Marc van Zandvoort

Professor

Prof. Marc A.M.J. van Zandvoort achieved his PhD degree in Biophysics at Utrecht University (1994) and worked as a postdoc at Universitá di Bologna and LENS institute, Florence (Italy). He returned to Utrecht University as a postdoc in 1996. In 1998, he moved to Maastricht University first as postdoc, from 2000 as assistant professor Biophysics. In 2007, he became associate professor at the department of Biomedical Engineering. In 2012, he moved to the department of Molecular Cell Biology. Currently, he is interim head of that department. In 2017 he obtained the chair 'Advanced Optical Microscopy' in Maastricht.

In 2009, he became professor Biophysics of Microscopy (part-time) at the Universitätsklinikum Aachen (Germany) and scientific leader of the Two-photon core-facility in Aachen.

He is board member of the conference series Focus on Microscopy, board member of the Dutch Society of Microscopy, and board member of the NL-BioImaging-AM initiative. He also is leader of the EuroBioImaging Node Maastricht.

His research currently zooms on the application of advanced optical microscopy (multi-photon, high-resolution 3D-STED microscopy, spectral microscopy) to biomedical cardiovascular and oncological questions. As an example, his group recently developed a method to measure mouse carotid plaque microvessel functionality using in vivo multi-photon microscopy. He has also done a variety of studies on bimodal (e.g., optical-MRI, optical-US) imaging. In combination with the techniques used, a variety of systems can be studied, ranging from artificial systems, via cells in culture (e.g., lamin substructure, mitochondrial network and substructure), to whole tissues, organs, and animals.

He has tutored both scientists with background in physics and biomedical research. He is an experienced teacher for a wide range of students (medicine, biomedical engineering, science students) and in a variety of roles (mentor, tutor, internship). His research group currently encompasses technicians, PhD students and postdocs in Maastricht and Aachen. Finally, he has been organising the TripleM PhD/Postdoc course and conference series in Maastricht.

Department of Molecular Cell Biology
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
T: +31 (0)43 388 13 61

