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ERC Advanced Grant awarded to Prof. Andy Baker

ERC Advanced Grant awarded to Prof. Andy Baker

15 April 2024

Prof. Andy Baker (Dept of Pathology) has been awarded a European Research Council (ERC) Advanced Grant of €2,5M for his research project PolymiRize: Poly-miRNA targeting to prevent and reverse complex tissue remodelling after acute cardiovascular events'.

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Longer and better lives for patients with atrial fibrillation

Longer and better lives for patients with atrial fibrillation

15 April 2024

An international panel of experts published recommendations to improve management of atrial fibrillation (AF).

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Carim Maastricht
Carim Maastricht

Sylvia Heeneman

Professor

Sylvia Heeneman is a Professor of Health Profession Education at the Faculty of Health, Medicine and Life Sciences (FHML), CARIM and School of Health Profession Education (SHE), Maastricht University. She studied Health Sciences at Maastricht University (graduated 1991) and completed a PhD in Cardiovascular Research (CARIM), on changes in peripheral arteries after a myocardial infarction (graduated 1997). She completed the Master Health Profession Education (MHPE) programme, Maastricht University, in 2014 (with honours).

Research in cardiovascular research: mechanisms of atherosclerosis, specifically radiation-induced atherosclerosis, and molecular imaging of atherosclerosis.

Research in health profession education: (programmatic) assessment, professional performance, portfolio and mentoring.

 

Sylvia-heeneman

Department of Pathology
Verheylaan 10, 6229 HX Maastricht
Room number: 5M1.011
T: +31(0)43 387 66 29

