Michael Jacobs


Prof. Michael Jacobs has obtained his medical doctor degree at the University of Limburg, Maastricht. His PhD research focussed on microcirculation in patients with peripheral arterial disease. Following his surgical residency, he was trained as a cardiovascular surgeon at the Texas Heart Institute in Houston, USA. He was appointed chief of vascular surgery at the Amsterdam Medical Center in 1992 and started research programmes concentrating on assessment of spinal cord function in thoraco-abdominal aortic aneurysm (TAAA) repair and preventive strategies by means of selective organ perfusion and motor evoked potentials. In 2000, he was invited to Maastricht UMC+ to chair the Department of Surgery and create an integrated heart- and vascular center (HVC). Research addressed pre-operative imaging of the blood supplying arteries of the spinal cord in TAAA patients, and the role of arginine and nitric oxide (NO) metabolism in patients undergoing extensive aortic repair. In 2005, he also accepted the chair of Vascular Surgery at the RWTH University Hospital in Aachen, Germany.

He yearly organises the European Vascular Course, hosting around 2,000 cardiovascular specialists from all over the world.

Department of Vascular Surgery
P. Debyelaan 25, 6229 HX Maastricht 
PO Box 5800, 6202 AZ Maastricht                                                                                                      T: +31(0)43 387 22 79

  • 2022
    • Petsophonsakul, P., Burgmaier, M., Willems, B., Heeneman, S., Stadler, N., Gremse, F., Reith, S., Burgmaier, K., Kahles, F., Marx, N., Natour, E., Bidar, E., Jacobs, M., Mees, B., Reutelingsperger, C., Furmanik, M., & Schurgers, L. (2022). Nicotine promotes vascular calcification via intracellular Ca2+-mediated, Nox5-induced oxidative stress and extracellular vesicle release in vascular smooth muscle cells. Cardiovascular Research, 118(9), 2196-2210. https://doi.org/10.1093/cvr/cvab244
    • Heuts, S., Adriaans, B. P., Kawczynski, M. J., Daemen, J. H. T., Natour, E., Lorusso, R., Schalla, S., Maessen, J. G., Wildberger, J. E., Jacobs, M. J., Rylski, B., & Bidar, E. (2022). Extending Aortic Replacement Beyond the Proximal Arch in Acute Type A Aortic Dissection: A Meta-Analysis of Short Term Outcomes and Long Term Actuarial Survival. European Journal of Vascular and Endovascular Surgery, 63(5), 674-687. https://doi.org/10.1016/j.ejvs.2021.12.045
    • Piao, L., Barbati, M. E., Shekarchian, S., Jacobs, M. J., Razavi, M., Rass, K., & Jalaie, H. (2022). Comparison of endovascular strategy versus hybrid procedure in treatment of chronic venous obstructions involving the confluence of common femoral vein. Journal of Vascular Surgery. Venous and Lymphatic Disorders, 10(2), 334-341. https://doi.org/10.1016/j.jvsv.2021.08.016
    • Gombert, A., Ketting, S., Rückbeil, M. V., Hundertmark, A-K., Barbati, M., Keschenau, P., Pedersoli, F., Schurink, G. W., Mees, B., Kotelis, D., & Jacobs, M. J. (2022). Perioperative and long-term outcome after ascending aortic and arch repair with elephant trunk and open thoracoabdominal aortic aneurysm repair. Journal of Vascular Surgery, 75(3), 824-832. https://doi.org/10.1016/j.jvs.2021.09.026
  • 2021
    • Jacobs, M. J., & Gombert, A. (2021). Distal aortic perfusion-still of relevance for spinal cord protection during complex aortic surgery?European Journal of Cardio-Thoracic Surgery, 60(3), 577-578. https://doi.org/10.1093/ejcts/ezab212
    • Keschenau, P. R., Gombert, A., Barbati, M. E., Jalaie, H., Kalder, J., Jacobs, M. J., & Kotelis, D. (2021). Xenogeneic materials for the surgical treatment of aortic infections. Journal of Thoracic Disease, 13(5), 3021-3032. https://doi.org/10.21037/jtd-20-3481
    • Czerny, M., van den Berg, J., Chiesa, R., Jacobs, M., Jakob, S., Jenni, H. J., Lorusso, R., Pacini, D., Quintana, E., Rylski, B., Staier, K., Tsilimparis, N., Wyss, T., Gottardi, R., & Schmidli, J. (2021). Management of acute and chronic aortic disease during the COVID-19 pandemic-Results from a web-based ad hoc platform. Journal of Cardiac Surgery, 36(5), 1683-1692. https://doi.org/10.1111/jocs.15093