2017
- Haeren, R. H. L., Vink, H., Staals, J., van Zandvoort, M. A. M. J., Dings, J., van Overbeeke, J. J., Hoogland, G., Rijkers, K., & Schijns, O. E. M. G. (2017). Protocol for intraoperative assessment of the human cerebrovascular glycocalyx. BMJ Open, 7(1), Article 013954. https://doi.org/10.1136/bmjopen-2016-013954
2016
- Gemmink, A., Bosma, M., Kuijpers, H. J. H., Hoeks, J., Schaart, G., van Zandvoort, M., Schrauwen, P., & Hesselink, M. K. C. (2016). Decoration of intramyocellular lipid droplets with PLIN5 modulates fasting-induced insulin resistance and lipotoxicity in humans. Diabetologia, 59(5), 1040–1048. https://doi.org/10.1007/s00125-016-3865-z
- Daemen, S., van Zandvoort, M. A. M. J., Parekh, S. H., & Hesselink, M. K. C. (2016). Microscopy tools for the investigation of intracellular lipid storage and dynamics. Molecular Metabolism, 5(3), 153-163. https://doi.org/10.1016/j.molmet.2015.12.005
- Schueth, A., Spronck, B., van Zandvoort, M. A. M. J., & van Koeveringe, G. A. (2016). Age-related changes in murine bladder structure and sensory innervation: a multiphoton microscopy quantitative analysis. Age, 38(1), Article 17. https://doi.org/10.1007/s11357-016-9878-1
- Haeren, R. H. L., van de Ven, S. E. M., van Zandvoort, M. A. M. J., Vink, H., van Overbeeke, J. J., Hoogland, G., & Rijkers, K. (2016). Assessment and Imaging of the Cerebrovascular Glycocalyx. Current Neurovascular Research, 13(3), 249-260. https://doi.org/10.2174/1567202613666160504104434
2015
- Jurak, E., Patyshakuliyeva, A., Kapsokalyvas, D., Xing, L., van Zandvoort, M. A. M. J., de Vries, R. P., Gruppen, H., & Kabel, M. A. (2015). Accumulation of recalcitrant xylan in mushroom-compost is due to a lack of xylan substituent removing enzyme activities of Agaricus bisporus. Carbohydrate Polymers, 132, 359-368. https://doi.org/10.1016/j.carbpol.2015.06.065
- Curaj, A., Wu, Z., Fokong, S., Liehn, E. A., Weber, C., Burlacu, A., Lammers, T., van Zandvoort, M., & Kiessling, F. (2015). Noninvasive Molecular Ultrasound Monitoring of Vessel Healing After Intravascular Surgical Procedures in a Preclinical Setup. Arteriosclerosis Thrombosis and Vascular Biology, 35(6), 1366-1373. https://doi.org/10.1161/ATVBAHA.114.304857
- Lammers, T., Koczera, P., Fokong, S., Gremse, F., Ehling, J., Vogt, M., Pich, A., Storm, G., van Zandvoort, M., & Kiessling, F. (2015). Theranostic USPIO-Loaded Microbubbles for Mediating and Monitoring Blood-Brain Barrier Permeation. Advanced Functional Materials, 25(1), 36-43. https://doi.org/10.1002/adfm.201401199
- Mertens, M. E., Koch, S., Schuster, P., Wehner, J., Wu, Z., Gremse, F., Schulz, V., Rongen, L., Wolf, F., Frese, J., Gesche, V. N., van Zandvoort, M., Mela, P., Jockenhoevel, S., Kiessling, F., & Lammers, T. (2015). USPIO-labeled textile materials for non-invasive MR imaging of tissue-engineered vascular grafts. Biomaterials, 39, 155-163. https://doi.org/10.1016/j.biomaterials.2014.10.076
- Shi, Y., Kunjachan, S., Wu, Z., Gremse, F., Moeckel, D., van Zandvoort, M., Kiessling, F., Storm, G., van Nostrum, C. F., Hennink, W. E., & Lammers, T. (2015). Fluorophore labeling of core-crosslinked polymeric micelles for multimodal in vivo and ex vivo optical imaging. Nanomedicine, 10(7), 1111-1125. https://doi.org/10.2217/NNM.14.170
2014
