Dietbert Neumann

Associate professor

Dr Dietbert Neumann studied chemistry, as well as biology at the University of Cologne, Germany. After his double diploma, he worked at the NMI in Reutlingen Germany under the supervision of Dr T. Joos. Subsequently, he joined the lab of Prof. T. Wallimann at ETH Zurich. Dietbert received his doctorate with distinction and was awarded the ETH medal. After a short postdoctoral period in Oxford, UK, under the guidance of Prof. L. N. Johnson, he returned to ETH Zurich to complete his postdoctoral training, where he became Research Group Leader at the Institute of Cell Biology.

Since 2011, he is Associate Professor at Maastricht University. His research focus is on the integration of cellular metabolism into the protein kinase signalling network, in particular AMPK. Among his major achievements is the development of a method for bacterial production of the AMPK heterotrimer, a prerequisite for its structural investigation, which was consequently adopted by virtually all AMPK enthusiasts working in structural biology labs around the globe. Dietbert Neumann is also involved in coordination of various educational activities and teaches in biomedical courses using student-centered approaches. Furthermore, he initiated the ’European Workshop on AMPK’ conference series.

 

Department of Pathology
P. Debyelaan 25, 6229 HX Maastricht
PO Box 616, 6200 MD Maastricht
Room number: 5.08
T: +31(0)43 387 71 67

  • 2020
    • Vervoorts, J., Neumann, D., & Luscher, B. (2020). The CCNY (cyclin Y)-CDK16 kinase complex: a new regulator of autophagy downstream of AMPK. Autophagy, 16(9), 1724-1726. https://doi.org/10.1080/15548627.2020.1795423
    • Luiken, J. J. F. P., Nabben, M., Neumann, D., & Glatz, J. F. C. (2020). Understanding the distinct subcellular trafficking of CD36 and GLUT4 during the development of myocardial insulin resistance. Biochimica et Biophysica Acta-Molecular Basis of Disease, 1866(7), [165775]. https://doi.org/10.1016/j.bbadis.2020.165775
    • Dohmen, M., Krieg, S., Agalaridis, G., Zhu, X., Shehata, S. N., Pfeiffenberger, E., Amelang, J., Buetepage, M., Buerova, E., Pfaff, C. M., Chanda, D., Geley, S., Preisinger, C., Sakamoto, K., Lüscher, B., Neumann, D., & Vervoorts, J. (2020). AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy. Nature Communications, 11(1), [1032]. https://doi.org/10.1038/s41467-020-14812-0
  • 2019
    • Zou, M-H., Kirkpatrick, S. S., Davis, B. J., Nelson, J. S., Wiles, W. G., Schlattner, U., Neumann, D., Brownlee, M., Freeman, M. B., & Goldman, M. H. (2019). Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo: Role of mitochondrial reactive nitrogen species (Retraction of Vol 279, Pg 43940, 2004). Journal of Biological Chemistry, 294(36), 13525-13525. https://doi.org/10.1074/jbc.W119.010595
    • Neumann, D., & Viollet, B. (2019). AMP-Activated Protein Kinase Signalling. International journal of molecular sciences, 20(3), [766]. https://doi.org/10.3390/ijms20030766
    • Liu, Y., Rodriguez-Calvo, R., Wang, S., Zhu, X., Broers, J. L. V., Glatz, J. F. C., Luiken, J. J. F. P., & Neumann, D. (2019). Fluorescent labelling of membrane fatty acid transporter CD36 (SR-B2) in the extracellular loop. PLOS ONE, 14(1), [0210704]. https://doi.org/10.1371/journal.pone.0210704
    • Chanda, D., Neumann, D., & Glatz, J. F. C. (2019). The endocannabinoid system: Overview of an emerging multi-faceted therapeutic target. Prostaglandins Leukotrienes and Essential Fatty Acids, 140, 51-56. https://doi.org/10.1016/j.plefa.2018.11.016
  • 2018
