Hans Vink

Associate professor

Hans Vink received his physics degree in 1989 at the University of Amsterdam. After receiving his PhD in Medicine in 1994 and a post-doctoral fellowship at the Dept. of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA, he returned to the University of Amsterdam and developed a research programme on the endothelial glycocalyx (www.glycocalyx.nl), supported by grants from the Netherlands Organisation for Scientific Research (NWO 1997-1999) and a fellowship from the Royal Netherlands Academy of Sciences (KNAW 2000–2005). In 2006, he was awarded an Established Investigatorship by the Dutch Heart Foundation and moved to the University of Maastricht as a Principal Investigator at CARIM. His research on the endothelial glycocalyx progresses towards clinically applicable tools for early diagnosis of cardiovascular risk and new therapeutic approaches to protect the vascular wall against atherogenic challenges.

The endothelial glycocalyx forms a complex, hydrated mesh of cell surface proteoglycans, glycosaminoglycans, and plasma proteins that is situated between the vascular wall and flowing blood. Strategically situated between flowing blood and the vascular surface, an intact glycocalyx forms the first line of defence of blood vessels against atherogenic challenges by limiting leakage of atherogenic lipoproteins into the vessel wall and preventing adhesion of circulating coagulatory and inflammatory cells to the vascular endothelial lining. Recent clinical studies have demonstrated that monitoring glycocalyx damage identifies early vascular vulnerability in patients with e.g. early cognitive impairment (neurology), premature atherosclerosis and coronary microvascular disease (cardiology), impaired renal function (nephrology), insulin resistance (diabetes) and acute vascular vulnerability in critically ill patients (ICU).

As a spin-off of Maastricht UMC+, GlycoCheck BV is developing a non-invasive test for early detection of personal vascular vulnerability in the context of increased cardiovascular risk by e.g. diabetes. The test is based on automated analysis of clinical videomicroscopic recordings of microvascular hemodynamics to check the quality of the endothelial glycocalyx, a protective coating on the luminal surface of blood vessels.

 

Department of Physiology
Universiteitsingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht

  • 2020
    • Phung Khanh Lam, McBride, A., Duyen Huynh Thi Le, Trieu Trung Huynh, Vink, H., Wills, B., & Yacoub, S. (2020). Visual and Biochemical Evidence of Glycocalyx Disruption in Human Dengue Infection, and Association With Plasma Leakage Severity. Frontiers in medicine, 7, [545813]. https://doi.org/10.3389/fmed.2020.545813
  • 2019
    • Zhang, C. E., Staals, J., van Oostenbrugge, R. J., & Vink, H. (2019). Uncoupling of Microvascular Blood Flow and Capillary Density in Vascular Cognitive Impairment. Frontiers in Neurology, 10, [1268]. https://doi.org/10.3389/fneur.2019.01268
    • van den Berg, B. M., Wang, G., Boels, M. G. S., Avramut, M. C., Jansen, E., Sol, W. M. P. J., Lebrin, F., van Zonneveld, A. J., de Koning, E. J. P., Vink, H., Groene, H-J., Carmeliet, P., van der Vlag, J., & Rabelink, T. J. (2019). Glomerular Function and Structural Integrity Depend on Hyaluronan Synthesis by Glomerular Endothelium. Journal of the American Society of Nephrology, 30(10), 1886-1897. https://doi.org/10.1681/ASN.2019020192
    • Rovas, A., Seidel, L. M., Vink, H., Pohlkoetter, T., Pavenstaedt, H., Ertmer, C., Hessler, M., & Kuempers, P. (2019). Association of sublingual microcirculation parameters and endothelial glycocalyx dimensions in resuscitated sepsis. Critical Care, 23, [260]. https://doi.org/10.1186/s13054-019-2542-2
    • Astapenko, D., Pouska, J., Benes, J., Skulec, R., Lehmann, C., Vink, H., & Cerny, V. (2019). Neuraxial anesthesia is less harmful to the endothelial glycocalyx during elective joint surgery compared to general anesthesia. Clinical Hemorheology and Microcirculation, 72(1), 11-21. https://doi.org/10.3233/CH-180428
  • 2018
    • Haeren, R. H. L., Rijkers, K., Schijns, O. E. M. G., Dings, J., Hoogland, G., van Zandvoort, M. A. M. J., Vink, H., & van Overbeeke, J. J. (2018). In vivo assessment of the human cerebral microcirculation and its glycocalyx: A technical report. Journal of Neuroscience Methods, 303, 114-125. https://doi.org/10.1016/j.jneumeth.2018.03.009
    • Rovas, A., Lukasz, A-H., Vink, H., Urban, M., Sackarnd, J., Pavenstadt, H., & Kumpers, P. (2018). Bedside analysis of the sublingual microvascular glycocalyx in the emergency room and intensive care unit: the GlycoNurse study. Scandinavian Journal of Trauma Resuscitation & Emergency Medicine, 26, [16]. https://doi.org/10.1186/s13049-018-0483-4
  • 2017
    • Jaarsma, C., Vink, H., van Haare, J., Bekkers, S. C. A. M., van Rooijen, B. D., Backes, W. H., Wildberger, J. E., Crijns, H. J., van Teeffelen, J., & Schalla, S. (2017). Non-invasive assessment of microvascular dysfunction in patients with microvascular angina. International Journal of Cardiology, 248, 433-439. https://doi.org/10.1016/j.ijcard.2017.05.010
    • Machin, D. R., Gates, P. E., Vink, H., Frech, T. M., & Donato, A. J. (2017). Automated Measurement of Microvascular Function Reveals Dysfunction in Systemic Sclerosis: A Cross-sectional Study. Journal of Rheumatology, 44(11), 1603-1611. https://doi.org/10.3899/jrheum.170120
    • van Haare, J., Kooi, M. E., van Teeffelen, J. W. G. E., Vink, H., Slenter, J., Cobelens, H., Strijkers, G. J., Koehn, D., Post, M. J., & van Bilsen, M. (2017). Metformin and sulodexide restore cardiac microvascular perfusion capacity in diet-induced obese rats. Cardiovascular Diabetology, 16, [47]. https://doi.org/10.1186/s12933-017-0525-7
    • Haeren, R. H. L., Vink, H., Staals, J., van Zandvoort, M. A. M. J., Dings, J., van Overbeeke, J. J., Hoogland, G., Rijkers, K., & Schijns, O. E. M. G. (2017). Protocol for intraoperative assessment of the human cerebrovascular glycocalyx. BMJ Open, 7(1), [013954]. https://doi.org/10.1136/bmjopen-2016-013954
  • 2016
    • Koning, N. J., Vonk, A. B. A., Vink, H., & Boer, C. (2016). Side-by-Side Alterations in Glycocalyx Thickness and Perfused Microvascular Density During Acute Microcirculatory Alterations in Cardiac Surgery. Microcirculation, 23(1), 69-74. https://doi.org/10.1111/micc.12260
    • Haeren, R. H. L., van de Ven, S. E. M., van Zandvoort, M. A. M. J., Vink, H., van Overbeeke, J. J., Hoogland, G., & Rijkers, K. (2016). Assessment and Imaging of the Cerebrovascular Glycocalyx. Current Neurovascular Research, 13(3), 249-260. https://doi.org/10.2174/1567202613666160504104434
  • 2015