- de Jong, S., van Middendorp, L. B., Hermans, R. H. A., de Bakker, J. M. T., Bierhuizen, M. F. A., Prinzen, F. W., van Rijen, H. V. M., Losen, M., Vos, M. A., & van Zandvoort, M. A. M. J. (2014). Ex Vivo and In Vivo Administration of Fluorescent CNA35 Specifically Marks Cardiac Fibrosis. Molecular Imaging, 13. https://doi.org/10.2310/7290.2014.00036
- Schueth, A., van Zandvoort, M. A. M. J., Buurman, W. A., & van Koeveringe, G. A. (2014). Murine bladder imaging by 2-photon microscopy: an experimental study of morphology. Journal of Urology, 192(3), 973-980. https://doi.org/10.1016/j.juro.2014.03.103
- Kapsokalyvas, D., Schiffers, P. M. H., Maij, N., Suylen, D. P., Hackeng, T. M., van Zandvoort, M. A. M. J., & De Mey, J. G. R. (2014). Imaging evidence for endothelin ETA/ETB receptor heterodimers in isolated rat mesenteric resistance arteries. Life Sciences, 111(1-2), 36-41. https://doi.org/10.1016/j.lfs.2014.07.007
- Sadat, U., Jaffer, F. A., van Zandvoort, M. A. M. J., Nicholls, S. J., Ribatti, D., & Gillard, J. H. (2014). Inflammation and Neovascularization Intertwined in Atherosclerosis Imaging of Structural and Molecular Imaging Targets. Circulation, 130(9), 786-794. https://doi.org/10.1161/CIRCULATIONAHA.114.010369
- Angin, Y., Schwenk, R. W., Nergiz-Unal, R., Hoebers, N., Heemskerk, J. W. M., Kuijpers, M. J., Coumans, W. A., van Zandvoort, M. A. M. J., Bonen, A., Neumann, D., Glatz, J. F. C., & Luiken, J. (2014). Calcium signaling recruits substrate transporters GLUT4 and CD36 to the sarcolemma without increasing cardiac substrate uptake. American Journal of Physiology : Endocrinology and Metabolism, 307(2), E225-E236. https://doi.org/10.1152/ajpendo.00655.2013
- Weinandy, S., Laffar, S., Unger, R. E., Flanagan, T. C., Loesel, R., Kirkpatrick, C. J., van Zandvoort, M., Hermanns-Sachweh, B., Dreier, A., Klee, D., & Jockenhoevel, S. (2014). Biofunctionalized Microfiber-Assisted Formation of Intrinsic Three-Dimensional Capillary-Like Structures. Tissue Engineering, 20(13-14), 1858-1869. https://doi.org/10.1089/ten.tea.2013.0330
- Lemmens, K. J., van de Wier, B., Vaes, N., Ghosh, M., van Zandvoort, M. A., van der Vijgh, W., Bast, A., & Haenen, G. R. (2014). The flavonoid 7-mono-O-(beta-hydroxyethyl)-rutoside is able to protect endothelial cells by a direct antioxidant effect. Toxicology in Vitro, 28(4), 538-543. https://doi.org/10.1016/j.tiv.2013.12.019
- Dittmar, R., van Dijk, B. G. M., van Zandvoort, M. A. M. J., & Ito, K. (2014). In Situ Label-Free Cell Viability Assessment of Nucleus Pulposus Tissue. Journal of Orthopaedic Research, 32(4), 545-550. https://doi.org/10.1002/jor.22576
- Li, X., Zhu, M., Penfold, M. E., Koenen, R. R., Thiemann, A., Heyll, K., Akhtar, S., Koyadan, S., Wu, Z., Gremse, F., Kiessling, F., van Zandvoort, M., Schall, T. J., Weber, C., & Schober, A. (2014). Activation of CXCR7 Limits Atherosclerosis and Improves Hyperlipidemia by Increasing Cholesterol Uptake in Adipose Tissue. Circulation, 129(11), 1244-1253. https://doi.org/10.1161/CIRCULATIONAHA.113.006840
- Campos, D. F. D., Vogt, M., Lindner, M., Kirsten, A., Weber, M., Megens, R. T. A., Pyta, J., Zenke, M., Van Zandvoort, M., & Fischer, H. (2014). Two-Photon Laser Scanning Microscopy as a Useful Tool for Imaging and Evaluating Macrophage-, IL-4 Activated Macrophage-and Osteoclast-based In Vitro Degradation of Beta-Tricalcium Phosphate Bone Substitute Material. Microscopy Research and Technique, 77(2), 143-152. https://doi.org/10.1002/jemt.22321