    • de Theije, C. C., Schols, A. M. W. J., Lamers, W. H., Neumann, D., Kohler, S. E., & Langen, R. C. J. (2018). Hypoxia impairs adaptation of skeletal muscle protein turnover- and AMPK signaling during fasting-induced muscle atrophy. PLOS ONE, 13(9), [0203630]. https://doi.org/10.1371/journal.pone.0203630
    • Liu, Y., Neumann, D., Glatz, J. F. C., & Luiken, J. J. F. P. (2018). Molecular mechanism of lipid-induced cardiac insulin resistance and contractile dysfunction. Prostaglandins Leukotrienes and Essential Fatty Acids, 136, 131-141. https://doi.org/10.1016/j.plefa.2016.06.002
    • Neumann, D. (2018). Is TAK1 a Direct Upstream Kinase of AMPK?International journal of molecular sciences, 19(8), [2412]. https://doi.org/10.3390/ijms19082412
    • Ho, P-Y., Li, H., Pavlov, T. S., Tuerk, R. D., Tabares, D., Brunisholz, R., Neumann, D., Staruschenko, A., & Hallows, K. R. (2018). β1Pix exchange factor stabilizes the ubiquitin ligase Nedd4-2 and plays a critical role in ENaC regulation by AMPK in kidney epithelial cells. Journal of Biological Chemistry, 293(29), 11612-11624. https://doi.org/10.1074/jbc.RA118.003082
    • Geraets, I. M. E., Chanda, D., van Tienen, F. H. J., van den Wijngaard, A., Kamps, R., Neumann, D., Liu, Y., Glatz, J. F. C., Luiken, J. J. F. P., & Nabben, M. (2018). Human embryonic stem cell-derived cardiomyocytes as an in vitro model to study cardiac insulin resistance. Biochimica et Biophysica Acta-Molecular Basis of Disease, 1864(5), 1960-1967. https://doi.org/10.1016/j.bbadis.2017.12.025
  • 2017
    • Liu, Y., Steinbusch, L. K. M., Nabben, M., Kapsokalyvas, D., van Zandvoort, M., Schonleitner, P., Antoons, G., Simons, P. J., Coumans, W. A., Geomini, A., Chanda, D., Glatz, J. F. C., Neumann, D., & Luiken, J. J. F. P. (2017). Palmitate-Induced Vacuolar-Type H(+)-ATPase Inhibition Feeds Forward Into Insulin Resistance and Contractile Dysfunction. Diabetes, 66(6), 1521-1534. https://doi.org/10.2337/db16-0727
    • Rodriguez-Calvo, R., Chanda, D., Oligschlaeger, Y., Miglianico, M., Coumans, W. A., Barroso, E., Tajes, M., Luiken, J. J. F. P., Glatz, J. F. C., Vazquez-Carrera, M., & Neumann, D. (2017). Small heterodimer partner (SHP) contributes to insulin resistance in cardiomyocytes. Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, 1862(5), 541-551. https://doi.org/10.1016/j.bbalip.2017.02.006
    • Chanda, D., Oligschlaeger, Y., Geraets, I., Liu, Y., Zhu, X., Li, J., Nabben, M., Coumans, W., Luiken, J. J. F. P., Glatz, J. F. C., & Neumann, D. (2017). 2-Arachidonoylglycerol ameliorates inflammatory stress-induced insulin resistance in cardiomyocytes. Journal of Biological Chemistry, 292(17), 7105-7114. https://doi.org/10.1074/jbc.M116.767384
  • 2016
    • Luiken, J. J. F. P., Chanda, D., Nabben, M., Neumann, D., & Glatz, J. F. C. (2016). Post-translational modifications of CD36 (SR-B2): Implications for regulation of myocellular fatty acid uptake. Biochimica et Biophysica Acta-Molecular Basis of Disease, 1862(12), 2253-2258. https://doi.org/10.1016/j.bbadis.2016.09.004
    • Al-bataineh, M. M., Li, H., Ohmi, K., Gong, F., Marciszyn, A. L., Naveed, S., Zhu, X., Neumann, D., Wu, Q., Cheng, L., Fenton, R. A., Pastor-Soler, N. M., & Hallows, K. R. (2016). Activation of the metabolic sensor AMP-activated protein kinase inhibits aquaporin-2 function in kidney principal cells. American Journal of Physiology-Renal Physiology, 311(5), F890-F900. https://doi.org/10.1152/ajprenal.00308.2016
