Arina ten Cate-Hoek

Associate professor

Dr Arina ten Cate-Hoek graduated as a medical doctor at the University of Amsterdam and as a Clinical Epidemiologist at the University of Maastricht. Her PhD thesis was on new developments in diagnosis and treatment of deep venous thrombosis. She currently holds a clinical position at the Heart+Vascular Center of Maastricht UMC+ and her specialty is in the prevention and treatment of venous thrombotic disease, especially the Post Thrombotic Syndrome. She is the medical director of the Anticoagulation Clinic as well as the medical coordinator of the Thrombosis Expertise Centre Maastricht. She gained some laboratory experience in the laboratory of the Harvard University Beth Israel Deaconess Medical Center in Boston and the Laboratory of the Netherlands Red Cross Blood Transfusion Service (CLB)in Amsterdam.

Since 2003, she has been working at the Maastricht UMC+ where she combines clinical work with clinical and translational research. The main topic of het research is prevention and treatment of the Post Thrombotic Syndrome. She received research grants mainly from ZonMw Efficiency research.

Department of Internal Medicine
P. Debyelaan 25, 6229 HX Maastricht
PO Box 612, 6200 MD Maastricht

  • 2019
    • Leader, A., Ten Cate, V., Ten Cate-Hoek, A. J., Spectre, G., Beckers, E. A. M., Raanani, P., Giaccherini, C., Pereg, D., Schouten, H. C., Falanga, A., & Ten Cate, H. (2019). Managing Anti-Platelet Therapy in Thrombocytopaenic Patients with Haematological Malignancy: A Multinational Clinical Vignette-Based Experiment. Thrombosis and Haemostasis, 119(1), 163-174. https://doi.org/10.1055/s-0038-1676520
  • 2018
    • Amin, E. E., Bistervels, I. M., Meijer, K., Tick, L. W., Middeldorp, S., Mostard, G., van de Poel, M., Serne, E. H., Otten, H. M., Klappe, E. M., Joore, M. A., ten Cate, H., ten Wolde, M., & ten Cate-Hoek, A. J. (2018). Reduced incidence of vein occlusion and postthrombotic syndrome after immediate compression for deep vein thrombosis. Blood, 132(21), 2298-2304. https://doi.org/10.1182/blood-2018-03-836783
    • Amin, E. E., ten Cate-Hoek, A. J., Bouman, A. C., Meijer, K., Tick, L., Middeldorp, S., Mostard, G., ten Wolde, M., van den Heiligenberg, S., van Wissen, S., van de Poet, M., Villalta, S., Serne, E., Otten, H. M., Klappe, E., Prandoni, P., Prins, M. H., ten Cate, H., & Joore, M. A. (2018). Individually shortened duration versus standard duration of elastic compression therapy for prevention of post-thrombotic syndrome: a cost-effectiveness analysis. The Lancet Haematology, 5(11), E512-E519. https://doi.org/10.1016/S2352-3026(18)30151-0
    • Pernot, C. C. E. G., Zwiers, I., ten Cate-Hoek, A. J., & Wittens, C. H. A. (2018). The need for a timely diagnostic workup for patients with venous leg ulcers. Journal of Wound Care, 27(11), 758-763. https://doi.org/10.12968/jowc.2018.27.11.758
    • Amin, E. E., Joore, M. A., ten Cate, H., Meijer, K., Tick, L. W., Middeldorp, S., Mostard, G. J. M., ten Wolde, M., Van den Heiligenberg, S. M., Van Wissen, S., Van de Poel, M. H. W., Villalta, S., Serne, E. H., Otten, H.-M., Klappe, E. H., Prandoni, P., & ten Cate-Hoek, A. J. (2018). Clinical and economic impact of compression in the acute phase of deep vein thrombosis. Journal of Thrombosis and Haemostasis, 16(8), 1555-1563. https://doi.org/10.1111/jth.14163
    • Amin, E. E., van Kuijk, S. M. J., Joore, M. A., Prandoni, P., ten Cate, H., & ten Cate-Hoek, A. J. (2018). Development and Validation of a Practical Two-Step Prediction Model and Clinical Risk Score for Post-Thrombotic Syndrome. Thrombosis and Haemostasis, 118(7), 1242-1249. https://doi.org/10.1055/s-0038-1655743