  • 2017
    • van der Meulen, M. W., Boerebach, B. C. M., Smirnova, A., Heeneman, S., Egbrink, M. G. A. O., van der Vleuten, C. P. M., Arah, O. A., & Lombarts, K. M. J. M. H. (2017). Validation of the INCEPT: A Multisource Feedback Tool for Capturing Different Perspectives on Physicians' Professional Performance. Journal of Continuing Education in the Health Professions, 37(1), 9-18. https://doi.org/10.1097/CEH.0000000000000143
  • 2016
    • van der Vleuten, C., & Heeneman, S. (2016). On the issue of costs in programmatic assessment. Perspectives on Medical Education, 5(5), 303–307. Article 303. https://doi.org/10.1007/s40037-016-0295-z
    • Donners, M. M. P. C., Bai, L., Lutgens, S., Wijnands, E., Johnson, J., Schurgers, L. J., Liu, C.-L., Daemen, M., Cleutjens, K. B. J. M., Shi, G.-P., Biessen, E. A. L., & Heeneman, S. (2016). Cathepsin K Deficiency Prevents the Aggravated Vascular Remodeling Response to Flow Cessation in ApoE(-/-) Mice. PLOS ONE, 11(9), Article e0162595. https://doi.org/10.1371/journal.pone.0162595
    • van Hoof, R. H. M., Heeneman, S., Wildberger, J. E., & Kooi, E. (2016). Dynamic Contrast-Enhanced MRI to Study Atherosclerotic Plaque Microvasculature. Current Atherosclerosis Reports, 18(6), Article 33. https://doi.org/10.1007/s11883-016-0583-4
    • Vöö, S., Kwee, R. M., Sluimer, J. C., Schreuder, F. H. B. M., Wierts, R., Bauwens, M., Heeneman, S., Cleutjens, J. P. M., van Oostenbrugge, R. J., Daemen, J.-W. H., Daemen, M. J. A. P., Mottaghy, F. M., & Kooi, E. (2016). Imaging Intraplaque Inflammation in Carotid Atherosclerosis With F-18-Fluorocholine Positron Emission Tomography-Computed Tomography Prospective Study on Vulnerable Atheroma With Immunohistochemical Validation. Circulation-Cardiovascular Imaging, 9(5), Article e004467. https://doi.org/10.1161/CIRCIMAGING.115.004467
  • 2015
    • Heeneman, S., Pool, A. O., Schuwirth, L. W. T., van der Vleuten, C. P. M., & Driessen, E. W. (2015). The impact of programmatic assessment on student learning: theory versus practice. Medical Education, 49(5), 487-498. https://doi.org/10.1111/medu.12645
    • Herias, V., Biessen, E. A. L., Beckers, C., Delsing, D., Liao, M., Daemen, M. J., Pham, C. C. T. N., & Heeneman, S. (2015). Leukocyte Cathepsin C Deficiency Attenuates Atherosclerotic Lesion Progression by Selective Tuning of Innate and Adaptive Immune Responses. Arteriosclerosis Thrombosis and Vascular Biology, 35(1), 79-86. https://doi.org/10.1161/ATVBAHA.114.304292
    • Sluimer, J. C., Gijbels, M. J., & Heeneman, S. (2015). Detection of Intraplaque Hemorrhage in Mouse Atherosclerotic Lesions. Methods in Molecular Biology, 1339, 339-48. https://doi.org/10.1007/978-1-4939-2929-0_24
    • van Berlo, J., Heeneman, S., Verhoeven, B., & van der Vleuten, C. (2015). Een Mindmap-gebaseerd Portfolio ter Ondersteuning van Reflectie in een Competentiegericht Onderwijsprogramma. Tijdschrift voor Hoger Onderwijs, 34-54.
    • van der Vleuten, C. P. M., Schuwirth, L. W. T., Driessen, E. W., Govaerts, M. J. B., & Heeneman, S. (2015). Twelve Tips for programmatic assessment. Medical Teacher, 37(7), 641-646. https://doi.org/10.3109/0142159X.2014.973388
  • 2014
    • Hanssen, N. M. J., Wouters, K., Huijberts, M. S., Gijbels, M. J., Sluimer, J. C., Scheijen, J. L. J. M., Heeneman, S., Biessen, E. A. L., Daemen, M. J. A. P., Brownlee, M., de Kleijn, D. P., Stehouwer, C. D. A., Pasterkamp, G., & Schalkwijk, C. G. (2014). Higher levels of advanced glycation endproducts in human carotid atherosclerotic plaques are associated with a rupture-prone phenotype. European Heart Journal, 35(17), 1137-1146. https://doi.org/10.1093/eurheartj/eht402
