Jack Cleutjens

Associate professor

Dr Jack Cleutjens has been working for Maastricht University since 1985. After finishing his thesis 'Basement membrane heterogeneity' in 1989, he started working in the cardiovascular field as a post-doc on the regulation of the wound healing after myocardial infarction. His main interest is in the area of extracellular matrix remodeling, mainly collagen synthesis and degradation.

His area of focus is education and cardiovascular research. He is a specialist in the field of morphometry and (digital) microscopy. Jack Cleutjens is a member of the Dutch Society of Pathology, Experimental Pathology section and of the Dutch Society for Matrix Biology.

Focus areas:
• Cardiovascular examination
• Extracellular matrix turnover
• Myocardial infarction / atherosclerosis
• (Digital) microscopy
• Morphometry


Department of Pathology
Verheylaan 10, 6229 HX Maastricht
Room number: VH10 5.M1-002
T: +31(0)43 387 66 31

  • 2018
    • Bijnen, M., Beelen, N., Wetzels, S., van De Gaar, J., Vroomen, M., Wijnands, E., Scheijen, J. L., van de Waarenburg, M. P. H., Gijbels, M. J., Cleutjens, J. P., Biessen, E. A. L., Stehouwer, C. D. A., Schalkwijk, C. G., & Wouters, K. (2018). RAGE deficiency does not affect non-alcoholic steatohepatitis and atherosclerosis in Western type diet-fed Ldlr(-/-) mice. Scientific Reports, 8, [15256]. https://doi.org/10.1038/s41598-018-33661-y
    • van den Hil, L. C. L., Vogels, R. R. M., van Barneveld, K. W. Y., Gijbels, M. J. J., Peutz-Kootstra, C. J., Cleutjens, J. P. M., Schreinemacher, M. H. F., & Bouvy, N. D. (2018). Comparability of histological outcomes in rats and humans in a hernia model. Journal of Surgical Research, 229, 271-276. https://doi.org/10.1016/j.jss.2018.03.019
    • Barkhuizen, M., van Dijck, F. J. P., Jellema, R. K., Gussenhoven, R., Engelbertink, I., van Mechele, R., Cleutjens, J. P. M., Seehase, M., Steinbusch, H. W. M., Zimmerman, L. J., Gavilanes, A. W. D., & Kramer, B. W. (2018). The influence of anesthetics on substantia nigra tyrosine hydroxylase expression and tau phosphorylation in the hypoxic-ischemic near-term lamb. Pediatric Research, 83(6), 1190-1199. https://doi.org/10.1038/pr.2018.42
    • Henatsch, D., Alsulami, S., Duijvestijn, A. M., Cleutjens, J. P., Peutz-Kootstra, C. J., & Stokroos, R. J. (2018). Histopathological and Inflammatory Features of Chronically Discharging Open Mastoid Cavities Secondary Analysis of a Randomized Clinical Trial. JAMA Otolaryngology - Head and Neck Surgery, 144(3), 211-217. https://doi.org/10.1001/jamaoto.2017.2801
  • 2017
    • Kessels, J., Voeten, L., Nelemans, P., Cleutjens, J., Hillen, L. M., Mosterd, K., & Kelleners-Smeets, N. W. J. (2017). Topical Sinecatechins, 10%, Ointment for Superficial Basal Cell Carcinoma: A Randomized Clinical Trial. JAMA Dermatology, 153(10), 1061-1063. https://doi.org/10.1001/jamadermatol.2017.2529