    • Vaidya, A., Kleinegris, M.-C., Severens, J. L., Ramaekers, B. L., ten Cate-Hoek, A. J., ten Cate, H., & Joore, M. A. (2018). Comparison of EQ-5D and SF-36 in untreated patients with symptoms of intermittent claudication. Journal of Comparative Effectiveness Research, 7(6), 535-548. https://doi.org/10.2217/cer-2017-0029
    • ten Cate, H., Olie, R. H., ten Cate-Hoek, A. J., & Henskens, Y. M. C. (2018). Direct oral anticoagulants: When to consider laboratory testing?International Journal of Laboratory Hematology, 40(S1), 30-33. https://doi.org/10.1111/ijlh.12816
    • ten Cate-Hoek, N. J. (2018). Prevention and treatment of the post-thrombotic syndrome. Research and practice in thrombosis and haemostasis, 2(2), 209-219. https://doi.org/10.1002/rth2.12085
    • Nagler, M., ten Cate, H., Prins, M. H., & ten Cate-Hoek, A. J. (2018). Risk factors for recurrence in deep vein thrombosis patients following a tailored anticoagulant treatment incorporating residual vein obstruction. Research and practice in thrombosis and haemostasis, 2(2), 299-309. https://doi.org/10.1002/rth2.12079
    • Spronk, H. M. H., Padro, T., Siland, J. E., Prochaska, J. H., Winters, J., van der Wal, A. C., Posthuma, J. J., Lowe, G., d'Alessandro, E., Wenzel, P., Coenen, D. M., Reitsma, P. H., Ruf, W., van Gorp, R. H., Koenen, R. R., Vajen, T., Alshaikh, N. A., Wolberg, A. S., Macrae, F. L., ... ten Cate, H. (2018). Atherothrombosis and Thromboembolism: Position Paper from the Second Maastricht Consensus Conference on Thrombosis. Thrombosis and Haemostasis, 118(2), 229-250. https://doi.org/10.1160/TH17-07-0492
    • Henskens, Y. M. C., Gulpen, A. J. W., van Oerle, R., Wetzels, R., Verhezen, P., Spronk, H., Schalla, S., Crijns, H. J., ten Cate, H., & ten Cate-Hoek, A. (2018). Detecting clinically relevant rivaroxaban or dabigatran levels by routine coagulation tests or thromboelastography in a cohort of patients with atrial fibrillation. Thrombosis Journal, 16, Article 3. https://doi.org/10.1186/s12959-017-0160-2
    • ten Cate-Hoek, A. J., Amin, E. E., Bouman, A. C., Meijer, K., Tick, L. W., Middeldorp, S., Mostard, G. J. M., ten Wolde, M., van den Heiligenberg, S. M., van Wissen, S., van de Poel, M. H. W., Villalta, S., Serne, E. H., Otten, H.-M., Klappe, E. H., Bistervels, I. M., Lauw, M. N., Piersma-Wichers, M., Prandoni, P., ... IDEAL DVT Investigators (2018). Individualised versus standard duration of elastic compression therapy for prevention of post-thrombotic syndrome (IDEAL DVT): a multicentre, randomised, single-blind, allocation-concealed, non-inferiority trial. The Lancet Haematology, 5(1), 25-33. https://doi.org/10.1016/S2352-3026(17)30227-2
  • 2017
    • Stolk, L. M., de Vries, F., Ebbelaar, C., de Boer, A., Schalekamp, T., Souverein, P., ten Cate-Hoek, A., & Burden, A. M. (2017). Risk of myocardial infarction in patients with atrial fibrillation using vitamin K antagonists, aspirin or direct acting oral anticoagulants. British Journal of Clinical Pharmacology, 83(8), 1835-1843. https://doi.org/10.1111/bcp.13264
    • Bloemen, S., Zwaveling, S., ten Cate, H., ten Cate-Hoek, A., & de Laat, B. (2017). Prediction of bleeding risk in patients taking vitamin K antagonists using thrombin generation testing. PLOS ONE, 12(5), Article e0176967. https://doi.org/10.1371/journal.pone.0176967
    • Kleinegris, M.-C. F., Konings, J., Daemen, J. W., Henskens, Y., de Laat, B., Spronk, H. M. H., ten Cate-Hoek, A. J., & ten Cate, H. (2017). Increased Clot Formation in the Absence of Increased Thrombin Generation in Patients with Peripheral Arterial Disease: A Case-Control Study. Frontiers in Cardiovascular Medicine, 4, Article 23. https://doi.org/10.3389/fcvm.2017.00023
