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MUMC+ Award Prof. Michael Jacobs

MUMC+ Award Prof. Michael Jacobs

3 May 2024

With a symposium in the St. Janskerk and a farewell lecture in the aula, vascular surgeon and professor Michael Jacobs bid farewell last Friday. From board chairman Helen Mertens, he received the MUMC+ Award, the highest distinction within the MUMC+, in recognition of all he has meant for Maastricht UMC+ and its patients.

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Prof. Kevin Vernooy Director HVC

Prof. Kevin Vernooy Director HVC

30 April 2024

Prof. Kevin Vernooy will become the medical director of the Heart+Vascular Center (HVC) at Maastricht UMC+.

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Carim Maastricht
Carim Maastricht

Bas van Bussel

Assistant Professor

Dr Bas van Bussel graduated in Medicine at Maastricht University in 2008. The title of his PhD thesis was: 'Endothelial dysfunction and low-grade inflammation: determined by diet and cause of arterial stiffness'. He obtained a Master in Epidemiology at Vrije Universiteit Amsterdam and was registered as Epidemiologist B. He started his training in internal medicine in 2012 and specialized both in acute medicine and intensive care medicine in Maastricht University Medical Centre+ (Maastricht UMC+) and Zuyderland Medical Centre. Bas started working as internist-intensivist at Maastricht UMC+ in 2019.

Dr Bas van Bussel primarily participates in (big) data and monitoring projects; such as the hospital standardized mortality rate project supported by Maastricht UMC+ and the variability and ease of access in proxy quality of life interviews at the ICU project supported by Euroqol Foundation. He likes team science, guiding students and nurses in research and multi-disciplinairy collaboration. He designed the Euregio Intensive Care Covid cohort and Co-PIed the international project entitled: 'Cross-border clinical-practice-variation-based development of COvid-19 Data-driven consensus treatment guidelines and the creation of an Euregio COVID-19 data Platform to anticipate a new wave project'. In addition, he has designed the MaastrICCht cohort, fostering a collaboration between many departments within and outside Maastricht UMC+. This resulted in his participation in several ZonMw grants, amongst him Co-PIing the project 'CoLab-score and viability PCR for SARSCoV-2: routine blood test algorithm proven by elimination of viable SARSCoV-2 to identify patients in order to facilitate discharge and/or deisolation'. Since 2020 Bas is active as board member in the National Intensive Care Evaluation (NICE). He has participated as cluster coordinator 'Acute Zorg' and 'Pandemie in Beeld' in the '2021 IMPACT Rapport of the Samenwerkende KwaliteitsRegistraties'. Furthermore, he is founder and board member of 'Stichting ICUdata' that aims to aggregate multi-centre highly granular healthcare data in the Netherlands.

Bas van bussel 64afff0e9469d

Department of Intensive Care
P. Debyelaan 25
6229 HX, Maastricht
Room number: 3.B2.009  
T: +31(0)43 387 63 87 

