Werner Mess


Prof. Werner Mess received his medical degree in 1989 at the University of Düsseldorf, whereafter he was a resident in neurology in Mannheim/Heidelberg and Düsseldorf until 1994. As a certified neurologist he went to Nieuwegein (NL), where he worked as a clinical neurophysiologist for two years. In 1997, he became staff member and subsequently (2006) chairman of the Department of Clinical Neurophysiology at Maastricht University. In 2003, he received his PhD in Medicine at Maastricht University on the physical properties of microembolus detection and in 2007 became professor of clinical neurophysiology.

He has been involved in ultrasound since his first scientific activities resulting in a thesis based on CW Doppler measurements of the carotid and vertebral arteries in patients with an asymptomatic vascular disease. Since then, he has performed and participated in multiple studies on plaque morphology as well as microembolus detection. The latter led to his PhD degree and focussed on the physical aspects of the method. Currently, he focusses on long-term embolus detection, as well as the combined evaluation of functional, and anatomical properties of the carotid artery by means of ultrasound. He is an internationally recognised expert in this field and a member of the ESNCH and board member of the Neurosonology Research Group.

Department of Clinical Neurophysiology
P. Debyelaan 25, 6229 HX Maastricht 
PO Box 5800, 6202 AZ Maastricht
: +31(0)43 387 52 73

  • 2020
    • van der Velde, J. H. P. M., Koster, A., Strotmeyer, E. S., Mess, W. H., Hilkman, D., Reulen, J. P. H., Stehouwer, C. D. A., Henry, R. M. A., Schram, M. T., van der Kallen, C. J. H., Schalkwijk, C. G., Savelberg, H. H. C. M., & Schaper, N. C. (2020). Cardiometabolic risk factors as determinants of peripheral nerve function: the Maastricht Study. Diabetologia, 63(8), 1648-1658. https://doi.org/10.1007/s00125-020-05194-5
    • Stevens, R. R. F., Donders, W. P., Quicken, S., van de Vosse, F. N., Mess, W. H., Delhaas, T., & Huberts, W. (2020). The Role of One-Dimensional Model-Generated Inter-Subject Variations in Systemic Properties on Wall Shear Stress Indices of Intracranial Aneurysms. Ieee Transactions on Biomedical Engineering, 67(4), 1030-1039. https://doi.org/10.1109/TBME.2019.2928416
  • 2019
    • Crombag, G. A. J. C., van Hoof, R. H. M., Holtackers, R. J., Schreuder, F. H. B. M., Truijman, M. T. B., Schreuder, T. A. H. C. M. L., van Orshoven, N. P., Mess, W. H., Hofman, P. A. M., van Oostenbrugge, R. J., Wildberger, J. E., & Kooi, M. E. (2019). Symptomatic Carotid Plaques Demonstrate Less Leaky Plaque Microvasculature Compared With the Contralateral Side: A Dynamic Contrast-Enhanced Magnetic Resonance Imaging Study. Journal of the American Heart Association, 8(8), [011832]. https://doi.org/10.1161/JAHA.118.011832
    • Crombag, G. A. J. C., Schreuder, F. H. B. M., van Hoof, R. H. M., Truijman, M. T. B., Wijnen, N. J. A., Voo, S. A., Nelemans, P. J., Heeneman, S., Nederkoorn, P. J., Daemen, J-W. H., Daemen, M. J. A. P., Mess, W. H., Wildberger, J. E., van Oostenbrugge, R. J., & Kooi, M. E. (2019). Microvasculature and intraplaque hemorrhage in atherosclerotic carotid lesions: a cardiovascular magnetic resonance imaging study. Journal of Cardiovascular Magnetic Resonance, 21, [15]. https://doi.org/10.1186/s12968-019-0524-9
  • 2018