    • Vries, M. J. A., Bouman, H. J., Olie, R. H., Veenstra, L. F., Zwaveling, S., Verhezen, P. W. M., ten Cate-Hoek, A. J., ten Cate, H., Henskens, Y. M. C., & van der Meijden, P. E. J. (2017). Determinants of agreement between proposed therapeutic windows of platelet function tests in vulnerable patients. European Heart Journal-Cardiovascular Pharmacotherapy, 3(1), 11-17. https://doi.org/10.1093/ehjcvp/pvw026
  • 2016
    • Boersma, R. S., Hamulyak, K., van Oerle, R., Tuinenburg, A., Ten Cate - Hoek, A., & Schouten, H. C. (2016). Biomarkers for Prediction of Central Venous Catheter Related-Thrombosis in Patients With Hematological Malignancies. Clinical and Applied Thrombosis-Hemostasis, 22(8), 779-784. https://doi.org/10.1177/1076029615579098
    • Cheung, Y. W., Middeldorp, S., Prins, M. H., Pap, A. F., Lensing, A. W. A., Hoek - ten Cate, A., Villalta, S., Milan, M., Beyer-Westendorf, J., Verhamme, P., Bauersachs, R. M., & Prandoni, P. (2016). Post-thrombotic syndrome in patients treated with rivaroxaban or enoxaparin/vitamin K antagonists for acute deep-vein thrombosis A post-hoc analysis. Thrombosis and Haemostasis, 116(4), 733-738. https://doi.org/10.1160/TH16-01-0041
    • Hoek - ten Cate, A. (2016). Stockings to prevent post-thrombotic syndrome. BMJ, 353, Article i2897. https://doi.org/10.1136/bmj.i2897
    • Eijgenraam, P., ten Cate, H., Henskens, Y., van den Ham, R., & ten Cate - Hoek , A. (2016). Effects of peri-operative bridging with low molecular weight heparins on coagulation during interruption of vitamin K antagonists: A mechanistic study. Thrombosis Research, 140, 59-65. https://doi.org/10.1016/j.thromres.2016.02.019
    • Cheung, Y. W., Bouman, A. C., Castoldi, E., Wielders, S. J., Spronk, H. M. H., ten Cate, H., Hoek - ten Cate, A., & ten Wolde, M. (2016). Toll-like receptor 9 gene expression in the post-thrombotic syndrome, residual thrombosis and recurrent deep venous thrombosis: A case-control study. Thrombosis Research, 140, 106-109. https://doi.org/10.1016/j.thromres.2016.02.025
    • Amin, E., Joore, M. A., & Hoek - ten Cate, A. (2016). Compression to prevent PTS: a controversy?Phlebology: The Journal of Venous Disease, 31(1 suppl), 41-47. https://doi.org/10.1177/0268355516632986
    • Bouman, A. C., Ten Cate - Hoek, A., Dirksen, C. D., & Joore, M. A. (2016). Eliciting patients' preferences for elastic compression stocking therapy in patients after deep vein thrombosis: a potential for improving compliance. Journal of Thrombosis and Haemostasis, 14(3), 510–517. https://doi.org/10.1111/jth.13228
    • Tten Cate - Hoek, A., Henke, P. K., & Wakefield, T. W. (2016). The post thrombotic syndrome: Ignore it and it will come back to bite you. Blood Reviews, 30(2), 131-137. https://doi.org/10.1016/j.blre.2015.09.002
    • Nagler, M., Bachmann, L. M., ten Cate, H., & ten Cate - Hoek, A. (2016). Diagnostic value of immunoassays for heparin-induced thrombocytopenia: a systematic review and meta-analysis. Blood, 127(5), 546-557. https://doi.org/10.1182/blood-2015-07-661215
    • Bouman, A. C., McPherson, H., Cheung, Y. W., ten Wolde, M., ten Cate, H., Ariëns, R., & Ten Cate - Hoek, A. (2016). Clot structure and fibrinolytic potential in patients with post thrombotic syndrome. Thrombosis Research, 137, 85-91. https://doi.org/10.1016/j.thromres.2015.11.013
    • Vries, M. J. A., van der Meijden, P. E. J., Henskens, Y. M. C., Ten Cate - Hoek, A., & ten Cate, H. (2016). Assessment of bleeding risk in patients with coronary artery disease on dual antiplatelet therapy A systematic review. Thrombosis and Haemostasis, 115(1), 7-24. https://doi.org/10.1160/TH15-04-0355
    • Hoek - ten Cate, A. (2016). Efficacy of compression for the prevention of post-thrombotic syndrome: an unsolved clinical conundrum: Comment on Burgstaller et al, 141-147. Vasa-European Journal of Vascular Medicine, 45(2), 85-86. https://doi.org/10.1024/0301-1526/a000502