  • 2021
    • Strauch, U., Florack, M. C. D. M., Jansen, J., van Bussel, B. C. T., Beckers, S. K., Habers, J., Winkens, B., van der Horst, I. C. C., van Mook, W. N. K. A., & Bergmans, D. C. J. J. (2021). The QUality of Interhospital Transportation in the Euregion Meuse-Rhine (QUIT-EMR) score: a cross-validation study. BMJ Open, 11(11), Article e051100. https://doi.org/10.1136/bmjopen-2021-051100
    • Klinkhammer, S., Horn, J., Visser-Meilij, J. M. A., Verwijk, E., Duits, A., Slooter, A. J. C., van Heugten, C. M., NeNeSCo study group, Aries, M., van Bussel, B., Janssen, M., Postma - Jacobi, L., & van Santen, S. (2021). Dutch multicentre, prospective follow-up, cohort study comparing the neurological and neuropsychological sequelae of hospitalised non-ICU- and ICU-treated COVID-19 survivors: a study protocol. BMJ Open, 11(10), Article e054901. https://doi.org/10.1136/bmjopen-2021-054901
    • van Gassel, R. J. J., Bels, J., Remij, L., van Bussel, B. C. T., Posthuma, R., Gietema, H. A., Verbunt, J., van der Horst, I. C. C., Damink, S. W. M. O., van Santen, S., & van de Poll, M. C. G. (2021). Functional Outcomes and Their Association With Physical Performance in Mechanically Ventilated Coronavirus Disease 2019 Survivors at 3 Months Following Hospital Discharge: A Cohort Study. Critical Care Medicine, 49(10), 1726-1738. https://doi.org/10.1097/CCM.0000000000005089
    • Gijs, M., Veugen, J. M. J., Wolffs, P. F. G., Savelkoul, P. H. M., Tas, J., van Bussel, B. C. T., de Kruif, M. D., Henry, R. M. A., Webers, C. A. B., Dickman, M. M., & Nuijts, R. M. M. A. (2021). In-Depth Investigation of Conjunctival Swabs and Tear Fluid of Symptomatic COVID-19 Patients, an Observational Cohort Study. Translational Vision Science & Technology, 10(12), Article 32. https://doi.org/10.1167/tvst.10.12.32
    • Hulshof, A. M., Braeken, D. C. W., Ghossein-Doha, C., van Santen, S., Sels, J. W. E. M., Kuiper, G. J. A. J. M., van der Horst, I. C. C., ten Cate, H., van Bussel, B. C. T., Olie, R. H., & Henskens, Y. M. C. (2021). Hemostasis and fibrinolysis in COVID-19 survivors 6 months after intensive care unit discharge. Research and practice in thrombosis and haemostasis, 5(6), Article e12579. https://doi.org/10.1002/rth2.12579
    • Driessen, R. G. H., Kiers, D., Schalkwijk, C. G., Scheijen, J. L. J. M., Gerretsen, J., Pickkers, P., van de Poll, M. C. G., van der Horst, I. C. C., Bergmans, D. C. J. J., Kox, M., & van Bussel, B. C. T. (2021). Systemic inflammation down-regulates glyoxalase-1 expression: an experimental study in healthy males. Bioscience Reports, 41(7), Article BSR20210954. https://doi.org/10.1042/BSR20210954
    • Mulder, M. M. G., Brandts, LI., Brüggemann, R. A. G., Koelmann, M., Streng, A. S., Olie, R. H., Gietema, H. A., Spronk, H. M. H., van der Horst, I. C. C., Sels, J.-W. E. M., Wildberger, J. E., van Kuijk, S. M. J., Schnabel, R. M., Ten Cate, H., Henskens, Y. M. C., & van Bussel, B. C. T. (2021). Serial markers of coagulation and inflammation and the occurrence of clinical pulmonary thromboembolism in mechanically ventilated patients with SARS-CoV-2 infection; the prospective Maastricht intensive care COVID cohort. Thrombosis Journal, 19(1), Article 35. https://doi.org/10.1186/s12959-021-00286-7
    • van de Berg, T. W., Hulshof, A.-M. M., Nagy, M., van Oerle, R., Sels, J.-W., van Bussel, B., Ten Cate, H., Henskens, Y., Spronk, H. M. H., & Dutch Covid-19 and Thrombosis Coalition (2021). Suggestions for global coagulation assays for the assessment of COVID-19 associated hypercoagulability. Thrombosis Research, 201, 84-89. https://doi.org/10.1016/j.thromres.2021.02.026