    • Hilkman, D. M. W., van Mook, W. N. K. A., Mess, W. H., & van Kranen-Mastenbroek, V. H. J. M. (2018). The Use of Continuous EEG Monitoring in Intensive Care Units in The Netherlands: A National Survey. Neurocritical Care, 29(2), 195-202. https://doi.org/10.1007/s12028-018-0525-9
    • Crombag, G. A. J. C., Spronk, H. M., Nelemans, P., Schreuder, F. H. B. M., Truijman, M. T. B., van Dijk, A. C., de Rotte, A. A. J., Liem, M. I., Daemen, M. J. A. P., van der Steen, A. F. W., Mess, W. H., Nederkoorn, P. J., Hendrikse, J., van der Lugt, A., Wildberger, J. E., ten Cate, H., van Oostenbrugge, R. J., & Kooi, M. E. (2018). No Association between Thrombin Generation and Intra-Plaque Haemorrhage in Symptomatic Carotid Atherosclerotic Plaques: The Plaque at RISK (PARISK) Study. Thrombosis and Haemostasis, 118(8), 1461-1469. https://doi.org/10.1055/s-0038-1666858
    • Steinbuch, J., Schreuder, F. H. B. M., Reesink, K. D., Hoeks, A. P. G., & Mess, W. H. (2018). ORTHOGONAL B-MODE EVALUATION OF COMMON CAROTID ARTERY PLAQUES REVEALS THE ABSENCE OF OUTWARD REMODELING. Ultrasound in Medicine and Biology, 44(5), 986-994. https://doi.org/10.1016/j.ultrasmedbio.2017.12.013
    • Gombert, A., Grommes, J., Hilkman, D., Kotelis, D., Mess, W. H., & Jacobs, M. J. (2018). Recovery of lost motor evoked potentials in open thoracoabdominal aortic aneurysm repair using intercostal artery bypass. Journal of Vascular Surgery Cases and Innovative Techniques, 4(1), 54-57. https://doi.org/10.1016/j.jvscit.2017.12.004
  • 2017
    • Steinbuch, J., van Dijk, A. C., Schreuder, F. H. B. M., Truijman, M. T. B., de Rotte, A. A. J., Nederkoorn, P. J., van der Lugt, A., Hermeling, E., Hoeks, A. P. G., & Mess, W. H. (2017). High Spatial Inhomogeneity in the Intima-Media Thickness of the Common Carotid Artery is Associated with a Larger Degree of Stenosis in the Internal Carotid Artery: The PARISK Study. Ultraschall in der Medizin - European Journal of Ultrasound, 38(5), 523-529. https://doi.org/10.1055/s-0042-112220
    • van Hoof, R. H. M., Voo, S. A., Sluimer, J. C., Wijnen, N. J. A., Hermeling, E., Schreuder, F. H. B. M., Truijman, M. T. B., Cleutjens, J. P. M., Daemen, M. J. A. P., Daemen, J-W. H., van Oostenbrugge, R. J., Mess, W. H., Wildberger, J. E., Heeneman, S., & Kooi, M. E. (2017). Vessel Wall and Adventitial DCE-MRI Parameters Demonstrate Similar Correlations With Carotid Plaque Microvasculature on Histology. Journal of Magnetic Resonance Imaging, 46(4), 1053-1059. https://doi.org/10.1002/jmri.25648
    • Steinbuch, J., van Dijk, A. C., Schreuder, F. H. B. M., Truijman, M. T. B., Hendrikse, J., Nederkoorn, P. J., van der Lugt, A., Hermeling, E., Hoeks, A. P. G., & Mess, W. H. (2017). Definition of common carotid wall thickness affects risk classification in relation to degree of internal carotid artery stenosis: the Plaque At RISK (PARISK) study. Cardiovascular Ultrasound, 15, [9]. https://doi.org/10.1186/s12947-017-0097-4
    • van Hoof, R. H. M., Schreuder, F. H. B. M., Nelemans, P., Truijman, M. T. B., van Orshoven, N. P., Schreuder, T. H., Mess, W. H., Heeneman, S., van Oostenbrugge, R. J., Wildberger, J. E., & Kooi, M. E. (2017). Ischemic Stroke Patients Demonstrate Increased Carotid Plaque Microvasculature Compared to (Ocular) Transient Ischemic Attack Patients. Cerebrovascular Diseases, 44(5-6), 297-303. https://doi.org/10.1159/000481146
  • 2016