    • van Hoof, R. H. M., Voo, S. A., Sluimer, J. C., Wijnen, N. J. A., Hermeling, E., Schreuder, F. H. B. M., Truijman, M. T. B., Cleutjens, J. P. M., Daemen, M. J. A. P., Daemen, J-W. H., van Oostenbrugge, R. J., Mess, W. H., Wildberger, J. E., Heeneman, S., & Kooi, M. E. (2017). Vessel Wall and Adventitial DCE-MRI Parameters Demonstrate Similar Correlations With Carotid Plaque Microvasculature on Histology. Journal of Magnetic Resonance Imaging, 46(4), 1053-1059. https://doi.org/10.1002/jmri.25648
    • Theodorou, K., van der Vorst, E. P. C., Gijbels, M. J., Wolfs, I. M. J., Jeurissen, M., Theelen, T. L., Sluimer, J. C., Wijnands, E., Cleutjens, J. P., Li, Y., Jansen, Y., Weber, C., Ludwig, A., Bentzon, J. F., Bartsch, J. W., Biessen, E. A. L., & Donners, M. M. P. C. (2017). Whole body and hematopoietic ADAM8 deficiency does not influence advanced atherosclerotic lesion development, despite its association with human plaque progression. Scientific Reports, 7, [11670]. https://doi.org/10.1038/s41598-017-10549-x
    • Vink, R. G., Roumans, N. J., Cajlakovic, M., Cleutjens, J. P. M., Boekschoten, M. V., Fazelzadeh, P., Vogel, M. A. A., Blaak, E. E., Mariman, E. C., van Baak, M. A., & Goossens, G. H. (2017). Diet-induced weight loss decreases adipose tissue oxygen tension with parallel changes in adipose tissue phenotype and insulin sensitivity in overweight humans. International Journal of Obesity, 41(5), 722-728. https://doi.org/10.1038/ijo.2017.38
    • Uitterdijk, A., Springeling, T., Hermans, K. C. M., Merkus, D., de Beer, V. J., Gorsse-Bakker, C., Mokelke, E., Daskalopoulos, E. P., Wielopolski, P. A., Cleutjens, J. P. M., Blankesteijn, W. M., Prinzen, F. W., van der Giessen, W. J., van Geuns, R-J. M., & Duncker, D. J. (2017). Intermittent pacing therapy favorably modulates infarct remodeling. Basic Research in Cardiology, 112(3), [28]. https://doi.org/10.1007/s00395-017-0616-3
    • Swarts, D. R. A., Rudelius, M., Claessen, S. M. H., Cleutjens, J. P., Seidl, S., Volante, M., Ramaekers, F. C. S., & Speel, E. J. M. (2017). Limited additive value of the Ki-67 proliferative index on patient survival in World Health Organization-classified pulmonary carcinoids. Histopathology, 70(3), 412-422. https://doi.org/10.1111/his.13096
    • Vanagt, W., Amin, H., Brouwers, A., Pottgens, C. C. H., Wolfs, T., Cleutjens, J., Swennen, Q., Delhaas, T., & Prinzen, F. (2017). Sildenafil Postconditioning in a Rat Model of Ventricular Fibrillation/Resuscitation. Journal of Clinical & Experimental Cardiology, 8(6), 530. https://doi.org/10.4172/2155-9880.1000530
  • 2016
    • Poort, L. J., Kiewiet, C. C., Cleutjens, J. P. M., Houben, R., Hoebers, F. J. P., & Kessler, P. A. W. H. (2016). Osseointegration and implant stability of extraoral implants in Gottingen minipigs after irradiation. Journal of Cranio-Maxillofacial Surgery, 44(11), 1842-1848. https://doi.org/10.1016/j.jcms.2016.08.019
    • Vöö, S., Kwee, R. M., Sluimer, J. C., Schreuder, F. H. B. M., Wierts, R., Bauwens, M., Heeneman, S., Cleutjens, J. P. M., van Oostenbrugge, R. J., Daemen, J-W. H., Daemen, M. J. A. P., Mottaghy, F. M., & Kooi, E. (2016). Imaging Intraplaque Inflammation in Carotid Atherosclerosis With F-18-Fluorocholine Positron Emission Tomography-Computed Tomography Prospective Study on Vulnerable Atheroma With Immunohistochemical Validation. Circulation-Cardiovascular Imaging, 9(5), [e004467]. https://doi.org/10.1161/CIRCIMAGING.115.004467
