606-607.
    • Schurgers, L. J., Burgmaier, M., Ueland, T., Schutters, K., Aakhus, S., Hofstra, L., Gullestad, L., Aukrust, P., Hellmich, M., Narula, J., & Reutelingsperger, C. P. (2016). Circulating annexin A5 predicts mortality in patients with heart failure. Journal of Internal Medicine, 279(1), 89-97.
    • Maggioli, E., McArthur, S., Mauro, C., Kieswich, J., Kusters, D. H. M., Reutelingsperger, C. P. M., Yaqoob, M., & Solito, E. (2016). Estrogen protects the blood-brain barrier from inflammation-induced disruption and increased lymphocyte trafficking. Brain Behavior and Immunity, 51, 212-222.
    • Schlieper, G., Schurgers, L., Brandenburg, V., Reutelingsperger, C., & Floege, J. (2016). Vascular calcification in chronic kidney disease: an update. Nephrology Dialysis Transplantation, 31(1), 31-39.
  • 2015
    • Kusters, D. H., Chatrou, M. L., Willems, B. A., De Saint-Hubert, M., Bauwens, M., van der Vorst, E., Bena, S., Biessen, E. A., Perretti, M., Schurgers, L. J., & Reutelingsperger, C. P. (2015). Pharmacological Treatment with Annexin A1 Reduces Atherosclerotic Plaque Burden in LDLR-/- Mice on Western Type Diet. PLOS ONE, 10(6), [e0130484].
  • 2014
    • Burgmaier, M., Schutters, K., Willems, B., Van der Vorst, E. P. C., Kusters, D., Chatrou, M., Norling, L., Biessen, E. A. L., Cleutjens, J., Perretti, M., Schurgers, L. J., & Reutelingsperger, C. (2014). AnxA5 reduces plaque inflammation of advanced atherosclerotic lesions in apoE(-/-) mice. Journal of Cellular and Molecular Medicine, 18(10), 2117-2124.
    • De Saint-Hubert, M., Bauwens, M., Deckers, N., Drummen, M., Douma, K., Granton, P., Hendrikx, G., Kusters, D., Bucerius, J., Reutelingsperger, C. P. M., & Mottaghy, F. M. (2014). In Vivo Molecular Imaging of Apoptosisand Necrosis in Atherosclerotic PlaquesUsing MicroSPECT-CT and MicroPET-CT Imaging. Molecular Imaging and Biology, 16(2), 246-254.
    • Ungethüm, L., Chatrou, M., Kusters, D., Schurgers, L., & Reutelingsperger, C. P. (2014). Molecular imaging of cell death in tumors. Increasing annexin A5 size reduces contribution of phosphatidylserine-targeting function to tumor uptake. PLOS ONE, 9(5), e96749.
  • 2013
    • Arends, S. J., Damoiseaux, J. G., Duijvestijn, A. M., Debrus-Palmans, L., Vroomen, M., Boomars, K. A., Brunner-La Rocca, H. P., Reutelingsperger, C. P., Tervaert, J. W., & van Paassen, P. (2013). Immunoglobulin G anti-endothelial cell antibodies: inducers of endothelial cell apoptosis in pulmonary arterial hypertension?Clinical and Experimental Immunology, 174(3), 433-440.
    • Bauwens, M., De Saint-Hubert, M., Cleynhens, J., Vandeputte, C., Li, J., Devos, E., Hendrickx, S., Ni, Y., Reutelingsperger, C. P., Mortelmans, L., Mottaghy, F. M., & Verbruggen, A. (2013). In vitro and in vivo comparison of 18F and 123I-labeled ML10 with 68Ga-Cys2-AnxA5 for molecular imaging of apoptosis.Quarterly Journal of Nuclear Medicine and Molecular Imaging, 57(2), 187-200.
    • Schutters, K., Kusters, D. H. M., Chatrou, M. L. L., Montero-Melendez, T., Donners, M., Deckers, N. M., Krysko, D. V., Vandenabeele, P., Perretti, M., Schurgers, L. J., & Reutelingsperger, C. P. M. (2013). Cell surface-expressed phosphatidylserine as therapeutic target to enhance phagocytosis of apoptotic cells. Cell Death and Differentiation, 20(1), 49-56.
  • 2011
    • Chatrou, M. L. L., Reutelingsperger, C. P., & Schurgers, L. J. (2011). Role of vitamin K-dependent proteins in the arterial vessel wall. Hämostaseologie, 31(4), 251-257.
    • de Saint Hubert, M., Wang, H., Devos, E., Vunckx, K., Zhou, L., Reutelingsperger, C. P., Verbruggen, A., Mortelmans, L., Ni, Y., & Mottaghy, F. M. (2011). Preclinical imaging of therapy response using metabolic and apoptosis molecular imaging. Molecular Imaging and Biology, 13(5), 995-1002.