    • Li, J., Chanda, D., van Gorp, P., Jeurissen, M. L. J., Houben, T., Walenbergh, S. M. A., Debets, J., Oligschläger, Y., Gijbels, M. J. J., Neumann, D., & Shiri-Sverdlov, R. (2016). Macrophage Stimulating Protein Enhances Hepatic Inflammation in alpha NASH Model. PLOS ONE, 11(9), [e0163843]. https://doi.org/10.1371/journal.pone.0163843
    • Chanda, D., Li, J., Oligschläger, Y., Jeurissen, M. L. J., Houben, T., Walenbergh, S. M. A., Shiri-Sverdlov, R., & Neumann, D. (2016). MSP is a negative regulator of inflammation and lipogenesis in ex vivo models of non-alcoholic steatohepatitis. Experimental and Molecular Medicine, 48, [e258]. https://doi.org/10.1038/emm.2016.79
    • Zhu, X., Dahlmans, V., Thali, R., Preisinger, C., Viollet, B., Voncken, J. W., & Neumann, D. (2016). AMP-activated Protein Kinase Up-regulates Mitogen-activated Protein (MAP) Kinase-interacting Serine/Threonine Kinase 1a-dependent Phosphorylation of Eukaryotic Translation Initiation Factor 4E. Journal of Biological Chemistry, 291(33), 17020-17027. https://doi.org/10.1074/jbc.C116.740498
    • Nabben, M., & Neumann, D. (2016). GSK-3 Inhibitors: Anti-Diabetic Treatment Associated with Cardiac Risk?Cardiovascular Drugs and Therapy, 30(3), 233-235. https://doi.org/10.1007/s10557-016-6669-y
    • Miglianico, M., Nicolaes, G. A. F., & Neumann, D. (2016). Pharmacological Targeting of AMP-Activated Protein Kinase and Opportunities for Computer-Aided Drug Design. Journal of Medicinal Chemistry, 59(7), 2879-2893. https://doi.org/10.1021/acs.jmedchem.5b01201
    • Oligschläger, Y., Miglianico, M., Dahlmans, V. E., Rubio-Villena, C., Chanda, D., Adelaida Garcia-Gimeno, M., Coumans, W. A., Liu, Y., Voncken, J. W., Luiken, J. J. F. P., Glatz, J. F. C., Sanz, P., & Neumann, D. (2016). The interaction between AMPK beta 2 and the PP1-targeting subunit R6 is dynamically regulated by intracellular glycogen content. Biochemical Journal, 473(7), 937-947. https://doi.org/10.1042/BJ20151035
  • 2015
    • Luiken, J. J. F. P., Glatz, J. F. C., & Neumann, D. (2015). Cardiac contraction-induced GLUT4 translocation requires dual signaling input. Trends in Endocrinology and Metabolism, 26(8), 404-410. https://doi.org/10.1016/j.tem.2015.06.002
    • Neumann, D., Luiken, J. J. F. P., Nabben, M., & Glatz, J. F. C. (2015). Letter by Neumann et al Regarding Article, "Myostatin Regulates Energy Homeostasis in the Heart and Prevents Heart Failure". Circulation Research, 116(10), E95-E96. https://doi.org/10.1161/CIRCRESAHA.115.306463
    • Oligschlaeger, Y., Miglianico, M., Chanda, D., Scholz, R., Thali, R. F., Tuerk, R., Stapleton, D. I., Gooley, P. R., & Neumann, D. (2015). The Recruitment of AMP-activated Protein Kinase to Glycogen Is Regulated by Autophosphorylation. Journal of Biological Chemistry, 290(18), 11715-11728. https://doi.org/10.1074/jbc.M114.633271
    • Prickaerts, P., Niessen, H. E. C., Dahlmans, V. E. H., Spaapen, F., Salvaing, J., Vanhove, J., Geijselaers, C., Bartels, S. J. J., Partouns, I., Neumann, D., Speel, E-J., Takihara, Y., Wouters, B. G., & Voncken, J. W. (2015). MK3 Modulation Affects BMI1-Dependent and Independent Cell Cycle Check-Points. PLOS ONE, 10(4), [e0118840]. https://doi.org/10.1371/journal.pone.0118840
    • Rodriguez-Calvo, R., Vazquez-Carrera, M., Masana, L., & Neumann, D. (2015). AICAR Protects against High Palmitate/High Insulin-Induced Intramyocellular Lipid Accumulation and Insulin Resistance in HL-1 Cardiac Cells by Inducing PPAR-Target Gene Expression. Ppar Research, [785783]. https://doi.org/10.1155/2015/785783
  • 2014
