Marc van Zandvoort


Prof. Marc A.M.J. van Zandvoort achieved his PhD degree in Biophysics at Utrecht University (1994) and worked as a postdoc at Universitá di Bologna and LENS institute, Florence (Italy). He returned to Utrecht University as a postdoc in 1996. In 1998, he moved to Maastricht University first as postdoc, from 2000 as assistant professor Biophysics. In 2007, he became associate professor at the department of Biomedical Engineering. In 2012, he moved to the department of Molecular Cell Biology. Currently, he is interim head of that department. In 2017 he obtained the chair 'Advanced Optical Microscopy' in Maastricht.

In 2009, he became professor Biophysics of Microscopy (part-time) at the Universitätsklinikum Aachen (Germany) and scientific leader of the Two-photon core-facility in Aachen.

He is board member of the conference series Focus on Microscopy, board member of the Dutch Society of Microscopy, and board member of the NL-BioImaging-AM initiative. He also is leader of the EuroBioImaging Node Maastricht.

His research currently zooms on the application of advanced optical microscopy (multi-photon, high-resolution 3D-STED microscopy, spectral microscopy) to biomedical cardiovascular and oncological questions. As an example, his group recently developed a method to measure mouse carotid plaque microvessel functionality using in vivo multi-photon microscopy. He has also done a variety of studies on bimodal (e.g., optical-MRI, optical-US) imaging. In combination with the techniques used, a variety of systems can be studied, ranging from artificial systems, via cells in culture (e.g., lamin substructure, mitochondrial network and substructure), to whole tissues, organs, and animals.

He has tutored both scientists with background in physics and biomedical research. He is an experienced teacher for a wide range of students (medicine, biomedical engineering, science students) and in a variety of roles (mentor, tutor, internship). His research group currently encompasses technicians, PhD students and postdocs in Maastricht and Aachen. Finally, he has been organising the TripleM PhD/Postdoc course and conference series in Maastricht.

Department of Molecular Cell Biology
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
T: +31 (0)43 388 13 61

  • 2020
    • Stiekema, M., van Zandvoort, M. A. M. J., Ramaekers, F. C. S., & Broers, J. L. (2020). Structural and Mechanical Aberrations of the Nuclear Lamina in Disease. Cells, 9(8), [1884].
    • Kapsokalyvas, D., Loos, J., Boogers, I. A. L. A., Appeldoorn, M. M., Kabel, M. A., & Van Zandvoort, M. (2020). Quantification of morphochemical changes during in situ enzymatic hydrolysis of individual biomass particles based on autofluorescence imaging. Biopolymers, 111(3), [e23347].
    • Gomez, I., Ward, B., Souilhol, C., Recarti, C., Ariaans, M., Johnston, J., Burnett, A., Mahmoud, M., Le Anh Luong, West, L., Long, M., Parry, S., Woods, R., Hulston, C., Benedikter, B., Niespolo, C., Bazaz, R., Francis, S., Kiss-Toth, E., ... Ridger, V. (2020). Neutrophil microvesicles drive atherosclerosis by delivering miR-155 to atheroprone endothelium. Nature Communications, 11(1), [214].
  • 2019
    • Vig, S., Buitinga, M., Rondas, D., Crevecoeur, I., van Zandvoort, M., Waelkens, E., Eizirik, D. L., Gysemans, C., Baatsen, P., Mathieu, C., & Overbergh, L. (2019). Cytokine-induced translocation of GRP78 to the plasma membrane triggers a pro-apoptotic feedback loop in pancreatic beta cells. Cell Death & Disease, 10, 1-13. [309].
    • Bartmann, L., Schumacher, D., von Stillfried, S., Sternkopf, M., Alampour-Rajabi, S., van Zandvoort, M. A. M. J., Kiessling, F., & Wu, Z. (2019). Evaluation of Riboflavin Transporters as Targets for Drug Delivery and Theranostics. Frontiers in Pharmacology, 10, 1-12. [79].