    • Maessen, D. E., Brouwers, O., Gaens, K. H., Wouters, K., Cleutjens, J. P., Janssen, B. J., Miyata, T., Stehouwer, C. D., & Schalkwijk, C. G. (2016). Delayed Intervention With Pyridoxamine Improves Metabolic Function and Prevents Adipose Tissue Inflammation and Insulin Resistance in High-Fat Diet-Induced Obese Mice. Diabetes, 65(4), 956-966. https://doi.org/10.2337/db15-1390
  • 2015
    • Chatrou, M. L. L., Cleutjens, J. P., van der Vusse, G. J., Roijers, R. B., Mutsaers, P. H. A., & Schurgers, L. J. (2015). Intra-Section Analysis of Human Coronary Arteries Reveals a Potential Role for Micro-Calcifications in Macrophage Recruitment in the Early Stage of Atherosclerosis. PLOS ONE, 10(11), [e0142335]. https://doi.org/10.1371/journal.pone.0142335
    • Medina, I., Cougoule, C., Drechsler, M., Bermudez, B., Koenen, R. R., Sluimer, J., Wolfs, I., Doering, Y., Herias, V., Gijbels, M., Bot, I., de Jager, S. C. A., Weber, C., Cleutjens, J., van Berkel, T. J. C., Sikkink, K-J., Mocsai, A., Maridonneau-Parini, I., Soehnlein, O., & Biessen, E. A. L. (2015). Hck/Fgr Kinase Deficiency Reduces Plaque Growth and Stability by Blunting Monocyte Recruitment and Intraplaque Motility. Circulation, 132(6), 490-501. https://doi.org/10.1161/CIRCULATIONAHA.114.012316
    • Theelen, T. L., Lappalainen, J. P., Sluimer, J. C., Gurzeler, E., Cleutjens, J. P., Gijbels, M. J., Biessen, E. A. L., Daemen, M. J. A. P., Alitalo, K., & Yla-Herttuala, S. (2015). Angiopoietin-2 blocking antibodies reduce early atherosclerotic plaque development in mice. Atherosclerosis, 241(2), 297-304. https://doi.org/10.1016/j.atherosclerosis.2015.05.018
    • Alexander, B. E., Achlatis, M., Osinga, R., van der Geest, H. G., Cleutjens, J. P. M., Schutte, B., & de Goeij, J. M. (2015). Cell kinetics during regeneration in the sponge Halisarca caerulea: how local is the response to tissue damage?PEERJ, 3, [e820]. https://doi.org/10.7717/peerj.820
  • 2014
    • Alexander, B. E., Liebrand, K., Osinga, R., van der Geest, H. G., Admiraal, W., Cleutjens, J. P. M., Schutte, B., Verheyen, F., Ribes, M., van Loon, E., & de Goeij, J. M. (2014). Cell Turnover and Detritus Production in Marine Sponges from Tropical and Temperate Benthic Ecosystems. PLOS ONE, 9(10), [e109486]. https://doi.org/10.1371/journal.pone.0109486
    • Hanssen, N. M. J., Brouwers, O., Gijbels, M. J., Wouters, K., Wijnands, E., Cleutjens, J. P. M., De Mey, J. G., Miyata, T., Biessen, E. A., Stehouwer, C. D. A., & Schalkwijk, C. G. (2014). Glyoxalase 1 overexpression does not affect atherosclerotic lesion size and severity in ApoE(-/-) mice with or without diabetes. Cardiovascular Research, 104(1), 160-170. https://doi.org/10.1093/cvr/cvu189
    • Burgmaier, M., Schutters, K., Willems, B., Van der Vorst, E. P. C., Kusters, D., Chatrou, M., Norling, L., Biessen, E. A. L., Cleutjens, J., Perretti, M., Schurgers, L. J., & Reutelingsperger, C. (2014). AnxA5 reduces plaque inflammation of advanced atherosclerotic lesions in apoE(-/-) mice. Journal of Cellular and Molecular Medicine, 18(10), 2117-2124. https://doi.org/10.1111/jcmm.12374