- Wijnands, K. A., Hoeksema, M. A., Meesters, D. M., van den Akker, N. M., Molin, D. G., Briede, J. J., Ghosh, M., Kohler, S. E., van Zandvoort, M. A., de Winther, M. P., Buurman, W. A., Lamers, W. H., & Poeze, M. (2014). Arginase-1 Deficiency Regulates Arginine Concentrations and NOS2-Mediated NO Production during Endotoxemia. PLOS ONE, 9(1), Article e86135. https://doi.org/10.1371/journal.pone.0086135
- Schmitt, M. M. N., Megens, R. T. A., Zernecke, A., Bidzhekov, K., van den Akker, N. M., Rademakers, T., van Zandvoort, M. A., Hackeng, T. M., Koenen, R. R., & Weber, C. (2014). Endothelial Junctional Adhesion Molecule-A Guides Monocytes Into Flow-Dependent Predilection Sites of Atherosclerosis. Circulation, 129(1), 66–76. https://doi.org/10.1161/CIRCULATIONAHA.113.004149
- Gaens, K. H., Goossens, G. H., Niessen, P. M., van Greevenbroek, M. M., van der Kallen, C. J., Niessen, H. W., Rensen, S. S., Buurman, W. A., Greve, J. W., Blaak, E. E., van Zandvoort, M. A., Bierhaus, A., Stehouwer, C. D., & Schalkwijk, C. G. (2014). Nε-(Carboxymethyl)lysine-Receptor for Advanced Glycation End Product Axis Is a Key Modulator of Obesity-Induced Dysregulation of Adipokine Expression and Insulin Resistance. Arteriosclerosis Thrombosis and Vascular Biology, 34(6), 1199-1208. https://doi.org/10.1161/ATVBAHA.113.302281
2013
- Wu, Z., Curaj, A., Fokong, S., Liehn, E. A., Weber, C., Lammers, T., Kiessling, F., & van Zandvoort, M. (2013). Rhodamine-Loaded Intercellular Adhesion Molecule-1-targeted Microbubbles for Dual-Modality Imaging Under Controlled Shear Stresses. Circulation-Cardiovascular Imaging, 6(6), 974-981. https://doi.org/10.1161/CIRCIMAGING.113.000805
- Rademakers, T., Douma, K., Hackeng, T. M., Post, M. J., Sluimer, J. C., Daemen, M. J. A. P., Biessen, E. A. L., Heeneman, S., & van Zandvoort, M. A. M. J. (2013). Plaque-Associated Vasa Vasorum in Aged Apolipoprotein E-Deficient Mice Exhibit Proatherogenic Functional Features In Vivo. Arteriosclerosis Thrombosis and Vascular Biology, 33(2), 249–256. https://doi.org/10.1161/ATVBAHA.112.300087
- Wolters, M., van Hoof, R. H., Wagenaar, A., Douma, K., van Zandvoort, M. A., Hackeng, T. M., Post, M. J., Backes, W. H., & Kooi, M. E. (2013). MRI artifacts in the ferric chloride thrombus animal model: an alternative solution: preventing MRI artifacts after thrombus induction with a non-ferromagnetic Lewis acid. Journal of Thrombosis and Haemostasis, 11(9), 1766-1769. https://doi.org/10.1111/jth.12340
- Ghosh, M., van den Akker, N. M., Wijnands, K. A., Poeze, M., Weber, C., McQuade, L. E., Pluth, M. D., Lippard, S. J., Post, M. J., Molin, D. G., & van Zandvoort, M. A. (2013). Specific visualization of nitric oxide in the vasculature with two-photon microscopy using a copper based fluorescent probe. PLOS ONE, 8(9), Article e75331. https://doi.org/10.1371/journal.pone.0075331
2012
- Angin, Y., Steinbusch, L. K. M., Simons, P. J., Greulich, S., Hoebers, N. T. H., Douma, K., van Zandvoort, M. A. M. J., Coumans, W. A., Wijnen, W., Diamant, M., Ouwens, D. M., Glatz, J. F. C., & Luiken, J. J. F. P. (2012). CD36 inhibition prevents lipid accumulation and contractile dysfunction in rat cardiomyocytes. Biochemical Journal, 448, 43-53. https://doi.org/10.1042/BJ20120060