    • van Zandvoort, M. (2019). Guy Cox, Fundamentals of Fluorescence Imaging, 2019, Jenny Stanford Publishing; Singapore.Micron, 124, [102707].
  • 2018
    • Gemmink, A., Daemen, S., Kuijpers, H. J. H., Schaart, G., Duimel, H., Lopez-Iglesias, C., van Zandvoort, M. A. M. J., Knoops, K., & Hesselink, M. K. C. (2018). Super-resolution microscopy localizes perilipin 5 at lipid droplet-mitochondria interaction sites and at lipid droplets juxtaposing to perilipin 2. Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, 1863(11), 1423-1432.
    • Kapsokalyvas, D., Wilbers, A., Boogers, I. A. L. A., Appeldoorn, M. M., Kabel, M. A., Loos, J., & Van Zandvoort, M. A. M. J. (2018). Biomass Pretreatment and Enzymatic Hydrolysis Dynamics Analysis Based on Particle Size Imaging. Microscopy and Microanalysis, 24(5), 517-525.
    • Sutanto, H., van Sloun, B., Schönleitner, P., van Zandvoort, M. A. M. J., Antoons, G., & Heijman, J. (2018). The Subcellular Distribution of Ryanodine Receptors and L-Type Ca2+ Channels Modulates Ca2+-Transient Properties and Spontaneous Ca2+-Release Events in Atrial Cardiomyocytes. Frontiers in physiology, 9, [1108].
    • Haeren, R. H. L., Rijkers, K., Schijns, O. E. M. G., Dings, J., Hoogland, G., van Zandvoort, M. A. M. J., Vink, H., & van Overbeeke, J. J. (2018). In vivo assessment of the human cerebral microcirculation and its glycocalyx: A technical report. Journal of Neuroscience Methods, 303, 114-125.
    • Bisha, M., Dao, T-V., Gholamreza-Fahimi, E., Vogt, M., van Zandvoort, M., Weber, S., Bas, M., Khosravani, F., Kojda, G., & Suvorava, T. (2018). The role of bradykinin receptor type 2 in spontaneous extravasation in mice skin: implications for non-allergic angio-oedema. British Journal of Pharmacology, 175(10), 1607-1620.
    • Curaj, A., Wu, Z., Rix, A., Gresch, O., Sternkopf, M., Alampour-Rajabi, S., Lammers, T., van Zandvoort, M., Weber, C., Koenen, R. R., Liehn, E. A., & Kiessling, F. (2018). Molecular Ultrasound Imaging of Junctional Adhesion Molecule A Depicts Acute Alterations in Blood Flow and Early Endothelial Dysregulation. Arteriosclerosis Thrombosis and Vascular Biology, 38(1), 40-48.
  • 2017
    • Kapsokalyvas, D., van Hoof, M., Wigren, S., Chimhanda, T., Kuijpers, H. J., Ramaekers, F. C. S., Stokroos, R. J., & van Zandvoort, M. A. M. J. (2017). Investigating the race for the surface and skin integration in clinically retrieved abutments with two-photon microscopy. Colloids and Surfaces B-Biointerfaces, 159, 97-107.
    • Wu, Z., Rademakers, T., Kiessling, F., Vogt, M., Westein, E., Weber, C., Megens, R. T. A., & van Zandvoort, M. (2017). Multi-photon microscopy in cardiovascular research. Methods, 130, 79-89.
    • Schueth, A., Spronck, B., van Zandvoort, M. A. M. J., & van Koeveringe, G. A. (2017). Computer-assisted three-dimensional tracking of sensory innervation in the murine bladder mucosa with two-photon microscopy. Journal of Chemical Neuroanatomy, 85, 43-49.