    • Wubbeke, L. F., Kremers, B., Daemen, J-W. H. C., Snoeijs, M. G. J., Jacobs, M. J., & Mees, B. M. E. (2021). Mortality in Octogenarians With Chronic Limb Threatening Ischaemia After Revascularisation or Conservative Therapy Alone. European Journal of Vascular and Endovascular Surgery, 61(2), 350-351. https://doi.org/10.1016/j.ejvs.2020.09.018
  • 2020
    • Zechendorf, E., Gombert, A., Bulow, T., Frank, N., Beckers, C., Peine, A., Kotelis, D., Jacobs, M. J., Marx, G., & Martin, L. (2020). The Role of Ribonuclease 1 and Ribonuclease Inhibitor 1 in Acute Kidney Injury after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair. Journal of Clinical Medicine, 9(10), [3292]. https://doi.org/10.3390/jcm9103292
    • Gombert, A., Jacobs, M. J., & Boor, P. (2020). Histomorphologische und molekuläre Mechanismen des akuten Nierenschadens bei offenem thorakoabdominellen Aortenersatz – Vorstellung eines Studienkonzepts. Gefässchirurgie, 25(5), 352-355. https://doi.org/10.1007/s00772-020-00649-w
    • Wubbeke, L. F., Conings, J. Z. M., Elshof, J-W., Scheltinga, M. R., Daemen, J-W. H. C., Jacobs, M. J., & Mees, B. M. (2020). Outcome of rectus femoris muscle flaps for groin coverage after vascular surgery. Journal of Vascular Surgery, 72(3), 1050-1057.e2. https://doi.org/10.1016/j.jvs.2019.11.031
    • Wubbeke, L. F., Naves, C. C. L. M., Daemen, J. W. H. C., Jacobs, M. J., & Mees, B. M. E. (2020). Editor's Choice – Mortality and Major Amputation after Revascularisation in Octogenarians Versus Non-Octogenarians with Chronic Limb Threatening Ischaemia: A Systematic Review and Meta-Analysis. European Journal of Vascular and Endovascular Surgery, 60(2), 231-241. https://doi.org/10.1016/j.ejvs.2020.04.027
    • Gombert, A., Ruckbeil, M. V., Kotelis, D., Burger, S., Brugmayer, T., Mess, W. H., & Jacobs, M. J. (2020). Assessment of Neurone-Specific Enolase, Glial Fibrillary Acidic Protein and S100 B as Spinal Cord Ischemia Biomarkers in Patients Undergoing Open and Endovascular Complex Aortic Surgery: A Single-Center Experience. Annals of Vascular Surgery, 66, 424-433. https://doi.org/10.1016/j.avsg.2020.01.003
    • Keschenau, P. R., Sattler, C., Berger, T., Kotelis, D., Jacobs, M. J., & Kalder, J. (2020). Changes in Target Vessel Anatomy Following Fenestrated Endovascular Aneurysm Repair: Midterm Results. Journal of Endovascular Therapy, 27(3), 445-451. https://doi.org/10.1177/1526602820915492
    • Gombert, A., & Jacobs, M. J. (2020). Sometimes Less May Be More: Thoughts About a Low Dose Protocol for Iatrogenic Femoral Pseudoaneurysm. European Journal of Vascular and Endovascular Surgery, 59(6), 1026-1026. https://doi.org/10.1016/j.ejvs.2019.12.028
    • Keschenau, P. R., Kaisaris, N., Jalaie, H., Grommes, J., Kotelis, D., Kalder, J., & Jacobs, M. J. (2020). Management strategies for true and dissecting visceral artery aneurysms. Journal of Cardiovascular Surgery, 61(3), 340-346. https://doi.org/10.23736/S0021-9509.19.11036-1
    • Gombert, A., & Jacobs, M. J. (2020). Keep Your Knife Sharp - An Appeal for More Education in Open Aortic Surgery. European Journal of Vascular and Endovascular Surgery, 59(5), 766-766. https://doi.org/10.1016/j.ejvs.2019.12.030
    • Keschenau, P. R., Alkassam, H., Kotelis, D., Jacobs, M. J., & Kalder, J. (2020). Intraoperative contrast-enhanced ultrasound examination for endoleak detection after complex and infrarenal endovascular aortic repair. Journal of Vascular Surgery, 71(4), 1200-1206. https://doi.org/10.1016/j.jvs.2019.07.060