    • van Haare, J., Kooi, M. E., Vink, H., Post, M. J., van Teeffelen, J. W. G. E., Slenter, J., Munts, C., Cobelens, H., Strijkers, G. J., Koehn, D., & van Bilsen, M. (2015). Early impairment of coronary microvascular perfusion capacity in rats on a high fat diet. Cardiovascular Diabetology, 14, [150]. https://doi.org/10.1186/s12933-015-0312-2
    • Potter, D. R., van Teeffelen, J., Vink, H., & van den Berg, B. M. (2015). Perturbed mechanotransduction by endothelial surface glycocalyx modification greatly impairs the arteriogenic process. American Journal of Physiology-heart and Circulatory Physiology, 309(4), H711-H717. https://doi.org/10.1152/ajpheart.00257.2015
    • Dane, M. J. C., van den Berg, B. M., Lee, D. H., Boels, M. G. S., Tiemeier, G. L., Avramut, M. C., van Zonneveld, A. J., van der Vlag, J., Vink, H., & Rabelink, T. J. (2015). A microscopic view on the renal endothelial glycocalyx. American Journal of Physiology-Renal Physiology, 308(9), F956-F966. https://doi.org/10.1152/ajprenal.00532.2014
  • 2014
    • Lee, D. H., Dane, M. J. C., van den Berg, B. M., Boels, M. G. S., van Teeffelen, J. W., de Mutsert, R., den Heijer, M., Rosendaal, F. R., van der Vlag, J., van Zonneveld, A. J., Vink, H., & Rabelink, T. J. (2014). Deeper Penetration of Erythrocytes into the Endothelial Glycocalyx Is Associated with Impaired Microvascular Perfusion. PLOS ONE, 9(5), [e96477]. https://doi.org/10.1371/journal.pone.0096477
    • Dane, M. J. C., Khairoun, M., Lee, D. H., van den Berg, B. M., Eskens, B. J. M., Boels, M. G. S., van Teeffelen, J. W. G. E., Rops, A. L. W. M. M., van der Vlag, J., van Zonneveld, A. J., Reinders, M. E. J., Vink, H., & Rabelink, T. J. (2014). Association of Kidney Function with Changes in the Endothelial Surface Layer. Clinical journal of the American Society of Nephrology, 9(4), 698-704. https://doi.org/10.2215/CJN.08160813
    • Cornelis, T., Broers, N. J. H., Titulaer, D. C. L. M., Henskens, Y. M., van Oerle, R., van der Sande, F. M., Spronk, H. M., Vink, H., Leunissen, K. M., ten Cate, H., & Kooman, J. P. (2014). Effects of Ultrapure Hemodialysis and Low Molecular Weight Heparin on the Endothelial Surface Layer. Blood Purification, 38(3-4), 203-210. https://doi.org/10.1159/000369055
    • Donati, A., Damiani, E., Luchetti, M. M., Domizi, R., Scorcella, C., Carsetti, A., Gabbanelli, V., Carletti, P., Bencivenga, R., Vink, H., Adrario, E., Piagnerelli, M., Gabrielli, A., Pelaia, P., & Ince, C. (2014). Microcirculatory effects of the transfusion of leukodepleted or non-leukodepleted red blood cells in patients with sepsis: a pilot study. Critical Care, 18(1), [R33]. https://doi.org/10.1186/cc13730
  • 2013
    • VanTeeffelen, J. W. G. E., Brands, J., Janssen, B. J. A., & Vink, H. (2013). Effect of acute hyaluronidase treatment of the glycocalyx on tracer-based whole body vascular volume estimates in mice. Journal of Applied Physiology, 114(9), 1132-1140. https://doi.org/10.1152/japplphysiol.00842.2012
    • Dane, M. J. C., van den Berg, B. M., Avramut, M. C., Faas, F. G. A., van der Vlag, J., Rops, A. L. W. M. M., Ravelli, R. B. G., Koster, B. J., van Zonneveld, A. J., Vink, H., & Rabelink, T. J. (2013). Glomerular Endothelial Surface Layer Acts as a Barrier against Albumin Filtration. American Journal of Pathology, 182(5), 1532-1540. https://doi.org/10.1016/j.ajpath.2013.01.049
    • Eskens, B. J. M., Mooij, H. L., Cleutjens, J. P. M., Roos, J. M. A., Cobelens, J. E., Vink, H., & VanTeeffelen, J. W. G. E. (2013). Rapid Insulin-Mediated Increase in Microvascular Glycocalyx Accessibility in Skeletal Muscle May Contribute to Insulin-Mediated Glucose Disposal in Rats. PLOS ONE, 8(1), [e55399]. https://doi.org/10.1371/journal.pone.0055399
    • Martens, R. J. H., Vink, H., van Oostenbrugge, R. J., & Staals, J. (2013). Sublingual Microvascular Glycocalyx Dimensions in Lacunar Stroke Patients. Cerebrovascular Diseases, 35(5), 451-454. https://doi.org/10.1159/000348854
  • 2012
    • Vlahu, C. A., Lemkes, B. A., Struijk, D. G., Koopman, M. G., Krediet, R. T., & Vink, H. (2012). Damage of the Endothelial Glycocalyx in Dialysis Patients. Journal of the American Society of Nephrology, 23(11), 1900-1908. https://doi.org/10.1681/ASN.2011121181
    • Pacella, J. J., Kameneva, M. V., Brands, J., Lipowsky, H. H., Vink, H., Lavery, L. L., & Villanueva, F. S. (2012). Modulation of Pre-Capillary Arteriolar Pressure with Drag-Reducing Polymers: A Novel Method for Enhancing Microvascular Perfusion. Microcirculation, 19(7), 580-585. https://doi.org/10.1111/j.1549-8719.2012.00190.x
