Floor Heubel-Moenen

Post doc

Dr Floor Heubel-Moenen is an internist-hematologist and postdoctoral researcher at Maastricht University Medical Center+ (MUMC+), where she works within the Hemophilia Treatment Center (HBC) and the NFU-recognized Expertise Center for Hemophilia and Allied Bleeding Disorders. Her clinical and research focus lies in improving diagnostics and care for patients with mild or unexplained bleeding symptoms. Floor graduated in Medicine at Maastricht University and completed her specialist training in Internal Medicine and Hematology at MUMC+. She obtained her PhD in 2022 with her thesis ‘Diagnostics and Mechanisms of Hemostasis in patients with mild bleeding disorders and thrombocytopenia’, at Maastricht University. Her research focused on developing and validating novel diagnostic approaches for patients with mild bleeding disorders and unexplained bleeding.

Dr Floor Heubel-Moenen’s research line is firmly rooted in daily clinical practice. Starting from unmet diagnostic needs observed during outpatient consultations, she works to identify gaps in current diagnostic algorithms and translates these questions into targeted laboratory research. Her work spans from clinical phenotyping and standardized bleeding assessment tools to advanced hemostasis assays such as thrombin generation, ROTEM, and flow-based platelet function analysis. In recognition of this translational approach, she was awarded a Translate2Clinic Fellowship in 2024 by Maastricht University. This internal, competitive program supports researchers in bridging the gap between fundamental research and clinical implementation. The fellowship has support to expand her research line, supervise students, and translate innovation from bench to bedside. Floor coordinates the national multicenter BDUC-iN study and is an active member of the ISTH Scientific Subcommittee on von Willebrand Disease and BDUC. She collaborates with national and international experts to define BDUC as a distinct clinical entity and explore pathways for ICD-code recognition. She also contributes to national guideline development and co-leads educational initiatives on bleeding disorders. Through her combined role in clinical care, diagnostics, and translational research, she aims to build a sustainable line of innovation that improves the diagnostic process and personalized treatment of patients with bleeding symptoms.

Department of Internal Medicine - Hematology 
Maastricht UMC+, P. Debyelaan 25, 6229 HX Maastricht

T: +31(0)43 387 7976

  • 2025
    • Monard, A. L. L., Hellenbrand, D., Verhezen, P., Beckers, E. A. M., Henskens, Y. C. M., & Heubel-Moenen, F. C. J. I. (2025). tPA-ROTEM identifies hyperfibrinolytic profile in a significant proportion of patients with bleeding disorder of unknown cause (BDUC). Thrombosis Research, 253, Article 109404. https://doi.org/10.1016/j.thromres.2025.109404
    • Atiq, F., Blok, R., van Kwawegen, C., Hulshof, A.-M., Doherty, D., Lavin, M., van der Bom, J. G., O'Connell, N. M., de Meris, J., Ryan, K., Schols, S. E. M., van Heerde, W. L., Doyle, M. M., Byrne, M. B., Heubel-Moenen, F. C. J. I., van Galen, K. P. M., Preston, R. J. S., Cnossen, M. H., Fijnvandraat, K., ... O'Donnell, J. S. (2025). Clinical phenotype and pathophysiological mechanisms underlying qualitative Low VWF. Blood, 146(3), 369-381. https://doi.org/10.1182/blood.2024028035