    • Oostveen, C. N., Weerwind, P. W., Bergs, P. P. E., Schmidli, J., Buhlmann, R., Schefold, J. C., Eberle, B., Consiglio, J., Schaelte, G., Kotelis, D., Hollands, A. W. H., Buhre, W. F. F. A., Schurink, G. W. H., Jacobs, M. J., van Mook, W. N. K. A., Mess, W. H., & Sutedja, N. A. (2020). Neurophysiological and paraspinal oximetry monitoring to detect spinal cord ischemia in patients during and after descending aortic repair: An international multicenter explorative study. Contemporary Clinical Trials Communications, 17, [100545]. https://doi.org/10.1016/j.conctc.2020.100545
    • Averdunk, L., Ruckbeil, M. V., Zarbock, A., Martin, L., Marx, G., Jalaie, H., Jacobs, M. J., Stoppe, C., & Gombert, A. (2020). SLPI - a Biomarker of Acute Kidney Injury after Open and Endovascular Thoracoabdominal Aortic Aneurysm (TAAA) Repair. Scientific Reports, 10(1), [3453]. https://doi.org/10.1038/s41598-020-60482-9
    • Karkkainen, J. M., Tenorio, E. R., Oksala, N., Macedo, T. A., Sen, I., Mendes, B. C., DeMartino, R. R., Jacobs, M. J., Mees, B., & Oderich, G. S. (2020). Pre-operative Psoas Muscle Size Combined With Radiodensity Predicts Mid-Term Survival and Quality of Life After Fenestrated-Branched Endovascular Aortic Repair. European Journal of Vascular and Endovascular Surgery, 59(1), 31-39. https://doi.org/10.1016/j.ejvs.2019.06.021
  • 2019
    • Kalder, J., Gombert, A., Kotelis, D., & Jacobs, M. J. (2019). Feasibility and Twelve-month Patency of a Six-fold Fenestrated Stent Graft for Type IV Thoracoabdominal Aneurysm Repair. Annals of Vascular Surgery, 60, [478.e1-478.e5]. https://doi.org/10.1016/j.avsg.2019.03.004
    • Keschenau, P. R., Simons, N., Klingel, H., Reuter, S., Foldenauer, A. C., Viess, J., Weidener, D., Andruszkow, J., Bluemich, B., Tolba, R., Jacobs, M. J., & Kalder, J. (2019). Perfusion-related changes in intestinal diffusion detected by NMR-MOUSE® monitoring in minipigs. Microvascular Research, 125, [103876]. https://doi.org/10.1016/j.mvr.2019.04.006
    • Jalaie, H., Steitz, J., Afify, M., Barbati, M. E., Hoeft, K., Assar, M. A. M., Hermanns-Sachweh, B., Tolba, R. H., Jacobs, M. J., & Schleimer, K. (2019). In vivo endothelialization and neointimal hyperplasia assessment after angioplasty of sheep carotid artery with a novel polycarbonate polyurethane patch. Journal of Biomaterials Applications, 34(2), 208-218. https://doi.org/10.1177/0885328219849368
    • Kalder, J., Isfort, P., Reinartz, S. D., Gremse, F., Yamoah, G. G., Gesche, V., Kotelis, D., Tolba, R., Jacobs, M. J., & Jalaie, H. (2019). New Large Animal Model for Aortic Aneurysms in the Viscerorenal Segment. Journal of Surgical Research, 240, 156-164. https://doi.org/10.1016/j.jss.2019.02.054
    • Petsophonsakul, P., Furmanik, M., Forsythe, R., Dweck, M., Schurink, G. W., Natour, E., Reutelingsperger, C., Jacobs, M., Mees, B., & Schurgers, L. (2019). Role of Vascular Smooth Muscle Cell Phenotypic Switching and Calcification in Aortic Aneurysm Formation Involvement of Vitamin K-Dependent Processes. Arteriosclerosis Thrombosis and Vascular Biology, 39(7), 1351-1368. https://doi.org/10.1161/ATVBAHA.119.312787
    • Gombert, A., & Jacobs, M. J. (2019). Great Power Brings Great Responsibility: Some Thoughts About a Promising Approach to Standardised Data Assessment in Registry Studies. European Journal of Vascular and Endovascular Surgery, 57(6), 822-822. https://doi.org/10.1016/j.ejvs.2019.03.018
    • Gombert, A., Grommes, J., & Jacobs, M. J. (2019). Die klinische Relevanz von DAMP („damage-associated molecular pattern“) für den postoperativen Verlauf nach thorakoabdomineller Aortenchirurgie. Gefässchirurgie, 24(2), 173-175. https://doi.org/10.1007/s00772-019-0510-4
    • Gombert, A., Kirner, L., Ketting, S., Rueckbeil, M., Mees, B., Barbati, M. E., Keschenau, P. R., Kalder, J., Schurink, G. W., Kotelis, D., & Jacobs, M. J. (2019). Editor's Choice - Outcomes After One Stage Versus Two Stage Open Repair of Type II Thoraco-abdominal Aortic Aneurysms. European Journal of Vascular and Endovascular Surgery, 57(3), 340-348. https://doi.org/10.1016/j.ejvs.2018.09.007