    • Hulshof, A.-M., Brüggemann, R. A. G., Mulder, M. M. G., van de Berg, T. W., Sels, J.-W. E. M., Olie, R. H., Spaetgens, B., Streng, A. S., Verhezen, P., van der Horst, I. C. C., Ten Cate, H., Spronk, H. M. H., van Bussel, B. C. T., & Henskens, Y. M. C. (2021). Serial EXTEM, FIBTEM, and tPA Rotational Thromboelastometry Observations in the Maastricht Intensive Care COVID Cohort-Persistence of Hypercoagulability and Hypofibrinolysis Despite Anticoagulation. Frontiers in Cardiovascular Medicine, 8, Article 654174. https://doi.org/10.3389/fcvm.2021.654174
    • Bels, J. L. M., van Kuijk, S. M. J., Ghossein-Doha, C., Tijssen, F. H., van Gassel, R. J. J., Tas, J., Schnabel, R. M., Aries, M. J. H., van de Poll, M. M. G., Bergmans, D. C. J. J., Meex, S. J. R., van Mook, W. N. K. A., van der Horst, I. C. C., van Bussel, B. C. T., & MaastrICCht Collaborators (2021). Decreased serial scores of severe organ failure assessments are associated with survival in mechanically ventilated patients; the prospective Maastricht Intensive Care COVID cohort. Journal of Critical Care, 62, 38-45. https://doi.org/10.1016/j.jcrc.2020.11.006
    • Kaptein, F. H. J., Stals, M. A. M., Grootenboers, M., Braken, S. J. E., Burggraaf, J. L. I., van Bussel, B. C. T., Cannegieter, S. C., Ten Cate, H., Endeman, H., Gommers, D. A. M. P. J., van Guldener, C., de Jonge, E., Juffermans, N. P., Kant, K. M., Kevenaar, M. E., Koster, S., Kroft, L. J. M., Kruip, M. J. H. A., Leentjens, J., ... Dutch COVID & Thrombosis Coalition (2021). Incidence of thrombotic complications and overall survival in hospitalized patients with COVID-19 in the second and first wave. Thrombosis Research, 199, 143-148. https://doi.org/10.1016/j.thromres.2020.12.019
    • Raadsen, M., Du Toit, J., Langerak, T., van Bussel, B., van Gorp, E., & Goeijenbier, M. (2021). Thrombocytopenia in Virus Infections. Journal of Clinical Medicine, 10(4), Article 877. https://doi.org/10.3390/jcm10040877
    • van Gassel, R. J. J., Bels, J. L. M., Raafs, A., van Bussel, B. C. T., van de Poll, M. C. G., Simons, S. O., van der Meer, L. W. L., Gietema, H. A., Posthuma, R., & van Santen, S. (2021). High Prevalence of Pulmonary Sequelae at 3 Months after Hospital Discharge in Mechanically Ventilated Survivors of COVID-19. American Journal of Respiratory and Critical Care Medicine, 203(3), 371-374. https://doi.org/10.1164/rccm.202010-3823LE
  • 2020
    • Bruggemann, R. A. G., Spaetgens, B., Gietema, H. A., Brouns, S. H. A., Stassen, P. M., Magdelijns, F. J., Rennenberg, R. J., Henry, R. M. A., Mulder, M. M. G., van Bussel, B. C. T., Schnabel, R. M., van der Horst, I. C. C., Wildberger, J. E., Stehouwer, C. D. A., & ten Cate, H. (2020). The prevalence of pulmonary embolism in patients with COVID-19 and respiratory decline: A three-setting comparison. Thrombosis Research, 196, 486-490. https://doi.org/10.1016/j.thromres.2020.10.012
    • Schiffer, V. M. M. M., Janssen, E. B. N. J., van Bussel, B. C. T., Jorissen, L. L. M., Tas, J., Sels, J.-W. E. M., Bergmans, D. C. J. J., Dinh, T. H. T., van Kuijk, S. M. J., Hana, A., Mehagnoul-Schipper, J., Scheeren, C. I. E., Mesotten, D., Stessel, B., Marx, G., Hof, A. W. J. V. T., Spaanderman, M. E. A., van Mook, W. N. K. A., van der Horst, I. C. C., & Ghossein-Doha, C. (2020). The "sex gap" in COVID-19 trials: a scoping review. EClinicalMedicine, 29-30, Article 100652. https://doi.org/10.1016/j.eclinm.2020.100652