    • Monard, A., Henskens, Y., & Heubel-Moenen, F. (2025). The diagnostic value of the platelet function analyzer in mild to moderate bleeding disorders. Journal of Thrombosis and Haemostasis, 23(7), 2116-2118. https://doi.org/10.1016/j.jtha.2025.03.041
    • Mussert, C. M. A., Monard, A. L. L., van Duijl, T. T., Henskens, Y. M. C., van den Biggelaar, M., Schutgens, R. E. G., Schols, S. E. M., Fijnvandraat, K. J., Meijer, K., den Exter, P. L., Nieuwenhuizen, L., van Moort, I., Kruip, M. J. H. A., Cnossen, M. H., Heubel-Moenen, F. C. J. I., & BDUC-iN Study group (2025). Current Practice Regarding Bleeding Disorders of Unknown Cause in the Netherlands: A National Survey. Haemophilia, 31(4), 752-760. https://doi.org/10.1111/hae.70065
    • Mansouritorghabeh, H., Monard, A., Heubel-Moenen, F., Leentjens, J., Stroobants, A., & Henskens, Y. (2025). The Utility of Total Thrombus-Formation Analysis System (T-TAS) in the Thrombosis and Hemostasis Field: A Scoping Review. International Journal of Laboratory Hematology, 47(2), 201-211. https://doi.org/10.1111/ijlh.14403
    • van Kwawegen, C. B., Pastoor, H., Eikenboom, J., Fijnvandraat, K., Ypma, P., Heubel-Moenen, F. C. J. I., van Galen, K. P. M., Mauser-Bunschoten, E. P., Meijer, K., Schols, S. E. M., Cnossen, M. H., van der Bom, J. G., de Meris, J., Atiq, F., Kruip, M. J. H. A., Leebeek, F. W. G., & WiN Study Group (2025). Sexuality and bleeding in von Willebrand disease. Research and practice in thrombosis and haemostasis, 9(2), Article e102712. https://doi.org/10.1016/j.rpth.2025.102712
    • van der Zwet, K., de Vos, A. D. W., Cnossen, M. H., Heubel-Moenen, F. C. J. I., Schols, S. E. M., Ypma, P. F., den Exter, P. L., Hooimeijer, H. L., Coppens, M., Mathôt, R. A. A., Janssen, A., Donners, A. A. M. T., Kruis, I., Urbanus, R. T., van Vulpen, L. F. D., Eckhardt, C. L., Schutgens, R. E. G., Fischer, K., Cnossen, M. H., ... Schutgens, R. E. G. (2025). Pharmacokinetic-guided dose reduction of emicizumab in congenital hemophilia A: interim analysis of the DosEmi study. Journal of Thrombosis and Haemostasis. Advance online publication. https://doi.org/10.1016/j.jtha.2025.10.029
  • 2024
    • Jooss, N. J., Diender, M. G., Fernandez, D. I., Huang, J., Heubel-Moenen, F. C. J., van der Veer, A., Kuijpers, M. J. E., Poulter, N. S., Henskens, Y. M. C., te Loo, M., & Heemskerk, J. W. M. (2024). Restraining of glycoprotein VI- and integrin α2β1-dependent thrombus formation by platelet PECAM1. Cellular and Molecular Life Sciences, 81(1), Article 44. https://doi.org/10.1007/s00018-023-05058-2
    • Monard, A. L. L., Mussert, C. M. A., van Duijl, T. T., Kruip, M. J. H. A., Henskens, Y. M. C., van den Biggelaar, M., Schutgens, R. E. G., Schols, S. E. M., Fijnvandraat, K. J., Meijer, K., den Exter, P. L., Nieuwenhuizen, L., van Moort, I., Baker, R. I., O'Donnell, J. S., Cnossen, M. H., Heubel-Moenen, F. C. J. I., & BDUC-iN Study group (2024). Bleeding disorder of unknown cause: an illustrated review on current practice, knowledge gaps, and future perspectives. Research and practice in thrombosis and haemostasis, 8(8), Article 102625. https://doi.org/10.1016/j.rpth.2024.102625
    • Monard, A., Castoldi, E., De Simone, I., Wichapong, K., van Duijl, T., van den Biggelaar, M., Spada, S., van Doorn, W., Hellenbrand, D., van der Meijden, P., Swieringa, F., Stork, A., ten Cate, H., Beckers, E., Heubel-Moenen, F., & Henskens, Y. (2024). Case Report: Laboratory detection of a thrombotic tendency in a family with hypodysfibrinogenemia and a novel FGG mutation. Frontiers in Cardiovascular Medicine, 11, Article 1488602. https://doi.org/10.3389/fcvm.2024.1488602