    • Hoeksema, M. A., Gijbels, M. J. J., Van den Bossche, J., van der Velden, S., Sijm, A., Neele, A. E., Seijkens, T., Stoger, J. L., Meiler, S., Boshuizen, M. C. S., Dallinga-Thie, G. M., Levels, J. H. M., Boon, L., Mullican, S. E., Spann, N. J., Cleutjens, J. P., Glass, C. K., Lazar, M. A., de Vries, C. J. M., ... de Winther, M. P. J. (2014). Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions. EMBO Molecular Medicine, 6(9), 1124-1132. https://doi.org/10.15252/emmm.201404170
    • Eurlings, I. M. J., Dentener, M. A., Cleutjens, J. P. M., Peutz, C. J., Rohde, G. G. U., Wouters, E. F. M., & Reynaert, N. L. (2014). Similar matrix alterations in alveolar and small airway walls of COPD patients. BMC Pulmonary Medicine, 14(1), [90]. https://doi.org/10.1186/1471-2466-14-90
    • Marsch, E., Theelen, T. L., Demandt, J. A., Jeurissen, M., van Gink, M., Verjans, R., Janssen, A., Cleutjens, J. P., Meex, S. J., Donners, M. M., Haenen, G., Schalkwijk, C. G., Dubois, L. J., Lambin, P., Mallat, Z., Gijbels, M. J., Heemskerk, J. W., Fisher, E. A., Biessen, E. A., ... Sluimer, J. C. (2014). Reversal of hypoxia in murine atherosclerosis prevents necrotic core expansion by enhancing efferocytosis. Arteriosclerosis Thrombosis and Vascular Biology, 34(12), 2545-2553. https://doi.org/10.1161/ATVBAHA.114.304023
  • 2013
    • Theys, J., Yahyanejad, S., Habets, R., Span, P., Dubois, L., Paesmans, K., Kattenbeld, B., Cleutjens, J., Groot, A. J., Schuurbiers, O. C. J., Lambin, P., Bussink, J., & Vooijs, M. (2013). High NOTCH activity induces radiation resistance in non small cell lung cancer. Radiotherapy and Oncology, 108(3), 440-445. https://doi.org/10.1016/j.radonc.2013.06.020
    • Jetten, N., Donners, M. M. P. C., Wagenaar, A., Cleutjens, J. P. M., van Rooijen, N., de Winther, M. P. J., & Post, M. J. (2013). Local Delivery of Polarized Macrophages Improves Reperfusion Recovery in a Mouse Hind Limb Ischemia Model. PLOS ONE, 8(7), [e68811]. https://doi.org/10.1371/journal.pone.0068811
    • Eskens, B. J. M., Mooij, H. L., Cleutjens, J. P. M., Roos, J. M. A., Cobelens, J. E., Vink, H., & VanTeeffelen, J. W. G. E. (2013). Rapid Insulin-Mediated Increase in Microvascular Glycocalyx Accessibility in Skeletal Muscle May Contribute to Insulin-Mediated Glucose Disposal in Rats. PLOS ONE, 8(1), [e55399]. https://doi.org/10.1371/journal.pone.0055399
    • Jellema, R. K., Passos, V. L., Zwanenburg, A., Ophelders, D. R. M. G., De Munter, S., Vanderlocht, J., Germeraad, W. T. V., Kuypers, E., Collins, J. J. P., Cleutjens, J. P. M., Jennekens, W., Gavilanes, A. W. D., Seehase, M., Vles, H. J., Steinbusch, H., Andriessen, P., Wolfs, T. G. A. M., & Kramer, B. W. (2013). Cerebral inflammation and mobilization of the peripheral immune system following global hypoxia-ischemia in preterm sheep. Journal of Neuroinflammation, 10, [13]. https://doi.org/10.1186/1742-2094-10-13