    • Zafarnia, S., Bzyl-Ibach, J., Spivak, I., Li, Y., Koletnik, S., Doleschel, D., Rix, A., Pochon, S., Tardy, I., Koyadan, S., van Zandvoort, M., Palmowski, M., Kiessling, F., & Lederle, W. (2017). Nilotinib Enhances Tumor Angiogenesis and Counteracts VEGFR2 Blockade in an Orthotopic Breast Cancer Xenograft Model with Desmoplastic Response. Neoplasia (Online), 19(11), 896-907.
    • Koczera, P., Appold, L., Shi, Y., Liu, M., Dasgupta, A., Pathak, V., Ojha, T., Fokong, S., Wu, Z., van Zandvoort, M., Iranzo, O., Kuehne, A. J. C., Pich, A., Kiessling, F., & Lammers, T. (2017). PBCA-based polymeric microbubbles for molecular imaging and drug delivery. Journal of Controlled Release, 259, 128-135.
    • Liu, Y., Steinbusch, L. K. M., Nabben, M., Kapsokalyvas, D., van Zandvoort, M., Schonleitner, P., Antoons, G., Simons, P. J., Coumans, W. A., Geomini, A., Chanda, D., Glatz, J. F. C., Neumann, D., & Luiken, J. J. F. P. (2017). Palmitate-Induced Vacuolar-Type H(+)-ATPase Inhibition Feeds Forward Into Insulin Resistance and Contractile Dysfunction. Diabetes, 66(6), 1521-1534.
    • Kuppe, C., van Roeyen, C., Leuchtle, K., Kabgani, N., Vogt, M., Van Zandvoort, M., Smeets, B., Floege, J., Groene, H-J., & Moellert, M. J. (2017). Investigations of Glucocorticoid Action in GN. Journal of the American Society of Nephrology, 28(5), 1408-1420.
    • Haeren, R. H. L., Vink, H., Staals, J., van Zandvoort, M. A. M. J., Dings, J., van Overbeeke, J. J., Hoogland, G., Rijkers, K., & Schijns, O. E. M. G. (2017). Protocol for intraoperative assessment of the human cerebrovascular glycocalyx. BMJ Open, 7(1), [013954].
  • 2016
    • Gemmink, A., Bosma, M., Kuijpers, H. J. H., Hoeks, J., Schaart, G., van Zandvoort, M., Schrauwen, P., & Hesselink, M. K. C. (2016). Decoration of intramyocellular lipid droplets with PLIN5 modulates fasting-induced insulin resistance and lipotoxicity in humans. Diabetologia, 59(5), 1040–1048.
    • Daemen, S., van Zandvoort, M. A. M. J., Parekh, S. H., & Hesselink, M. K. C. (2016). Microscopy tools for the investigation of intracellular lipid storage and dynamics. Molecular Metabolism, 5(3), 153-163.
    • Schueth, A., Spronck, B., van Zandvoort, M. A. M. J., & van Koeveringe, G. A. (2016). Age-related changes in murine bladder structure and sensory innervation: a multiphoton microscopy quantitative analysis. Age, 38(1), [17].
    • Haeren, R. H. L., van de Ven, S. E. M., van Zandvoort, M. A. M. J., Vink, H., van Overbeeke, J. J., Hoogland, G., & Rijkers, K. (2016). Assessment and Imaging of the Cerebrovascular Glycocalyx. Current Neurovascular Research, 13(3), 249-260.
  • 2015
    • Jurak, E., Patyshakuliyeva, A., Kapsokalyvas, D., Xing, L., van Zandvoort, M. A. M. J., de Vries, R. P., Gruppen, H., & Kabel, M. A. (2015). Accumulation of recalcitrant xylan in mushroom-compost is due to a lack of xylan substituent removing enzyme activities of Agaricus bisporus. Carbohydrate Polymers, 132, 359-368.
    • Curaj, A., Wu, Z., Fokong, S., Liehn, E. A., Weber, C., Burlacu, A., Lammers, T., van Zandvoort, M., & Kiessling, F. (2015). Noninvasive Molecular Ultrasound Monitoring of Vessel Healing After Intravascular Surgical Procedures in a Preclinical Setup. Arteriosclerosis Thrombosis and Vascular Biology, 35(6), 1366-1373.