    • Mussert, C., Monard, A., & Heubel-Moenen, F. (2024). How to treat patients with bleeding disorder of unknown cause?Research and practice in thrombosis and haemostasis, 8(7), Article 102585. https://doi.org/10.1016/j.rpth.2024.102585
    • Haisma, B., Schols, S. E. M., van Oerle, R. G. M., Verbeek-Knobbe, K., Hellenbrand, D., Verwoerd, E. J., Heubel-Moenen, F. C. J. I., Stroobants, A. K., Meijer, D., Rijpma, S. R., & Henskens, Y. M. C. (2024). Comparative analysis of thrombin generation platforms for patients with coagulation factor deficiencies: A comprehensive assessment. Thrombosis Research, 240, Article 109045. https://doi.org/10.1016/j.thromres.2024.109045
    • Punt, M., van Leusden, F., Bloemenkamp, K., Coppens, M., Driessens, M., Heubel-Moenen, F., Lely, T., Mäkelburg, A., Nieuwenhuizen, L., Haitjema, S., van Solinge, W., Saes, J., Schols, S., Schutgens, R., Eikenboom, J., Kruip, M., & van Galen, K. (2024). Primary postpartum hemorrhage in women with von Willebrand disease and carriers of hemophilia: a retrospective analysis. Research and practice in thrombosis and haemostasis, 8(5), Article 102508. https://doi.org/10.1016/j.rpth.2024.102508
    • Baker, R. I., Choi, P., Curry, N., Gebhart, J., Gomez, K., Henskens, Y., Heubel-Moenen, F., James, P., Abdul Kadir, R., Kouides, P., Lavin, M., Lordkipanidze, M., Lowe, G., Mumford, A., Mutch, N., Nagler, M., Othman, M., Pabinger, I., Sidonio, R., ... ISTH SSC Von Willebrand Factor, Platelet Physiology and Women’s Health Issues in Thrombosis and Haemostasis. (2024). Standardization of definition and management for bleeding disorder of unknown cause: Communication from the SSC of the ISTH. Journal of Thrombosis and Haemostasis, 22(7), 2059-2070. https://doi.org/10.1016/j.jtha.2024.03.005
    • Monard, A., Thomas, W., & Heubel-Moenen, F. (2024). Bleeding disorders of unknown cause; the role of physiological anticoagulants. Thrombosis Research, 237, 216-217. https://doi.org/10.1016/j.thromres.2024.02.025
    • Atiq, F., Blok, R., van Kwawegen, C., Doherty, D., Lavin, M., van der Bom, J. G., O'Connell, N. M., de Meris, J., Ryan, K., Schols, S. E. M., Byrne, M. B., Heubel-Moenen, F. C. J. I., van Galen, K. P. M., Preston, R. J. S., Cnossen, M. H., Fijnvandraat, K., Baker, R. I., Meijer, K., James, P. D., ... O'Donnell, J. S. (2024). Type 1 VWD classification revisited - novel insights from combined analysis of the LoVIC and WiN studies. Blood, 143(14), 1414-1424. https://doi.org/10.1182/blood.2023022457
    • Goedhart, T. M. H. J., Bukkems, L. H., Zwagemaker, A. F., Coppens, M., Fijnvandraat, K., Schols, S. E. M., Schutgens, R. E. G., Eikenboom, J., Heubel-Moenen, F. C. J. I., Ypma, P. F., Nieuwenhuizen, L., Meijer, K., Leebeek, F. W. G., Mathôt, R. A. A., Cnossen, M. H., & OPTI-CLOT study group and SYMPHONY consortium (2024). Predictive performance of pharmacokinetic-guided prophylactic dosing of factor concentrates in hemophilia A and B. Research and practice in thrombosis and haemostasis, 8(3), Article 102397. https://doi.org/10.1016/j.rpth.2024.102397