    • Gabriels, K., Hoving, S., Gijbels, M. J., Pol, J. F., te Poele, J. A., Biessen, E. A., Daemen, M. J., Stewart, F. A., & Heeneman, S. (2014). Irradiation of existing atherosclerotic lesions increased inflammation by favoring pro-inflammatory macrophages. Radiotherapy and Oncology, 110(3), 455-460. https://doi.org/10.1016/j.radonc.2014.01.006
  • 2013
    • Borissoff, J. I., Otten, J. J. T., Heeneman, S., Leenders, P., van Oerle, R., Soehnlein, O., Loubele, S. T. B. G., Hamulyak, K., Hackeng, T. M., Daemen, M. J. A. P., Degen, J. L., Weiler, H., Esmon, C. T., van Ryn, J., Biessen, E. A. L., Spronk, H. M. H., & ten Cate, H. (2013). Genetic and Pharmacological Modifications of Thrombin Formation in Apolipoprotein E-deficient Mice Determine Atherosclerosis Severity and Atherothrombosis Onset in a Neutrophil-Dependent Manner. PLOS ONE, 8(2), Article e55784. https://doi.org/10.1371/journal.pone.0055784
    • Rademakers, T., Douma, K., Hackeng, T. M., Post, M. J., Sluimer, J. C., Daemen, M. J. A. P., Biessen, E. A. L., Heeneman, S., & van Zandvoort, M. A. M. J. (2013). Plaque-Associated Vasa Vasorum in Aged Apolipoprotein E-Deficient Mice Exhibit Proatherogenic Functional Features In Vivo. Arteriosclerosis Thrombosis and Vascular Biology, 33(2), 249–256. https://doi.org/10.1161/ATVBAHA.112.300087
    • Nergiz-Unal, R., Kuijpers, M. J. E., de Witt, S. M., Heeneman, S., Feijge, M. A. H., Garcia Caraballo, S., Biessen, E. A., Haenen, G. R. M. M., Cosemans, J. M., & Heemskerk, J. W. (2013). Atheroprotective effect of dietary walnut intake in ApoE-deficient mice: Involvement of lipids and coagulation factors.Thrombosis Research, 131(5), 411-417. https://doi.org/10.1016/j.thromres.2013.01.003
    • Gaens, M. E., Backes, W. H., Rozel, S., Lipperts, M., Sanders, S. N., Jaspers, K., Cleutjens, J. P. M., Sluimer, J. C., Heeneman, S., Daemen, M. J. A. P., Welten, R. J., Daemen, J. W., Wildberger, J. E., Kwee, R. M., & Kooi, M. E. (2013). Dynamic Contrast-enhanced MR Imaging of Carotid Atherosclerotic Plaque: Model Selection, Reproducibility, and Validation.Radiology, 266(1), 271-279. https://doi.org/10.1148/radiol.12120499
  • 2012
    • Hoving, S., Heeneman, S., Gijbels, M. J. J., Poele, J. A. M. T., Visser, N. L., Cleutjens, J., Russell, N. S., Daemen, M. J. A. P., & Stewart, F. A. (2012). Irradiation induces different inflammatory and thrombotic responses in carotid arteries of wildtype C57BL/6J and atherosclerosis-prone ApoE(-/-) mice. Radiotherapy and Oncology, 105(3), 365-370. https://doi.org/10.1016/j.radonc.2012.11.001
    • Gabriels, K., Hoving, S., Seemann, I., Visser, N. L., Gijbels, M. J., Pol, J. F., Daemen, M. J. A. P., Stewart, F. A., & Heeneman, S. (2012). Local heart irradiation of ApoE(-/-) mice induces microvascular and endocardial damage and accelerates coronary atherosclerosis. Radiotherapy and Oncology, 105(3), 358-364. https://doi.org/10.1016/j.radonc.2012.08.002
    • Stadler, N., Heeneman, S., Voo, S., Stanley, N., Giles, G. I., Gang, B. P., Croft, K. D., Mori, T. A., Vacata, V., Daemen, M. J. A. P., Waltenberger, J., & Davies, M. J. (2012). Reduced metal ion concentrations in atherosclerotic plaques from subjects with Type 2 diabetes mellitus. Atherosclerosis, 222(2), 512-518. https://doi.org/10.1016/j.atherosclerosis.2012.03.015
    • Seemann, I., Gabriels, K., Visser, N. L., Hoving, S., te Poele, J. A., Pol, J. F., Gijbels, M. J., Janssen, B. J., Van Leeuwen, F. W., Daemen, M. J., Heeneman, S., & Stewart, F. A. (2012). Irradiation induced modest changes in murine cardiac function despite progressive structural damage to the myocardium and microvasculature. Radiotherapy and Oncology, 103(2), 143-150. https://doi.org/10.1016/j.radonc.2011.10.011
  • 2011
    • Hoving, S., Heeneman, S., Gijbels, M. J. J., Poele, J. A. M. T., Pol, J. F. C., Gabriels, K., Russell, N. S., Daernen, M. J. A. P., & Stewart, F. A. (2011). Anti-inflammatory and anti-thrombotic intervention strategies using atorvastatin, clopidogrel and knock-down of CD40L do not modify radiation-induced atherosclerosis in ApoE null mice. Radiotherapy and Oncology, 101(1), 100-108. https://doi.org/10.1016/j.radonc.2011.09.019