    • Wijnands - Kentgens, K. A. P., Vink, H., Briedé, J. J., van Faassen, E. E., Lamers, W. H., Buurman, W. A., & Poeze, M. (2012). Citrulline a more suitable substrate than arginine to restore NO production and the microcirculation during endotoxemia. PLOS ONE, 7(5), [e37439]. https://doi.org/10.1371/journal.pone.0037439
  • 2011
    • Brands, J., Vink, H., & Van Teeffelen, J. W. G. E. (2011). Comparison of four mathematical models to analyze indicator-dilution curves in the coronary circulation. Medical & Biological Engineering & Computing, 49(12), 1471-1479. https://doi.org/10.1007/s11517-011-0845-9
    • Lekakis, J., Abraham, P., Balbarini, A., Blann, A., Boulanger, C. M., Cockcroft, J., Cosentino, F., Deanfield, J., Gallino, A., Ikonomidis, I., Kremastinos, D., Landmesser, U., Protogerou, A., Stefanadis, C., Tousoulis, D., Vassalli, G., Vink, H., Werner, N., Wilkinson, I., & Vlachopoulos, C. (2011). Methods for evaluating endothelial function: a position statement from the European Society of Cardiology Working Group on Peripheral Circulation. European Journal of Cardiovascular Prevention & Rehabilitation, 18(6), 775-789. https://doi.org/10.1177/1741826711398179
    • Reitsma, S., Egbrink, M. G. A. O., Heijnen, V. V. T., Megens, R. T. A., Engels, W., Vink, H., Slaaf, D. W., & van Zandvoort, M. A. M. J. (2011). Endothelial glycocalyx thickness and platelet-vessel wall interactions during atherogenesis. Thrombosis and Haemostasis, 106(5), 939-946. https://doi.org/10.1160/TH11-02-0133
    • Broekhuizen, L. N., van Wijk, D. F., Vink, H., Stalmach, A., Crozier, A., Hutten, B. A., Kastelein, J. J. P., Hugenholtz, P. G., Koenig, W., & Stroes, E. S. G. (2011). Reduction of monocyte chemoattractant protein 1 and macrophage migration inhibitory factor by a polyphenol-rich extract in subjects with clustered cardiometabolic risk factors. British Journal of Nutrition, 106(9), 1416-1422. https://doi.org/10.1017/S0007114511002431
    • Constantinescu, A. A., Spaan, J. A. E., Arkenbout, E. K., Vink, H., & VanTeeffelen, J. W. G. E. (2011). Degradation of the endothelial glycocalyx is associated with chylomicron leakage in mouse cremaster muscle microcirculation. Thrombosis and Haemostasis, 105(5), 790-801. https://doi.org/10.1160/TH10-08-0560
    • Reitsma, S., Egbrink, M. G. A. O., Vink, H., van den Berg, B. M., Passos, V. L., Engels, W., Slaaf, D. W., & van Zandvoort, M. A. M. J. (2011). Endothelial Glycocalyx Structure in the Intact Carotid Artery: A Two-Photon Laser Scanning Microscopy Study. Journal of Vascular Research, 48(4), 297-306. https://doi.org/10.1159/000322176
  • 2010
    • Meuwese, M. C., Broekhuizen, L. N., Kuikhoven, M., Heeneman, S., Lutgens, E., Gijbels, M. J. J., Nieuwdorp, M., Peutz, C. J., Stroes, E. S. G., Vink, H., & van den Berg, B. M. (2010). Endothelial Surface Layer Degradation by Chronic Hyaluronidase Infusion Induces Proteinuria in Apolipoprotein E-Deficient Mice. PLOS ONE, 5(12), 7. https://doi.org/10.1371/journal.pone.0014262
    • Broekhuizen, L. N., Lemkes, B. A., Mooij, H. L., Meuwese, M. C., Verberne, H. J., Holleman, F., Schlingemann, R. O., Nieuwdorp, M., Stroes, E. S. G., & Vink, H. (2010). Effect of sulodexide on endothelial glycocalyx and vascular permeability in patients with type 2 diabetes mellitus. Diabetologia, 53(12), 2646-2655. https://doi.org/10.1007/s00125-010-1910-x
    • Snoeijs, M. G., Vink, H., Voesten, N., Christiaans, M. H., Daemen, J. W., Peppelenbosch, A. G., Tordoir, J. H. M., Peutz-Kootstra, C. J., Buurman, W. A., Schurink, G. W. H., & van Heurn, E. L. (2010). Acute ischemic injury to the renal microvasculature in human kidney transplantation.American Journal of Physiology-Renal Physiology, 299(5), F1134-F1140. https://doi.org/10.1152/ajprenal.00158.2010
    • VanTeeffelen, J. W. G. E., Brands, J., & Vink, H. (2010). Agonist-induced impairment of glycocalyx exclusion properties: contribution to coronary effects of adenosine. Cardiovascular Research, 87(2), 311-319. https://doi.org/10.1093/cvr/cvq114
    • Brands, J., Spaan, J. A. E., Van den Berg, B. M., Vink, H., & VanTeeffelen, J. W. G. E. (2010). Acute attenuation of glycocalyx barrier properties increases coronary blood volume independently of coronary flow reserve. American Journal of Physiology-heart and Circulatory Physiology, 298(2), H515-H523. https://doi.org/10.1152/ajpheart.01306.2008