    • Romano, L. G. R., Schütte, L. M., van Hest, R. M., Meijer, K., Laros-van Gorkom, B. A. P., Nieuwenhuizen, L., Eikenboom, J., Heubel-Moenen, F. C. J. I., Uitslager, N., Coppens, M., Fijnvandraat, K., Driessens, M. H. E., Polinder, S., Cnossen, M. H., Leebeek, F. W. G., Mathôt, R. A. A., Kruip, M. J. H. A., & DAVID and SYMPHONY Consortium (2024). Tachyphylaxis and reproducibility of desmopressin response in perioperative persons with nonsevere hemophilia A: implications for clinical practice. Research and practice in thrombosis and haemostasis, 8(3), Article 102367. https://doi.org/10.1016/j.rpth.2024.102367
    • Romano, L. G. R., Schutte, L. M., van Hest, R. M., Meijer, K., Laros-van Gorkom, B. A. P., Nieuwenhuizen, L., Eikenboom, J., Heubel-Moenen, F. C. J. I., Uitslager, N., Coppens, M., Fijnvandraat, K., Driessens, M. H. E., Polinder, S., Cnossen, M. H., Leebeek, F. W. G., Mathot, R. A. A., Kruip, M. J. H. A., & DAVID SYMPHONY Consortium (2024). Peri-operative desmopressin combined with pharmacokinetic-guided factor VIII concentrate in non-severe haemophilia A patients. Haemophilia, 30(2), 355-366. https://doi.org/10.1111/hae.14946
  • 2023
    • Van de Berg, T. W., Beckers, E. A. M., Heubel-Moenen, F. C. J. I., Henskens, Y. M. C., Thomassen, M. C. L. G. D., & Hackeng, T. M. (2023). Sensitive Measurement of Clinically Relevant Factor VIII Levels in Thrombin Generation Assays Requires Presence of Factor XIa. Thrombosis and Haemostasis, 123(11), 1034-1041. https://doi.org/10.1055/a-2101-7961
    • Brands, M. R., Janssen, E. A. M., Cnossen, M. H., Smit, C., van Vulpen, L. F. D., van der Valk, P. R., Eikenboom, J., Heubel-Moenen, F. C. J. I., Hooimeijer, L., Ypma, P., Nieuwenhuizen, L., Coppens, M., Schols, S. E. M., Laros-van Gorkom, B. A. P., Leebeek, F. W. G., Driessens, M. H. E., Rosendaal, F. R., van der Bom, J. G., Fijnvandraat, K., & Gouw, S. C. (2023). Transition readiness among adolescents and young adults with haemophilia in the Netherlands: Nationwide questionnaire study. Haemophilia, 29(5), 1191-1201. https://doi.org/10.1111/hae.14834
    • Romano, L. G. R., van Vulpen, L. F. D., den Exter, P. L., Heubel-Moenen, F. C. J. I., Hooijmeijer, H. L., Coppens, M., Fijnvandraat, K., Schols, S. E. M., Ypma, P. F., Smit, C., Driessens, M. H. E., Md, F. R. R., van der Bom, J. G., Gouw, S. C., & Kruip, M. J. H. A. (2023). Desmopressin in nonsevere hemophilia A: patient perspectives on use and efficacy. Research and practice in thrombosis and haemostasis, 7(5), Article 100281. https://doi.org/10.1016/j.rpth.2023.100281
    • Schaap, C. C. M., Heubel-Moenen, F. C. J. I., Nur, E., Bartels, M., van der Heijden, O. W. H., de Jonge, E., Preijers, F. W. M. B., Blijlevens, N. M. A., Langemeijer, S. M. C., & Dutch PNH Working Group (2023). Nationwide study of eculizumab in paroxysmal nocturnal hemoglobinuria: Evaluation of treatment indications and outcomes. European Journal of Haematology, 110(6), 648-658. https://doi.org/10.1111/ejh.13946
    • Kempers, E. K., van Kwawegen, C. B., de Meris, J., Spaander, M. C. W., Schols, S. E. M., Ypma, P. F., Heubel-Moenen, F. C. J. I., van Vulpen, L. F. D., Coppens, M., van der Bom, J. G., Fijnvandraat, K., Meijer, K., Eikenboom, J., Gouw, S. C., Leebeek, F. W. G., & Kruip, M. J. H. A. (2023). Colorectal cancer screening in patients with inherited bleeding disorders: high cancer detection rate in hemophilia patients. Journal of Thrombosis and Haemostasis, 21(5), 1177-1188. https://doi.org/10.1016/j.jtha.2022.12.004
    • Heubel-Moenen, F. C. J. I., Ansems, L. E. M., Verhezen, P. W. M., Wetzels, R. J. H., van Oerle, R. G. M., Straat, R. J. M. H. E., Megy, K., Downes, K., Henskens, Y. M. C., Beckers, E. A. M., & Joore, M. A. (2023). Effectiveness and costs of a stepwise versus an all-in-one approach to diagnose mild bleeding disorders. British Journal of Haematology, 200(6), 792-801. https://doi.org/10.1111/bjh.18570