    • Klooster, D. C. W., de Louw, A. J. A., Aldenkamp, A. P., Besseling, R. M. H., Mestrom, R. M. C., Carrette, S., Zinger, S., Bergmans, J. W. M., Mess, W. H., Vonck, K., Carrette, E., Breuer, L. E. M., Bernas, A., Tijhuis, A. G., & Boon, P. (2016). Technical aspects of neurostimulation: Focus on equipment, electric field modeling, and stimulation protocols. Neuroscience and Biobehavioral Reviews, 65, 113-141. https://doi.org/10.1016/j.neubiorev.2016.02.016
    • Bouwmans, A. E. P., Weber, W. E. J., Leentjens, A. F. G., & Mess, W. H. (2016). Transcranial sonography findings related to depression in parkinsonian disorders: cross-sectional study in 126 patients. PEERJ, 4, [e2037]. https://doi.org/10.7717/peerj.2037
    • Koppen, H., Palm-Meinders, I. H., Mess, W. H., Keunen, R. W., Terwindt, G. M., Launer, L. J., van Buchem, M. A., Kruit, M. C., & Ferrari, M. D. (2016). Systemic right-to-left shunts, ischemic brain lesions, and persistent migraine activity. Neurology, 86(18), 1668-1675. https://doi.org/10.1212/WNL.0000000000002538
    • Breuer, L. E. M., Boon, P., Bergmans, J. W. M., Mess, W. H., Besseling, R. M. H., de Louw, A., Tijhuis, A. G., Zinger, S., Bernas, A., Klooster, D. C. W., & Aldenkamp, A. P. (2016). Cognitive deterioration in adult epilepsy: Does accelerated cognitive ageing exist?Neuroscience and Biobehavioral Reviews, 64, 1-11. https://doi.org/10.1016/j.neubiorev.2016.02.004
    • Steinbuch, J., Hoeks, A. P. G., Hermeling, E., Truijman, M. T. B., Schreuder, F. H. B. M., & Mess, W. (2016). Standard B-Mode Ultrasound Measures Local Carotid Artery Characteristics as Reliably as Radiofrequency Phase Tracking in Symptomatic Carotid Artery Patients. Ultrasound in Medicine and Biology, 42(2), 586-595. https://doi.org/10.1016/j.ultrasmedbio.2015.07.030
    • Bouwmans, A. E. P., Leentjens, A. F. G., Mess, W. H., & Weber, W. E. J. (2016). Abnormal Echogenicity of the Substantia Nigra, Raphe Nuclei, and Third-Ventricle Width as Markers of Cognitive Impairment in Parkinsonian Disorders: A Cross-Sectional Study. Parkinson's Disease, 2016, [4058580]. https://doi.org/10.1155/2016/4058580
  • 2015
    • Severdija, E. E., Gommer, E. D., Weerwind, P. W., Reulen, J. P. H., Mess, W. H., & Maessen, J. G. (2015). Assessment of dynamic cerebral autoregulation and cerebral carbon dioxide reactivity during normothermic cardiopulmonary bypass. Medical & Biological Engineering & Computing, 53(3), 195-203. https://doi.org/10.1007/s11517-014-1225-z
  • 2014
    • Gommer, E. D., Bogaarts, G., Martens, E. G. H. J., Mess, W. H., & Reulen, J. P. H. (2014). Visually evoked blood flow responses and interaction with dynamic cerebral autoregulation: Correction for blood pressure variation. Medical Engineering & Physics, 36(5), 613-619. https://doi.org/10.1016/j.medengphy.2014.01.006
  • 2013
    • Goedee, H. S., Brekelmans, G. J. F., van Asseldonk, J. T. H., Beekman, R., Mess, W. H., & Visser, L. H. (2013). High resolution sonography in the evaluation of the peripheral nervous system in polyneuropathy - a review of the literature. European Journal of Neurology, 20(10), 1342-1351. https://doi.org/10.1111/ene.12182
    • Schurink, G. W. H., De Haan, M. W., Peppelenbosch, A. G., Mess, W., & Jacobs, M. (2013). Spinal cord function monitoring during endovascular treatment of thoracoabdominal aneurysms: implications for staged procedures. Journal of Cardiovascular Surgery, 54(1), 117-124.