    • Lammers, T., Koczera, P., Fokong, S., Gremse, F., Ehling, J., Vogt, M., Pich, A., Storm, G., van Zandvoort, M., & Kiessling, F. (2015). Theranostic USPIO-Loaded Microbubbles for Mediating and Monitoring Blood-Brain Barrier Permeation. Advanced Functional Materials, 25(1), 36-43.
    • Mertens, M. E., Koch, S., Schuster, P., Wehner, J., Wu, Z., Gremse, F., Schulz, V., Rongen, L., Wolf, F., Frese, J., Gesche, V. N., van Zandvoort, M., Mela, P., Jockenhoevel, S., Kiessling, F., & Lammers, T. (2015). USPIO-labeled textile materials for non-invasive MR imaging of tissue-engineered vascular grafts. Biomaterials, 39, 155-163.
    • Shi, Y., Kunjachan, S., Wu, Z., Gremse, F., Moeckel, D., van Zandvoort, M., Kiessling, F., Storm, G., van Nostrum, C. F., Hennink, W. E., & Lammers, T. (2015). Fluorophore labeling of core-crosslinked polymeric micelles for multimodal in vivo and ex vivo optical imaging. Nanomedicine, 10(7), 1111-1125.
  • 2014
    • de Jong, S., van Middendorp, L. B., Hermans, R. H. A., de Bakker, J. M. T., Bierhuizen, M. F. A., Prinzen, F. W., van Rijen, H. V. M., Losen, M., Vos, M. A., & van Zandvoort, M. A. M. J. (2014). Ex Vivo and In Vivo Administration of Fluorescent CNA35 Specifically Marks Cardiac Fibrosis. Molecular Imaging, 13.
    • Schueth, A., van Zandvoort, M. A. M. J., Buurman, W. A., & van Koeveringe, G. A. (2014). Murine Bladder Imaging by 2-Photon Microscopy: An Experimental Study of Morphology. Journal of Urology, 192(3), 973-980.
    • Kapsokalyvas, D., Schiffers, P. M. H., Maij, N., Suylen, D. P., Hackeng, T. M., van Zandvoort, M. A. M. J., & De Mey, J. G. R. (2014). Imaging evidence for endothelin ETA/ETB receptor heterodimers in isolated rat mesenteric resistance arteries. Life Sciences, 111(1-2), 36-41.
    • Sadat, U., Jaffer, F. A., van Zandvoort, M. A. M. J., Nicholls, S. J., Ribatti, D., & Gillard, J. H. (2014). Inflammation and Neovascularization Intertwined in Atherosclerosis Imaging of Structural and Molecular Imaging Targets. Circulation, 130(9), 786-794.
    • Angin, Y., Schwenk, R. W., Nergiz-Unal, R., Hoebers, N., Heemskerk, J. W. M., Kuijpers, M. J., Coumans, W. A., van Zandvoort, M. A. M. J., Bonen, A., Neumann, D., Glatz, J. F. C., & Luiken, J. (2014). Calcium signaling recruits substrate transporters GLUT4 and CD36 to the sarcolemma without increasing cardiac substrate uptake. American Journal of Physiology : Endocrinology and Metabolism, 307(2), E225-E236.
    • Weinandy, S., Laffar, S., Unger, R. E., Flanagan, T. C., Loesel, R., Kirkpatrick, C. J., van Zandvoort, M., Hermanns-Sachweh, B., Dreier, A., Klee, D., & Jockenhoevel, S. (2014). Biofunctionalized Microfiber-Assisted Formation of Intrinsic Three-Dimensional Capillary-Like Structures. Tissue Engineering, 20(13-14), 1858-1869.
    • Lemmens, K. J., van de Wier, B., Vaes, N., Ghosh, M., van Zandvoort, M. A., van der Vijgh, W., Bast, A., & Haenen, G. R. (2014). The flavonoid 7-mono-O-(beta-hydroxyethyl)-rutoside is able to protect endothelial cells by a direct antioxidant effect. Toxicology in Vitro, 28(4), 538-543.