    • Busch, M. H., Timmermans, S. A. M. E. G., Nagy, M., Visser, M., Huckriede, J., Aendekerk, J. P., de Vries, F., Potjewijd, J., Jallah, B., Ysermans, R., Oude Lashof, A. M. L., Breedveld, P. H., van de Poll, M. C. G., van de Horst, I. C. C., van Bussel, B. C. T., Theunissen, R. O. M. F. I. H., Spronk, H. M. H., Damoiseaux, J. G. M. C., ten Cate, H., ... van Paassen, P. (2020). Neutrophils and Contact Activation of Coagulation as Potential Drivers of COVID-19. Circulation, 142(18), 1787-1790. https://doi.org/10.1161/CIRCULATIONAHA.120.050656
    • Streng, A. S., Delnoij, T. S. R., Mulder, M. M. G., Sels, J. W. E. M., Wetzels, R. J. H., Verhezen, P. W. M., Olie, R. H., Kooman, J. P., van Kuijk, S. M. J., Brandts, L., Ten Cate, H., Lorusso, R., van der Horst, I. C. C., van Bussel, B. C. T., & Henskens, Y. M. C. (2020). Monitoring of Unfractionated Heparin in Severe COVID-19: An Observational Study of Patients on CRRT and ECMO. TH open : companion journal to thrombosis and haemostasis, 4(4), e365-e375. https://doi.org/10.1055/s-0040-1719083
    • Aries, M., Segers, R., van Bussel, B., & van Mook, W. (2020). Transiently relieving visual impairment due to subcutaneous emphysema: a simple, bedside intervention. BMJ case Reports, 13(9), Article e232499. https://doi.org/10.1136/bcr-2019-232499
    • Wynants, L., Van Calster, B., Collins, G. S., Riley, R. D., Heinze, G., Schuit, E., Albu, E., Arshi, B., Bellou, V., Bonten, M. M. J., Dahly, D. L., Damen, J. A., Debray, T. P. A., de Jong, V. M. T., De Vos, M., Dhiman, P., Ensor, J., Gao, S., Haller, M. C., ... van Royen, F. S. (2020). Update to living systematic review (vol 369, m1328, 2020). BMJ, 369, Article m2204. https://doi.org/10.1136/bmj.m2204
    • Wynants, L., Van Calster, B., Collins, G. S., Riley, R. D., Heinze, G., Schuit, E., Bonten, M. M. J., Dahly, D. L., Damen, J. A. A., Debray, T. P. A., de Jong, V. M. T., De Vos, M., Dhiman, P., Haller, M. C., Harhay, M. O., Henckaerts, L., Heus, P., Kammer, M., Kreuzberger, N., ... van Smeden, M. (2020). Prediction models for diagnosis and prognosis of covid-19: systematic review and critical appraisal. BMJ, 369, Article m1328. https://doi.org/10.1136/bmj.m1328
    • Tas, J., van Gassel, R. J. J., Heines, S. J. H., Mulder, M. M. G., Heijnen, N. F. L., Acampo-de Jong, M. J., Bels, J. L. M., Bennis, F. C., Koelmann, M., Groven, R. V. M., Donkers, M. A., van Rosmalen, F., Hermans, B. J. M., Meex, S. J. R., Mingels, A., Bekers, O., Savelkoul, P., Oude Lashof, A. M. L., Wildberger, J., ... van Bussel, B. C. T. (2020). Serial measurements in COVID-19-induced acute respiratory disease to unravel heterogeneity of the disease course: design of the Maastricht Intensive Care COVID cohort (MaastrICCht). BMJ Open, 10(9), Article 040175. https://doi.org/10.1136/bmjopen-2020-040175
  • 2018
    • van Bussel, B. C. T., Henry, R. M. A., Schalkwijk, C. G., Dekker, J. M., Nijpels, G., Feskens, E. J. M., & Stehouwer, C. D. A. (2018). Alcohol and red wine consumption, but not fruit, vegetables, fish or dairy products, are associated with less endothelial dysfunction and less low-grade inflammation: the Hoorn Study. European Journal of Nutrition, 57(4), 1409-1419. https://doi.org/10.1007/s00394-017-1420-4
  • 2017
    • van Bussel, B. C. T., van de Poll, M. C. G., Schalkwijk, C. G., & Bergmans, D. C. J. J. (2017). Increased Dicarbonyl Stress as a Novel Mechanism of Multi-Organ Failure in Critical Illness. International journal of molecular sciences, 18(2), Article 346. https://doi.org/10.3390/ijms18020346
  • 2016
  • 2015