    • Gombert, A., Martin, L., Foldenauer, A. C., Krajewski, C., Greiner, A., Kotelis, D., Stoppe, C., Marx, G., Grommes, J., Schuerholz, T., Jacobs, M. J., & Kalder, J. (2019). Comparison of urine and serum neutrophil gelatinase-associated lipocalin after open and endovascular thoraco-abdominal aortic surgery and their meaning as indicators of acute kidney injury. Vasa-European Journal of Vascular Medicine, 48(1), 79-87. https://doi.org/10.1024/0301-1526/a000736
  • 2018
    • Keschenau, P. R., Ketting, S., Mees, B., Barbati, M. E., Grommes, J., Gombert, A., Schurink, G. W. H., Kotelis, D., & Jacobs, M. J. (2018). Editor's Choice - Open Thoracic and Thoraco-abdominal Aortic Repair After Prior Endovascular Therapy. European Journal of Vascular and Endovascular Surgery, 56(1), 57-67. https://doi.org/10.1016/j.ejvs.2018.03.015
    • Gombert, A., van Issum, L., Barbati, M. E., Grommes, J., Keszei, N., Kotelis, D., Jalaie, H., Greiner, A., Jacobs, M. J., & Kalder, J. (2018). Extra-Thoracic Supra-aortic Bypass Surgery Is Safe in Thoracic Endovascular Aortic Repair and Arterial Occlusive Disease Treatment. European Journal of Vascular and Endovascular Surgery, 55(6), 861-866. https://doi.org/10.1016/j.ejvs.2018.03.020
    • Gombert, A., Grommes, J., Hilkman, D., Kotelis, D., Mess, W. H., & Jacobs, M. J. (2018). Recovery of lost motor evoked potentials in open thoracoabdominal aortic aneurysm repair using intercostal artery bypass. Journal of Vascular Surgery Cases and Innovative Techniques, 4(1), 54-57. https://doi.org/10.1016/j.jvscit.2017.12.004
  • 2017
    • Keschenau, P. R., Kotelis, D., Bisschop, J., Barbati, M. E., Grommes, J., Mees, B., Gombert, A., Peppelenbosch, A. G., Schurink, G. W. H., Kalder, J., & Jacobs, M. J. (2017). Editor's Choice - Open Thoracic and Thoraco-abdominal Aortic Repair in Patients with Connective Tissue Disease. European Journal of Vascular and Endovascular Surgery, 54(5), 588-596. https://doi.org/10.1016/j.ejvs.2017.07.026
    • Gombert, A., Stoppe, C., Foldenauer, A. C., Schuerholz, T., Martin, L., Kalder, J., Schaelte, G., Marx, G., Jacobs, M., & Grommes, J. (2017). Macrophage Migration Inhibitory Factor Predicts Outcome in Complex Aortic Surgery. International journal of molecular sciences, 18(11), [2374]. https://doi.org/10.3390/ijms18112374
    • Sutedja, N. A., Hollands, A. W. H., & Jacobs, M. J. (2017). MEP monitoring during aortic surgery: what we truly know. Journal of Anesthesia, 31(4), 640-640. https://doi.org/10.1007/s00540-017-2367-6
    • Martin, L., Gombert, A., Chen, J., Liebens, J., Verleger, J., Kalder, J., Marx, G., Jacobs, M., Thiemermann, C., & Schuerholz, T. (2017). The β-D-Endoglucuronidase Heparanase Is a Danger Molecule That Drives Systemic Inflammation and Correlates with Clinical Course after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair: Lessons Learnt from Mice and Men. Frontiers in Immunology, 8, [681]. https://doi.org/10.3389/fimmu.2017.00681
    • Gombert, A., Kotelis, D., Griepenkerl, U. M., Fraedrich, G., Klocker, J., Glodny, B., Jacobs, M. J., Greiner, A., & Grommes, J. (2017). Functional Assessment and Evaluation of Outcome After Endovascular Therapy With Coverage of the Left Subclavian Artery in Case of Blunt Thoracic Aortic Injury. Annals of Vascular Surgery, 40, 98-104. https://doi.org/10.1016/j.avsg.2016.07.089
    • Gombert, A., Barbati, M. E., Storck, M., Kotelis, D., Keschenau, P., Pape, H-C., Andruszkow, H., Lefering, R., Hildebrand, F., Greiner, A., Jacobs, M. J., & Grommes, J. (2017). Treatment of blunt thoracic aortic injury in Germany-Assessment of the TraumaRegister DGU®. PLOS ONE, 12(3), [0171837]. https://doi.org/10.1371/journal.pone.0171837
    • Gombert, A., Grommes, J., Schick, G., Binneboesel, M., Klink, C., Jacobs, M. J., & Kotelis, D. (2017). Sarcoidosis-Associated Aortoesophageal Fistula-Multistage Interdisciplinary Surgical Therapy for a Rare and Life-Threatening Condition. Annals of Vascular Surgery, 39, 287.e15-287 e.20. https://doi.org/10.1016/j.avsg.2016.06.034
  • 2016