- Fokong, S., Theek, B., Wu, Z., Koczera, P., Appold, L., Jorge, S., Resch-Genger, U., van Zandvoort, M., Storm, G., Kiessling, F., & Lammers, T. (2012). Image-guided, targeted and triggered drug delivery to tumors using polymer-based microbubbles. Journal of Controlled Release, 163(1), 75-81. https://doi.org/10.1016/j.jconrel.2012.05.007
- Rahimi, N., Molin, D. G., Cleij, T. J., van Zandvoort, M. A., & Post, M. J. (2012). Electrosensitive Polyacrylic Acid/Fibrin Hydrogel Facilitates Cell Seeding and Alignment. Biomacromolecules, 13(5), 1448-1457. https://doi.org/10.1021/bm300161r
- Dittmar, R., Potier, E., van Zandvoort, M., & Ito, K. (2012). Assessment of Cell Viability in Three-Dimensional Scaffolds Using Cellular Auto-Fluorescence. Tissue Engineering. Part C. Methods , 18(3), 198-204. https://doi.org/10.1089/ten.tec.2011.0334
- Megens, R. T. A., Vijayan, S., Lievens, D., Doering, Y., van Zandvoort, M. A. M. J., Grommes, J., Weber, C., & Soehnlein, O. (2012). Presence of luminal neutrophil extracellular traps in atherosclerosis. Thrombosis and Haemostasis, 107(3), 597-598. https://doi.org/10.1160/TH11-09-0650
2011
- Reitsma, S., Egbrink, M. G. A. O., Heijnen, V. V. T., Megens, R. T. A., Engels, W., Vink, H., Slaaf, D. W., & van Zandvoort, M. A. M. J. (2011). Endothelial glycocalyx thickness and platelet-vessel wall interactions during atherogenesis. Thrombosis and Haemostasis, 106(5), 939-946. https://doi.org/10.1160/TH11-02-0133
- Laeremans, H., Hackeng, T. M., van Zandvoort, M. A. M. J., Thijssen, V. L. J. L., Janssen, B. J. A., Ottenheijm, H. C. J., Smits, J. F. M., & Blankesteijn, W. M. (2011). Blocking of Frizzled Signaling With a Homologous Peptide Fragment of Wnt3a/Wnt5a Reduces Infarct Expansion and Prevents the Development of Heart Failure After Myocardial Infarction. Circulation, 124(15), 1626-U107. https://doi.org/10.1161/CIRCULATIONAHA.110.976969
- Soehnlein, O., Wantha, S., Simsekyilmaz, S., Doering, Y., Megens, R. T. A., Mause, S. F., Drechsler, M., Smeets, R., Weinandy, S., Schreiber, F., Gries, T., Jockenhoevel, S., Moeller, M., Vijayan, S., van Zandvoort, M. A. M. J., Agerberth, B., Pham, C. C. T. N., Gallo, R. L., Hackeng, T. M., ... Weber, C. (2011). Neutrophil-Derived Cathelicidin Protects from Neointimal Hyperplasia. Science Translational Medicine, 3(103), 10. https://doi.org/10.1126/scitranslmed.3002531
- van Almen, G. C., Verhesen, W., van Leeuwen, R. E. W., van de Vrie, M., Eurlings, C., Schellings, M. W. M., Swinnen, M., Cleutjens, J. P. M., van Zandvoort, M. A. M. J., Heymans, S., & Schroen, B. (2011). MicroRNA-18 and microRNA-19 regulate CTGF and TSP-1 expression in age-related heart failure. Aging Cell, 10(5), 769-779. https://doi.org/10.1111/j.1474-9726.2011.00714.x
- Weber, C., Meiler, S., Doering, Y., Koch, M., Drechsler, M., Megens, R. T. A., Rowinska, Z., Bidzhekov, K., Fecher, C., Ribechini, E., van Zandvoort, M. A. M. J., Binder, C. J., Jelinek, I., Hristov, M., Boon, L., Jung, S., Korn, T., Lutz, M. B., Foerster, I., ... Zernecke, A. (2011). CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice. Journal of Clinical Investigation, 121(7), 2898-2910. https://doi.org/10.1172/JCI44925