    • Gaens, M. E., Backes, W. H., Rozel, S., Lipperts, M., Sanders, S. N., Jaspers, K., Cleutjens, J. P. M., Sluimer, J. C., Heeneman, S., Daemen, M. J. A. P., Welten, R. J., Daemen, J. W., Wildberger, J. E., Kwee, R. M., & Kooi, M. E. (2013). Dynamic Contrast-enhanced MR Imaging of Carotid Atherosclerotic Plaque: Model Selection, Reproducibility, and Validation.Radiology, 266(1), 271-279. https://doi.org/10.1148/radiol.12120499
  • 2012
    • Hoving, S., Heeneman, S., Gijbels, M. J. J., Poele, J. A. M. T., Visser, N. L., Cleutjens, J., Russell, N. S., Daemen, M. J. A. P., & Stewart, F. A. (2012). Irradiation induces different inflammatory and thrombotic responses in carotid arteries of wildtype C57BL/6J and atherosclerosis-prone ApoE(-/-) mice. Radiotherapy and Oncology, 105(3), 365-370. https://doi.org/10.1016/j.radonc.2012.11.001
    • Collins, J. J. P., Kuypers, E., Nitsos, I., Pillow, J. J., Polglase, G. R., Kemp, M. W., Newnham, J. P., Cleutjens, J. P., Frints, S. G. M., Kallapur, S. G., Jobe, A. H., & Kramer, B. W. (2012). LPS-induced chorioamnionitis and antenatal corticosteroids modulate Shh signaling in the ovine fetal lung. American Journal of Physiology-Lung Cellular and Molecular Physiology, 303(9), L778-L787. https://doi.org/10.1152/ajplung.00280.2011
    • Goossens, G. H., Moors, C. C., van der Zijl, N. J., Venteclef, N., Alili, R., Jocken, J. W., Essers, Y., Cleutjens, J. P. M., Clement, K., Diamant, M., & Blaak, E. E. (2012). Valsartan improves adipose tissue function in humans with impaired glucose metabolism: a randomized placebo-controlled double-blind trial. PLOS ONE, 7(6), [39930]. https://doi.org/10.1371/journal.pone.0039930
  • 2011
    • Poggi, M., Engel, D., Christ, A., Beckers, L., Wijnands, E., Boon, L., Driessen, A., Cleutjens, J., Weber, C., Gerdes, N., & Lutgens, E. (2011). CD40L Deficiency Ameliorates Adipose Tissue Inflammation and Metabolic Manifestations of Obesity in Mice. Arteriosclerosis Thrombosis and Vascular Biology, 31(10), 2251-U248. https://doi.org/10.1161/ATVBAHA.111.231357
    • van Almen, G. C., Verhesen, W., van Leeuwen, R. E. W., van de Vrie, M., Eurlings, C., Schellings, M. W. M., Swinnen, M., Cleutjens, J. P. M., van Zandvoort, M. A. M. J., Heymans, S., & Schroen, B. (2011). MicroRNA-18 and microRNA-19 regulate CTGF and TSP-1 expression in age-related heart failure. Aging Cell, 10(5), 769-779. https://doi.org/10.1111/j.1474-9726.2011.00714.x
    • van Almen, G. C., Swinnen, M., Carai, P., Verhesen, W., Cleutjens, J. P. M., D'hooge, J., Verheyen, F. K., Pinto, Y. M., Schroen, B., Carmeliet, P., & Heymans, S. (2011). Absence of thrombospondin-2 increases cardiomyocyte damage and matrix disruption in doxorubicin-induced cardiomyopathy. Journal of Molecular and Cellular Cardiology, 51(3), 318-328. https://doi.org/10.1016/j.yjmcc.2011.05.010
    • Goossens, G. H., Bizzarri, A., Venteclef, N., Essers, Y., Cleutjens, J. P. M., Konings, E., Jocken, J. W., Cajlakovic, M., Ribitsch, V., Clement, K., & Blaak, E. E. (2011). Increased adipose tissue oxygen tension in obese compared with lean men is accompanied by insulin resistance, impaired adipose tissue capillarization, and inflammation. Circulation, 124(1), 67-76. https://doi.org/10.1161/CIRCULATIONAHA.111.027813