  • 2022
    • Veninga, A., Handtke, S., Aurich, K., Tullemans, B., Brouns, S., Schwarz, S. L., Heubel-Moenen, F. C., Greinacher, A., Heemskerk, J. W. M., van der Meijden, P., & Thiele, T. (2022). GPVI expression is linked to platelet size, age, and reactivity. Blood advances, 6(14), 4162-4173. https://doi.org/10.1182/bloodadvances.2021006904
    • Heubel-Moenen, F. C. J. I., Brouns, S. L. N., Herfs, L., Boerenkamp, L. S., Jooss, N. J., Wetzels, R. J. H., Verhezen, P. W. M., Machiels, P., Megy, K., Downes, K., Heemskerk, J. W. M., Beckers, E. A. M., & Henskens, Y. M. C. (2022). Multiparameter platelet function analysis of bleeding patients with a prolonged platelet function analyser closure time. British Journal of Haematology, 196(6), 1388-1400. https://doi.org/10.1111/bjh.18003
    • Post, D. S., van der Veer, A., Schijns, O. E. M. G., Klinkenberg, S., Rijkers, K., Wagner, G. L., van Kranen-Mastenbroek, V. H. J. M., Willems, P. C. P. H., Verhezen, P. W. M., Beckers, E. A. M., Heubel-Moenen, F. C. J. I., & Henskens, Y. M. C. (2022). Assessment of need for hemostatic evaluation in patients taking valproic acid: A retrospective cross-sectional study. PLOS ONE, 17(2), Article e0264351. https://doi.org/10.1371/journal.pone.0264351
    • Goedhart, T. M. H. J., Bukkems, L. H., Coppens, M., Fijnvandraat, K. J., Schols, S. E. M., Schutgens, R. E. G., Eikenboom, J., Heubel-Moenen, F. C. J. I., Ypma, P. F., Nieuwenhuizen, L., Meijer, K., Leebeek, F. W. G., Mathôt, R. A. A., & Cnossen, M. H. (2022). Design of a Prospective Study on Pharmacokinetic-Guided Dosing of Prophylactic Factor Replacement in Hemophilia A and B (OPTI-CLOT TARGET Study). TH open : companion journal to thrombosis and haemostasis, 6(1), e60-e69. https://doi.org/10.1055/a-1760-0105
  • 2021
    • Herfs, L., Swieringa, F., Jooss, N., Kozlowski, M., Heubel-Moenen, F. C. J., van Oerle, R., Machiels, P., Henskens, Y., & Heemskerk, J. W. M. (2021). Multiparameter microfluidics assay of thrombus formation reveals increased sensitivity to contraction and antiplatelet agents at physiological temperature. Thrombosis Research, 203, 46-56. https://doi.org/10.1016/j.thromres.2021.04.014
    • Bukkems, L. H., Heijdra, J. M., de Jager, N. C. B., Hazendonk, H. C. A. M., Fijnvandraat, K., Meijer, K., Eikenboom, J. C. J., Laros-Van Gorkom, B. A. P., Leebeek, F. W. G., Cnossen, M. H., Mathôt, R. A. A., Coppens, K. F. M., Kruip, M. J. H. A., Polinder, S., Lock, J., Hazendonk, H. C. A. M., van Moort, I., Heijdra, J. M., Goedhart, M. C. H. J., ... OPTI-CLOT Study Group (2021). Population pharmacokinetics of the von Willebrand factor-factor VIII interaction in patients with von Willebrand disease. Blood advances, 5(5), 1513-1522. https://doi.org/10.1182/BLOODADVANCES.2020003891
    • Perrella, G., Huang, J., Provenzale, I., Swieringa, F., Heubel-Moenen, F. C. J., Farndale, R. W., Roest, M., van der Meijden, P. E. J., Thomas, M., Ariens, R. A. S., Jandrot-Perrus, M., Watson, S. P., & Heemskerk, J. W. M. (2021). Nonredundant Roles of Platelet Glycoprotein VI and Integrin αIIbβ3 in Fibrin-Mediated Microthrombus Formation. Arteriosclerosis Thrombosis and Vascular Biology, 41(2), E97-E111. https://doi.org/10.1161/ATVBAHA.120.314641
  • 2020