    • Dittmar, R., van Dijk, B. G. M., van Zandvoort, M. A. M. J., & Ito, K. (2014). In Situ Label-Free Cell Viability Assessment of Nucleus Pulposus Tissue. Journal of Orthopaedic Research, 32(4), 545-550.
    • Li, X., Zhu, M., Penfold, M. E., Koenen, R. R., Thiemann, A., Heyll, K., Akhtar, S., Koyadan, S., Wu, Z., Gremse, F., Kiessling, F., van Zandvoort, M., Schall, T. J., Weber, C., & Schober, A. (2014). Activation of CXCR7 Limits Atherosclerosis and Improves Hyperlipidemia by Increasing Cholesterol Uptake in Adipose Tissue. Circulation, 129(11), 1244-1253.
    • Campos, D. F. D., Vogt, M., Lindner, M., Kirsten, A., Weber, M., Megens, R. T. A., Pyta, J., Zenke, M., Van Zandvoort, M., & Fischer, H. (2014). Two-Photon Laser Scanning Microscopy as a Useful Tool for Imaging and Evaluating Macrophage-, IL-4 Activated Macrophage-and Osteoclast-based In Vitro Degradation of Beta-Tricalcium Phosphate Bone Substitute Material. Microscopy Research and Technique, 77(2), 143-152.
    • Wijnands, K. A., Hoeksema, M. A., Meesters, D. M., van den Akker, N. M., Molin, D. G., Briede, J. J., Ghosh, M., Kohler, S. E., van Zandvoort, M. A., de Winther, M. P., Buurman, W. A., Lamers, W. H., & Poeze, M. (2014). Arginase-1 Deficiency Regulates Arginine Concentrations and NOS2-Mediated NO Production during Endotoxemia. PLOS ONE, 9(1), [e86135].
    • Schmitt, M. M. N., Megens, R. T. A., Zernecke, A., Bidzhekov, K., van den Akker, N. M., Rademakers, T., van Zandvoort, M. A., Hackeng, T. M., Koenen, R. R., & Weber, C. (2014). Endothelial Junctional Adhesion Molecule-A Guides Monocytes Into Flow-Dependent Predilection Sites of Atherosclerosis. Circulation, 129(1), 66-+.
    • Gaens, K. H., Goossens, G. H., Niessen, P. M., van Greevenbroek, M. M., van der Kallen, C. J., Niessen, H. W., Rensen, S. S., Buurman, W. A., Greve, J. W., Blaak, E. E., van Zandvoort, M. A., Bierhaus, A., Stehouwer, C. D., & Schalkwijk, C. G. (2014). Nε-(Carboxymethyl)lysine-Receptor for Advanced Glycation End Product Axis Is a Key Modulator of Obesity-Induced Dysregulation of Adipokine Expression and Insulin Resistance. Arteriosclerosis Thrombosis and Vascular Biology, 34(6), 1199-1208.
  • 2013
    • Wu, Z., Curaj, A., Fokong, S., Liehn, E. A., Weber, C., Lammers, T., Kiessling, F., & van Zandvoort, M. (2013). Rhodamine-Loaded Intercellular Adhesion Molecule-1-targeted Microbubbles for Dual-Modality Imaging Under Controlled Shear Stresses. Circulation-Cardiovascular Imaging, 6(6), 974-981.
    • Rademakers, T., Douma, K., Hackeng, T. M., Post, M. J., Sluimer, J. C., Daemen, M. J. A. P., Biessen, E. A. L., Heeneman, S., & van Zandvoort, M. A. M. J. (2013). Plaque-Associated Vasa Vasorum in Aged Apolipoprotein E-Deficient Mice Exhibit Proatherogenic Functional Features In Vivo. Arteriosclerosis Thrombosis and Vascular Biology, 33(2), 249-+.