  • 2005
    • Asai, K., Buurman, W. A., Reutelingsperger, C. P. M., Schutte, B., & Kaminishi, M. (2005). Modular effects of estradiol on ethanol-induced apoptosis in human intestinal epithelial cells. Scandinavian Journal of Gastroenterology, 40(3), 326-335.
  • 2003
    • Asai, K., Buurman, W. A., Reutelingsperger, C. P. M., Schutte, B., & Kaminishi, M. (2003). Low concentrations of ethanol induce apoptosis in human intestinal cells. Scandinavian Journal of Gastroenterology, 38(11), 1154-1161.
    • Notenboom, R. G., van den Bergh, M. A., Dingemans, K. P., Vermeulen, J. L., van den Eijnde, S. M., Reutelingsperger, C. P. M., Hut, H., Willemsen, R., Offerhaus, G. J., & Lamers, W. H. (2003). Timing and sequence of differentiation of embryonic rat hepatocytes along the biliary epithelial lineage. Hepatology, 38(3), 683-691.
  • 2002
    • Franssen, E. J., Rombout-Sestrienkova, E., van Pampus, E. C. M., Buurman, W. A., Reutelingsperger, C. P. M., & Maessen, J. G. (2002). Prestorage leucocyte reduction of red cell components prevents release of bactericidal permeability increasing protein and defensins. Vox Sanguinis, 83(2), 119-124.
  • 2001
  • 2000
    • Terwel, D., Nieland, L. J. W., Schutte, B., Reutelingsperger, C. P. M., Ramaekers, F. C. S., & Steinbusch, H. W. M. (2000). S-nitroso-N-acetylpenicillamine and nitroprusside induce apoptosis in a neuronal cell line by the production of different reactive molecules.European Journal of Pharmacology, 400, 400-400.
  • 1999
    • Heemskerk, J. W. M., Siljander, P. R. M., Vuist, M. W. J., Breikers, G., Reutelingsperger, C. P. M., Barnes, M. J., Knight, C. G., Lassila, R., & Farndale, R. W. (1999). Function of glycoprotein VI and integrin alpha2beta1 in the procoagulant response of single, collagen-adherent platelets.Thrombosis and Haemostasis, 81(5), 782-792.
    • van Gorp Beisser, R. M. A., Broers, J. L. V., Reutelingsperger, C. P. M., Bronnenberg, N. M. H. J., Hornstra, G., Mieras-van Dam, M. C. E., & Heemskerk, J. W. M. (1999). Peroxide-induced membrane blebbing in endothelial cells associated with glutathione oxidation but not apoptosis.American Journal of Physiology (Consolidated), 277(1 Pt 1), C20-C28.
  • 1997
  • 1996
    • IJzendoorn, S. C. D., van Gool, R. G. J., Reutelingsperger, C. P. M., & Heemskerk, J. W. M. (1996). Unstimulated platelets evoke calcium responses in human umbilical vein endothelial cells.Biochimica et Biophysica Acta. Mucoproteins and Mucopolysaccharides, 1311, 64-70.
  • 1994
    • van Heerde, W. L., Sakariassen, K. S., Hemker, H. C., Sixma, J. J., Reutelingsperger, C. P. M., & de Groot, P. G. (1994). Annexin V inhibits the procoagulant activity of matrices of TNF-stimulated endothelium under blood flow conditions. Arteriosclerosis and thrombosis, 14(5), 824-830.
  • 1992
    • Lindhout, T., Blezer, R., Schoen, P., Nordfang, O., Reutelingsperger, C., & Hemker, H. C. (1992). Activation of factor X and its regulation by tissue factor pathway inhibitor in small-diameter capillaries lined with human endothelial cells. Blood, 79(11), 2909-2916.
    • Andree, H. A. M., Stuart, M. C. A., Hermens, W. T., Reutelingsperger, C. P. M., Hemker, H. C., Frederik, P. M., & Willems, G. M. (1992). Clustering of lipid-bound Annexin V may explain its anticoagulant effect. Journal of Biological Chemistry, 267(25), 17907-17912.
  • 1990
    • Andree, H. A. M., Reutelingsperger, C. P. M., Hauptmann, R., Hemker, H. C., Hermens, W. T., & Willems, G. (1990). Binding of vascular anticoagulant α(VACα) to Planar Phospholipid Bilayers. Journal of Biological Chemistry, 265(9), 4923-4928.
  • 1988
    • Reutelingsperger, C. P. M., Kop, J. M. M., Hornstra, G., & Hemker, H. C. (1988). Purification and characterization of a novel protein from bovine aorta that inhibits coagulation. European Journal of Biochemistry, 173(1), 171-178.
  • 1985
    • Reutelingsperger, C. P. M., Hornstra, G., & Hemker, H. C. (1985). Isolation and partial purification of a novel anticoagulant from arteries of human umbilical cord. European Journal of Biochemistry, 151(3), 625-629.