  • 2010
    • Meuwese, M. C., Broekhuizen, L. N., Kuikhoven, M., Heeneman, S., Lutgens, E., Gijbels, M. J. J., Nieuwdorp, M., Peutz, C. J., Stroes, E. S. G., Vink, H., & van den Berg, B. M. (2010). Endothelial Surface Layer Degradation by Chronic Hyaluronidase Infusion Induces Proteinuria in Apolipoprotein E-Deficient Mice. PLOS ONE, 5(12), 7. https://doi.org/10.1371/journal.pone.0014262
    • Donners, M. P. C., Wolfs, I. M. J., Olieslagers, S., Mohammadi-Motahhari, Z., Tchaikovski, V., Heeneman, S., van Buul, J. D., Caolo, V., Molin, D. G. M., Post, M. J., & Waltenberger, J. (2010). A Disintegrin and Metalloprotease 10 Is a Novel Mediator of Vascular Endothelial Growth Factor: Induced Endothelial Cell Function in Angiogenesis and Is Associated With Atherosclerosis. Arteriosclerosis Thrombosis and Vascular Biology, 30(11), 2188-U382. https://doi.org/10.1161/ATVBAHA.110.213124
    • Hoving, S., Heeneman, S., Gijbels, M. J. J., Poele, J. A. M. T., Bolla, M., Pol, J. F. C., Simons, M. Y., Russell, N. S., Daemen, M. J. A. P., & Stewart, F. A. (2010). NO-Donating Aspirin and Aspirin Partially Inhibit Age-Related Atherosclerosis but Not Radiation-Induced Atherosclerosis in ApoE Null Mice. PLOS ONE, 5(9), 10. https://doi.org/10.1371/journal.pone.0012874
    • Borissoff, J. I., Heeneman, S., Kilinc, E., Kassak, P., Van Oerle, R., Winckers, K., Govers-Riemslag, J. W. P., Hamulyak, K., Hackeng, T. M., Daemen, M. J. A. P., Ten Cate, H., & Spronk, H. M. H. (2010). Early Atherosclerosis Exhibits an Enhanced Procoagulant State. Circulation, 122(8), 821-U145. https://doi.org/10.1161/CIRCULATIONAHA.109.907121
    • Bai, L., Gabriels, K., Wijnands, E., Rousch, M., Daemen, M. J. A. P., Tervaert, J. W. C., Biessen, E. A. L., & Heeneman, S. (2010). Low- but not high-dose FK506 treatment confers atheroprotection due to alternative macrophage activation and unaffected cholesterol levels. Thrombosis and Haemostasis, 104(1), 143-150. https://doi.org/10.1160/TH09-07-0502
    • Lobbes, M. B. I., Heeneman, S., Passos, V. L., Welten, R., Kwee, R. M., van der Geest, R. J., Wiethoff, A. J., Caravan, P., Misselwitz, B., Daemen, M. J., van Engelshoven, J. M. A., Leiner, T., & Kooi, M. E. (2010). Gadofosveset-Enhanced Magnetic Resonance Imaging of Human Carotid Atherosclerotic Plaques A Proof-of-Concept Study. Investigative Radiology, 45(5), 275-281. https://doi.org/10.1097/RLI.0b013e3181d5466b
    • Bai, L., Beckers, L., Wijnands, E., Lutgens, S. P. M., Herias, M. V., Saftig, P., Daemen, M. J. A. P., Cleutjens, K., Lutgens, E., Biessen, E. A. L., & Heeneman, S. (2010). Cathepsin K gene disruption does not affect murine aneurysm formation. Atherosclerosis, 209(1), 96-103. https://doi.org/10.1016/j.atherosclerosis.2009.09.001
    • Lobbes, M. B., Kooi, M. E., Lutgens, E., Lima Passos, V., Braat, S. H. J. G., Rousch, M. J. M., ten Cate, H., van Engelshoven, J. M., Daemen, M. J., & Heeneman, S. (2010). Leukocyte counts, myeloperoxidase, and pregnancy-associated plasma protein a as biomarkers for cardiovascular disease: towards a multi-biomarker approach.International Journal of Vascular Medicine, 2010(726207). https://doi.org/10.1155/2010/726207
  • 2009
    • Lobbes, M. B., Miserus, R. J. H. M., Heeneman, S., Lima Passos, V., Mutsaers, PH., Debernardi, N., Misselwitz, B., Post, M. J., Daemen, M. J. A. P., van Engelshoven, J. M. A., Leiner, T., & Kooi, M. E. (2009). Atherosclerosis: Contrast-enhanced MR imaging of vessel wall in rabbit model - comparison of gadofosveset and gadopentetate dimeglumine. Radiology, 250(3), 682-691. https://doi.org/10.1148/radiol.2503080875