    • Gulpen, A. J. W., Hoek - ten Cate, A., & Ten Cate, H. (2016). Upstream versus downstream thrombin inhibition. Expert review of cardiovascular therapy, 14(11), 1273-1282. https://doi.org/10.1080/14779072.2016.1224179
  • 2015
    • Tjon-Kon-Fat, R. I., Bensdorp, A. J., Bossuyt, P. M. M., Koks, C., Oosterhuis, G. J. E., Hoek - ten Cate, A., Hompes, P., Broekmans, F. J., Verhoeve, H. R., de Bruin, J. P., van Golde, R., Repping, S., Cohlen, B. J., Lambers, M. D. A., van Bommel, P. F., Slappendel, E., Perquin, D., Smeenk, J., Pelinck, M. J., ... van Wely, M. (2015). Is IVF-served two different ways-more cost-effective than IUI with controlled ovarian hyperstimulation?Human Reproduction, 30(10), 2331-2339. https://doi.org/10.1093/humrep/dev193
    • Vissenberg, R., van Dijk, M. M., Fliers, E., van der Post, J. A. M., van Wely, M., Bloemenkamp, K. W. M., Hoek - ten Cate, A., Kuchenbecker, W. K., Verhoeve, H. R., Scheepers, H. C. J., Rombout-de Weerd, S., Koks, C., Zwart, J. J., Broekmans, F., Verpoest, W., Christiansen, O. B., Post, M., Papatsonis, D. N. M., Verberg, M. F. G., ... Goddijn, M. (2015). Effect of levothyroxine on live birth rate in euthyroid women with recurrent miscarriage and TPO antibodies (T4-LIFE study). Contemporary Clinical Trials, 44, 134-138. https://doi.org/10.1016/j.cct.2015.08.005
    • Hoek - ten Cate, A. J., ten Cate, H., Henskens, Y., van der Meijden, P. E. J., Spronk, H. M. H., & Wittens, C. (2015). Maastricht Consensus Conference on Thrombosis (MCCT): A roadmap for future research, February 11-13, 2015, Maastricht, The Netherlands. Thrombosis Research, 136, S1-S2. https://doi.org/10.1016/j.thromres.2015.07.033
    • ten Cate-Hoek, A. J., Weitz, J. I., Gailani, D., Meijer, K., Philippou, H., Bouman, A. C., Whitney Cheung, Y., van Mens, T. E., Govers-Riemslag, J. W., Vries, M., Bleker, S., Biedermann, J. S., Stoof, S. C. M., & Buller, H. R. (2015). Theme 3: Non-invasive management of (recurrent) venous thromboembolism (VTE) and post thrombotic syndrome (PTS). Thrombosis Research, 136(Supplement 1), S13-S18. https://doi.org/10.1016/j.thromres.2015.07.036
    • Hermanns, M. I., Grossmann, V., Spronk, H. M. H., Schulz, A., Juenger, C., Laubert-Reh, D., Mazur, J., Gori, T., Zeller, T., Pfeiffer, N., Beutel, M., Blankenberg, S., Muenzel, T., Lackner, K. J., Hoek - ten Cate, A. J., ten Cate, H., & Wild, P. S. (2015). Distribution, genetic and cardiovascular determinants of FVIII:c - Data from the population-based Gutenberg Health Study. International Journal of Cardiology, 187, 166-174. https://doi.org/10.1016/j.ijcard.2015.03.330
    • Nagy, R. A., van Montfoort, A. P. A., Dikkers, A., van Echten-Arends, J., Homminga, I., Land, J. A., Hoek - ten Cate, A., & Tietge, U. J. F. (2015). Presence of bile acids in human follicular fluid and their relation with embryo development in modified natural cycle IVF. Human Reproduction, 30(5), 1102-1109. https://doi.org/10.1093/humrep/dev034
    • Strijkers, R. H. W., de Wolf, M. A. F., Arnoldussen, C. W. K. P., Timbergen, M. J. M., de Graaf, R., Hoek - ten Cate, A. J., & Wittens, C. H. A. (2015). Venous In-stent Thrombosis Treated by Ultrasound Accelerated Catheter Directed Thrombolysis. European Journal of Vascular and Endovascular Surgery, 49(4), 440-447. https://doi.org/10.1016/j.ejvs.2015.01.006
    • Eijgenraam, P., Meertens, N., van den Ham, R., ten Cate, H., & Hoek - ten Cate, A. (2015). The effect of clinical decision support on adherence to thrombosis prophylaxis guidelines in medical patients; A single center experience. Thrombosis Research, 135(3), 464-471. https://doi.org/10.1016/j.thromres.2014.12.012