- Zhou, Z., Subramanian, P., Sevilmis, G., Globke, B., Soehnlein, O., Karshovska, E., Megens, R., Heyll, K., Chun, J., Saulnier-Blache, J. S., Reinholz, M., van Zandvoort, M., Weber, C., & Schobert, A. (2011). Lipoprotein-Derived Lysophosphatidic Acid Promotes Atherosclerosis by Releasing CXCL1 from the Endothelium. Cell Metabolism, 13(5), 592-600. https://doi.org/10.1016/j.cmet.2011.02.016
- Reitsma, S., Egbrink, M. G. A. O., Vink, H., van den Berg, B. M., Passos, V. L., Engels, W., Slaaf, D. W., & van Zandvoort, M. A. M. J. (2011). Endothelial Glycocalyx Structure in the Intact Carotid Artery: A Two-Photon Laser Scanning Microscopy Study. Journal of Vascular Research, 48(4), 297-306. https://doi.org/10.1159/000322176
- Douma, K., Megens, R. T. A., & van Zandvoort, M. A. M. J. (2011). Optical molecular imaging of atherosclerosis using nanoparticles: shedding new light on the darkness. Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology, 3(4), 376-388. https://doi.org/10.1002/wnan.139
2010
- Drechsler, M., Megens, R. T. A., van Zandvoort, M., Weber, C., & Soehnlein, O. (2010). Hyperlipidemia-Triggered Neutrophilia Promotes Early Atherosclerosis. Circulation, 122(18), 1837–1845. https://doi.org/10.1161/CIRCULATIONAHA.110.961714
- Subramanian, P., Karshovska, E., Reinhard, P., Megens, R. T. A., Zhou, Z., Akhtar, S., Schumann, U., Li, X., van Zandvoort, M., Ludin, C., Weber, C., & Schober, A. (2010). Lysophosphatidic Acid Receptors LPA1 and LPA3 Promote CXCL12-Mediated Smooth Muscle Progenitor Cell Recruitment in Neointima Formation. Circulation Research, 107(1), 96-U197. https://doi.org/10.1161/CIRCRESAHA.109.212647
- Langer, H. F., von der Ruhr, J. W., Daub, K., Schoenberger, T., Stellos, K., May, A. E., Schnell, H., Gauss, A., Hafner, R., Lang, P., Schumm, M., Buehring, H.-J., Klingel, K., Conrad, S., Schaller, M., van Zandvoort, M., Jung, G., Dimmeler, S., Skutella, T., & Gawaz, M. (2010). Capture of endothelial progenitor cells by a bispecific protein/monoclonal antibody molecule induces reendothelialization of vascular lesions. Journal of Molecular Medicine, 88(7), 687-699. https://doi.org/10.1007/s00109-010-0614-5
- Oostendorp, M., Douma, K., Hackeng, T. M., Post, M. J., van Zandvoort, M. A. M. J., & Backes, W. H. (2010). Gadolinium-Labeled Quantum Dots for Molecular Magnetic Resonance Imaging: R-1 Versus R-2 Mapping. Magnetic Resonance in Medicine, 64(1), 291-298. https://doi.org/10.1002/mrm.22342
- Meens, M. J. P. M. T., Compeer, M. G., Hackeng, T. M., van Zandvoort, M. A., Janssen, B. J. A., & De Mey, J. G. R. (2010). Stimuli of Sensory-Motor Nerves Terminate Arterial Contractile Effects of Endothelin-1 by CGRP and Dissociation of ET-1/ETA-Receptor Complexes. PLOS ONE, 5(6), 11. https://doi.org/10.1371/journal.pone.0010917
- Douma, K., Oostendorp, M., Slaaf, D. W., Post, M. J., Backes, W. H., & van Zandvoort, M. A. M. J. (2010). Evaluation of Magnetic Resonance Vessel Size Imaging by Two-Photon Laser Scanning Microscopy. Magnetic Resonance in Medicine, 63(4), 930-939. https://doi.org/10.1002/mrm.22248

Overview

Latest news & events

Professorship Julie Staals

22 April 2024

ERC Advanced Grant awarded to Prof. Andy Baker

15 April 2024

Marc van Zandvoort

Professor