    • Kwee, R. M., Schreuder, F. H., Mess, W. H., van Oostenbrugge, R. J., Triebels, V. H., van de Akker, L. H., Heeneman, S., Hofman, P. A. M., van Engelshoven, J. M., Wildberger, J. E., & Kooi, M. E. (2009). Images in cardiovascular medicine: development of carotid intraplaque hemorrhage demonstrated by serial magnetic resonance imaging. Circulation, 120(16), 1637-9. https://doi.org/10.1161/CIRCULATIONAHA.109.873513
    • Miserus, R. J., Herias, M. V., Prinzen, L., Lobbes, M. B., van Suylen, R. J., Dirksen, A., Hackeng, T. M., Heemskerk, J. W., van Engelshoven, J. M., Daemen, M. J. A. P., van Zandvoort, M. A. M. J., Heeneman, S., & Kooi, M. E. (2009). Molecular MRI of early thrombus formation using a bimodal alpha2-antiplasmin-based contrast agent. JACC-Cardiovascular Imaging, 2(8), 987-96. https://doi.org/10.1016/j.jcmg.2009.03.015
    • Miserus, R., Dirksen, A., Suylen, D. P., Herias, V., Prinzen, L., van Zandvoort, M. A. M. J., Kooi, M. E., Dawson, P., Heeneman, S., Daemen, M. J., & Hackeng, T. M. (2009). Total Chemical Synthesis of Bimodal-Labeled Rantes as a Pet/Tplsm Probe for in Vivo Molecular Imaging of Atherosclerotic Plaque Instability. Biopolymers, 92(4), 376-376. http://gateway.isiknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ResearchSoft&SrcApp=EndNote&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000266753100412
  • 2006
    • Lobbes, M. B., Lutgens, E., Heeneman, S., Cleutjens, K. B. J. M., Kooi, M. E., van Engelshoven, J. M. A., Daemen, M. J., & Nelemans, P. J. (2006). Is there more than C-reactive protein and fibrinogen? The prognostic value of soluble CD40 ligand, interleukin-6 and oxidized low-density lipoprotein with respect to coronary and cerebral vascular disease. Atherosclerosis, 187(1), 18-25. https://doi.org/10.1016/j.atherosclerosis.2005.11.005
  • 2005
    • Cappendijk, V. C., Cleutjens, K. B. J. M., Kessels, A. G. H., Heeneman, S., Schurink, G. W. H., Welten, R. J., Mess, W. H., Daemen, M. J., van Engelshoven, J. M. A., & Kooi, M. E. (2005). Assessment of human atherosclerotic carotid plaque components with multisequence MR imaging: initial experience. Radiology, 234(2), 487-492. https://doi.org/10.1148/radiol.2342032101
    • Lutgens, E., Faber, B. C. G., Schapira, K. B., Evelo, C. T., van Haaften, R., Heeneman, S., Cleutjens, K. B. J. M., Bijnens, A. P. J. J., Beckers, L., Porter, J. G., Mackay, C. R., Rennert, P., Bailly, V., Jarpe, M., Dolinski, B., Koteliansky, V., de Fougerolles, T., & Daemen, M. J. (2005). Gene profiling in atherosclerosis reveals a key role for small inducible cytokines: validation using a novel monocyte chemoattractant protein monoclonal antibody. Circulation, 111(25), 3443-3452. https://doi.org/10.1161/CIRCULATIONAHA.104.510073
    • Donners, M. M. P. C., Verluyten, M. J., Bouwman, F. G., Mariman, E. C., Devreese, B., Vanrobaeys, F., van Beeumen, J., van den Akker, L. H., Daemen, M. J., & Heeneman, S. (2005). Proteomic analysis of differential protein expression in human atherosclerotic plaque progression. Journal of Pathology, 206(1), 39-45. https://doi.org/10.1002/path.1749
  • 2002
    • van Gorp Beisser, R. M. A., Heeneman, S., Broers, J. L. V., Bronnenberg, N. M. H. J., Mieras-van Dam, M. C. E., & Heemskerk, J. W. M. (2002). Glutathione oxidation in calcium- and p38 MAPK-dependent membrane blebbing of endothelial cells. Biochimica et Biophysica Acta. Mucoproteins and Mucopolysaccharides, 19(1591 (1-3)), 129-138. https://doi.org/10.1016/S0167-4889(02)00273-2
  • 1997
    • de Blaauw, I., Heeneman, S., Deutz, N. E. P., & von Meyenfeldt, M. F. (1997). Increased whole-body protein and glutamine turnover in advanced cancer is not matched by an increased muscle protein and glutamine turnover.Journal of Surgical Research, 68(1), 44-55. https://doi.org/10.1006/jsre.1997.5007
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