    • Bensdorp, A. J., Tjon-Kon-Fat, R. I., Bossuyt, P. M. M., Koks, C. A. M., Oosterhuis, G. J. E., Hoek - ten Cate, A., Hompes, P. G. A., Broekmans, F. J. M., Verhoeve, H. R., de Bruin, J. P., van Golde, R., Repping, S., Cohlen, B. J., Lambers, M. D. A., van Bommel, P. F., Slappendel, E., Perquin, D., Smeenk, J. M., Pelinck, M. J., ... van Wely, M. (2015). Prevention of multiple pregnancies in couples with unexplained or mild male subfertility: randomised controlled trial of in vitro fertilisation with single embryo transfer or in vitro fertilisation in modified natural cycle compared with intrauterine insemination with controlled ovarian hyperstimulation. BMJ, 350, Article g7771. https://doi.org/10.1136/bmj.g7771
    • Bouman, A. C., ten Cate-Hoek, A. J., Ramaekers, B. L. T., & Joore, M. A. (2015). Sample Size Estimation for Non-Inferiority Trials: Frequentist Approach versus Decision Theory Approach. PLOS ONE, 10(6), Article e0130531. https://doi.org/10.1371/journal.pone.0130531
    • Hendriksen, J. M. T., Geersing, G. J., van Voorthuizen, S. C., Oudega, R., ten Cate-Hoek, A. J., Joore, M. A., Moons, K. G. M., & Koffijberg, H. (2015). The cost-effectiveness of point-of-care D-dimer tests compared with a laboratory test to rule out deep venous thrombosis in primary care. Expert Review of Molecular Diagnostics, 15(1), 125-136. https://doi.org/10.1586/14737159.2015.976202
    • ten Cate-Hoek, A. J. (2015). Posttrombotisch syndroom, is de kous af?Nederlands Tijdschrift voor Geneeskunde, 159, Article A8726.
  • 2014
    • Kleinegris, M. C., Bos, M. H., Roest, M., Henskens, Y., Ten Cate-Hoek, A., Van Deursen, C., Spronk, H. M., Reitsma, P. H., De Groot, P. G., ten Cate, H., & Koek, G. (2014). Cirrhosis patients have a coagulopathy that is associated with decreased clot formation capacity. Journal of Thrombosis and Haemostasis, 12(10), 1647-1657. https://doi.org/10.1111/jth.12706
    • Eijgenraam, P., ten Cate, H., & ten Cate-Hoek, A. J. (2014). Practice of bridging anticoagulation: guideline adherence and risk factors for bleeding. Netherlands Journal of Medicine, 72(3), 157-164.
    • Geersing, G. J., Zuithoff, N. P. A., Kearon, C., Anderson, D. R., ten Cate-Hoek, A. J., Elf, J. L., Bates, S. M., Hoes, A. W., Kraaijenhagen, R. A., Oudega, R., Schutgens, R. E. G., Stevens, S. M., Woller, S. C., Wells, P. S., & Moons, K. G. M. (2014). Exclusion of deep vein thrombosis using the Wells rule in clinically important subgroups: individual patient data meta-analysis. BMJ, 348, Article g1340. https://doi.org/10.1136/bmj.g1340
    • Hoek - ten Cate, A. (2014). Elastic compression stockings-is there any benefit?Lancet, 383(9920), 851-853. https://doi.org/10.1016/S0140-6736(13)62347-8
    • Vaidya, A., Joore, M. A., Hoek - ten Cate, A. J., ten Cate, H., & Severens, J. L. (2014). Screen or not to screen for peripheral arterial disease: guidance from a decision model. BMC Public Health, 14(1), Article 89. https://doi.org/10.1186/1471-2458-14-89
    • Vaidya, A., Joore, M. A., ten Cate-Hoek, A. J., Kleinegris, M. C., ten Cate, H., & Severens, J. L. (2014). A systematic review of model-based economic evaluations of diagnostic and therapeutic strategies for lower extremity artery disease. Thrombosis and Haemostasis, 111(1), 19-28. https://doi.org/10.1160/TH13-06-0498
    • Bouman, A. C., Cheung, Y. W., Spronk, H. M., Schalkwijk, C. G., ten Cate, H., ten Wolde, M., & ten Cate-Hoek, A. J. (2014). Biomarkers for post thrombotic syndrome: A case-control study. Thrombosis Research, 134(2), 369-375. https://doi.org/10.1016/j.thromres.2014.06.010
    • Vaidya, A., Joore, M. A., ten Cate-Hoek, A. J., ten Cate, H., & Severens, J. L. (2014). Cost-effectiveness of risk assessment and tailored treatment for peripheral arterial disease patients. Biomarkers in Medicine, 8(8), 989-999. https://doi.org/10.2217/BMM.14.45