    • Steegh, F. M., Gelens, M. A., Nieman, F. H. M., van Hooff, J. P., Cleutjens, J. P., van Suylen, R. J., Daemen, M. J., van Heurn, E. L., Christiaans, M. H., & Peutz-Kootstra, C. J. (2011). Early loss of peritubular capillaries after kidney transplantation.Journal of the American Society of Nephrology, 22(6), 1024-1029. https://doi.org/10.1681/ASN.2010050531
    • Roijers, R. B., Debernardi, N., Cleutjens, J. P. M., Schurgers, L. J., Mutsaers, P. H. A., & van der Vusse, G. J. (2011). Microcalcifications in Early Intimal Lesions of Atherosclerotic Human Coronary Arteries. American Journal of Pathology, 178(6), 2879-2887. https://doi.org/10.1016/j.ajpath.2011.02.004
  • 2010
    • Daniels, A., van Bilsen, M., Janssen, B. J. A., Brouns, A. E., Cleutjens, J. P. M., Roemen, T. H., Schaart, G., van der Velden, J., van der Vusse, G. J., & van Nieuwenhoven, F. A. (2010). Impaired cardiac functional reserve in type 2 diabetic db/db mice is associated with metabolic, but not structural, remodelling. Acta Physiologica, 200(1), 11-22. https://doi.org/10.1111/j.1748-1716.2010.02102.x
    • Babiker, F. A., Lorenzen-Schmidt, I., Mokelke, E., Vanagt, W. Y., Delhaas, T., Waltenberger, J., Cleutjens, J. P., & Prinzen, F. W. (2010). Long-term protection and mechanism of pacing-induced postconditioning in the heart. Basic Research in Cardiology, 105(4), 523-533. https://doi.org/10.1007/s00395-010-0095-2
    • Lutgens, E., Lievens, D., Beckers, L., Wijnands, E., Soehnlein, O., Zernecke, A., Seijkens, T., Engel, D., Cleutjens, J., Keller, A. M., Naik, S. H., Boon, L., Oufella, H. A., Mallat, Z., Ahonen, C. L., Noelle, R. J., de Winther, M. P., Daemen, M. J. A. P., Biessen, E. A., & Weber, C. (2010). Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile. Journal of Experimental Medicine, 207(2), 391-404. https://doi.org/10.1084/jem.20091293
  • 2009
    • Debats, I. B., Wolfs, T. G., Gotoh, T., Cleutjens, J. P., Kootstra, C. J., & van der Hulst, R. R. (2009). Role of arginine in superficial wound healing in man.Nitric Oxide-Biology and Chemistry, 21(3-4), 175-183. https://doi.org/10.1016/j.niox.2009.07.006
  • 2004
    • Lutgens, L. C. H. W., Deutz, N., Granzier-Peeters, M., Beets-Tan, R. G. H., de Ruysscher, D. K. M., Gueulette, J., Cleutjens, J. P. M., Berger, M. P. F., Wouters, B. G., von Meyenfeldt, M. F., & Lambin, P. (2004). Plasma citrulline concentration: a surrogate end point for radiation-induced mucosal atrophy of the small bowel. A feasibility study in 23 patients.International Journal of Radiation Oncology Biology Physics, 60(1), 275-85. https://doi.org/10.1016/j.ijrobp.2004.02.052
  • 2003
    • Lutgens, L. C. H. W., Deutz, N. E. P., Gueulette, J., Cleutjens, J. P. M., Berger, M. P. F., Wouters, B. G., von Meyenfeldt, M. F., & Lambin, P. (2003). Citrulline: a physiologic marker enabling quantitation and monitoring of epithelial radiation-induced small bowel damage. International Journal of Radiation Oncology Biology Physics, 57(4), 1067-1074. https://doi.org/10.1016/S0360-3016(03)00781-8