    • Dirkx, E., van Eys, G. J. J. M., Schwenk, R. W., Steinbusch, L. K. M., Hoebers, N., Coumans, W. A., Peters, T., Janssen, B. J., Brans, B., Vogg, A. T., Neumann, D., Glatz, J. F. C., & Luiken, J. J. F. P. (2014). Protein kinase-D1 overexpression prevents lipid-induced cardiac insulin resistance. Journal of Molecular and Cellular Cardiology, 76, 208-217. https://doi.org/10.1016/j.yjmcc.2014.08.017
    • Rios, S. R., Lamarche, F., Cottet-Rousselle, C., Klaus, A., Tuerk, R., Thali, R., Auchli, Y., Brunisholz, R., Neumann, D., Barret, L., Tokarska-Schlattner, M., & Schlattner, U. (2014). Regulation of brain-type creatine kinase by AMP-activated protein kinase: Interaction, phosphorylation and ER localization. Biochimica et Biophysica Acta-bioenergetics, 1837(8), 1271-1283. https://doi.org/10.1016/j.bbabio.2014.03.020
    • Angin, Y., Schwenk, R. W., Nergiz-Unal, R., Hoebers, N., Heemskerk, J. W. M., Kuijpers, M. J., Coumans, W. A., van Zandvoort, M. A. M. J., Bonen, A., Neumann, D., Glatz, J. F. C., & Luiken, J. (2014). Calcium signaling recruits substrate transporters GLUT4 and CD36 to the sarcolemma without increasing cardiac substrate uptake. American Journal of Physiology : Endocrinology and Metabolism, 307(2), E225-E236. https://doi.org/10.1152/ajpendo.00655.2013
    • Bullen, J. W., Balsbaugh, J. L., Chanda, D., Shabanowitz, J., Hunt, D. F., Neumann, D., & Hart, G. W. (2014). Cross-talk between Two Essential Nutrient-sensitive Enzymes O-GlcNAc TRANSFERASE ( OGT) AND AMP-ACTIVATED PROTEIN KINASE ( AMPK). Journal of Biological Chemistry, 289(15), 10592-10606. https://doi.org/10.1074/jbc.M113.523068
  • 2013
    • Alzamora, R., Al-Bataineh, M. M., Liu, W., Gong, F., Li, H., Thali, R. F., Joho-Auchli, Y., Brunisholz, R. A., Satlin, L. M., Neumann, D., Hallows, K. R., & Pastor-Soler, N. M. (2013). AMP-activated protein kinase regulates the vacuolar H+-ATPase via direct phosphorylation of the A subunit (ATP6V1A) in the kidney. American Journal of Physiology-Renal Physiology, 305(7), F943-F956. https://doi.org/10.1152/ajprenal.00303.2013
  • 2012
    • Garcia-Haro, L., Adelaida Garcia-Gimeno, M., Neumann, D., Beullens, M., Bollen, M., & Sanz, P. (2012). Glucose-dependent regulation of AMP-activated protein kinase in MIN6 beta cells is not affected by the protein kinase A pathway. Febs Letters, 586(23), 4241-4247. https://doi.org/10.1016/j.febslet.2012.10.032
    • King, J. D. J., Lee, J., Riemen, C. E., Neumann, D., Xiong, S., Foskett, J. K., Mehta, A., Muimo, R., & Hallows, K. R. (2012). Role of Binding and Nucleoside Diphosphate Kinase A in the Regulation of the Cystic Fibrosis Transmembrane Conductance Regulator by AMP-activated Protein Kinase. Journal of Biological Chemistry, 287(40), 33389-33400. https://doi.org/10.1074/jbc.M112.396036
    • Tokarska-Schlattner, M., Epand, R. F., Meiler, F., Zandomeneghi, G., Neumann, D., Widmer, H. R., Meier, B. H., Epand, R. M., Saks, V., Wallimann, T., & Schlattner, U. (2012). Phosphocreatine Interacts with Phospholipids, Affects Membrane Properties and Exerts Membrane-Protective Effects. PLOS ONE, 7(8), [e43178]. https://doi.org/10.1371/journal.pone.0043178
    • Chen, L., Wang, J., Zhang, Y-Y., Yan, S. F., Neumann, D., Schlattner, U., Wang, Z-X., & Wu, J-W. (2012). AMP-activated protein kinase undergoes nucleotide-dependent conformational changes. Nature Structural and Molecular Biology, 19(7), 716-+. https://doi.org/10.1038/nsmb.2319
    • Bieri, M., Mobbs, J. I., Koay, A., Louey, G., Mok, Y-F., Hatters, D. M., Park, J-T., Park, K-H., Neumann, D., Stapleton, D., & Gooley, P. R. (2012). AMP-Activated Protein Kinase beta-Subunit Requires Internal Motion for Optimal Carbohydrate Binding. Biophysical Journal, 102(2), 305-314. https://doi.org/10.1016/j.bpj.2011.12.012