    • Bouwmans, A. E. P., Vlaar, A. M. M., Mess, W. H., Kessels, A. G., & Weber, W. E. J. (2013). Specificity and sensitivity of transcranial sonography of the substantia nigra in the diagnosis of Parkinson's disease: prospective cohort study in 196 patients. BMJ Open, 3(4), [e002613]. https://doi.org/10.1136/bmjopen-2013-002613
  • 2012
    • Greiner, A., Mess, W. H., Schmidli, J., Debus, E. S., Grommes, J., Dick, F., & Jacobs, M. J. (2012). Cyber medicine enables remote neuromonitoring during aortic surgery. Journal of Vascular Surgery, 55(5), 1227-1233. https://doi.org/10.1016/j.jvs.2011.11.121
    • Gommer, E. D., Martens, E. G. H. J., Aalten, P., Shijaku, E., Verhey, F. R. J., Mess, W. H., Ramakers, I. H. G. B., & Reulen, J. P. H. (2012). Dynamic Cerebral Autoregulation in Subjects with Alzheimer's Disease, Mild Cognitive Impairment, and Controls: Evidence for Increased Peripheral Vascular Resistance with Possible Predictive Value. Journal of Alzheimer's Disease, 30(4), 805-813. https://doi.org/10.3233/JAD-2012-111628
  • 2011
    • Kwee, R. M., Hofman, P. A., Gronenschild, E. H., van Oostenbrugge, R. J., Mess, W. H., Ter Berg, J. W., Franke, CL., Korten, A. G., Meems, B. J., van Engelshoven, J. M., Wildberger, J. E., & Kooi, M. E. (2011). Association between carotid plaque characteristics and cerebral white matter lesions: one-year follow-up study by MRI. PLOS ONE, 6(2), [e17070]. https://doi.org/10.1371/journal.pone.0017070
  • 2010
    • Langer, S., Koeppel, T. A., Greiner, A., Kalder, J., Keschenau, P. R., Mess, W. H., & Jacobs, M. J. (2010). Intraoperative Neuromonitoring for Prevention of Neurological Complications in Aortic Surgery. Zentralblatt für Chirurgie, 135(5), 421-426. https://doi.org/10.1055/s-0030-1247383
    • Mommertz, G., Das, M., Langer, S., Koeppel, T. A., Krings, T., Mess, W. H., Schiefer, J., & Jacobs, M. J. (2010). Early control of distal internal carotid artery during carotid endarterectomy: does it reduce cerebral microemboli?Journal of Cardiovascular Surgery, 51(3), 369-375.
    • Braakman, H. M. H., Lodder, J., Postma, A. A., Span, L. F. R., & Mess, W. H. (2010). Vasospasm is a significant factor in cyclosporine-induced neurotoxicity: Case report. BMC Neurology, 10, 30. https://doi.org/10.1186/1471-2377-10-30
    • Koeppel, T. A., Mess, W. H., & Jacobs, M. J. (2010). Motor Evoked Potentials in Thoracoabdominal Aortic Surgery: PRO. Cardiology Clinics, 28(2), 351-+. https://doi.org/10.1016/j.ccl.2010.01.013
    • Graf, I. M., Schreuder, F. H. B. M., Mess, W. H., Reneman, R. S., & Hoeks, A. P. G. (2010). Spatial Distension Variations Are Associated with Focal Atherosclerotic Plaques. Cerebrovascular Diseases, 29(2), 199-205. https://doi.org/10.1159/000267280
  • 2009
    • Vlaar, A. M. M., Tromp, S. C., Weber, W. E., Hubens-Hustinx, R. M., & Mess, W. H. (2009). The reliability of transcranial duplex scanning in parkinsonian patients: comparison of different observers and ultrasound systems. Movement Disorders, 24, S217-S218.
  • 2005
    • Cappendijk, V. C., Cleutjens, K. B. J. M., Kessels, A. G. H., Heeneman, S., Schurink, G. W. H., Welten, R. J., Mess, W. H., Daemen, M. J., van Engelshoven, J. M. A., & Kooi, M. E. (2005). Assessment of human atherosclerotic carotid plaque components with multisequence MR imaging: initial experience. Radiology, 234(2), 487-492. https://doi.org/10.1148/radiol.2342032101
  • 2003
    • Rodriguez-Hernandez, S., Kroon, A. A., van Boxtel, M. P. J., Mess, W. H., Lodder, J., Jolles, J., & de Leeuw, P. W. (2003). Is there a side predilection for cerebrovascular disease?Hypertension, 42, 56-60. https://doi.org/10.1161/01.HYP.0000077983.66161.6F
  • 2002
    • Rodriguez-Hernandez, S., van Boxtel, M. P. J., Kroon, A. A., Mess, W. H., Lodder, J., & Jolles, J. (2002). Carotid intima media thickness asymetry in an untreated uncomplicated hypertensive population.Cerebrovascular Diseases, 13(suppl 4, 1-53.