    • van Bussel, B. C. T., Henry, R. M. A., Ferreira, I., van Greevenbroek, M. M. J., van der Kallen, C. J. H., Twisk, J. W. R., Feskens, E. J. M., Schalkwijk, C. G., & Stehouwer, C. D. A. (2015). A Healthy Diet is Associated with Less Endothelial Dysfunction and Less Low-Grade Inflammation over a 7-Year Period in Adults at Risk of Cardiovascular Disease. Journal of Nutrition, 145(3), 532-540. https://doi.org/10.3945/jn.114.201236
    • van Bussel, F. C. G., van Bussel, B. C. T., Hoeks, A. P. G., op 't Roodt, J., Henry, R. M. A., Ferreira, I., Vanmolkot, F. H. M., Schalkwijk, C. G., Stehouwer, C. D. A., & Reesink, K. D. (2015). A Control Systems Approach to Quantify Wall Shear Stress Normalization by Flow-Mediated Dilation in the Brachial Artery. PLOS ONE, 10(2), Article e0115977. https://doi.org/10.1371/journal.pone.0115977
  • 2013
    • van Bussel, B. C. T., Soedamah Muthu, S. S., Henry, R. M., Schalkwijk, C. G., Ferreira, I., Chaturvedi, N., Toeller, M., Fuller, J. H., & Stehouwer, C. D. A. (2013). Unhealthy dietary patterns associated with inflammation and endothelial dysfunction in type 1 diabetes: The EURODIAB study. Nutrition Metabolism and Cardiovascular Diseases, 23(8), 758-764. https://doi.org/10.1016/j.numecd.2012.04.005
    • van Bussel, B. C. T., Ferreira, I., van de Waarenburg, M. P., van Greevenbroek, M. M. J., van der Kallen, C. J. H., Henry, R. M., Feskens, E. J., Stehouwer, C. D. A., & Schalkwijk, C. G. (2013). Multiple inflammatory biomarker detection in a prospective cohort study: a cross-validation between well-established single-biomarker techniques and an electrochemiluminescense-based multi-array platform.PLOS ONE, 8(3), Article 58576. https://doi.org/10.1371/journal.pone.0058576
    • van de Laar, R. J. J., Stehouwer, C. D. A., van Bussel, B. C. T., Prins, M. H., Twisk, J. W., & Ferreira, I. (2013). Adherence to a Mediterranean dietary pattern in early life is associated with lower arterial stiffness in adulthood: the Amsterdam Growth and Health Longitudinal Study.Journal of Internal Medicine, 273(1), 79-93. https://doi.org/10.1111/j.1365-2796.2012.02577.x
  • 2012
    • van de Laar, R. J. J., Stehouwer, C. D. A., van Bussel, B. C. T., te Velde, S. J., Prins, M. H., Twisk, J. W., & Ferreira, I. (2012). Lower lifetime dietary fiber intake is associated with carotid artery stiffness: the Amsterdam Growth and Health Longitudinal Study. American Journal of Clinical Nutrition, 96(1), 14-23. https://doi.org/10.3945/ajcn.111.024703
    • van Bussel, B. C. T., Henry, R. M., Schalkwijk, C. G., Dekker, J. M., Nijpels, G., & Stehouwer, C. D. A. (2012). Low-grade inflammation, but not endothelial dysfunction, is associated with greater carotid stiffness in the elderly: the Hoorn Study. Journal of Hypertension, 30(4), 744-752. https://doi.org/10.1097/HJH.0b013e328350a487
  • 2011
    • van Bussel, B. C. T., Schouten, F., Henry, R. M., Schalkwijk, C. G., de Boer, M. R., Ferreira, I., Smulders, Y. M., Twisk, J. W., & Stehouwer, C. D. A. (2011). Endothelial Dysfunction and Low-Grade Inflammation Are Associated With Greater Arterial Stiffness Over a 6-Year Period. Hypertension, 58(4), 588-595. https://doi.org/10.1161/HYPERTENSIONAHA.111.174557
    • van Bussel, B. C. T., Henry, R. M., Schalkwijk, C. G., Ferreira, I., Feskens, E. J., Streppel, M. T., Smulders, Y. M., Twisk, J. W., & Stehouwer, C. D. A. (2011). Fish consumption in healthy adults is associated with decreased circulating biomarkers of endothelial dysfunction and inflammation during a 6-year follow-up. Journal of Nutrition, 141(9), 1719-1725. https://doi.org/10.3945/jn.111.139733
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