    • van Lier, Y. F., Davids, M., Haverkate, N. J. E., de Groot, P. F., Donker, M. L., Meijer, E., Heubel-Moenen, F. C. J. I., Nur, E., Zeerleder, S. S., Nieuwdorp, M., Blom, B., & Hazenberg, M. D. (2020). Donor fecal microbiota transplantation ameliorates intestinal graft-versus-host disease in allogeneic hematopoietic cell transplant recipients. Science Translational Medicine, 12(556), Article 8926. https://doi.org/10.1126/scitranslmed.aaz8926
    • Thaventhiran, J. E. D., Lango Allen, H., Burren, O. S., Rae, W., Greene, D., Staples, E., Zhang, Z., Farmery, J. H. R., Simeoni, I., Rivers, E., Maimaris, J., Penkett, C. J., Stephens, J., Deevi, S. V. V., Sanchis-Juan, A., Gleadall, N. S., Thomas, M. J., Sargur, R. B., Gordins, P., ... Smith, K. (2020). Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort. Nature, 584(7819), E2-E2. https://doi.org/10.1038/s41586-020-2556-6
    • Thaventhiran, J. E. D., Allen, H. L., Burren, O. S., Rae, W., Greene, D., Staples, E., Zhang, Z., Farmery, J. H. R., Simeoni, I., Rivers, E., Maimaris, J., Penkett, C. J., Stephens, J., Deevi, S. V. V., Sanchis-Juan, A., Gleadall, N. S., Thomas, M. J., Sargur, R. B., Gordins, P., ... Smith, K. G. C. (2020). Whole-genome sequencing of a sporadic primary immunodeficiency cohort. Nature, 583(7814), 90-95. https://doi.org/10.1038/s41586-020-2265-1
  • 2019
    • Heubel-Moenen, F. C. J. I., Henskens, Y. M. C., Verhezen, P. W. M., Wetzels, R. J. H., Schouten, H. C., & Beckers, E. A. M. (2019). Fibrinolysis in patients with chemotherapy-induced thrombocytopenia and the effect of platelet transfusion. Journal of Thrombosis and Haemostasis, 17(7), 1073-1084. https://doi.org/10.1111/jth.14465
    • Moenen, F. C. J., Vries, M. J. A., Nelemans, P. J., van Rooy, K. J. M., Vranken, J. R. R. A., Verhezen, P. W. M., Wetzels, R. J. H., ten Cate, H., Schouten, H. C., Beckers, E. A. M., & Henskens, Y. M. C. (2019). Screening for platelet function disorders with Multiplate and platelet function analyzer. Platelets, 30(1), 81-87. https://doi.org/10.1080/09537104.2017.1371290
  • 2018
    • Baaten, C. C. F. M. J., Moenen, F. C. J. I., Henskens, Y. M. C., Swieringa, F., Wetzels, R. J. H., van Oerle, R., Heijnen, H. F. G., ten Cate, H., Holloway, G. P., Beckers, E. A. M., Heemskerk, J. W. M., & van der Meijden, P. E. J. (2018). Impaired mitochondrial activity explains platelet dysfunction in thrombocytopenic cancer patients undergoing chemotherapy. Haematologica-the Hematology Journal, 103(9), 1557-1567. https://doi.org/10.3324/haematol.2017.185165
    • Moenen, F. C. J. I., Nelemans, P. J., Schols, S. E. M., Schouten, H. C., Henskens, Y. M. C., & Beckers, E. A. M. (2018). The diagnostic accuracy of bleeding assessment tools for the identification of patients with mild bleeding disorders: A systematic review. Haemophilia, 24(4), 525-535. https://doi.org/10.1111/hae.13486
  • 2016
    • Baaten, C. C. F. M. J., Moenen, F. C. J. I., Henskens, Y. M. C., Swieringa, F., Wetzels, R., van Oerle, R., ten Cate, H., Beckers, E. A. M., Heemskerk, J. W. M., & van der Meijden, P. E. J. (2016). Multiple functional defects in platelets from thrombocytopenic cancer patients undergoing chemotherapy. Thrombosis Research, 140S1, S171-S171. https://doi.org/10.1016/s0049-3848(16)30125-6
    • Moenen, F. C. J. I., Bakers, F. C. H., & Bos, G. (2016). Pancreatic atrophy after allogeneic peripheral blood stem cell transplantation. British Journal of Haematology, 172(2), 155-155. https://doi.org/10.1111/bjh.13643